Clinical trials: Complication, Postoperative
Postoperative Pain
Effect of Intravenous Acetaminophen on Postoperative Opioid-related Complications
Some patients have respiratory depression (decreased breaths per minute) after surgery. Acetaminophen, an FDA approved pain medication, may prevent this problem.
- Trial name
- NCT02156154
- Testing
- Intravenous Acetaminophen
- Where
- United States
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Emergence Agitation
Comparison of Emergence Agitation Between Sevoflurane and Desflurane Anesthesia After Orthognathic Surgery
Emergence agitation is a major concern in patients undergoing orthognathic surgery. The patients may experience the sense of suffocation during emergence due to nasotracheal intubation and orofacial edema.
- Trial name
- NCT01878656
- Testing
- Sevoflurane, Desflurane
- Where
- South Korea
- Volunteers
- 144 people
- Sponsor
- Chung-Ang University Hospital
Goal Directed Therapy, Fluid Therapy
Goal Directed Therapy Versus Standard Care in Lung Resection Surgery (GDT-thorax Study).
The primary aim of this study is to quantify and compare the hemodynamic control of cardiac index in patients who receive either goal-directed therapy or standard hemodynamic management in lung resection surgery
- Trial name
- GDT-thorax (NCT03245372)
- Testing
- Standard care, Goal directed therapy
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
POSTOPERATIVE PAIN
Comparative Study of Two Different Techniques to Perform TAP-blocks
The TAP is a space between the muscle layers of the abdominal wall that houses nerves supplying the abdominal skin. Injecting the local anesthetic ropivacaine into this space will block these nerves and prevent pain following…
- Trial name
- Surgical-TAP (NCT02571439)
- Testing
- Surgical TAP block, Conventional TAP block, 0.5% ropivacaine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Maimonides Medical Center
Chronic Post Surgical Pain
A Post Market Study to Assess the Spinal Modulation Dorsal Root Ganglion Stimulator System in Chronic Post Surgical Pain
20-SMI-2013 is a post market, observational, questionnaire based study to assess the effectiveness of the commercially available Axium neurostimulator in the management of chronic post surgical pain
- Trial name
- NCT02335229
- Testing
- Axium DRG Neurostimulator
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Abbott Medical Devices
Short Bowel Syndrome
Efficacy, Safety and Tolerability of Enteric-Coated Cholestyramine Capsules for Adult Short Bowel Syndrome
A new Enteric-Coated Cholestyramine (ECC) capsule has been developed to manage diarrhea associated with Short Bowel Syndrome (SBS) in adults.
- Trial name
- NCT04046328
- Testing
- Enteric-Coated Cholestyramine (ECC) Capsule
- Where
- 3 sites in Poland
- Volunteers
- 13 people
- Sponsor
- Pharmascience Inc.
Urinary Tract Infection
Suppressive Therapy With Oral Antibiotics for Prevention of Postoperative Urinary Tract Infection (UTI)
This is a study of patients undergoing gynecologic surgery who require post-operative catheterization to determine if prophylactic antibiotic treatment decreases the risk of post-operative urinary tract infection in these…
- Trial name
- STOPP UTI (NCT01450800)
- Testing
- Nitrofurantoin
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- Duke University
Pain, Postoperative
Pain Control in Pediatric Posterior Spine Fusion Patients: The Effect of Gabapentin
The purpose of this study is to evaluate the patient experience when using gabapentin with other pain control medications after posterior spinal fusion surgery for scoliosis in adolescents.
- Trial name
- NCT01977937
- Testing
- Gabapentin 250mg/5mL NDC:59762-5025-01, Simple Syrup
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Oregon Health and Science University
Pain, Postoperative
Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery
This study will compare IV (intravenous) versus oral (PO) acetaminophen for postoperative pain after scheduled, elective Cesarean delivery.
- Trial name
- NCT02487303
- Testing
- Acetaminophen Intravenous, Acetaminophen Oral
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Incisional Hernia
ProGripTM Self-Gripping Polyester Mesh in Incisional Hernia Prevention
Interventional, prospective, multicenter, post-marketing clinical follow-up study. After midline laparotomy, the probability to develop an incisional hernia ranges from 10% to 50% depending on the complexity of the surgery and…
- Trial name
- POETRY (NCT03912662)
- Testing
- Mesh augmented reinforcement
- Where
- 11 sites in France
- Volunteers
- 32 people
- Sponsor
- Medtronic - MITG
Respiratory Disorders, Intensive Care, Neonatal
Timing of Planned Caesarean Section and Morbidity of the Newborn
The caesarean section rate is rising globally. About 10% of the newborns are submitted to a neonatal department after planned caesarean section, primarily with respiratory disorders.
