Clinical trials: Community Pneumonia, active
Community-acquired Pneumonia
Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams
The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.
- Trial name
- AD-CAP (NCT07164131)
- Testing
- Doxycycline, Azithromycin
- Where
- 5 sites in United States
- Volunteers
- 1,120 people
- Sponsor
- Mayo Clinic
Covid19
Community Developed Technology-Based Messaging to Increase COVID-19 Vaccine Uptake Among People Who Inject Drugs
People who inject drugs (PWID) experience disproportionate risk of being infected with SARS-CoV-2, the virus that causes COVID-19, yet due to stigma, fear of mistreatment, and other factors, PWID are far less likely to be…
- Trial name
- NCT04924803
- Testing
- No video, Video Text
- Where
- United States
- Volunteers
- 545 people, healthy volunteers welcome
- Sponsor
- NDRI-USA, Inc.
Pneumocystis Jiroveci Pneumonia
Corticosteroids for PJP in Non-HIV Immunocompromised Adults
Pneumocystis jirovecii pneumonia (PJP) is one of the common severe complications in immunocompromised patients, with a reported mortality rate of 60-80%.
- Trial name
- CAPSTONE-PJP (NCT07152613)
- Testing
- Saline (0.9%, sterile, for infusion), Low Dose Corticosteroids, Moderate dose corticosteroids
- Volunteers
- 240 people
- Sponsor
- Qingyuan Zhan
Severe Community-acquired Pneumonia (sCAP)
Randomized Adaptive Platform Trial of Pathogen-Directed Anti-inflammatory Therapy in Severe Community-Acquired Pneumonia(Core Protocal)
Severe community-acquired pneumonia (sCAP) has a high mortality rate of 25-50%. Excessive host inflammatory responses contribute to poor outcomes.
- Trial name
- PANDA-SCAP (NCT07152587)
- Testing
- Low dose steroids, Moderate dose steroids, Saline (0.9% NaCl)
- Volunteers
- 1,500 people
- Sponsor
- Qingyuan Zhan
Community Acquired Pneumonia in Children, Mycoplasma Pneumoniae
A Trial of Placebo Versus Macrolide for Mycoplasma Pneumoniae Childhood Pneumonia: MYTHIC Study
The goal of this clinical trial is to compare a placebo (a look-alike substance that contains no active drug) with a commonly used antibiotic in children with Mycoplasma pneumoniae (a specific bacterium) induced…
- Conditions
- Community Acquired Pneumonia in Children, Mycoplasma Pneumoniae, Mycoplasma Pneumoniae Pneumonia
- Trial name
- MYTHIC (NCT06325293)
- Testing
- Azithromycin Pfizer®
- Where
- 13 sites in Switzerland
- Volunteers
- 376 people
- Sponsor
- Christoph Berger
Community-Acquired Pneumonia (CAP)
Clinical Trial of Fei Re Qing Granules in the Treatment of Elderly Community-Acquired Pneumonia
This study aims to evaluate the clinical efficacy of traditional Chinese medicine formula granules (Fei Re Qing Granules) in the treatment of elderly community-acquired pneumonia, establish a treatment protocol, and obtain…
- Trial name
- NCT06747325
- Testing
- Fei Re Qing Granules, Routine standard treatments
- Volunteers
- 120 people
- Sponsor
- Henan University of Traditional Chinese Medicine
COVID-19
Working Towards Empowered Community-driven Approaches to Increase Vaccination and Preventive Care Engagement
This study will optimize, implement, and test the impact of our multicomponent health program that includes three primary implementation strategies (Cultural Weavers and co-creation, mHealth strategies using culturally meaningful…
- Trial name
- WEAVE (NCT05841810)
- Testing
- mHealth Outreach, Care Coordination
- Where
- 4 sites in United States
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Community-acquired Pneumonia
Awake Prone Positioning of Patients Suffering Community Acquired Pneumonia Requiring Nasal High Flow Therapy
Community acquired pneumonia, in particular when requiring oxygen therapy because of acute hypoxemic respiratory failure and meeting acute respiratory distress syndrome (ARDS) criteria frequently leads to tracheal intubation and…
- Trial name
- PRONECAP (NCT06966310)
- Testing
- Prone position
- Where
- 38 sites in France
- Volunteers
- 1,078 people
- Sponsor
- University Hospital, Tours
Sepsis, Community Acquired Pneumonia (CAP)
OPT101 in Patients With Community Acquired Pneumonia (CAP) With Sepsis
OPT101-100-40 is a multicenter, randomized, placebo-controlled, multiple-ascending-dose, sequential-group, investigator- and participant-blinded, sponsor-unblinded, study of OPT101 vs placebo when administered for up to 4 days to…
- Trial name
- NCT06669403
- Testing
- OPT101
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Op-T LLC
Inflammation, Community Acquired Pneumonia (CAP)
Targeting Vascular INflammation in Patients With Community-Acquired Pneumonia
The goal of this clinical trial is to learn if icosapent ethyl (Vascepa) works to lessen the amount of inflammation in adults diagnosed with Community-Acquired Pneumonia (CAP).
