Clinical trials: Comparison of the Efficacy
NSCLC Stage IV
MYL-1402O Compared With Avastin®, in Patients With Stage IV nsNSCLC
Assess the Efficacy and Safety of MYL-1402O Compared with Avastin®, in the First-line Treatment of Patients with Stage IV Non-Squamous Non-Small Cell Lung Cancer
- Trial name
- NCT04633564
- Testing
- Bevacizumab as MYL-1402O, Bevacizumab as Avastin
- Where
- 102 sites in Belarus, Bosnia and Herzegovina and 15 more
- Volunteers
- 671 people
- Sponsor
- Mylan Pharmaceuticals Inc
Major Depressive Disorder, Insomnia
A Study to Evaluate the Safety, Tolerability, and Efficacy of SAGE-217 Compared to Placebo in Adult Participants With Comorbid Major Depressive Disorder (MDD) and Insomnia
This study is a randomized, double-blind, placebo-controlled study of the safety, tolerability, and efficacy of SAGE-217 compared to placebo in adult participants with comorbid major depressive disorder (MDD) and insomnia.
- Trial name
- NCT03771664
- Testing
- SAGE-217
- Where
- 28 sites in United States
- Volunteers
- 87 people
- Sponsor
- Biogen
Acute Migraine Headache
Comparison of Oral Paracetamol and Zolmitriptan Efficacy in the Treatment of Acute Migraine in Emergency Department
Migraine is a chronic and sometimes progressive disorder, characterized by headache, recurrent episodes, and other associated symptoms.
- Trial name
- NCT03145467
- Testing
- Paracetamol, Zolmitriptan
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Pamukkale University
Analgesic Efficacy
The Analgesic Efficacy of Erector Spinae Block in Comparison to Thoracic Epidural Anesthesia in Oesophageal Surgeries
a total of 80 patients age of 36 years old to 65 years old, (ASA) physical status I and II undergoing oesophageal procedures.The patients will randomised using concealed envelope method into 2 groups, allocation of patients to…
- Trial name
- NCT03504371
- Testing
- bilateral erector spinae block, Thoracic epidural anesthesia
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Metastatic Colorectal Cancer
Study of Modified FOLFOX6 Plus or Minus Sorafenib in Stage IV Metastatic Colorectal Carcinoma (mCRC) Subjects
To determine if sorafenib when added to chemotherapy will slow disease progression more than chemotherapy alone in patients previously untreated for metastatic colorectal cancer.
- Trial name
- NCT00865709
- Testing
- Sorafenib (Nexavar, BAY43-9006) + mFOLFOX6 (5-FU, levo-leucovorin, oxaliplatin)
- Where
- 116 sites in United States, Belgium and 8 more
- Volunteers
- 198 people
- Sponsor
- Bayer
Infant, Newborn, NRDS
Efficacy of Surfactant and Perinatal Risk Factors in NRDS With Different Gestational Ages
Since exogenous surfactant replacement therapy was first used to prevent neonatal respiratory distress syndrome (NRDS)，it has become the main method of treatment of NRDS.
- Trial name
- NCT03385863
- Testing
- Surfactant, Pulmonary，Curosurf, Perinatal risk factors of NRDS
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Nasal Decolonization of Staphylococcus Aureus
A Study to Evaluate the Safety and Efficacy of 3% LTX-109 for Nasal Decolonisation of Staphylococcus
A Phase I/IIa, double-blind, placebo-controlled, randomised study designed to evaluate the safety, tolerability, exploratory efficacy and exposure of LTX-109 administered topically to the anterior nares in subjects with…
- Trial name
- NCT04767321
- Testing
- LTX-109 gel, 3% w/w
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Pharma Holdings AS
Primary Hypertension
A Study to Compare the Efficacy, Safety and Tolerability of Selomax With Its Individual Components
This is a randomised, open-label; parallel group, multicentric study comparing the efficacy and safety of fixed-dose-combinations of Metoprolol XL plus Amlodipine with individual components of the combination.
- Trial name
- MARS (NCT00819104)
- Testing
- Metoprolol XL 50mg + Amlodipine 5mg, Metoprolol XL 25 mg + Amlodipine 2.5mg, Metoprolol XL 50mg
- Where
- 11 sites in India
- Volunteers
- 402 people
- Sponsor
- AstraZeneca
Child Behaviour
Comparison of a Needle-free Local Anesthetic Technique With Traditional Syringe [ Needle Syringe] Technique for the Restoration of Primary Molars and Permanent Molars
The goal of this clinical trial is to compare the effectiveness of needle free system and dental needle system [Traditional syringe system] for restoration of Primary and young permanent teeth.
- Trial name
- NCT06448507
- Testing
- INJEX [Needle less anesthesia], Syringe Needle [ Traditional technique]
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- University of Jazan
Atrial Fibrillation
Efficacy and Safety of MAA868 in Patients With Atrial Fibrillation
The purpose of this study is to evaluate the pharmacokinetics, pharmacodynamics, safety and tolerability of MAA868 compared to apixaban in patients with atrial fibrillation.
- Trial name
- NCT03398434
- Testing
- MAA868, Apixaban
- Sponsor
- Novartis Pharmaceuticals
Grade II Internal Hemorrhoids With Bleeding
A Phase III Clinical Trial Evaluating the Efficacy and Safety of TriThien Duoc Capsules in Grade II Internal Haemorrhoids Patients With Bleeding Compared to Diosmin.
A Phase III, randomized, double-blind, placebo-controlled clinical trial has been conducted to evaluate the efficacy and safety of Trĩ Thiên Dược capsules in people with grade II internal hemorrhoids with bleeding.
- Trial name
- NCT07369635
- Testing
- Intervention Group: Tri Thien Duoc Capsules, Control group (diosmin)
- Where
- Vietnam
- Volunteers
- 172 people
- Sponsor
- Hanoi Medical University
Post COVID-19 Diffuse Lung Disease
Comparison of Two Corticosteroid Regimens for Post COVID-19 Diffuse Lung Disease
A proportion of patients with COVID-19 pneumonia have a prolonged course of illness. Some of these patients continue to have considerable respiratory symptoms or persistent hypoxemia.
- Trial name
- COLDSTER (NCT04657484)
- Testing
- Medium dose prednisolone, Low dose prednisolone
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Degenerative Arthritis of Left Glenohumeral Joint, Degenerative Arthritis of Right Glenohumeral Joint
Costs and Consequences of Three Common Orthopedic Procedures on the Upper Extremity
This study compares costs and effectiveness / utility of three common orthopedic surgeries in shoulder and hand from the perspective of the Swiss health system and the clinic.
- Conditions
- Degenerative Arthritis of Left Glenohumeral Joint, Degenerative Arthritis of Right Glenohumeral Joint, Rotator Cuff Tear Arthropathy, Rotator Cuff Tear
- Trial name
- NCT01954433
- Testing
- Operated TSA Patients, Operated RCR Patients, Resection interposition suspension arthroplasty (RISA)
- Where
- Switzerland
- Volunteers
- 450 people
- Sponsor
- Schulthess Klinik
Trichomonal Vaginitis, Bacterial Vaginosis
Evaluation of Efficacy and Safety of Two New Formulations Compared to Gynomax® XL Ovule
Efficacy and safety of two new formulations compared to Gynomax® XL ovule in the treatment of trichomonal vaginitis, bacterial vaginosis, candidal vulvovaginitis and mixed vaginal infections was evaluated in this randomized…
- Conditions
- Trichomonal Vaginitis, Bacterial Vaginosis, Candidal Vulvovaginitis, Mixed Vaginal Infections
- Trial name
- One-Shot (NCT06056947)
- Testing
- EVEGYN A, EVEGYN B, Gynomax® XL Vaginal Ovule
- Where
- Turkey (Türkiye)
- Volunteers
- 577 people
- Sponsor
- Ege University
Cataract
Clinical Study of the Efficacy of the Ophthalmic Emulsion PRO-145 for Inflammation and Pain After Phacoemulsification
objective: To evaluate the efficacy of the ophthalmic emulsion PRO-145 in the treatment of inflammation and pain after phacoemulsification.
- Trial name
- PRO-145/III (NCT03693989)
- Testing
- Difluprednate 0.05%, Prednefrin
- Where
- 5 sites in Mexico
- Volunteers
- 178 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Non-Hodgkin's Lymphoma, Burkitt's
To Compare the Efficacy of a Prophylactic Use of Tenofovir by Duration for the Non-Hodgkin's Lymphoma
The objective of this study is to analyze factors affecting Hepatitis B Virus (HBV) reactivation in anti-HBc positive patients with Non-Hodgkin's lymphoma treated with rituximab and compare HBV reactivation rates by duration of…
- Trial name
- NCT02585947
- Testing
- Tenofovir
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Chronic Kidney Disease Stage 3
A Study to Investigate the Safety, Tolerability, and Preliminary Efficacy With AION-301 Administered by Intravenous Infusion Compared With Placebo Administered by Intravenous Infusion Investigational Intervention in Participants Aged 35 to 75 Years of Age With Chronic Kidney Disease (CKD)
The goal of this clinical trial is to learn about the safety (good or bad) of giving two AION-301 intravenous (IV) infusions, in adults with Stage 3 Chronic Kidney Disease (CKD).
- Trial name
- UC-MSC-CKD (NCT06721143)
- Testing
- AION-301
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- AION Healthspan, Inc.
Post-surgical Dental Pain
Post-operative Dental Pain Study Comparing Two Different Dosage of Analgesic Efficacy
GlaxoSmithKline will be conducting this trial to compare analgesic efficacy of paracetamol 1000 mg vs 650 mg. The post-surgical dental pain model will be used to evaluate the analgesic efficacy of paracetamol.
- Trial name
- NCT01075243
- Testing
- Paracetamol 1000 mg, Paracetamol 650 mg
- Where
- United States
- Volunteers
- 401 people
- Sponsor
- GlaxoSmithKline
Parkinson's Disease, Idiopathic
A Double-blind Study to Investigate Efficacy and Safety of Buntanetap Compared With Placebo in Participants With Early PD
The purpose of this study is to measure safety and efficacy of buntanetap/posiphen capsules compared with placebo capsules in participants with early PD. Study details include: The study duration will be up to 7-8 months.
- Trial name
- NCT05357989
- Testing
- buntanetap/posiphen
- Where
- 69 sites in United States, Germany and 4 more
- Volunteers
- 523 people
- Sponsor
- Annovis Bio Inc.
Rheumatoid Arthritis
Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Rheumatoid Arthritis (RA)
This is a two part study comparing CHS-0214 to Enbrel in patients with active rheumatoid arthritis and an inadequate response with Methotrexate (MTX) who are naive to biologic therapies.
- Trial name
- CHS-0214-02 (NCT02115750)
- Testing
- Etanercept, CHS-0214
- Where
- 141 sites in United States, Belarus and 10 more
- Volunteers
- 647 people
- Sponsor
- Coherus Oncology, Inc.
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