Clinical trials: Comparative Effectiveness Study, active
Treatment of Periodontal Intra-bony Defects
The Present Study Was Performed to Evaluate the Efficacy of Lyophilized-PRF in Treatment of Periodontal Intra-bony Defects
The present study will be performed to evaluate the efficacy of lyophilized platelet-rich fibrin alone and combined with nanocrystalline hydroxyapatite in treatment of periodontal intra-bony defects through: 1.
- Trial name
- NCT06625528
- Testing
- open flap debridement
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Atrial Fibrillation (AF)
Comparative Study on the Safety and Efficacy of Using AccuSafe Transseptal Guidewire Versus Traditional Transseptal Needle for Transseptal Puncture in non-or Free- Guidance
1. Research Title: Comparative study on the safety and effectiveness of AccuSafe transseptal guidewire versus traditional transseptal needle for transseptal puncture without X-ray guidance 2.
- Trial name
- NCT07515040
- Testing
- Transseptal puncture needle
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Hidradenitis Suppurativa (HS)
Nd:YAG vs Alexandrite Laser Treatment in Hidradenitis Suppurativa
The purpose of this study is to evaluate whether Alexandrite laser treatment is non-inferior to Nd:YAG (neodymium-doped yttrium aluminum garnet) laser treatment of hidradenitis suppurativa (HS).
- Trial name
- NCT06960447
- Testing
- Nd:YAG Laser, Alexandrite Laser
- Volunteers
- 21 people
- Sponsor
- Geisinger Clinic
Peripheral Pulmonary Lesions (PPLs)
CLE vs. ROSE for Ex Vivo Lung Biopsy Assessment
The goal of this observational study is to evaluate the diagnostic efficacy of Confocal Laser Endomicroscopy (CLE) compared to Rapid On-Site Evaluation (ROSE) for ex vivo lung biopsy specimens obtained via bronchoscopy.
- Trial name
- NCT07725510
- Testing
- Ex Vivo Confocal Laser Endomicroscopy (CLE) Imaging and Interpretation, Rapid On-Site Evaluation (ROSE) Imaging and Interpretation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guangzhou Medical University
Diabete Mellitus, Ischemic Cardiovascular Disease
Traditional Chinese Medicine Intervention for Ischemic Cardiovascular Disease Comorbid With Diabetes Mellitus: An Efficacy Comparative Study
The population with comorbid ischemic cardiovascular disease (ICD) and diabetes mellitus (DM) has been growing rapidly, characterized by high mortality rates and frequent vascular event recurrence.
- Trial name
- TICDEs (NCT07088523)
- Testing
- Xintong Oral Liquid (Sequential Phase), Xintong Oral Liquid (Intensive Phase), TCM Syndrome Differentiation Decoction
- Where
- China
- Volunteers
- 4,205 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Ulcerative Colitis (UC), Crohn's Disease
Efficacy and Safety of Discontinuing 5-ASA in Patients With Inflammatory Bowel Disease
This study aims to evaluate the long-term outcomes of discontinuing 5-ASA in UC and CD patients receiving stable biologic or immunomodulator therapy using a prospective cohort based in the Busan-Ulsan-Gyeongnam region.
- Conditions
- Ulcerative Colitis (UC), Crohn's Disease, Inflammatory Bowel Disease (IBD)
- Trial name
- NCT06878495
- Testing
- Discontinuation of 5-ASA
- Volunteers
- 100 people
- Sponsor
- Pusan National University Hospital
Limb Edema, Surgical Site Infections
Prevention of Edema After Coronary Artery Bypass Graft by Customized Pressure-guided Elastic Bandages
The study aimed to assess the efficacy of customized pressure-guided elastic bandages (CPG-EB) in preventing postoperative edema and complications in Coronary Artery Bypass Graft (CABG) patients.
- Conditions
- Limb Edema, Surgical Site Infections, Leg Swelling, Compression Bandages
- Trial name
- PEACCE (NCT06603961)
- Testing
- CPG-EB group
- Where
- 2 sites in Thailand
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Advanced or Metastatic NSCLC
A Study to Investigate Efficacy and Safety of Ceralasertib Plus Durvalumab in Participants Aged ≥ 18 Years With Advanced or Metastatic Non-small Cell Lung Cancer Whose Disease Progressed on or After Prior Anti-PD-(L)1 Therapy and Platinum-based Chemotherapy
A study to investigate efficacy and safety of ceralasertib plus durvalumab in participants aged ≥ 18 years with advanced or metastatic non-small cell lung cancer whose disease progressed on or after prior anti-PD-(L)1 therapy and…
- Trial name
- LOTOS (NCT05941897)
- Testing
- Ceralasertib, Durvalumab
- Where
- 8 sites in Russia
- Volunteers
- 39 people
- Sponsor
- AstraZeneca
Smoker, Smoking Cessation
The Options 2 Study
The goal of this clinical trial is to investigate how well nicotine pouches and nicotine mini lozenges serve as substitutes for cigarettes when people try to switch from smoking to using these alternate nicotine products.
