Clinical trials: Comorbidity
Obesity, Overweight, or Chronic Weight Management
A Phase 2b, Dose-range Finding Study of the Efficacy and Safety of Multiple Doses of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity
This study is a randomized, double-blind, placebo-controlled, dose-range finding study of the efficacy, safety, tolerability, PK, and PD of multiple doses of aleniglipron in participants living with overweight or obesity with at…
- Trial name
- ACCESS (NCT06693843)
- Testing
- Aleniglipron
- Where
- 39 sites in United States
- Volunteers
- 230 people
- Sponsor
- Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Colon Cancer, Malnutrition
The Patient in Laparoscopic Colon Surgery:Impact of Comorbidities,Frailty,Malnutrition and Sarcopenia on Short-term Mortality
There are many factors involved in outlining the patient's profile and in defining which factors can be configured as risks related to the surgical act; for the modern surgeon it is no longer possible to identify the patient at…
- Conditions
- Colon Cancer, Malnutrition, Sarcopenia, Comorbidities and Coexisting Conditions
- Trial name
- NCT04729738
- Where
- Italy
- Volunteers
- 420 people
- Sponsor
- University Hospital of Ferrara
Lower Urinary Tract Symptoms, Pelvic Organ Prolapse
Population-based Estimates of Medical Comorbidities in Women With Lower Urinary Tract Symptoms or Pelvic Organ Prolapse
The purpose of this study is to investigate the comorbidities of lower urinary tract symptoms or pelvic organ prolapse in a nationwide population-based data in Taiwan during the study period of 2001-2010, a total of 10 years.
- Trial name
- NCT01590576
- Where
- Taiwan
- Volunteers
- 2,500 people
- Sponsor
- Far Eastern Memorial Hospital
Behavioral Health With Medical Comorbidities
Dashboards for Clinician Monitoring of Patients Through a Mobile Sensing Platform
The purpose of this study is to determine whether the use of a mobile sensing platform in a primary care setting has an effect on provider workflows, patient outcomes, patient engagement, patient self-help behavior, health…
- Trial name
- NCT02167373
- Testing
- Cogito Companion Intervention, mobile phone application
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Cogito Health Inc
HIV/AIDS, Depression
Tailored Response to Psychiatric Comorbidity to Improve HIV Care Engagement in the United States
This pilot randomized clinical trial will randomize 60 participants 1:1 to either enhanced usual care or to adapted Common Elements Treatment Approach (CETA), a counseling intervention for HIV care engagement plus depression…
- Conditions
- HIV/AIDS, Depression, Anxiety, Post-traumatic Stress Disorder
- Trial name
- TRACE (NCT04163341)
- Testing
- Adapted Common Elements Treatment Approach
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Michael J Mugavero, MD
Elderly, Emergency Hospitalization
Validation of the Hospital Frailty Score in France
Older people are increasing users of health care globally. Constraints in bed capacity and resources raise important challenges with regards to management of older people with complex needs, which usually require assertive and…
- Conditions
- Elderly, Emergency Hospitalization, Frailty
- Trial name
- HFRS France (NCT03905629)
- Testing
- None (retrospective observational study)
- Where
- France
- Volunteers
- 1,000,000 people
- Sponsor
- Hospices Civils de Lyon
Erectile Dysfunction, Cardiovascular Diseases
Echocardiography in Men With Erectile Dysfunction
Cardiovascular disease is the leading cause of morbidity and mortality in the world. To curb disease development, there is, therefore, a need to identify more people at increased risk.
- Conditions
- Erectile Dysfunction, Cardiovascular Diseases, Cardiac Disease
- Trial name
- NCT05285280
- Testing
- Echocardiography
- Where
- Denmark
- Volunteers
- 386 people
- Sponsor
- Herlev and Gentofte Hospital
Multimorbidity, Comorbidity
Use of a Hypercaloric and Hyperprotein Supplement Enriched with Immunonutrients in Multi-pathological Malnourished Patients to Improve the Incidence and Prevalence of Pressure Sores
The goal of this study is to evaluate the efficacy of a hypercaloric, hyperproteic enteral formula enriched with immunonutrients in preventing and treating pressure injuries in hospitalized malnourished patients.
- Conditions
- Multimorbidity, Comorbidity, Malnutrition, Pressure Ulcer Prevention
- Trial name
- NCT06726486
- Testing
- Atémpero, Control (Standard treatment)
- Where
- Spain
- Volunteers
- 69 people
- Sponsor
- University of Cadiz
Colorectal Cancer
First-Line Capecitabine and Cetuximab for Metastatic Colorectal Ca in Elderly Patients
This is a Phase II clinical trial measuring the effectiveness of the combination of Capecitabine and cetuximab for first line treatment of colorectal cancer in elderly patients and/or those with multiple comorbidities unable to…
- Trial name
- NCT00251186
- Testing
- Capecitabine and Cetuximab
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Smoking
HIV-1 and Brain Interaction on Smoking Comorbidity
People living with HIV-1 have high rates of cigarette smoking, which may be related to nicotinic interaction with HIV-1 infection and brain function levels.
