Clinical trials: Complex Care, open to volunteers
Child Mental Health, Behavioral Symptoms
Wellbeing and Resilience Among 1-3 Years Old Children of Mothers with Complex Mental Health Problems: a Pragmatic Clinical Trial of Online VIPP-SD Vs. Care As Usual
Children of parents with severe mental disorders have an increased risk of mental disorders themselves, with more than half of this population diagnosed with a mental health condition during their life time.
- Conditions
- Child Mental Health, Behavioral Symptoms, Child of Impaired Parents
- Trial name
- WellCom (NCT06795347)
- Testing
- Online VIPP-SD, Care As Usual
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Southern Denmark
TBI (Traumatic Brain Injury), Status Epilepticus
Augmented Renal Clearance in Neurocritical Care
Stroke, severe brain injury, uncontrolled seizures and brain infections are the most common life-threatening neurological illnesses in the world with an estimated combined annual hospital management cost of up to 44 billion…
- Conditions
- TBI (Traumatic Brain Injury), Status Epilepticus, Bacterial Meningitis, Augmented Renal Clearance (ARC)
- Trial name
- Neuro-ARC (NCT07410624)
- Where
- 3 sites in United States, Canada
- Volunteers
- 512 people
- Sponsor
- University of Alberta
Postpartum Hemorrhage
THUMB: Multi-centre Cluster Trial for Caesarean Section Haemorrhage
The quality improvement project evaluating the delivery of a perioperative care complex intervention to improve haemorrhage-related outcomes in patients undergoing caesarean section.
- Trial name
- NCT07005349
- Testing
- Quality improvement program
- Where
- South Africa
- Volunteers
- 2,400 people
- Sponsor
- Bruce Biccard
Complex Care, Medical Complexity
Complexity in Health, Education, and Social Support for Children and Young People With Life-limiting Conditions.
Children and young people (CYP) with life-limiting conditions represent a growing population with complex care needs that span health, education, and social care systems.
- Conditions
- Complex Care, Medical Complexity, Pediatrics, Life-limiting Illness
- Trial name
- CHESS (NCT07102433)
- Testing
- Children and young people with life-limiting conditions, their parents/carers, and professionals across healthcare, education, and social care sectors.
- Where
- 5 sites in United Kingdom
- Volunteers
- 170 people
- Sponsor
- King's College London
Severe Mental Illness, Hospitalizations Psychiatric
Community-Based Intensive Treatment (CBIT): Meeting the Complex Needs of Rural Adults With Serious Mental Illness
The purpose for this research project is to successfully achieve the primary systems intervention outcome, maintaining fidelity to the intervention model and time to rehospitalization.
- Conditions
- Severe Mental Illness, Hospitalizations Psychiatric, Rural Healthcare-seeking Behaviour, Rural Health
- Trial name
- CBIT (NCT07887113)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Wound Surgical, Wounds and Injuries
Non-pharmacological Pain Care During Complex Wound Care Procedures
The main objective of this study is to evaluate the effect on pain and both Virtual Reality and Music Therapy as add-on therapy during wound car in adults.
- Conditions
- Wound Surgical, Wounds and Injuries, Virtual Reality, Wound Care
- Trial name
- NCT05744024
- Testing
- Virtual Reality system, Headphones
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Congenital Heart Disease, Complex Congenital Heart Disease
A Chinese Multicenter Study on Surgical Techniques and Outcomes Across the Lifespan in Congenital Heart Disease
The goal of this observational study is to learn about recovery after heart surgery for people with Complex Congenital Heart Disease (CCHD), build a comprehensive data platform for CCHD care across a person's whole life, and…
- Conditions
- Congenital Heart Disease, Complex Congenital Heart Disease, Surgery (Cardiac), Perioperative Care
- Trial name
- NCT07524998
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Hypoplastic Left Heart Syndrome (HLHS)
National Collaborative to Improve Care of Children With Complex Congenital Heart Disease
The purpose of this initiative is to improve care and outcomes for infants with HLHS by expanding the NPC-QIC national registry to gather clinical care process, outcome, and developmental data on infants with HLHS between…
- Trial name
- NPC-QIC (NCT02852031)
- Testing
- Collaborative Learning Network
- Where
- 63 sites in United States, Canada and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Palliative Care
Complex Decisions Regarding Antithrombotic Therapy: the QUIET Study
"Complex decisions regarding antithrombotic therapy: the QUIET study" is a monocentric observational study without drug intervention, conducted through the administration of a questionnaire (survey).The aim of this study is to…
- Trial name
- QUIET (NCT07486154)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pregnancy, Periodontal Disease
Lactoferrin-Based Oral Care for Periodontal Health in Pregnancy
This randomized controlled clinical trial aims to evaluate the effectiveness of a lactoferrin-based oral hygiene protocol in improving periodontal health during pregnancy.