- Trial name
- NCT06595459
- Testing
- Nicotine Pouches, Mini Nicotine lozenges
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Wisconsin, Madison
Trigger Finger, Splint Therapy
Comparative Evaluation of Finger Splint, Paraffin, and Peloidotherapy Interventions in the Management of Trigger Finger
Patients aged 18-75 years who present with trigger finger to a tertiary rehabilitation hospital and agree to participate will be included in the study.
- Conditions
- Trigger Finger, Splint Therapy, Paraffin Bath, Peloidotherapy
- Trial name
- NCT07256522
- Testing
- Finger orthosis, Paraffin bath, Peloidotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Cutibacterium Acnes Contamination
Wound Irrigation Comparative Effectiveness Study
The primary objective of this study is to compare the presence of C acnes in bacteriologic cultures taken from participant samples of subcutaneous and deep tissue prior to deep surgical irrigation using either Normal Saline…
- Trial name
- NCT06379919
- Testing
- Irrisept Irrigation, Saline Irrigation Solution Delivery
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Education and Research Institute (dba Hoag Orthopedics)
Overactive Bladder
Comparative Efficacy and Safety if Intravesical Botulinum Toxin A Versus Platelet-Rich Plasma in the Management of Refractory Overactive Bladder : A 2 Year Study
The goal of this clinical trial is to compare the efficacy and safety of intravesical Botulinum Toxin A versus intravesical Platelet-Rich Plasma (PRP) in adults with refractory overactive bladder who have not responded adequately…
- Trial name
- NCT07693192
- Testing
- Intravesical Botulinum Toxin A (100U), Intravesical Platelet-Rich Plasma
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mahmoud Mohamed Farag Ali
Pulmonary Embolism, Venous Thromboembolism
STRATEGY-PE: Real-World Treatment Strategies for Intermediate-High Risk Pulmonary Embolism
This study aims to compare the effectiveness and safety of three treatment strategies (Anticoagulation, Thrombolysis, and Mechanical Thrombectomy) for patients with intermediate-high risk acute pulmonary embolism (PE) in a…
- Trial name
- STRATEGY-PE (NCT07603700)
- Testing
- Anticoagulants, Thrombolytic Agents, Mechanical Thrombectomy Devices
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Massive Rotator Cuff Tears, Shoulder Disease
Effectiveness of Treatments for Massive Rotator Cuff Tears: Mixed Methodology.
The purpose of this study is: 1) to identify relevant treatment outcomes for people with massive rotator cuff tears of the shoulder joint, according to the experience of the affected people, to facilitate treatment shared…
- Trial name
- NCT05780229
- Testing
- Conservative treatment, Arthroscopic Decompression Surgery, Reverse Prosthesis
- Where
- 6 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Parc de Salut Mar
Muscle Strength, Body Composition
Effect of BioStrength Training on Muscle Strength and Satisfaction in Adults Aged 30-65
This study aims to evaluate the effectiveness of Technogyms BioStrength equipment compared to traditional strength training equipment over a 12-week intervention period.
- Conditions
- Muscle Strength, Body Composition, Physical Fitness
- Trial name
- BIO-STR (NCT06727695)
- Testing
- BioStrength Intervention, Conventional training
- Where
- Austria
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Graz
Acanthosis Nigricans
Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans
evaluate and compare the clinical Efficacy \& Safety Of Fractional Carbon Dioxide (Co₂) Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans.
- Trial name
- NCT07760181
- Testing
- Topical metformin
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Heart Transplant Failure and Rejection
A Comparative Effectiveness Study in Heart Transplant Patients of Rejection Surveillance With Cell-free DNA Versus Endomyocardial Biopsy
This is an open label Comparative Effectiveness Research (CER) study in which patients will be randomized at the site level to Prospera surveillance or EMB surveillance in a 2:1 ratio (Prospera to EMB) at each site.
- Trial name
- ACES-EMB (NCT06414603)
- Testing
- The Prospera™ Test
- Where
- 16 sites in United States
- Volunteers
- 250 people
- Sponsor
- Natera, Inc.
Head Lice
Safety and Efficacy of Head-lice Treatments Elimax Green Lotion and Walgreens Lice Killing Shampoo
Compare efficacy and safety of Elimax Green Lotion Emogreen (RID SUper Max Solution) to that of Walgreens Lice Killing Shampoo against headlice in infested individuals.
- Trial name
- NCT07191457
- Testing
- Elimax Green Lotion with Emogreen
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Oystershell NV
Locally Advanced Thyroid Gland Carcinoma
Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer
The current study aims to explore the potential advantages of anti-cancer therapy that is implemented based on drug sensitivity testing.
- Trial name
- NCT06482086
- Testing
- Anlotinib, Lenvatinib, Sorafenib
- Where
- China
- Volunteers
- 75 people
- Sponsor
- West China Hospital
Traumatic Brain Injury
Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury(Metric-TBI)
A prospective, multicenter, observational cohort study is designed to compare the effectiveness of intervention in multi-grade hospitals for acute traumatic brain injury and to optimize clinical outcomes.
- Trial name
- NCT06429774
- Testing
- Neurological function, Mental State, cognitive function, and life quality assessment, Peripheral blood test
- Where
- 64 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital