Clinical trials: Comparative Bioavailability
Bioequivalence
Single Dose Crossover Comparative Bioavailability Study of Bupropion Hcl MR Tablet 300mg
The objective of this study is to determine the bioequivalence of 2 different formulations of bupropion after a single oral dose administration under fasting conditions.
- Trial name
- NCT05160090
- Testing
- Bupropion HCl MR tablets 300mg
- Where
- 2 sites in Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Alembic Pharmaceuticals Ltd.
Healthy
Anastrozole 1 mg Tablets Under Fed Conditions
The objective of this study is to evaluate the comparative bioavailability between Anastrozole 1 mg Tablets (Teva Pharmaceuticals, USA) and Arimidex® 1 mg Tablets (AstraZeneca Pharmaceuticals LP, USA), after a single-dose in…
- Trial name
- NCT01183390
- Testing
- Anastrozole
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Healthy, Young
Bioavailability of Hydroxytyrosol in Humans Co-administered With EPA
The primary objective of this study is to evaluate the optimal formulation of a natural nutraceutical whose daily consumption at nutritional doses may confer benefits for cardiovascular health.
- Trial name
- HydroxyOmegaBd (NCT06735222)
- Testing
- Hydroxytyrosol acetate (HT-Ac), Hydroxytyrosol eicosapentanoate (HT-EPA), Oleacore®
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
To Determine Bioequivalence Under Fasting Conditions
Bioavailability Study of Clonazepam ODT Under Fasting Conditions
To compare the single-dose bioavailability of Clonazepam ODT 1 mg and Klonopin Wafers 1 mg ODT
- Trial name
- NCT00652912
- Testing
- Clonazepam, Klonopin Wafers
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Par Pharmaceutical, Inc.
Healthy
Bioequivalence Study of Amoxicillin 400 mg/Clavulanic Acid 57 mg Chewable Tablets Under Fed Conditions
The objective of this study was to compare the single-dose relative bioavailability of Ranbaxy and GlaxoSmithKline (Augmentin®) 400 mg amoxicillin (as the trihydrate) and 57 mg clavulnic acid (as the potassium salt) chewable…
- Trial name
- NCT00778284
- Testing
- Amoxicillin 400mg + clovalunic acid 57.5mg chewable tablets
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Enoxaparin Sodium is Administered to Healthy Volunteers
Bioavailability Study of Enoxaparin Sodium Chemi and Clexane s.c.
The primary objective of the trial is to assess the single-dose relative bioavailability of Chemi Enoxaparin (80 mg/0.8 mL) and Clexane® (80 mg/0.8 mL) administered by subcutaneous (s.c.) injection, under fasting conditions in…
- Trial name
- NCT02232802
- Testing
- Enoxaparin Sodium
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Chemi S.p.A.
Rheumatoid Arthritis, Osteoarthritis
Relative Bioavailability Study of Naproxen Delayed-Release Tablets (375 mg)
The purpose of this study is to demonstrate the relative bioavailability of Naproxen delayed-release tablets (375 mg).
- Trial name
- NCT00959439
- Testing
- Naproxen Delayed Release Tables, 375 (Gevena Pharmaceuticals, Inc.), Naproxen (EC-Narosyn) Delayed Release Tables, 375 (Syntex (USA), Inc.)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Sandoz
Hypertension
Comparative Bioavailability Study of Eplerenone 50 mg Tablets Under Fed Conditions
The purpose of this study is to demonstrate the relative bioequivalence of Eplerenone 50 mg Tablets Under Fed Conditions.
- Trial name
- NCT00865618
- Testing
- Eplerenone 50 mg Tablets Sandoz Inc., USA, Inspra 50 mg Tablets GD Searle LLC, USA
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sandoz
Allergies
To Demonstrate the Relative Bioavailability of Cetirizine Hydrochloride/Pseudoephedrine Hydrochloride 5 mg/120 mg Extended Release (ER) Tablets Under Fasting Conditions
To demonstrate the relative bioavailability of Cetirizine Hydrochloride/Pseudoephedrine Hydrochloride 5 mg/120 mg ER tablets under fasting conditions.
- Trial name
- NCT00881127
- Testing
- Cetirizine HCl/Pseudoephedrine HCl 5 mg/120 mg (Sandoz, USA), Zyrtec-D 12 Hour 5 mg/120 mg Extended Release Tablets (Pfizer, USA)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sandoz
Healthy
Oxcarbazepine 600 mg Tablets Under Fasting Conditions
The objective of this study is to evaluate the comparative bioavailability between Oxcarbazepine 600 mg Tablets (test) and Trileptal® 600 mg Tablets (reference) after a single-dose in healthy subjects under fasting conditions.
- Trial name
- NCT00850174
- Testing
- Oxcarbazepine, Trileptal®
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Healthy
Bioavailability of Amoxicillin Dissolved in Human Milk
The investigators propose to study amoxicillin absorption in a 2-stage program that will progressively produce, for the first time, information leading to pediatric pharmacology recommendations for the administration to children…
- Trial name
- NCT01435824
- Testing
- Human milk-dissolved amoxicillin, Water-dissolved amoxicillin
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Healthy
Bioavailability Study of 300 mg Trazodone Hydrochloride (New Polymer) vs. 300 mg Trazodone Hydrochloride (Contramid® Prolonged-release Tablets) Under Fasting Conditions
This study was designed to investigate the bioequivalence of the test and reference products when administered as single oral doses in two consecutive study periods, under fasting conditions.
- Trial name
- NCT05136521
- Testing
- Trazodone HCl - new polymer, Trazodone HCl - Contramid®
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Healthy
Bioequivalence Study of Meloxicam Tablets 15 mg of Dr.Reddy's Laboratories Limited Under Fasting Condition
The objective of this study is to determine the relative bioavailability of one 15 mg Meloxicam tablet (Dr. Reddy. Laboratories Ltd.,Generics) versus one 15 mg Mobic (meloxicam) Tablet (Boehringer Ingelheim Pharmaceuticals Inc.…
- Trial name
- NCT01161134
- Testing
- Meloxicam
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Cancer
Bioavailability Study of XS003 (Nilotinib)
An open label, single-center, randomized, two-treatment, two-period, two-sequence, single dose, crossover, study under fasted and fed conditions.
- Trial name
- XS003-14 (NCT07138352)
- Testing
- XS003 under fed and fasted condition
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Xspray Pharma AB
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Bioequivalence Study of Synflutide HFA Inhaler and Seretide Evohaler in Healthy Volunteers Without Charcoal Block
The objective of this pivotal study is to evaluate the relative bioavailability of Synflutide HFA 250/25 Inhaler and SeretideTM 250 EvohalerTM in healthy volunteers without charcoal block.
- Trial name
- NCT02466347
- Testing
- Fluticasone propionate, Salmeterol (as xinafoate)
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Intech Biopharm Ltd.
Healthy
Esomeprazole Bioavailability Study With 40 mg Oral Single Dose Fasted and Fed Administration
The present study will be conducted in order to compare the bioavailability of 40 mg Esomeprazole Mepha (Mepha Ltd., Switzerland) and of INexium 40 mg MUPS tablets (AstraZeneca, France) under single dose fasted and fed…
- Trial name
- NCT00889850
- Testing
- 40 mg Esomeprazole Mepha (Mepha Ltd., Switzerland), INexium 40 mg MUPS tablets (AstraZeneca, France)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mepha Ltd.
Healthy
Bioavailability Study of Anastrozole Tablets 1 mg of Dr.Reddy's Under Fed Conditions
The purpose of this study is to compare bioavailability in healthy, post menopausal women subjects under fed conditions.
- Trial name
- NCT01155960
- Testing
- Anastrozole
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
To Determine Bioequivalence Under Fasting Conditions
Bioavailability Study of Doxycycline Monohydrate Capsules and Monodox Under Fasting Conditions
To compare the rate and extent of absorption of doxycycline monohydrate capsules equivalent to 100 mg doxycycline (Par) versus Monodox (Oclassen Pharmaceuticals).
- Trial name
- NCT00653380
- Testing
- Doxycycline Monohydrate, Monodox
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Par Pharmaceutical, Inc.
Healthy
Bioavailability Study of Folate in Healthy Subjects
The aim of this prospective interventional study is to compare the bioavailability of the 6S-5-methyltetrahydrofolate (5-MTHF) glucosamine salt versus two other forms of 5- MTHF calcium salts by measuring serum 5-MTHF responses…
- Trial name
- NCT05699473
- Testing
- 5-MTHF glucosamine salt, 5-MTHF calcium salt 1, 5-MTHF calcium salt 2
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lesaffre International
Cough
Single Dose Trial of Extended Release Combination Tablet Codeine and Guaifenesin
The objectives of this study are (a) to determine if drug levels from a single dose of an extended-release Codeine/Guaifenesin tablet are similar to an immediate-release tablet given every four hours containing lower doses…
- Trial name
- NCT02157649
- Testing
- IR Tablet under Fasted conditions, ER Tablet under Fed Conditions, ER Tablet under Fasted Conditions
- Where
- Jordan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Nexgen Pharma, Inc