Clinical trials: Complex Coronary Artery Disease
Coronary Artery Disease
Prasugrel 5 mg vs. Ticagrelor 60 mg in CHIP (E5TION)
E5TION will evaluate the efficacy, safety and tolerability of tailored two regimens (prasugrel 5mg/d vs. ticagrelor 60mg bid) in high-risk patients undergoing PCI (CHIP: COmplex and Higher-Risk Indicated PCI/PatieNts).
- Trial name
- E-5TION (NCT04734353)
- Testing
- Prasugrel 5mg, Ticagrelor 60mg
- Where
- 8 sites in South Korea
- Volunteers
- 492 people
- Sponsor
- Gyeongsang National University Hospital
Multivessel Coronary Artery Disease
Insights From the FAST-TRACK CABG Trial: a Clinical Outcome Study in Patient With Previous Surgical Revascularization for Complex Three-vessel or Left Main Coronary Artery Disease Based on Coronary Computed Tomography Angiogram, and Fractional Flow Reserve Derived by Computed Tomography
Coronary computed tomography angiography (CCTA) is a non-invasive imaging tool that characterizes coronary artery anatomy and provides detailed assessments of plaque morphology, composition , inflammation, and hemodynamics, which…
- Trial name
- FAST-CABG (NCT07628270)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Centro Cardiologico Monzino
Coronary Artery Disease
Two-stent vs Provisional Stenting Techniques for Patients With Complex Coronary Bifurcation Lesions
The purpose of this study is to establish the optimal strategy for stenting in coronary bifurcation lesion.
- Trial name
- DEFINITION-II (NCT02284750)
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 660 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Disease, Coronary Artery Disease
COMPLEX Registry - a Prospective COhort Study to Describe the Management and Outcomes of Patients Presenting with CompLEX and Calcified Coronary Artery Disease
The purpose of the COMPLEX Registry is to prospectively and retrospectively collect baseline, clinical and procedural data of patients who have undergone PCI or CABG for complex and/ or calcified chronic CAD, irrespective of…
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis, Coronary Arteriosclerosis
- Trial name
- COMPLEX (NCT06075602)
- Testing
- Impact of current PCI techniques/ devices in complex coronary artery lesions
- Where
- Switzerland
- Volunteers
- 5,000 people
- Sponsor
- Luzerner Kantonsspital
Coronary Heart Disease
A Cohort Study of PCI Strategies for Severely Calcified Lesions of Complex Coronary Arteries in the Elderly
The aim of this observational study is to compare the prognostic outcomes of various PCI strategies in elderly patients with complex coronary calcified lesions.
- Trial name
- PSSCCE (NCT06168422)
- Testing
- DES, DCB
- Where
- China
- Volunteers
- 2,100 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Coronary Artery Disease, Myocardial Infarction
Intravascular Lithotripsy and/or Mechanical Debulking for Severely Calcified Coronary Artery Lesions
To evaluate intra-procedural and long-term effects of intravascular lithotripsy with the ShockWave System and/or non-balloon mechanical debulking devices, prior and/or after coronary stenting in an angiographically well-defined…
- Trial name
- ROLLING-STONE (NCT05016726)
- Testing
- Intravascular Lithotripsy
- Volunteers
- 400 people
- Sponsor
- SS Annunziata Hospital, Savigliano
Acute Myocardial Infarction, Myocardial Viability
The Assessment Of Myocardial Viability Based On CTA/MRI Hybrid Models
The aim of HYBRIDHEART study is to develop new imagistic prototype for a complex evaluation of the myocardial viability by superposing computed tomographic angiographic polar maps of the myocardium with magnetic resonance imaging…
- Conditions
- Acute Myocardial Infarction, Myocardial Viability, Vulnerable Coronary Plaques, Coronary Stenosis
- Trial name
- HYBRIDHEART (NCT04397198)
- Testing
- Speckle Tracking echocardiography
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Coronary Artery Disease, Coronary Artery Disease (Left Main)
Optimization of Complex Percutaneous Coronary Intervention With Liberal Use of Intracoronary Imaging Versus Contemporary Practice
Coronary artery disease remains a leading cause of mortality worldwide and is commonly treated with percutaneous coronary intervention (PCI). Typically, PCI is guided by invasive coronary angiography (ICA).
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (Left Main), Chronic Total Occlusion (CTO), Bifurcation Coronary Artery Disease
- Trial name
- OPTIMIZE-PCI 2 (NCT07114393)
- Testing
- Liberal use of intracoronary imaging during complex PCI
- Where
- Netherlands
- Volunteers
- 11,092 people
- Sponsor
- Cathreine BV
Coronary Artery Disease
An Assessment of the Glider Balloon in Complex Lesions
The purpose of this study is to collect data from real-world use with the Glider Percutaneous Transluminal Coronary Angioplasty (PTCA) Balloon Catheter to support the effectiveness of the Glider PTCA Balloon for crossing into…
- Trial name
- ANTELOPE (NCT02396186)
- Testing
- PTCA Balloon Angioplasty
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- TriReme Medical, LLC
Coronary Artery Disease
Stenting With or Without Coating Compared With Angioplasty in Non-benestent Disease
The purpose of this study is to evaluate the clinical and angiographic outcome of implantation of stents eluting or not eluting Sirolimus in patients with complex coronary artery lesions suitable for percutaneous coronary…
- Trial name
- NCT00192881
- Testing
- Bx Sonic & Cypher stent from Cordis
- Where
- Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Congenital Heart Disease, Pulmonary Arterial Hypertension
4DFlow Magnetic Resonance Imaging in Patients With Pulmonary Hypertension Associated With Congenital Heart Disease
Congenital heart disease is the most common congenital anomaly. The life expectancy of children with congenital heart disease has increased considerably in recent years.