- Conditions
- Inflammation, Community Acquired Pneumonia (CAP), Inflammation Plaque, Atherosclerotic
- Trial name
- TIN-CAP (NCT06710080)
- Testing
- Icosapent Ethyl 1000 MG Oral Capsule [Vascepa]
- Where
- Canada
- Volunteers
- 168 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Nosocomial Pneumonia, Community-acquired Pneumonia
High-dose Inhalations of Nitric Oxide in the Treatment of Pneumonia
This is a multicenter, prospective randomized controlled trial. At least 2 but no more than 5 centers are expected to participate in the study.
- Trial name
- NO PNEUMONIA (NCT06170372)
- Testing
- 200 ppm Nitric Oxide
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Community-acquired Pneumonia, Child, Only
Stopping Pneumonia Antibiotherapy Regimen Early
The hypothesis for this trial is that an antibiotic strategy for the management of non-severe community-acquired alveolar pneumonia in children aged 3 to 59 months, including amoxicillin 80-100 mg/kg/day for at least 3 days in…
- Trial name
- SPARE (NCT06291012)
- Testing
- Quick response: Amoxicillin for 3 days, Delayed response: Amoxicillin for 5 days, Quick response: Amoxicillin for 5 days
- Where
- France
- Volunteers
- 1,100 people
- Sponsor
- University Hospital, Montpellier
Pneumonia
Burden of Respiratory Viruses in India.
Trial Title: A Prospective Cohort Study To Compare The Burden Of Medically Attended and Community LRTI In Infants And Children Under 5 Years Of Age and adults (16-60 years) In India Primary Objectives: To determine the…
- Trial name
- NCT07403019
- Testing
- Nasopharyngeal swab for viral analysis
- Where
- India
- Volunteers
- 2,000 people
- Sponsor
- MAHAN Trust
COVID-19
Addressing Vaccine Acceptance in Carceral Settings Through Community Engagement
The goal of this study is to reduce morbidity and mortality from COVID-19 amongst people who are detained in and work in correctional facilities.
- Trial name
- NCT05796505
- Testing
- ADVANCE Steering Committee interventions
- Where
- United States
- Volunteers
- 37,122 people
- Sponsor
- Yale University
Community-Acquired Pneumonia, Fraility
Frailty and Outcomes in Older Emergency Department Patients With Pneumonia
Pneumonia is one of the leading causes of infection-related mortality in the older population. Traditional severity scores used in emergency departments, such as the Pneumonia Severity Index (PSI) and CURB-65, primarily focus on…
- Conditions
- Community-Acquired Pneumonia, Fraility, Hospitalizations
- Trial name
- NCT07442656
- Testing
- Clinical frailty scale, Clinical Frailty Scale (CFS)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ege University
Influenza A, Influenza B
Adaptive Platform Trial of Treatments for Respiratory Infections in Community Settings (TreatResp)
TreatResp is a double-blind, individually randomized, multi-centre adaptive platform trial. TreatResp aims to establish an adaptive platform trial aimed at evaluating the clinical- and cost-effectiveness, practical challenges…
- Conditions
- Influenza A, Influenza B, SAR-CoV-2, Acute Respiratory Infections (ARIs)
- Trial name
- TreatResp (NCT07314905)
- Testing
- Baloxavir
- Where
- Canada
- Volunteers
- 264 people
- Sponsor
- Unity Health Toronto
Respiratory Infection Virus, COVID -19
Preparedness Through Respiratory Virus Epidemiology and Community Engagement
The CHARM network will be established through three primary institutions-Beth Israel Deaconess Medical Center (BIDMC), the University of California San Diego (UCSD), and the University of Washington (UW)-along with their…
- Conditions
- Respiratory Infection Virus, COVID -19, RSV, FLU
- Trial name
- PREVENT (NCT07147517)
- Testing
- Component A0, Component A1, Component A2
- Where
- 2 sites in United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Acute Respiratory Infection
Expanded Diagnostic Strategy in Older Adults Hospitalized With Community-Acquired Acute Respiratory Infection
This study will evaluate whether an expanded diagnostic strategy can reduce antibiotic use in patients aged 65 years or older who are hospitalized with community-acquired acute respiratory infection, without negatively affecting…
- Trial name
- NeuBluMul (NCT07883902)
- Testing
- Expanded Diagnostic Strategy, Conventional Diagnostic Strategy
- Where
- Spain
- Volunteers
- 406 people
- Sponsor
- Santiago Lopez Gil
Pneumonia, Fungal Pneumonia
Derivation and Validation of the Fungal Pneumonia Assessment and Likelihood Predictor Score
The FUNGAL-P study is a single-center observational study designed to derive and validate a clinical prediction score for the early identification of fungal pneumonia in adult patients presenting with pneumonia.
- Conditions
- Pneumonia, Fungal Pneumonia, Aspergillosis Pneumonia, Pulmonary Aspergillosis
- Trial name
- FUNGAL-P (NCT07681583)
- Testing
- FUNGAL-P Score Assessment
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Community Acquired Pneumonia (CAP)
Comparing Hydrocortisone and Prednisolone for Community Acquired Pneumonia (CAP)
The goal of this cluster randomized controlled trial is to determine the optimal treatment for community aquired pneumonia (CAP).
- Trial name
- NCT06892197
- Testing
- Methylprednisolone (drug), hydrocortisone
- Where
- 14 sites in Denmark
- Volunteers
- 1,600 people
- Sponsor
- Copenhagen Respiratory Research