- Conditions
- Pregnancy, Periodontal Disease, Gingivitis, Oral Microbiota
- Trial name
- LBC-PREG (NCT07069140)
- Testing
- Lactoferrin-based Toothpaste and Mouthwash (Emoform Glic), Lactoferrin-Based Toothpaste Only (Emoform Glic)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Frailty
Supporting Uptake of Evidence for Physical Activity in Older Adults With Complex Health Care Needs
Physically frail older adults often have chronic conditions that contribute to a higher chance of them being limited in daily activities and becoming dependent.
- Trial name
- Moving_More (NCT06894914)
- Testing
- 24-hour Activity Counselling
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Postoperative Follow-up
PROMs-guided Perioperative Care in Patients With Complex Care Needs: An Open-label Randomized Controlled Trial
This research aims to identify, as early as the preoperative phase, groups of patients likely to experience maximum clinical improvement through structured paramedical follow-up based on PROMs.
- Trial name
- OPTICAIRE (NCT07338188)
- Testing
- Patient-Reported Outcomes-based perioperative follow-up (QoR-15 focus)
- Volunteers
- 276 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Kidney Disease (Stages 4 and 5)
Feasibility of the COMFORT (COmplex Symptom Management Intervention FOR adulTs With Advanced Kidney Disease) Intervention for Adults With Advanced Kidney Disease and Their Informal Caregivers
The purpose of this randomized feasibility study is to examine whether the COMFORT intervention is feasible and acceptable for adults with advanced kidney disease and their informal caregivers.
- Trial name
- COMFORT (NCT07815639)
- Testing
- COMFORT Intervention, Usual Care
- Where
- 2 sites in Denmark
- Volunteers
- 112 people
- Sponsor
- University of Aarhus
Liver Cancer, Rhabdomyosarcoma
Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors
Patients may be considered if the cancer has come back, has not gone away after standard treatment or the patient cannot receive standard treatment.
- Conditions
- Liver Cancer, Rhabdomyosarcoma, Malignant Rhabdoid Tumor, Liposarcoma
- Trial name
- NCT04715191
- Testing
- CARE T cells
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor College of Medicine
Endometriosis
Developing a Complex ex Vivo Endometrial Tissue Model to Improve Endometriosis Care
Endometriosis is a chronic gynaecological disease characterised by the growth of endometrium outside the uterus. It affects 10% of childbearing age women. There is no cure for endometriosis.
- Trial name
- OTEndo (NCT06331676)
- Testing
- Tissue collection, Data collection
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Complex Regional Pain Syndrome (CRPS)
Clinical and Cerebral Changes Following Multifaceted Rehabilitation of Complex Regional Pain Syndrome
This study investigates the clinical effects of an individually tailored rehabilitation program for patients with Complex Regional Pain Syndrome (CRPS).
- Trial name
- NCT02753335
- Testing
- Individualized CRPS Rehabilitation
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- University Hospital of North Norway
Diabetic Foot Ulcers (DFUs), Venous Leg Ulcers (VLUs)
Study of Miro3D Wound Matrix for Healing Wounds and Ulcers in Outpatient Care
This clinical study is being conducted to evaluate how well the Miro3D Wound Matrix helps heal difficult wounds and ulcerations in an outpatient care setting.
- Conditions
- Diabetic Foot Ulcers (DFUs), Venous Leg Ulcers (VLUs), Pressure Ulcers, Surgical Wound Dehiscence (SWD)
- Trial name
- NCT06939673
- Testing
- Acellular Porcine-Derived Wound Matrix
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Reprise Biomedical, Inc.
Palliative Care
Pilot Study Evaluating the Therapeutic Effects of Passive Exposure Virtual Reality on Pain, Anxiety, Fatigue, and Well-being in Patients With Complex Palliative Care Needs.
The EPURAVAS "Pilot Study Using Augmented and Virtual Reality to Ease Suffering in Palliative Care" study is designed to investigate a non-medication treatment for complex symptoms in palliative care.
- Trial name
- EPURAVAS (NCT07214090)
- Testing
- Transparent Augmented Reality with Real-World Video Feed Overlay (RVAT), Passive Multisensory Virtual Reality Immersion via Head-Mounted Display (RVEP)
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Advance Care Planning
Advanced Care Planning for the Severely Ill Home-dwelling Elderly
This study will develop and evaluate a complex intervention to implement advance care planning for severely ill home-dwelling elderly acutely admitted to hospital, by using a cluster randomized design.
- Trial name
- NCT05681585
- Testing
- Implementation support program
- Where
- 12 sites in Norway
- Volunteers
- 2,000 people
- Sponsor
- University of Oslo
Pediatric Medical Complexity Based on PMCA Score of 3
Comprehensive Assessment of Reactions to Pharmacogenetics in Complex Care Patients
The goal of this clinical trial is to determine the feasibility and acceptability of Pharmacogenetic Testing, and the attitudes towards the same in caregivers of complex care patients in Cincinnati, OH.
- Trial name
- CAREPICC (NCT07060300)
- Testing
- Agree to Pharmacogenetic Testing
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati