Clinical trials: Complication of Anesthesia
Hypoxemia, Postoperative Complications
Heated Humidified Oxygen in PACU Patients
This study aims to determine whether heated and humidified oxygen therapy, compared with conventional room-temperature oxygen therapy, reduces the incidence of early hypoxemia in adult patients recovering from general anesthesia…
- Conditions
- Hypoxemia, Postoperative Complications, Anesthesia Recovery Period
- Trial name
- NCT07778420
- Testing
- Heated and Humidified Oxygen Therapy, Room-Temperature Oxygen Therapy
- Where
- 8 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Anesthesia Intubation Complication, Laryngoscopy
Can the "Face Index"; an Anthropometric Measurement, Predict Difficult Laryngoscopy and Intubation?
Patient safety is the cornerstone of anesthetic practice, and maintaining adequate respiration represents its most critical initial step.
- Conditions
- Anesthesia Intubation Complication, Laryngoscopy, Intubation; Difficult or Failed, Anesthesia Morbidity
- Trial name
- NCT07366177
- Testing
- Face index
- Volunteers
- 1,000 people
- Sponsor
- Ordu University
Pain Management, Colorectal Surgery
Opioid-Free Anesthesia in Colorectal Surgery, 2025 (OFA-CRC-2025)
This study wants to find out if using a pain control method without opioids (Opioid-Free Anesthesia or OFA) works as well as or better than standard anesthesia (which uses opioids) for adults having minimally invasive…
- Conditions
- Pain Management, Colorectal Surgery, Opioid Free Anesthesia, Postoperative Complications
- Trial name
- OFA-CRC-2025 (NCT07771049)
- Testing
- Opioid-Free Anesthesia (OFA), Opioid-Based Anesthesia (OBA)
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitario La Fe
Cesarean Section Complications, Cesarean Section Pain
Insufficient Regional Anesthesia and Conversion to General Anesthesia for Cesarean Section A Qualitative Multicenter Study
Background In Denmark, approximately 20% of all children are born via cesarean section (C-section), making it the most common surgical procedure (also internationally).
- Conditions
- Cesarean Section Complications, Cesarean Section Pain, Regional Anesthesia
- Trial name
- NCT06669156
- Where
- 7 sites in Denmark
- Volunteers
- 21 people
- Sponsor
- Sygehus Lillebaelt
Anesthesia, Surgery
Perioperative Predictive Value of Physical Activity on Short- and Long-term Morbidity and Mortality
Over 300 million surgeries are performed globally every year. Complications after surgery - infections, cardiovascular conditions, postoperative pulmonary complications and renal impairment - affect survival and quality of life.
- Conditions
- Anesthesia, Surgery, Surgery Complications
- Trial name
- PeriopPrePA (NCT07603622)
- Where
- Sweden
- Volunteers
- 50,000 people
- Sponsor
- Karolinska Institutet
Heart Rate Monitoring, Vagal Bradycardia
Heart Rate Variability and Early Cytokine Profile in Pediatric Adenotonsillectomy
This prospective observational cohort study will assess whether perioperative short-term heart rate variability (HRV) indices and early inflammatory cytokine levels are associated with respiratory and cardiac adverse events in…
- Conditions
- Heart Rate Monitoring, Vagal Bradycardia, Adenotonsillar Hypertrophy, Tonsillitis; Hypertrophic
- Trial name
- NCT07719439
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Duzce University
Anesthesia, Postoperative Complications
Impact of a Transmission Checklist in Post Anesthesia Care Unit on Immediate Respiratory Complications
This work highlighted the beneficial role in terms of carers' satisfaction, quantity and quality of information transmitted.
- Conditions
- Anesthesia, Postoperative Complications, Anesthesia Complication
- Trial name
- TC-IRC (NCT03972423)
- Testing
- With or wiyhout a checklist
- Where
- France
- Volunteers
- 560 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists
Effect of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA) on Gastric Emptying
This study aims to assess the effect of using Glucagon-like peptide-1 receptor agonists (GLP-1) receptor agonists on gastric emptying on surgical patients and whether specific guidelines need to be established for these patients.
- Conditions
- Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists, Intermittent Fasting, Intraoperative Complication Due to Anesthesia
- Trial name
- NCT07140289
- Testing
- Ultrasound of gastric contents
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wael Saasouh, MD
Congenital Heart Disease, Airway Complication of Anesthesia
Video Laryngoscopy Versus Direct Laryngoscopy for Nasotracheal Intubation
The aim of this study is to perform a pilot study investigating the first attempt intubation success rate differing between video laryngoscope nasotracheal intubation and direct laryngoscope nasotracheal intubation.
- Trial name
- NCT05902013
- Testing
- laryngoscopy
- Where
- Austria
- Volunteers
- 152 people
- Sponsor
- Medical University of Vienna
Postoperative Nausea and Vomiting, Anesthesia Complication
Risk Factors for Postoperative Nausea and Vomiting (PONV) in Adults at the Post-Anaesthesia Care Unit of Dr. Cipto Mangunkusumo National General Hospital
The goal of this observational study is to determine the incidence of postoperative nausea and vomiting (PONV) and identify its risk factors in adult patients recovering in the post-anaesthesia care unit (PACU) after elective…
- Conditions
- Postoperative Nausea and Vomiting, Anesthesia Complication, Postoperative Complication
- Trial name
- PONV-RSCM (NCT07688811)
- Testing
- Routine perioperative anaesthesia care
- Where
- Indonesia
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Neuromuscular Blockade Reversal Agent, Perioperative Complications
Sugammadex-Induced Clenching During Neuromuscular Blockade Reversal
Study Objective: This study aims to evaluate the incidence, severity, and risk factors of sugammadex-induced mouth clenching during neuromuscular blockade (NMB) reversal in adult surgical patients.
- Conditions
- Neuromuscular Blockade Reversal Agent, Perioperative Complications, Anesthesia, General, Sugammadex
- Trial name
- NCT06962007
- Testing
- Sugammadex 1 mg/kg Group, Sugammadex 2 mg/kg Group, Sugammadex 4 mg/kg Group
- Where
- South Korea
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Anesthesia, Anesthesia Complication
Optimizing Patient-centred Outcomes Using Opioid Minimization Strategies: The OPUS Anesthesia Pilot Trial
Up to 40% of patients experience suboptimal recovery in the days following major surgery, limiting their return to functional independence.
- Conditions
- Anesthesia, Anesthesia Complication, Surgery, Quality of Life
- Trial name
- OPUS (NCT06884540)
- Testing
- Dexmedetomidine, lidocaine, control group
- Where
- 5 sites in Canada
- Volunteers
- 100 people
- Sponsor
- CHU de Quebec-Universite Laval
Postoperative Nausea and Vomiting (PONV), Gynecological Laparoscopic Surgery
Midazolam Adjunct Therapy for Prevention of PONV in Gynecological Laparoscopy
This randomized controlled trial was conducted to evaluate the efficacy of adding midazolam to standard dual antiemetic prophylaxis with dexamethasone and ondansetron for the prevention of postoperative nausea and vomiting (PONV)…
- Conditions
- Postoperative Nausea and Vomiting (PONV), Gynecological Laparoscopic Surgery, Anesthesia Complications
- Trial name
- MIDOD (NCT07668700)
- Testing
- Midazolam 0.05 mg/kg IV as adjunct to dexamethasone and ondansetron for PONV prevention
- Where
- Pakistan
- Volunteers
- 300 people
- Sponsor
- Hameed Latif Hospital, Lahore
Risk Factors, Complication of Surgical Procedure
ACUTE-Acute Surgical Care- Risk Factors and Outcomes for Patients in Need of Acute Surgical Care
Observational retrospective study of patients in need of acute surgical care admitted to Skåne University Hospital between 2009 and 2019.