- Trial name
- NCT00835003
- Testing
- Elective caesarean section
- Where
- 7 sites in Denmark
- Volunteers
- 1,273 people
- Sponsor
- Aarhus University Hospital
Postoperative Nausea and Vomiting
The Impact of Preoperative Olanzapine on Quality of Recovery After Discharge From Ambulatory Surgery
The primary objective of this phase 2 randomized controlled trial is to determine whether the pre-operative administration of olanzapine (5 mg PO) improves quality of recovery (assessed by the Quality of Recovery-40 (QoR-40)…
- Trial name
- NCT05676294
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- Yale University
Nausea and Vomiting, Postoperative
The Effects of IV vs Oral Dexamethasone on Postoperative Nausea, Vomiting, and Pain
The hypothesis being tested in this study is that perioperative oral administration of dexamethasone, when compared to intravenous (IV) administration, offers a similar reduction in postoperative nausea and vomiting (PONV), and…
- Trial name
- NCT04563494
- Testing
- dexamethasone
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Colorado, Denver
Of Bypass Graft of the Extremities, Peripheral Arterial Disease
Standard Versus PICO Dressings in Lower-Extremity Bypass Patients
The objective of this study is to compare the effectiveness of standard moist dressings and PICO single-use negative pressure dressings in post-operative lower extremity bypass patients.
- Conditions
- Of Bypass Graft of the Extremities, Peripheral Arterial Disease, Vascular Diseases, Cardiovascular Diseases
- Trial name
- PICO-LEB (NCT02492854)
- Testing
- PICO Single-Use Negative Pressure Dressings, Sterile Gauze Dressings
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Boston Medical Center
TSA, Bruise
Natural History of Pain After Shoulder Arthroplasty Conducted With Multimodal Analgesia
This study aims to identify the timeline of pain following total shoulder replacement with the goal of developing data for a subsequent randomized trial.
- Conditions
- TSA, Bruise, Pain, Postoperative
- Trial name
- TSA (NCT03021096)
- Testing
- Surveys
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Atrial Fibrillation New Onset, Hemorrhage
Randomized Double Blind Control Trial on Effects of Ranolazine on New Onset Atrial Fibrillation
The aim of this study is to evaluate the prophylactic effects of Ranolazine on new onset atrial fibrillation in post-operative coronary artery bypass graft and valve surgery patient population at Staten Island University hospital.
- Conditions
- Atrial Fibrillation New Onset, Hemorrhage, Prolonged QTc Interval, Ventricular Tachycardia
- Trial name
- NCT01590979
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwell Health
Breast Cancer Related Lymphedema
A Study Evaluating FT-SW in Unilateral Breast Cancer-Related Lymphedema Patients
The objective of the study is to demonstrate equivalency in treatment effect, as determined by objective measurements, between the modified therapy cycle software and the FDA-cleared Flexitouch therapy cycle software.
- Trial name
- NCT04073823
- Testing
- Flexitouch Plus, Flexitouch Plus FT with software modification
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Tactile Medical
Postoperative Pain
Lumbar Plexus Block for Postoperative Pain Control After Hip Arthroscopy. A Randomized Controlled Trial
The purpose of this study is to determine whether the use of a lumbar plexus block for arthroscopic hip surgery is superior to oral and intravenous opioid pain medications alone in treating pain.
- Trial name
- LPB Hip Scope (NCT01286805)
- Testing
- Lumbar Plexus Blockade, Control
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- Hospital for Special Surgery, New York
Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting
The purpose of this study is to determine whether doxycycline (Periostat) at a sub-antimicrobial dose will decrease reperfusion injury after coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB).
- Conditions
- Coronary Artery Bypass Grafting, Cardiopulmonary Bypass, Reperfusion Injury
- Trial name
- NCT00246740
- Testing
- Periostat
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University of Alberta
Pain, Postoperative
Postoperative Pain Management in Rhinoplasty
The primary purpose of the study is to determine adequacy of postoperative pain control after nasal surgery in patients prescribed Acetaminophen (325mg) + Hydrocodone (5mg) compared to Acetaminophen(325mg) + Ibuprofen (200mg)for…
- Trial name
- NCT03584152
- Testing
- Norco 5Mg-325Mg Tablet, Tylenol 325Mg Caplet, Ibuprofen 200 mg
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Stanford University
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