Clinical trials: Comorbidity
Coronary Artery Disease, Cardiac Rehabilitation
Electronic Cardiac Rehabilitation (eCardiacRehab) Feasibility Study
In Norway, more than 11,000 patients undergo percutaneous coronary intervention (PCI) annually. However, a very recent study utilizing registry data show a national average of cardiac rehabilitation (CR) participation of only…
- Conditions
- Coronary Artery Disease, Cardiac Rehabilitation, Ethics, Continuity of Patient Care
- Trial name
- eCardiacRehab (NCT06759805)
- Testing
- eCardiacRehab
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Haukeland University Hospital
Comorbidities and Coexisting Conditions, Ethics
eCardiacRehab - a Hybrid Patient-Centered eHealth Programme
The overall aim of eCardiacRehab trial is to meet rehabilitation needs of patients with coronary artery disease (CAD) regardless of their access to traditional place-based rehabilitation by developing and evaluating the efficacy…
- Conditions
- Comorbidities and Coexisting Conditions, Ethics, Continuity of Patient Care, Older Adults (65 Years and Older)
- Trial name
- eCardiacRehab (NCT07590635)
- Testing
- eCardiacRehab
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- Haukeland University Hospital
Kidney Transplant Access, Obese Patients
Access to Kidney Transplant of Obese Patients Beginning Dialysis
Obesity is in constant increase all over the world and affects 35% of the global population according to the World Health Organisation.
- Conditions
- Kidney Transplant Access, Obese Patients, Dialysis, Comorbidities
- Trial name
- Transplantob (NCT04748770)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Bladder Cancer, Comorbidity
Impact of COMORBIDities After Radical Cystectomy Using a Predictive Method With Artificial Intelligence
Clinician and the multidisciplinary team meeting in oncologic urology (MMO) play a key-role in the decision making. An unexplained surgeon attributable variance, probably linked to the subjective "eyeball test" effect, was…
- Conditions
- Bladder Cancer, Comorbidity, Deep Learning
- Trial name
- COMORBID-AI (NCT05204186)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Weight Loss, Adverse Events
The IGBallon (R) - for Use in the Treatment of Obesity
This study is a prospective, non-randomized, open-label, single-center study. The aim of this study is to assess the safety of the IGballoon in the human body.
- Conditions
- Weight Loss, Adverse Events, Comorbidities
- Trial name
- IGBallon (NCT07647991)
- Testing
- IGBalloon
- Where
- Austria
- Volunteers
- 5 people
- Sponsor
- Medical University of Vienna
Obesity, Sarcopenia
Effectiveness of Combined GLP-1/GIP Dual Agonist Therapy and Structured Exercise on Skeletal Muscle Morphology, Quality, and Physical Function in Overweight and Obese Individuals
This randomized controlled trial aims to investigate the effects of a 24-week home-based progressive resistance exercise program combined with tirzepatide treatment on skeletal muscle mass, muscle quality, and functional capacity…
- Conditions
- Obesity, Sarcopenia, Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities
- Trial name
- NCT07609160
- Testing
- Resistance exercise, Lifestyle recommendations
- Volunteers
- 108 people
- Sponsor
- Acibadem University
Asthma Bronchiale, Breast Neoplasms
Digital Implementation of the German S3 Clinical Practice Guideline for Multimorbidity
The web application gp-multitool.de is a digital tool for implementing the German S3 clinical practice guideline for multimorbidity of the German Society of General Practitioners and Family Physicians in primary care.
- Conditions
- Asthma Bronchiale, Breast Neoplasms, Coronary Disease, Diabetes Mellitus, Type 2
- Trial name
- NCT06831994
- Testing
- gp-multitool.de
- Where
- Germany
- Volunteers
- 659 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
AIDS (Acquired Immunodeficiency Syndrome), Cardiovascular and Cerebrovascular Diseases
BRAZILIAN REGISTRY OF CHRONIC NON-COMMUNICABLE DISEASES IN PEOPLE LIVING WITH HIV/AIDS
BRAVO proposes the establishment of a comprehensive registry of chronic noncommunicable diseases (NCDs), providing crucial data for the formulation of effective health policies for people living with HIV/AIDS (PLWHA).
- Conditions
- AIDS (Acquired Immunodeficiency Syndrome), Cardiovascular and Cerebrovascular Diseases, Respiratory Comorbidities, Chronic Kidney Disease
- Trial name
- BRAVO (NCT07118683)
- Where
- 9 sites in Brazil
- Volunteers
- 743 people
- Sponsor
- Hospital Alemão Oswaldo Cruz
Pulmonary Arterial Hypertension (PAH), Comorbidities
COMMODITIES Trial: Initial Dual Oral Therapy vs Monotherapy in PAH With Cardiovascular Comorbidities
Pulmonary arterial hypertension (PAH) is a rare, progressive disease associated with poor prognosis, especially in patients with cardiovascular comorbidities.