- Conditions
- Risk Factors, Complication of Surgical Procedure, Complication of Treatment, Complication of Anesthesia
- Trial name
- ACUTE (NCT05195697)
- Testing
- Observational study of different treatments and time to treatment
- Where
- Sweden
- Volunteers
- 3,000 people
- Sponsor
- Region Skane
Gastric Content Aspiration Risk, Gastrointestinal Endoscopy
BBCMADE Nomogram Validation for High-Risk Gastric Content in Sedative Endoscopy
This prospective observational study aims to validate the BBCMADE nomogram (Body Mass Index, Brain infarction, Cirrhosis, Male sex, Age, Diabetes, Esophageal reflux) for predicting high-risk gastric content in patients undergoing…
- Conditions
- Gastric Content Aspiration Risk, Gastrointestinal Endoscopy, Anesthesia Complications
- Trial name
- BBCMADE (NCT07638917)
- Testing
- BBCMADE Nomogram, Endoscopic Gastric Volume and pH Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 533 people
- Sponsor
- Fusun Gozen
POCD - Postoperative Cognitive Dysfunction, Recovery Time
The Effects of Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy
In this study, the investigators want to examine the effects of intravenous anesthetic drugs and gases on cognitive functions in the postoperative period in individuals who will undergo surgery for obesity.
- Conditions
- POCD - Postoperative Cognitive Dysfunction, Recovery Time, Postoperative Neurocognitive Disorder, Postoperative Delirium
- Trial name
- NCT07637357
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Acute Kidney Injury, Surgery Complications
Real-Time Acute Kidney Injury Perioperative Prediction Clinical Trial
This investigator-initiated, pragmatic trial evaluates whether displaying a machine learning (ML)- derived perioperative AKI risk score-alone or paired with an interruptive Best/Our Practice Advisory (BPA/OPA)-improves…
- Conditions
- Acute Kidney Injury, Surgery Complications, Anesthesia
- Trial name
- ML-AKI (NCT07604662)
- Testing
- EHR-Embedded AKI Risk Score, EHR-Embedded AKI Risk Score with Best Practice Advisory
- Where
- United States
- Volunteers
- 25,518 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Atelectasis, Pulmonary Complications
Low-Flow Anesthesia and Perioperative Atelectasis in Laparoscopic Bariatric Surgery
The goal of this clinical trial is to learn whether low-flow anesthesia reduces perioperative atelectasis compared to normal-flow anesthesia in adults undergoing laparoscopic bariatric surgery.
- Conditions
- Atelectasis, Pulmonary Complications, Ultrasonography, Bariatric Surgery
- Trial name
- NCT07041567
- Testing
- Sevoflurane with normal-flow anesthesia, Sevoflurane with low-flow anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Anesthesia, General, Postoperative Complications
Pre-operative Characteristics for Prediction of Supraglottic Airway Failure Using Machine Learning (ERICA)
Supraglottic airway devices (SGA) are a safe and well-established technique for airway management. Nowadays, up to 60% of general anaesthetics performed in European countries use SGA.
- Conditions
- Anesthesia, General, Postoperative Complications, Laryngeal Masks, Treatment Failure
- Trial name
- ERICA (NCT06617403)
- Testing
- non
- Where
- 2 sites in Germany
- Volunteers
- 44,000 people
- Sponsor
- University Hospital Ulm
Pregnancy Related, Cesarean Section Complications
Predictive Hemodynamic Monitoring During Elective Cesarean Section
Single shot spinal anesthesia (SA) is the most commonly used technique for Caesarean section (CS) . SA is associated with maternal hypotension (Post Spinal Hypotension - PSH) often accompanied by nausea, vomiting, bradycardia and…
- Conditions
- Pregnancy Related, Cesarean Section Complications, Hypotension on Induction, Anesthesia Complication
- Trial name
- PREDICTION (NCT06729827)
- Testing
- Hypotension prediction Index - HPI
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS