Clinical trials: Comparative Effectiveness Study
Comparative Effectiveness
Equivalence of Oral Melatonin and Oral Midazolam in Preoperative Anxiolysis for Pediatric Fast-Track Cardiac Surgery
Equivalence of Oral Melatonin and Oral Midazolam in Preoperative Anxiolysis for Pediatric Fast-Track Cardiac Surgery
- Trial name
- NCT07900321
- Testing
- Melatonin, Midazolam
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Video Laryngoscopy, Quality Improvement
OR Video-Laryngoscope Evaluations
The goal of this quality improvement protocol is to compare the evaluations between video laryngoscopes (VLs) available in the University of Colorado Health Hospital at Metro Denver operating rooms (ORs).
- Conditions
- Video Laryngoscopy, Quality Improvement, Operating Rooms, Comparative Effectiveness Study
- Trial name
- NCT07888946
- Testing
- AMBU Product, CMAC-Storz, Glidescope
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Colorado, Denver
Health Care, Pediatrics
Hospital-to-Home Transitional Care Interventions (H2H-TCI) Children/Youth With Special Health Care Needs (CYSHCN)
Aim 1: Compare the effectiveness of focused dose vs extended dose hospital-to-home Transitional Care Interventions (H2H-TCI) on health service use and parent-reported confidence for hospitalized CYSHCN.
- Conditions
- Health Care, Pediatrics, Transitional Care, Comparative Effectiveness
- Trial name
- H2H-CYSHCN (NCT06428175)
- Testing
- Focused Dose Hospital-to-Home Transitional Care Interventions, Extended Dose Hospital-to-Home Transitional Care Interventions
- Where
- 2 sites in United States
- Volunteers
- 480 people
- Sponsor
- Duke University
Neoplastic Syndromes, Hereditary, Comparative Effectiveness Research
Family History and Cancer Risk Study
Investigators from Vanderbilt University Medical Center (VUMC), Duke University, and Meharry Medical College (MMC) are collaborating on a family health history study to deploy a family health history (FHH) platform, MeTree.
- Trial name
- FOREST (NCT05079334)
- Where
- 2 sites in United States
- Volunteers
- 1,847 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Comparative Effectiveness Research, Regional Block
Serratus Posterior Superior Intercostal Plane Block Versus Erector Spinae Plane Block in Thoracic Spine Surgeries
Spinal surgeries coincide with high level of pain due to extensive dissection and muscle retraction so inadequate pain control delays patient recovery, rehabilitation and also is an important source of patient dissatisfaction…
- Trial name
- NCT07646184
- Testing
- Serratus Posterior Superior Intercostal Plane Block, Erector spinae block
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tanta University
Type 2 Diabetes, Comparative Effectiveness of Glycemia-lowering Medications
A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 Diabetes
The GRADE Study is a pragmatic, unmasked clinical trial that will compare commonly used diabetes medications, when combined with metformin, on glycemia-lowering effectiveness and patient-centered outcomes.
- Trial name
- GRADE (NCT01794143)
- Testing
- Sulfonylurea (glimepiride), DPP-4 inhibitor (sitagliptin), GLP-1 receptor agonist (liraglutide)
- Where
- 36 sites in United States
- Volunteers
- 7,850 people
- Sponsor
- GRADE Study Group
Intensive Care, Pupil Assessment
Pupillometry Use & Professional's Inspection : Leveling Subjectivity
This prospective, non interventionneal, mono-centric study aims to evaluate the accuracy and quality of pupil assessment among three different groups: senior physicians, anesthesiology residents, and nurses.
- Conditions
- Intensive Care, Pupil Assessment, Pupillometry, Neurological Examination
- Trial name
- PUPILS (NCT06733207)
- Testing
- Pupil examination
- Where
- France
- Volunteers
- 30 people
- Sponsor
- CHU de Reims
Clostridioides Difficile Infection, Clostridioides Difficile Infection Recurrence
STOP-CDI: Efficacy of Fecal Microbiota Transplantation vs Fidaxomicin vs Vancomycin in Treating and Preventing Relapse of Clostridioides Difficile Infection
The STOP-CDI study is a multicenter, randomized, open-label, three-arm clinical trial comparing the efficacy of fecal microbiota transplantation (FMT) preceded by vancomycin, fidaxomicin monotherapy, and standard-of-care…
- Conditions
- Clostridioides Difficile Infection, Clostridioides Difficile Infection Recurrence, Fecal Microbiota Transplantation (FMT), Comparative Effectiveness of CDI Treatments
- Trial name
- STOP-CDI (NCT07120490)
- Testing
- FMT (fecal microbiota transplantation), Fidaxomicin, Vancomycin (VAN) treatment
- Volunteers
- 424 people
- Sponsor
- Medical University of Warsaw
Comparative Effectiveness Research
Geriatric Team in ED: Effects on Rate of Hospitalization and on Community Health Management of Elderly (GerED-21)
The Ger-ED Intervention study focuses on early assessment and intervention in the emergency department (ED) by a specialized geriatric team, which includes a geriatrician, a nurse with expertise in geriatrics and continuity of…
- Trial name
- GerED-21 (NCT06788210)
- Testing
- Multiprofessional Geriatric Emergency Team applied front-door CGA to identify patients who require inpatient care and those who can safely be discharged.
- Where
- Italy
- Volunteers
- 624 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Acquired Brain Injury, Comparative Effectiveness Research
Efficacy of EFA in Acquired Brain Injury
Acquired brain injury (ABI) is one of the biggest cause of death and disability in the world. Patients with ABI often have difficulties with swallow and breath.
- Conditions
- Acquired Brain Injury, Comparative Effectiveness Research, Lung Diseases, Obstructive
- Trial name
- NCT05993364
- Testing
- Free Aspire with Expiratory Flow Accelerator (EFA) technology, In-Exufflator Machine, Traditional respiratory treatment
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Comparative Effectiveness Research
Comparative Functional Vision Outcomes: DAILIES TOTAL1 Toric vs. Spherical Lenses in Asian Astigmatic Patients
The goal of this comparative clinical trial is to assess the effectiveness of DAILIES TOTAL1 Toric Contact Lenses compared to Spherical Equivalent Contact Lenses in improving the functional vision of astigmatic patients, with a…
- Trial name
- NCT06230263
- Testing
- Visual acuity test
- Where
- Hong Kong
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mopsy Research
Comparative Effectiveness Study
Treatment and Exacerbation in COPD Subjects
This is a study comparing the effects of ICS containing treatments in patients with chronic obstructive pulmonary disease (COPD) in a real world setting, using the UK Clinical Practice Research Datalink (CPRD) linked with…
- Trial name
- NCT03375450
- Testing
- Standard of Care
- Where
- United Kingdom
- Volunteers
- 60,243 people
- Sponsor
- AstraZeneca
Clinical Trial, Comparative Effectiveness Research
Efficacy and Safety Study of Ultrasound Bone Strength Device to Measure Calcaneal Bone Strength Index of Human Subjects
The purpose of this study is to examine whether ultrasound bone strength device (Model Number: Oste-scan 500A) is effective and safe in measuring calcaneal bone strength index of human subjects, compared with a listed, similar…
- Conditions
- Clinical Trial, Comparative Effectiveness Research, Equipment Safety
- Trial name
- NCT02971527
- Testing
- Oste-scan 500A, SONOST3000
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Nanjing Medical University
Mental Disorders, Education Curriculum
Impact of a Mental Health Curriculum for High School Students on Knowledge and Stigma
This study examines the effectiveness of a school based mental health literacy intervention for high school students, on improving mental health knowledge and reducing stigma.
- Conditions
- Mental Disorders, Education Curriculum, Comparative Effectiveness Research, Early Intervention
- Trial name
- NCT02561780
- Testing
- Curriculum, eLearning Follow-up
- Volunteers
- 534 people
- Sponsor
- University of Ottawa
Comparative Effectiveness Research, Community-Based Participatory Research
Promoting Smoking Cessation in the Community Via Quit to Win Contest 2012
Background According to the report of Census \& Statistics Department, there are still 659,300 daily smokers (11.1%) in Hong Kong and smoking kills over 7,000 people per year.
- Trial name
- NCT01670864
- Testing
- Counseling group, SMS intervention group
- Where
- China
- Volunteers
- 1,193 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Health Services Research, Comparative Effectiveness
Population Versus Practice-based Interventions to Increase Immunizations
One of the nation's major health priorities, as outlined in Healthy People 2010, is to increase the proportion of children aged 19 to 35 months who have received all universally recommended vaccines.
- Conditions
- Health Services Research, Comparative Effectiveness, Immunization
- Trial name
- NCT01296906
- Testing
- Recall conducted by private practices, Recall conducted centrally by local health department
- Where
- United States
- Volunteers
- 31,567 people
- Sponsor
- University of Colorado, Denver
Comparative Effectiveness Research
Helping Smokers to Quit Via the Smoke-free Teen Contest 2011: A Randomized Controlled Trial
Background The home is the primary source of SHS exposure. The scientific evidence shows that there is no risk-free level of exposure to SHS that stop smoking is the sole way to completely eliminate the risk of SHS exposure.
- Trial name
- NCT01671553
- Testing
- Counseling group
- Where
- China
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong