Clinical trials: Complex Symptom Disorders
Cancer
Antithymocyte Globulin, Clofarabine, and Rituximab in Treating Patients After an Unsuccessful Stem Cell Transplant
RATIONALE: Antithymocyte globulin, clofarabine, and rituximab may stop the patient's immune system from rejecting the donor's stem cells when they do not exactly match the patient's blood.
- Trial name
- NCT00617929
- Testing
- anti-thymocyte globulin, rituximab, clofarabine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Fatigue
Evaluation and Diagnosis of People With Pain and Fatigue Syndromes
This study will examine people who have pain or fatigue symptoms with a known or unknown diagnosis to determine eligibility for other research studies. No treatment is offered under this protocol.
- Trial name
- NCT00677157
- Where
- United States
- Volunteers
- 367 people
- Sponsor
- National Institute of Nursing Research (NINR)
Sleep Disorder
Characterizing Sleep Disorders in Children and Adults With Tuberous Sclerosis Complex (TSC)
The proposed research project is aimed at further characterization of sleep problems and evaluation of their impact in children and adults with TSC, excluding epilepsy as contributing factor.
- Trial name
- NCT03326765
- Testing
- Questionnaires, electroencephalogram (EEG), polysomnography
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Mycobacterium Avium-Intracellulare Infection, HIV Infections
Tolerance, Safety, and Activity of Rifapentine Alone and in Combination Therapy in AIDS Patients With Mycobacterium Avium Complex Bacteremia.
To determine the antimicrobial activity and tolerability of rifapentine alone and in combination therapy in patients with AIDS and disseminated Mycobacterium avium complex (MAC) bacteremia.
- Trial name
- NCT00002192
- Testing
- Rifapentine, Ethambutol hydrochloride, Clarithromycin
- Where
- United States
- Sponsor
- Anderson Clinical Research
Palliative Care, Primary Palliative Care
Primary Palliative Care - a Feasibility Cluster Trial
This feasibility cluster-controlled randomized trial (RCT) evaluates a complex intervention for the delivery of primary palliative care in Family Health Units (FHUs).
- Conditions
- Palliative Care, Primary Palliative Care, Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- PrimPal (NCT07737899)
- Testing
- Primary Palliative Care Complex Intervention (PrimPal)
- Where
- 2 sites in Portugal
- Volunteers
- 30 people
- Sponsor
- University of Coimbra
Ischemic Stroke
Carotid Intima-media Thickness in Japan Statin Treatment Against Recurrent Stroke(J-STARS Echo)
Carotid ultrasound can reveal the intima-media complex thickness(IMT), that has been reported to be a marker of atherosclerosis as well as a risk of cardiovascular events, and to be attenuated by…
- Trial name
- NCT00361530
- Testing
- Statin
- Where
- 2 sites in Japan
- Volunteers
- 854 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Breast Cancer-Related Lymphedema, Autonomic Dysfunction
Evaluation of Sympathetic Skin Response and Its Relationship With Clinical Response to Complex Decongestive Therapy in Patients With Postmastectomy Lymphedema
This prospective observational single-center study aimed to evaluate sympathetic skin response (SSR) in patients with postmastectomy upper extremity lymphedema and to investigate the relationship between SSR parameters and…
- Conditions
- Breast Cancer-Related Lymphedema, Autonomic Dysfunction, Postmastectomy Lymphedema
- Trial name
- BCRL-SSR (NCT07585253)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Sinus Rhythm, Atrial Fibrillation
Prevention of Stroke and Sudden Cardiac Death by Recording of 1-Channel Electrocardiograms
Single-channel electrocardiograms (lead I of 12-lead surface ECG; 30 seconds) will be collected from subjects/patients at 11 clinical centers in Germany to train an Artificial Intelligence in the automatic diagnosis of regular…
- Conditions
- Sinus Rhythm, Atrial Fibrillation, Atrial Premature Complexes, Ventricular Premature Complexes
- Trial name
- PRICE (NCT04637230)
- Testing
- Electrocardiogram analysis by Artificial Intelligence
- Where
- Germany
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- A-Rhythmik GmbH
Chronic Pain, Complex Regional Pain Syndromes
Dance-therapy and Chronic Pain
Pain, when it becomes chronic, can be a threat to patients and it is very common to observe a fear of pain and a fear of movement (kinesiophobia).