- Trial name
- NCT03308331
- Testing
- Tobacco smoking and nicotine patch
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Pregnancy, Smoking Behavior
HISTOLOGICAL RESULTS IN TRANSGENDER INDIVIDUALS ASSIGNED TO FEMALES AT BIRTH UNDERGOING GENDER AFFIRMATION SURGERY AND IN TESTOSTERONE THERAPY
The aim of this study is to report histological results of genital organs removed during gender affirmg surgery in transgender people assigned female at birth (AFAB), to increase the knowledge about the long-term effects of…
- Conditions
- Pregnancy, Smoking Behavior, Testosterone Replacement Therapy, Drugs
- Trial name
- NCT06710496
- Testing
- analysis of medical records
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Diabetes Mellitus, Hypertension
Strengthening Primary Healthcare Delivery for Diabetes and Hypertension in Eswatini
The WHO-PEN@Scale project is a three-arm cluster-randomized trial that is investigating the population-level effects of a healthcare reform in Eswatini, which aims to strengthen primary care for diabetes and hypertension.
- Trial name
- NCT04183413
- Testing
- DSD, CDP
- Where
- Eswatini
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
COVID-19
The LUSZ COVID-19 Severity Index: A Prognostic and Predictive Score of Mortality for Hospitalized Patients With Covid-19
The coronavirus disease 2019 (COVID-19) has spread rapidly and caused a global pandemic, as defined by the WHO, within a short period of time.
- Trial name
- LUSZ_SCORE (NCT05848427)
- Testing
- LUSZ P
- Where
- 2 sites in Lebanon
- Volunteers
- 1,000 people
- Sponsor
- Lebanese University
Posttraumatic Stress Disorder, Depression
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
The overarching goal of this UH2-UH3 proposal is to work with the NIH Health Care Systems Research Collaboratory to develop and implement a large scale, cluster randomized pragmatic clinical trial demonstration project that…
- Conditions
- Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation
- Trial name
- TSOS6 (NCT02655354)
- Testing
- Motivational Interviewing, Cognitive Behavioral Therapy Elements, Care Management
- Where
- 24 sites in United States
- Volunteers
- 635 people
- Sponsor
- University of Washington
Cardiovascular Diseases
The LEARN Study for CVD Prevention
The investigator is testing a virtual environment (VE) to address prevention of HIV-related comorbidities.
- Trial name
- LEARN (NCT05242952)
- Testing
- Gaming in a virtual environment
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yale University
Severe Asthma
"SEVERE ASTHMA" in the COMMUNITY
SEVERE ASTHMA IN THE COMMUNITY- BACKGROUND Severe asthma is a common problem. In the world approximately 300 million people have asthma but it is estimated that only 5% of these patients have severe asthma.
- Trial name
- NCT01961258
- Testing
- Computerized data base analysis and sampling of patients for outpatient clinic evaluation
- Volunteers
- 250 people
- Sponsor
- Meir Medical Center
Posttraumatic Stress Disorder, Substance Use Disorder
Contingency Outcomes in Prolonged Exposure
The aim of this research is to assess whether Contingency Management is effective in improving treatment adherence in substance use disordered (SUD) patients with comorbid PTSD.
- Trial name
- COPE (NCT01693978)
- Testing
- Prolonged Exposure Therapy, Voucher-Based Reinforcement
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Johns Hopkins University
ACUTE MYELOGENOUS LEUKEMIA
Investigating the Relationship Between Physical Function, Comorbidity and Cytogenetic Risk Group in Older Adults With Acute Myelogenous Leukemia (AML)
AML is a disease of older adults, with a median age at diagnosis of 67 years . An estimated 13,410 new cases of AML will be diagnosed in 2007.
- Trial name
- NCT02662933
- Testing
- Bedside assessment
- Volunteers
- 82 people
- Sponsor
- Wake Forest University Health Sciences
Comorbidities and Coexisting Conditions
Prevalence of Comorbidities in Patients Undergoing Oncosurgeries at Tertiary Cancer Institute in North India.
Investigators plan to study the prevalence of comorbidities in patients undergoing oncosurgeries
- Trial name
- oncosurgery (NCT05038501)
- Testing
- To study comorbidities in patients undergoing Oncosurgeries
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Idiopathic Pulmonary Fibrosis
Health-related Quality of Life and Comorbidities in Danish Patients With Idiopathic Pulmonary Fibrosis - a Nationwide Follow-up
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a high mortality. Health-related quality of life (HRQL) is impaired in patients with IPF.
- Trial name
- NCT02818712
- Where
- 3 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- Aarhus University Hospital