Clinical trials: Comorbidities
Health Services, Comorbidity
Ambulatory ICU Study for Medically and Socially Complex Patients
This is a prospective randomized wait-list control study to determine whether a stand-alone, co-located team of physician, mental health behaviorist, and care coordinators with decreased panel size (aka "intensive primary care")…
- Conditions
- Health Services, Comorbidity, Primary Health Care
- Trial name
- SUMMIT (NCT03224858)
- Testing
- SUMMIT intervention, Enhanced usual care
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Chronic Kidney Failure, Chronic Kidney Disease stage3
Pathophysiological Characterization of the Neuromuscular Function of a Population With Multiple Comorbidities Suffering From Chronic Renal Failure in Pre-dialysis.
The evolution of chronic kidney disease (CKD) causes a systemic upheaval on the body and a deep fatigue is very often described by patients (50-70% of the patients) even before the start of dialysis (pre-dialysis).
- Conditions
- Chronic Kidney Failure, Chronic Kidney Disease stage3, Chronic Kidney Disease, Stage 4 (Severe), Chronic Kidney Disease Stage 5
- Trial name
- PIONNIER (NCT03998917)
- Testing
- Discrimination of neuromuscular alterations protocol
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier le Mans
Myocardial Infarction, Comorbidity
Web-Enhanced Guideline Implementation for Post MI CBOC Patients
To assist busy primary care clinicians in VA Community Based Outpatient Clinics (CBOCs) in managing complex patients by providing a single, interactive, and personalized source of information regarding applicable guidelines for…
- Trial name
- VA MI Plus (NCT00126750)
- Testing
- VA MI Plus Interactive
- Where
- 41 sites in United States, Puerto Rico
- Volunteers
- 847 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Eczema, Psoriasis
Non-invasive Photoacoustic Imaging of Skin Inflammatory Disorders With Machine Learning-assisted Scoring
Inflammatory skin disorders are usually assessed by disease scoring system such as Scoring AD (SCORAD)/Eczema Area and Severity Index (EASI) and Psoriasis Area and Severity Index (PASI) for atopic eczema and psoriasis…
- Trial name
- NCT04809571
- Testing
- Photoacoustic imaging and Confocal Raman spectroscopy measurement
- Where
- Singapore
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Institute of Bioengineering and Bioimaging (IBB)
Atopic Dermatitis Eczema, Atopic Dermatitis
Trends in the Epidemiology and Treatment of Atopic Dermatitis in the United Kingdom (UK)
Atopic dermatitis (AD), commonly called eczema, is one of the most frequently occurring skin conditions. It is estimated to affect around one fifth of children in developed countries and is also becoming increasingly common in…
- Conditions
- Atopic Dermatitis Eczema, Atopic Dermatitis, Eczema
- Trial name
- NCT03823794
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 148,166 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Tobacco Use Disorder, Schizophrenia
Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia
The objective of this study is to investigate the relative contributions of nicotine replacement and sensorimotor replacement (i.e., smoking denicotinized cigarettes) on abstinence-induced smoking urges, withdrawal-related…
- Trial name
- NCT01213524
- Testing
- sensorimotor replacement, 42 mg transdermal nicotine replacement, usual brand smoking
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Brown University
Obese With Comorbidities, Overweight With Comorbidities
Study for Multiple Doses of HM15136(Efpegerglucagon) in Obese or Overweight Subjects With Comorbidities
The planned period of each cohort is 22 weeks including subject screening, treatments for 12 weeks, and follow up period.
- Conditions
- Obese With Comorbidities, Overweight With Comorbidities, Type2 Diabetes
- Trial name
- NCT04167553
- Testing
- HM15136
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Binge Eating Disorder, Cognitive Therapy/Methods
Psychological Treatment of Overweight Binge Eaters
Cognitive-behavioral therapy (CBT) has documented efficacy for the treatment of binge eating disorder (BED). Interpersonal psychotherapy (IPT) has been shown to reduce binge eating but its long-term impact and time course on…
- Conditions
- Binge Eating Disorder, Cognitive Therapy/Methods, Mental Disorders/Epidemiology, Obesity/Epidemiology
- Trial name
- NCT01208272
- Testing
- Cognitive Behavioral Therapy (CBT), Interpersonal Therapy (IPT)
- Where
- 2 sites in United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Diabetes Mellitus, Hypertension
An International Prospective, Observational, Multi-centre Study on the Duration of Pre-operative Liquid Fasting
The investigators will be performing an international prospective, observational, multi-centre, cross-sectional study to determine the actual duration of preoperative liquid fasting time in European patients.
- Conditions
- Diabetes Mellitus, Hypertension, Ischaemic Heart Disease, Comorbidities and Coexisting Conditions
- Trial name
- THIRST (NCT06527703)
- Testing
- no intervention
- Where
- Malta
- Volunteers
- 5,100 people, healthy volunteers welcome
- Sponsor
- Mater Dei Hospital, Malta
Cancer, Cancer Comorbidities
The Cancer Stage Shifting Initiative: Registry and Biorepository to Research and Address Health Disparities in Cancer Care
The goal of this observational study is to establish a patient registry and a biorepository (sample collection and storage) to investigate health disparities, access, and barriers to cancer screening and early detection…
- Trial name
- CSSI (NCT07461493)
- Where
- 2 sites in United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- National Minority Quality Forum
Surgery, Surgery--Complications
Patterns and Outcomes of Neurosurgery in England Over a Five-year Period
Neurosurgical practice has seen many important changes over several decades with advances in treatments and the types of patients treated.
- Conditions
- Surgery, Surgery--Complications, Neurological Morbidity, Neurological Diseases or Conditions
- Trial name
- NCT05097066
- Testing
- Neurosurgical procedure
- Volunteers
- 371,418 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Facial Pain, Comorbidity
Somatosensory Investigation of Orofacial Pain Patients
Orofacial pain, specially neuropathic orofacial pain, is a challenge of diagnosis and treatment in orofacial pain. It is associated with sensory abnormalities.With increasing life expectancy of the population is more and more…
- Conditions
- Facial Pain, Comorbidity, Neuralgia
- Trial name
- QST (NCT02910336)
- Testing
- Quantitative Sensory Testing
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Metabolic Disturbance
Concurrent Training and Prediabetes Control
Despite exercise training decrease blood fasting glicaemy in 'average' terms, there is a wide inter-individual variability after exercise training explored mainly in adults but not in adults with prediabetes comorbidities.
- Trial name
- NCT03502304
- Testing
- Endurance training plus resistant training
- Where
- Chile
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas
Lichen Sclerosus
Genital Lichen Sclerosus - Epidemiology, Comorbidities and the Role of Vulvar and Penile Microbiome
In genital LSc, three pathological processes are implicated in disease development: inflammation, sclerosis/fibrosis and neoplasia. The role of genital microbiome is still to be investigated and explained.
- Trial name
- NCT05671263
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Region Jönköping County
HIV Infection Primary
Assessing Differential Adherence to Medications and Quality of Life Among People Living With HIV and Comorbidities
The investigators propose to utilize quantitative and qualitative methodology to better understand the impact of multiple drug use (polypharmacy) on medication adherence as well as the driving forces behind differential adherence…
- Trial name
- TEAMH (NCT03387397)
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Type 2 Diabetes
Type 2 Diabetes, Cardiovascular Comorbidity and Environmental Temperature
Both high and low environmental temperatures are associated worldwide with higher morbidity and mortality and an estimated 8% of the mortality is estimated to relate to non-optimum temperatures.
- Trial name
- DiabColdHeat (NCT04698200)
- Testing
- Cold exposure
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Depression, Anxiety
Description of the Lived Experiences of Family Caregivers for People With Mental Health Comorbidities
Mental health problems such as depression, trauma and anxiety are common in low-resource contexts, such as Zambia. Comorbidity, or having multiple mental health problems, is the norm.
- Conditions
- Depression, Anxiety, Trauma
- Trial name
- MCE (NCT07760701)
- Where
- Zambia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Heart Defects, Congenital
Impact of Congenital Heart Disease on Neurodevelopmental Outcome
The project aims toward clarifying the underlying mechanism and the long-term impact of congenital heart disease on neurodevelopment.
- Trial name
- NCT03871881
- Testing
- Magnetic Resonance Imaging, Neuropsychological assessment
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Multiple Sclerosis, Relapsing-Remitting
Physical Activity, Sedentary Behaviour and Cardiometabolic Health in Multiple Sclerosis
This study evaluates the association between sedentary behaviour, physical activity, and the cardiometabolic health of Multiple Sclerosis via several cardiovascular, metabolic and anthropometric parameters.
- Trial name
- NCT05752630
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Heart Failure, ADHF
Care Coordination to Assess Improvement in Outcomes in Hospital Readmissions
Heart failure is a syndrome that is defined by distinctive clinical, hemodynamic, and neurohormonal findings. HF represents a final common pathway for many different cardiovascular diseases, including coronary disease…
- Conditions
- Heart Failure, ADHF, Acute MI
- Trial name
- COMPASSION (NCT04905160)
- Testing
- COMPASSION Digital Biomarker
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Aventyn, Inc.