- Conditions
- Chronic Pain, Complex Regional Pain Syndromes, Tension-Type Headache
- Trial name
- ALGODANCE (NCT05689944)
- Testing
- Dance-therapy, Art-therapy, Yoga
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Hospices Civils de Lyon
HIV Infections
The Anti-HIV Effects of Saquinavir Soft Gelatin Capsules Versus Indinavir in Patients Who Have Used Saquinavir Hard Gelatin Capsules for One Year
To determine, in HIV-infected patients, whether switching to a new soft gelatin capsule formulation of saquinavir or to indinavir following prolonged use of the original hard capsule formulation of saquinavir results in an acute…
- Trial name
- NCT00000848
- Testing
- Indinavir sulfate, Saquinavir
- Where
- 16 sites in United States
- Volunteers
- 144 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Dementia
Modulation of Monocyte Activation by Atorvastatin in HIV Infection
Activated monocytes play a key role in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Individuals with HAND have expanded populations of activated monocytes.
- Trial name
- NCT01263938
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Perimenopausal Disorder, Depression
Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause"
Using neuroimaging, the investigator will study the effects of estrogen on mood and brain function in perimenopausal women with depression.
- Trial name
- Duavee (NCT03740009)
- Testing
- Bazedoxifene/Conjugated Estrogen
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Persistent Atrial Fibrillation
Benefit of CFAE Ablation
The optimal strategy for catheter ablation of persistent atrial fibrillation is not clearly defined. This study investigates if Complex Fractionated Atrial Electrogram (CFAE) ablation in addition to pulmonary vein isolation and…
- Trial name
- BOCA (NCT01711047)
- Testing
- Radiofrequency catheter Ablation
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- Oxford University Hospitals NHS Trust
Premature Ventricular Beats, Premature Ventricular Complexes
Flecainide in Idiopathic Premature Ventricular Contractions and Related Cardiomyopathy
The UNIFLECA study is a prospective, single-arm, observational cohort evaluating the efficacy, safety, and tolerability of flecainide (in the form of Sanocard) in adults with frequent idiopathic premature ventricular contractions…
- Conditions
- Premature Ventricular Beats, Premature Ventricular Complexes, Premature Ventricular Contraction (PVC), Arrhythmia Ventricular
- Trial name
- UNIFLECA (NCT06949748)
- Testing
- Flecainide (monotherapy)
- Where
- 6 sites in Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Athens
Glomerulonephritis, Membranous
Efficacy and Safety Study of Intravenous Belimumab Versus Placebo in Subjects With Idiopathic Membranous Nephropathy
The main clinical study will be a randomized, double-blind, placebo-controlled, long term study involving a 100 week treatment period.
- Trial name
- NCT01762852
- Testing
- Belimumab 10 mg
- Where
- 30 sites in United States, Australia and 8 more
- Sponsor
- GlaxoSmithKline
Premature Ventricular Complex
Electrocardiographic and Cardiac Magnetic Resonance Predictors of Ventricular Arrhythmias in Cardiomyopathic Patients
This study aims to assess ECG changes for predicting ventricular arrhythmia in cardiomyopathic patients
- Trial name
- NCT05078125
- Testing
- Holter monitoring
- Volunteers
- 79 people
- Sponsor
- Assiut University
Pain
The Effect of Intravenous Lidocaine on Allodynia
The purpose of this study is to study if lidocaine, given intravenously, reduces pain.
- Trial name
- NCT00659633
- Testing
- lidocaine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
Chronic Pain, Insomnia
Insomnia and Cognitive Performance in Chronic Pain
The aim of the present study is to examine cognitive function in a patient population with complex chronic pain to test the hypothesis that insomnia severity on its own predicts objective cognitive function, and that a…
- Trial name
- NCT03072745
- Testing
- Neuropsychological assessment
- Where
- Sweden
- Volunteers
- 22 people
- Sponsor
- Uppsala University
Complex Regional Pain Syndrome, Carpal Tunnel Syndrome
Examination of the Pathophysiologic Mechanisms of CRPS by Using QST, CPM, RIC, and Heart Rate Variability QST
This study aims for a better understanding of the pathophysiological mechanisms of the complex regional pain syndrome (CRPS). This will be done by testing the quantitative sensory testing, the remote ischemic conditioning, the…
- Conditions
- Complex Regional Pain Syndrome, Carpal Tunnel Syndrome, Neuralgia
- Trial name
- NCT02261012
- Where
- Germany
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Atrial Tachycardia
PVC Response ''Atrial Pace'' Inducing Atrial Tachycardias
Premature ventricular contractions (PVC) are common phenomenon and occasionally retrograde conduction from ventricle to atrium occurs and may cause pacemaker mediated tachycardia.
- Trial name
- NCT05344456
- Testing
- Change in the device PVC algorithm to ''Off''
- Where
- Finland
- Volunteers
- 16 people
- Sponsor
- Helsinki University Central Hospital