Clinical trials: Complication
Prosthesis Durability
Two Versus Four Implant-supported Fixed Full-arch Prosthesis
The aim of this study will be the evaluation of patient satisfaction and oral health-related-quality of life (OHRQoL) of two versus four implants supporting fixed full-arch screw-retained metal acrylic hybrid mandibular…
- Trial name
- NCT05290766
- Testing
- placement of four dental implants, placement of two dental implants, mandibular full arch prosthesis
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Wound Complications, Obesity
Early Versus Delayed Skin Staple Removal Following Cesarean Delivery in the Obese Patient
Whenever a person has a cesarean section there is a risk that there will be a problem with healing of the wound. The most common type of wound healing problem is separation and opening of the skin and fatty tissue just beneath…
- Trial name
- NCT01114451
- Testing
- Removal of surgical skin staples
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Preterm Birth, Obstetric Labor, Premature
Azithromycin to Improve Latency in Exam Indicated Cerclage Control Trial
Azithromycin is an antibiotic that is effective against bacteria that been associated with preterm birth (PTB). The purpose of this study is to evaluate if the addition of azithromycin prior to exam indicated cerclage prolongs…
- Conditions
- Preterm Birth, Obstetric Labor, Premature, Obstetric Labor Complications, Pregnancy Complications
- Trial name
- ALEC (NCT05132829)
- Testing
- Azithromycin 1 gram IV, Cefazolin and indomethacin
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Cardiovascular Diseases, Osteoporosis
Macrobiotic Diet and Flax Seed: Effects on Estrogens, Phytoestrogens, & Fibrinolytic Factors
This study will assess whether alternative, high phytoestrogen dietary interventions result in favorable effects on biological parameters that have been associated with hormone-dependent cancers, cardiovascular disease, and…
- Conditions
- Cardiovascular Diseases, Osteoporosis, Breast Cancer, Endometrial Cancer
- Trial name
- NCT00010829
- Testing
- American Heart Association Step 1 diet, American Heart Association Step 2 diet + 10 g/day flax seed, Macrobiotic dietary intervention
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Pelvic Girdle Pain, Diastasis Recti and Weakness of the Linea Alba
The Association Between Pelvic Floor Muscle Function, Diastasis Recti and Postpartum Pelvic Girdle Pain - a Matched Case Control Study.
Background: Pregnancy-related pelvic girdle pain (PGP) can appear during pregnancy, directly after labour or can be delayed to 3 weeks postpartum.
- Conditions
- Pelvic Girdle Pain, Diastasis Recti and Weakness of the Linea Alba, Pelvic Floor Disorders
- Trial name
- NCT04757077
- Where
- Poland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Żelazna Medical Centre, LLC
COVID, Pregnancy Complications
COVID-19 and Obstetric Transmission
The aim of this study is to capture data, laboratory markers, and clinical outcomes of obstetric and neonatal outcomes in cases of COVID-19 during pregnancy and of pregnancies exposed to a COVID-19 vaccine in Cuyahoga County.
- Trial name
- COVIDOB (NCT04418557)
- Testing
- RT-PCR and antibody testing
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Diabetes Mellitus, Kidney Disease
Impact of Antiglycemic & Immunosuppressive Therapies on NETosis in Diabetes & Kidney Disease (NETs - Neutrophil Traps)
This study aims to investigate whether new glucose-lowering medications, such as SGLT2 inhibitors (e.g., Forxiga/Jardiance) and GLP-1 receptor agonists (e.g., Ozempic), can reduce NETosis in diabetic patients, thereby mitigating…
- Trial name
- NETs (NCT06821919)
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Gestational Diabetes, Gestational Hypertension
Preventing Obstetric Complications With Dietary Intervention
The goal of this study is to learn whether access to healthy and fresh food, health coaching, and nutrition support intervention can reduce adverse birth outcomes in pregnant women.
- Conditions
- Gestational Diabetes, Gestational Hypertension, High Risk Pregnancy, Preeclampsia
- Trial name
- PLATE (NCT06320054)
- Testing
- Maternal Health Management Program
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders
Multi-observational Study for the Early Identification of Autism Spectrum Disorder (ASD) and Other Neurodevelopmental Disorders (NDD) in At-risk Populations
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects about 78 million people worldwide. Its prevalence and degree of impact on individuals and families place it among disorders of global importance.
