Clinical trials: Comparison of the Efficacy
Urinary Tract Infections, Bacterial Infections
A Study of the Safety and Effectiveness of Levofloxacin Compared With Lomefloxacin in the Treatment of Complicated Urinary Tract Infections
The purpose of the study is to compare the safety and effectiveness of oral levofloxacin (an antibiotic) with that of oral lomefloxacin in the treatment of complicated urinary tract infections in adults.
- Conditions
- Urinary Tract Infections, Bacterial Infections, Bacteriuria, Urologic Diseases
- Trial name
- NCT00258102
- Testing
- Levofloxacin
- Volunteers
- 603 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Asthma
Single-dose Crossover Study to Compare the Safety and Efficacy of FlutiForm With Fluticasone and Formoterol Concurrently or Alone in Asthma Patients
The primary purpose was to evaluate the efficacy of SKP FlutiForm HFA MDI compared to placebo or fluticasone and formoterol administered concurrently or alone in asthma patients.
- Trial name
- NCT00830102
- Testing
- fluticasone propionate, formoterol fumarate
- Where
- 6 sites in Ireland, United Kingdom
- Volunteers
- 64 people
- Sponsor
- SkyePharma AG
Prophylaxis Against Influenza
To Evaluate the Effectiveness(Immunogenicity) and Safety of 'GC3102C' Administered Intramuscularly in Healthy Adults
The primary objective is to demonstrate the immunological non-inferiority between GC3102C and GC FLU inj. influenza vaccines by assessing geometric mean titers(GMTs) in healthy adults
- Trial name
- NCT01750814
- Testing
- GC3102C, GC FLU inj.
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Green Cross Corporation
Cervical Spondylotic Myelopathy
Efficacy of Two Approaches in Cervical Single-door Laminoplasty for Spinal Canal Enlargement
The goal of this clinical trial is to learn if cervical single-door laminoplasty via the intermuscular space approach can better prevent axial symptom while reaching equal neurological outcome than the conventional approach in…
- Trial name
- NCT06941649
- Testing
- Expansive open-door laminoplasty via intermuscular space approach, cervical single-door laminoplasty via the conventional approach
- Volunteers
- 376 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
URTICARIA
Efficacy of Rupatadine 5, 10 and 20 mg in Chronic Idiopathic Urticaria
The objective of this study is to evaluate the efficacy and safety of rupatadine for the treatment of CIU symptoms.To assess the clinical efficacy of a dose ranging of rupatadine fumarate (5mg, 10mg, and 20 mg) compared with…
- Trial name
- NCT00199238
- Testing
- Rupatadine Fumarate
- Where
- France
- Volunteers
- 248 people
- Sponsor
- J. Uriach and Company
Clostridium Difficile Infection
A Study of SMT19969 Compared With Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhoea (CDAD)
The purpose of this research study is to evaluate the safety and effectiveness of a new oral antibiotic called SMT19969 in treating C. difficile Infection (CDI).
- Trial name
- NCT02092935
- Testing
- SMT19969, Vancomycin
- Where
- 26 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Summit Therapeutics
Acne
Efficacy and Safety of IDP-121 and IDP-121 Vehicle Lotion in the Treatment of Participants With Acne Vulgaris
The objective of this study was to evaluate the efficacy, safety, and tolerability of a once daily topical application of IDP-121 Lotion compared with its vehicle (IDP-121 Vehicle Lotion) in participants with moderate to severe…
- Trial name
- NCT02932306
- Testing
- IDP-121 Lotion, IDP-121 Vehicle Lotion
- Where
- 39 sites in United States
- Volunteers
- 820 people
- Sponsor
- Bausch Health Americas, Inc.
Infection, Sepsis
A Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically Ill Paediatric Patients
The goal of this clinical trial is to examine the success and safety of administering certain antibiotics (beta-lactams) given in a longer 3-hour infusion to children (0-17 years) who are critically ill and have severe infection.
- Conditions
- Infection, Sepsis, NICU, PICU
- Trial name
- PEBBLE (NCT07484633)
- Testing
- Extended infusion time of the following beta-lactam: meropenem, Short-term infusion time of the following beta-lactam: meropenem, Extended infusion time of the following beta-lactam: piperacillin/tazobactam
- Where
- 2 sites in Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Pain Management, Cesarean Section
To Compare the Efficacy and Patient's Satisfaction From Pain Management of Women After Cesarean Section by Pain Relievers' Administration in Fix Protocol Compared to Protocol Following Demand
Cesarean deliveries are prevalent. Unlike other operations, quick recovery is required for the mother to nurture the newborn child and establishing an appropriate mother-child bonding.
- Trial name
- NCT01764048
- Testing
- Fix protocol, medications following demand protocol
- Where
- Israel
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Vaginal Infections
Comparison of Two Topical Formulations Containing Clindamycin and Clotrimazole in Patients With Vaginal Infections
Randomized, Parallel Group, Active Controlled Trial to compare effectiveness and tolerability of 2 different vaginal formulations containing 200mg clotrimazole and clindamycin phosphate equivalent to 100mg clindamycin for 3 days…
- Trial name
- NCT01697826
- Testing
- ClinSupV3 -soft gelatin capsule, ClinSupV3ER- Extended release tablet
- Where
- India
- Volunteers
- 73 people
- Sponsor
- Dr Bharti Daswani
Pulmonary Tuberculosis
TBTC Study 22: Efficacy of Once-Weekly Rifapentine and Isoniazid in Treatment of Tuberculosis
Primary Objective: To compare, at the completion of the follow-up phase, the clinical and bacteriologic relapse rates associated with the two study regimens.
- Trial name
- NCT00023335
- Testing
- Rifapentine, Isoniazid
- Where
- 23 sites in United States, Canada
- Volunteers
- 1,000 people
- Sponsor
- Centers for Disease Control and Prevention
Type 1 Diabetes
Closing the Loop in Adults With Type 1 Diabetes (CLEAR)
The main objective of this study is to determine whether home use of fully closed-loop glucose control applying ultra-rapid Lispro insulin is superior to standard insulin pump therapy with continuous glucose monitoring (CGM) in…
- Trial name
- NCT04977908
- Testing
- CamAPS HX, Standard insulin pump therapy with CGM
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Cambridge
Inguinal Hernia
The (Cost-) Effectiveness of Paediatric Laparoscopic Hernia Repair Compared to Open Hernia Repair
This study assess the (cost-)effectiveness of open versus laparoscopic Percutaneous Inguinal Ring Suturing (PIRS) technique for unilateral inguinal hernia repair in children aged 0-16 years.
- Trial name
- HERNIIA-2 (NCT06451432)
- Testing
- Percutaneous Inguinal Ring Suturing (PIRS) technique
- Where
- 9 sites in Netherlands
- Volunteers
- 464 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Tongue Coating, Oral Biofilm
Comparison of Three Tongue Cleaners for Removing Tongue Coating
This randomised three-period crossover study compared the effectiveness of three tongue-cleaning devices - a bristled tongue brush, a plastic tongue scraper and a metal tongue scraper - in removing tongue biofilm.
- Conditions
- Tongue Coating, Oral Biofilm, Oral Hygiene, Dental Plaque
- Trial name
- NCT07767721
- Testing
- Bristled tongue brush, Plastic tongue scraper, Metal tongue scraper
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Kent University
Dyslipidemia, Vascular Disease
Atorvastatin Versus Ezetimibe and Fenofibrate as a Lipid-lowering Strategy
The primary aim of this study is to evaluate the efficacy and non-inferiority of a lipid-lowering medication regimen comprised of the medications ezetimibe and fenofibrate taken daily, versus atorvastatin daily in lowering levels…
- Trial name
- NCT00299884
- Testing
- Lipitor 20 mg, Combination Ezetrol 10 mg and Lipidil Supra 160 mg
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Queen's University
HIV-1 Infection
Gentian Violet Vs. Nystatin Oral Suspension for Treatment of Oropharyngeal Candidiasis
The purpose of this study was to see which one of two medicines (topical gentian violet [GV] or nystatin oral suspension) was better than the other in treating Oral Candidiasis (OC).
- Trial name
- NCT01427738
- Testing
- Gentian Violet, Nystatin oral suspension
- Where
- 10 sites in Botswana, India and 5 more
- Volunteers
- 221 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Chronic Obstructive Pulmonary Disease (COPD)
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy and Safety of Cavosonstat Administered Twice Daily Compared With Placebo for 24 Weeks in Adult Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Brief Summary: The purpose of this study is to to evaluate the efficacy and safety of Cavosonstat administered twice daily compared with Placebo for 24 Weeks in adult subjects with Chronic Obstructive Pulmonary Disease (COPD)…
- Trial name
- NCT04600778
- Testing
- Cavosonstat 5 mg, Cavosonstat 10 mg, Cavosonstat 25 mg
- Volunteers
- 108 people
- Sponsor
- GSNOR Therapeutics, Inc.
Mild to Moderate Uncomplicated Skin and Skin Structure Infections
A Study to Compare Cefdinir and Cephalexin for the Treatment of Mild to Moderate Uncomplicated Skin Infections
The purpose of this study is to compare the efficacy and tolerability of cefdinir to that of cephalexin in patients with mild to moderate uncomplicated skin/skin structure infections.
- Trial name
- NCT00234949
- Testing
- cefdinir, cephalexin
- Volunteers
- 380 people
- Sponsor
- Abbott
Chalazion
Safety and Efficacy Study of SUN 131 TDS as Compared to Placebo TDS in Adult Patients With a Chalazion
The purpose of this study is to evaluate the efficacy and safety of SUN-131 1.5% TDS as compared with placebo TDS in the treatment of chalazion based on the proportion of subjects that have complete response.
- Trial name
- NCT02338648
- Testing
- SUN-131 1.5% TDS
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Senju USA, Inc.
Temporomandibular Joint Osteoarthritis
Efficacy of Autologous Conditioned Serum in Temporomandibular Joint Disorder
Temporomandibular joint (TMJ) disorders are health conditions that can occur at any age and are recognized as the most common cause of chronic pain, affecting 5-12% of the population.
- Trial name
- NCT06839326
- Testing
- Autologous Conditioned Serum, Genesis Biyomedikal, Sanakin®-Acrs produce, Platelet Rich Plasma, Control Group/ Only Arthrocentesis
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Batman University
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