- Trial name
- 4DFlowHTAPCC (NCT03928002)
- Testing
- 4D Flow magnetic resonance imagery, Cardiac catheterization
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Atrial Fibrillation, Atrial Flutter
Triggers and Risk Factors for Recurrence of Atrial Arrhythmias With the Use of Long-term Monitoring
A prospective cohort study to evaluate the association between various triggers encountered in daily life and induction of atrial arrhythmias (atrial fibrillation, atrial flutter, atrial tachycardia and premature atrial…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Atrial Arrhythmia, Atrial Tachycardia
- Trial name
- TriggersAF (NCT05526170)
- Testing
- Devices for long-term monitoring of objective and subjective parameters of the body
- Where
- Lithuania
- Volunteers
- 182 people
- Sponsor
- Vilnius University
Coronary Artery Disease
SMart Angioplasty Research Team: CHoice of Optimal Anti-Thrombotic Strategy in Patients Undergoing Implantation of Coronary Drug-Eluting Stents 3
This study is a prospective, open-label, two-arm, randomized multicenter trial to compare the efficacy and safety of clopidogrel versus aspirin monotherapy beyond the standard duration of dual antiplatelet therapy (DAPT) (more…
- Trial name
- SMART-CHOICE3 (NCT04418479)
- Testing
- Aspirin, Clopidogrel
- Where
- South Korea
- Volunteers
- 5,506 people
- Sponsor
- Joo-Yong Hahn
Coronary Artery Disease, Atherosclerosis
Intravascular Imaging- Versus Angiography-Guided Percutaneous Coronary Intervention For Complex Coronary Artery Disease
The aim of the study is to compare clinical outcomes between intravascular imaging-guided versus angiography-guided percutaneous coronary intervention (PCI) in complex lesions.
- Trial name
- RENOVATE (NCT03381872)
- Testing
- Percutaneous coronary intervention for complex lesion, Drug-eluting stent, Intravascular imaging (IVUS or OCT)
- Where
- South Korea
- Volunteers
- 1,639 people
- Sponsor
- Samsung Medical Center
Pulmonary Arterial Hypertension
Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger Syndrome
Long-term study to evaluate if macitentan is safe, tolerable and efficient enough to be used for treatment of Eisenmenger syndrome.
- Trial name
- MAESTRO-OL (NCT01739400)
- Testing
- Macitentan 10 mg tablet, once daily.
- Where
- 51 sites in United States, Austria and 17 more
- Volunteers
- 217 people
- Sponsor
- Actelion
Coronary Artery Disease
Optical CoherenCe Tomography-gUided Coronary Intervention in Patients With Complex lesIons: a Randomized Controlled Trial (OCCUPI Trial)
There is no definite conclusive work about the benefit of OCT-guided PCI, which should be determined in complex PCI, assuming better stent optimization by OCT.
- Trial name
- NCT03625908
- Testing
- OCT-guided PCI, Angiography-guided PCI
- Where
- South Korea
- Volunteers
- 1,604 people
- Sponsor
- Yonsei University
ACS - Acute Coronary Syndrome, CYP2C19 Polymorphism
CYP2C19 Genotype-Guided P2Y12 Receptor Inhibitor Selection After Complex Percutaneous Coronary Intervention
In Ease Asia clinical trials, P2Y12 inhibitor (ticagrelor or clopidogrel) monotherapy after 3-month dual antiplatelet therapy (DAPT) resulted in a lower incidence of clinically significant bleeding, without increasing risk of…
- Trial name
- NCT06283888
- Testing
- CYP2C19 Genotype Guided DAPT, Conventional DAPT
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Zunyi Medical College
Coronary Artery Disease, Myocardial Ischemia
Safety and Feasibility Evaluation of Planning and Execution of Surgical Revascularization Solely Based on Coronary CTA and FFRCT in Patients With Complex Coronary Artery Disease (FASTTRACK CABG)
To assess the feasibility of coronary computed tomography angiography (CTA) and fractional flow reserve derived from CTA (FFRCT) to replace invasive coronary angiography (ICA) as a surgical guidance method for planning and…
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Disease, Heart Diseases
- Trial name
- NCT04142021
- Testing
- Coronary computed tomography angiography
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 114 people
- Sponsor
- National University of Ireland, Galway, Ireland
Atrial Fibrillation, Coronary Artery Disease
Antithrombotic Strategy for AF Patients With High Risk CAD
Anticoagulation therapy is recommended for patients with atrial fibrillation (AF) in order to prevent ischemic stroke and systemic embolism.
- Trial name
- ADAPT AFFIRM (NCT06866665)
- Testing
- Anticoagulation Monotherapy, Combination therapy
- Volunteers
- 1,400 people
- Sponsor
- Yonsei University
Coronary Artery Diseases, Multivessel Coronary Artery Disease
SYNTAX III REVOLUTION Trial: A Randomized Study Investigating the Use of CT Scan and Angiography of the Heart to Help the Doctors Decide Which Method is the Best to Improve Blood Supply to the Heart in Patients With Complex Coronary Artery Disease
The SYNTAX III Revolution trial is a randomized diagnostic research study that investigates the use of CT scan and angiogram of the heart to help doctors decide which method is the best to improve blood supply to the heart in…
- Conditions
- Coronary Artery Diseases, Multivessel Coronary Artery Disease, Heart Diseases, Cardiovascular Diseases
- Trial name
- SYNTAX III (NCT02813473)
- Testing
- Coronary Angiography, Computed Tomography (CT) scan
- Where
- 6 sites in Belgium, France and 3 more
- Volunteers
- 223 people
- Sponsor
- ECRI bv