- Trial name
- BABY@NET (NCT06915805)
- Where
- 5 sites in Italy
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Istituto Superiore di Sanità
Pain, Postoperative
Pre-incision Versus Post-incision Local Anesthetic During Robotic Sacrocolpopexy
Obtaining Likest-pain scale score on postoperative day one after injection of local anesthetic into incision sites of a laparoscopic/robotic-assisted sacrocolpopexy
- Trial name
- CLAPPS (NCT04996251)
- Testing
- Bupivacaine Injection
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Depression, Postpartum
Prevention of Postpartum Depression in Low-Income Women
This study will determine whether a prevention program reduces the incidence of postpartum depression in pregnant women who receive public assistance and are at risk for postpartum depression.
- Trial name
- NCT00053651
- Testing
- Survival Skills for Moms with New Babies
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Motivational Interviewing, Self Efficacy
The Effect of Motivational Interviewing on Self-Efficacy and Quality of Life in Gestational Diabetes Mellitus
This study is a randomized controlled experimental study planned to investigate the effect of motivational interviewing on health management self-efficacy and quality of life in pregnant women with gestational diabetes mellitus.
- Conditions
- Motivational Interviewing, Self Efficacy, Quality of Life, Gestational Diabetes Mellitus
- Trial name
- NCT06243939
- Testing
- Motivational Interview to Increase Health Management Self-Efficacy and Quality of Life in Pregnant Women Diagnosed with Gestational Diabetes Mellitus
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Pain, Post-Operative Pain
Ibuprofen Extended-Release Dental Pain Study
The purpose of this study is to evaluate the efficacy and safety of multiple doses of Ibuprofen 600 mg Extended-Release Tablets in a study of dental pain following extraction of third molar teeth.
- Conditions
- Pain, Post-Operative Pain, Third Molar Extraction
- Trial name
- NCT00707057
- Testing
- Ibuprofen 600 mg Extended-Release Tablets
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- SCOLR Pharma, Inc.
Worsening Chronic Heart Failure, Chronic Kidney Disease
A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should.
- Trial name
- NCT04908436
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bayer
Renal Impairment
Evaluation of Effect of Renal Impairment on the PK of Tenofovir Exalidex
This is a Phase 1 study to investigate the effects of Renal Impairment on the pharmacokinetics of Tenofovir exalidex
- Trial name
- NCT03284164
- Testing
- Tenofovir Exalidex (TXL)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ContraVir Pharmaceuticals, Inc.
Postpartum Hemorrhage
The PPHgb Study: Non-Invasive Hemoglobin Measurement
This project is a prospective observational study aimed to assess the use of non-invasive hemoglobin measurement in anticipating postpartum hemorrhage and predicting estimated blood loss.
- Trial name
- NCT05046964
- Testing
- Masimo Radical-7 Pulse CO-Oximeter
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- George Washington University
Diabetes Type 2, Diabetic Neuropathies
High vs Low Dose Vitamin D in Patients With Diabetic Peripheral Neuropathy
Aim. To assess the effect of different doses of vitamin D supplementation on peripheral neuropathy in patients with type 2 diabetes mellitus (T2DM).
- Conditions
- Diabetes Type 2, Diabetic Neuropathies, Vitamin D Deficiency
- Trial name
- NCT04377399
- Testing
- Vitamin D
- Where
- Russia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Seroma as Procedural Complication, Hematoma Postoperative
Study to Evaluate the Performance of a Sustained Vacuum System
The purpose of this study is to evaluate the performance of the SOMAVAC® 100 Sustained Vacuum System after oncologic resections.
- Trial name
- NCT04554407
- Testing
- SOMAVAC® 100 Sustained Vacuum System
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- SOMAVAC Medical Solutions
Healthy Volunteers
Early Environmental and Maternal Determinants of Airway Inflammation in Wheezing Disorders in Infants
This study collects data on microbiological, genetic and environmental factors, as well as lung function parameters (e.g. spirometry, body plethysmography, lung-MRI) to assess the complex interaction of predisposing risk factors…
- Trial name
- NCT04286464
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Endometriosis, Endometrioma
Genomic Maps of Endometrial Tissues of Patients With Endometriosis and Healthy Controls
Endometriosis is a chronic inflammatory disease that affects 10-17% of women in childbearing age, 35-60% of women with chronic pelvic pain and can cause infertility, costing as much as 2.8 billion dollars per year.
- Trial name
- NCT03687398
- Testing
- genetic testing with nanoclonal technique
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Acibadem University
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