- Conditions
- Pulmonary Arterial Hypertension (PAH), Comorbidities, Cardiovascular Disease (CVD)
- Trial name
- COMMODITIES (NCT07245680)
- Testing
- Tadalafil, Ambrisentan
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Toxicant Induced Chronic Multisymptom Illness and Associated Symptoms and Comorbidities
Mitigating Toxic Impact: The Role of Coenzyme Q10 in Post-Exposure Protection
This research study is being conducted to see if coenzyme Q10 (a nutritional supplement) might help to prevent and/or alleviate symptoms and health consequences and help to improve quality of life and physical function in…
- Trial name
- NCT06962657
- Testing
- Ubiquinone 100 mg Oral Soft Gel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Rectal Cancer, Comorbidities and Coexisting Conditions
Watch and Wait Management on Rectal Cancer Patients Using New Swift Local Therapy
Within our institution, the principal investigator have acquired expertise in endorectal brachytherapy, a localized treatment for colorectal cancer.
- Conditions
- Rectal Cancer, Comorbidities and Coexisting Conditions, Inoperable Disease, Brachytherapy
- Trial name
- Whistle (NCT04336202)
- Testing
- External beam radiotherapy + Endorectal brachytherapy
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Opioid-Related Disorders, Relationship, Professional Patient
A4i-O: A Platform for Complex Behavioral Health to Address OUD
For the purposes of beta testing the first version of A4i-O, 15 individuals with OUD will use the platform for one month. From a design perspective this sample size is viewed as being sufficient to answer questions regarding app…
- Conditions
- Opioid-Related Disorders, Relationship, Professional Patient, Mental Health Wellness 1, Mobile Phone Use
- Trial name
- NCT06215963
- Testing
- App for Independence-O (A4i-O)
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Centre for Addiction and Mental Health
Back Pain, Neck Pain
Exploring Multimorbidity in Patients With Spinal Pain
Spinal pain is frequently accompanied by other chronic conditions (multimorbidity) and the predicted rise in multimorbidity prevalence emphasizes the need for studies to understand its impact on patients with chronic pain…
- Conditions
- Back Pain, Neck Pain, Comorbidities and Coexisting Conditions
- Trial name
- NCT06402409
- Where
- Denmark
- Volunteers
- 2,000 people
- Sponsor
- Jacob Christiansen Gandløse
Hypertension, Diabete Type 2
Comorbidity-Oriented Primary Care and Integrated Management for Hypertension and Diabetes Mellitus
The COMPACT-HTDM study is a parallel, two-arm cluster randomized controlled trial designed to evaluate a comorbidity-oriented integrated primary care management model for elderly patients with coexisting hypertension and type 2…
- Conditions
- Hypertension, Diabete Type 2, Comorbidities and Coexisting Conditions
- Trial name
- COMPACT-HTDM (NCT07528391)
- Testing
- Integrated Comorbidity Management Package, Usual Care intervention
- Volunteers
- 960 people
- Sponsor
- Nanchang University
Heart Failure With Preserved Ejection Fraction, Sarcopenia
Effectiveness of a Cardiac Rehabilitation Program in Elderly Patients With Heart Failure.
The main objective of the study is to assess the effectiveness of a cardiac rehabilitation program on functionality, measured by kinematic analysis, cardiorespiratory capacity, and ventricular ejection fraction in elderly…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Sarcopenia, Frail Elderly Syndrome, Comorbidities and Coexisting Conditions
- Trial name
- FUNNEL+ (NCT05393362)
- Testing
- Cardiac Rehabilitation Program (CR), Control Group (CG)
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- University of Malaga
Cancer, Cancer Comorbidities
The Cancer Stage Shifting Initiative: Registry and Biorepository to Research and Address Health Disparities in Cancer Care
The goal of this observational study is to establish a patient registry and a biorepository (sample collection and storage) to investigate health disparities, access, and barriers to cancer screening and early detection…
- Trial name
- CSSI (NCT07461493)
- Where
- 2 sites in United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- National Minority Quality Forum
Depression and Quality of Life, Treatment Resistant Depression (TRD)
Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression
This observational study investigates the use of Esketamine Intranasal Spray in patients with Treatment-Resistant Depression in Real-World Settings.
- Conditions
- Depression and Quality of Life, Treatment Resistant Depression (TRD), Anhedonia, Apathy
- Trial name
- ESKPSY (NCT07146503)
- Testing
- Esketamine (Intranasal Spray)
- Where
- 5 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Riccardo Guglielmo
Obesity, Type 2 Diabetes Mellitus
Safety and Effectiveness of Tirzepatide in Patients With Obesity at Hospital de Clínicas, Paraguay
This is a Phase 4 observational study evaluating the safety and effectiveness of tirzepatide (T.G.) manufactured by INDUFAR S.A.
- Conditions
- Obesity, Type 2 Diabetes Mellitus, Overweight With Comorbidities
- Trial name
- NCT07492563
- Testing
- Tirzepatide (T.G.)
- Where
- Paraguay
- Volunteers
- 300 people
- Sponsor
- LABORATORIOS INDUFAR
Obesity, Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities
Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1)
This Phase 3 study evaluates the efficacy and safety of once-weekly subcutaneous tirzepatide (a dual GIP and GLP-1 receptor agonist) at 5 mg, 10 mg, or 15 mg versus placebo, each used with a reduced-calorie diet and increased…
- Trial name
- SURMOUNT-1 (NCT07481747)
- Testing
- Tirzepatide, Reduced-calorie diet
- Where
- China
- Volunteers
- 2,539 people
- Sponsor
- Hudson Biotech