Clinical trials: Complication of Dialysis
Dialysis; Complications
Assessment of Thyroid Dysfunction in Patients Undergoing Haemodialysis at Sohag University Hospital
Thyroid dysfunction is a prevalent endocrine disorder that significantly impacts the health of patients with chronic kidney disease (CKD), particularly those undergoing dialysis.
- Trial name
- NCT07022236
- Testing
- Thyroid profile
- Where
- Egypt
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Sohag University
Peritoneal Dialysis, Hemodialysis, Home
Experiences and Health-related Quality of Life of Informal Caregivers of Dialysis Patients
The goal of this prospective, observational, multicentre cohort study is to assess the trajectory of the experiences (both positive and negative) and health-related quality of life (HRQOL) of informal caregivers of patients who…
- Conditions
- Peritoneal Dialysis, Hemodialysis, Home, Hemodialysis, Quality of Life
- Trial name
- NCT05646615
- Where
- 33 sites in Belgium, Netherlands
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- B.C. van Jaarsveld
Hemodialysis Patients
Impact on the Proteolysis of Obesity in Dialysis
The objective of this study is to determine whether obesity has a protective effect on muscle proteolysis in hemodialysis patients submitted to a short starvation.
- Trial name
- IPOD (NCT01114789)
- Testing
- Proteolysis
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Kidney Diseases, Cardiovascular Diseases
Assessment of Protein Modification in Chronic Kidney Disease - Selected Clinical and Biochemical Aspects
The studies included the effect of chronic kidney disease advancement on the accumulation of oxidative stress markers in plasma. In patients with end-stage renal disease, the effect of replacement therapy was also assessed.
- Conditions
- Chronic Kidney Diseases, Cardiovascular Diseases, Dialysis; Complications
- Trial name
- NCT04939870
- Testing
- Biochemical parameters evaluation
- Where
- Poland
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Uremia
Elimination of Incretin Hormones in Patients With Severe Kidney Failure
The prevalence of type 2 diabetes (T2D) is increasing rapidly worldwide. T2D is characterized by a severely impaired incretin effect.
- Trial name
- NCT01391884
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bo Feldt-Rasmussen
Atypical Hemolytic Uremic Syndrome
Complement Inhibition in aHUS Dialysis Patients
This study evaluates the effect of CCX168, a C5aR Antagonist, Oral Administration on Ex Vivo Thrombus Formation and Disease Activity in ten patients with diagnosis of Atypical Hemolytic Uremic Syndrome with or without genetic…
- Trial name
- ACCESS (NCT02464891)
- Testing
- CCX168
- Where
- Italy
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Renal Insufficiency, Chronic
Effect of Hemodialysis on Upper Airways Collapsibility in Patients With Chronic Kidney Disease
Introduction: Currently, chronic kidney disease (CKD) is one of the most serious public health problems, becoming a global epidemic.
- Trial name
- NCT02390193
- Testing
- Hemodialysis
- Where
- Brazil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centro Universitário de Anapolis
Chronic Kidney Diseases, Dialysis; Complications
Cardiac Tissue Sodium Assessment in CKD Patients Using Sodium MRI
Chronic kidney disease (CKD) is prevalent worldwide and affects around 10% of people living in developed health economies. As the kidney loses its function in patients with CKD, the kidneys are unable to filter toxins out of the…
- Conditions
- Chronic Kidney Diseases, Dialysis; Complications, Sodium Retention
- Trial name
- NCT04848636
- Testing
- Cardiac Sodium and Proton MRI
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Renal Insufficiency
Pharmacokinetics and Safety of Fevipiprant in Patients With Renal Impairment Compared to Matched Healthy Subjects
The aim of the study is to assess whether renal impairment could affect fevipiprant pharmacokinetics (PK) to the extent that dosage adjustment is appropriate for this patient population.
- Trial name
- NCT03087942
- Testing
- QAW039, QAW39A, QAW39A2107
- Where
- 2 sites in United States, Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
End Stage Renal Failure on Dialysis
A Pilot Trial of Twice-weekly Versus Thrice-weekly Hemodialysis in Patients With Incident End-stage Kidney Disease
The optimal frequency of hemodialysis treatments in patients with incident end-stage kidney disease in not known. This pilot trial will randomize patients with incident end-stage kidney disease due to chronic kidney disease…
- Trial name
- TWOPLUS-HD (NCT03740048)
- Testing
- Hemodialysis, Patiromer Oral Product
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Renal Impairment
Study to Evaluate the Effect of Renal Impairment and Dialysis Treatment on the Pharmacokinetics of a Single 3 mg Cytisinicline Dose
The primary objectives of this study are: 1. To obtain information on the pharmacokinetics of cytisinicline following a single oral dose in subjects with varying degrees of renal impairment relative to matched controls with…
- Trial name
- NCT05631938
- Testing
- cytisinicline
- Where
- 6 sites in Portugal, Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Achieve Life Sciences
Renal Impairment
A Study to Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal Impairment
The purpose of this study is to evaluate the drug levels of mezigdomide in participants with renal impairment.
- Trial name
- NCT06318676
- Testing
- Mezigdomide
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Celgene
Atherosclerosis of Artery, Inflammation
The Impact of Selected Factors on the Cardiovascular System in Chronic Kidney Disease
Chronic kidney disease (CKD), is characterized by accelerated development of atherosclerosis and advanced remodelling of vessels and the heart.
- Conditions
- Atherosclerosis of Artery, Inflammation, Chronic Kidney Diseases, Dialysis; Complications
- Trial name
- NCT05214872
- Testing
- laboratory parameters - complete blood count, body mass index (BMI) [kg/m^2] calculation, selected parameters of oxidative stress (1)
- Where
- Poland
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Cardiovascular Diseases, Carotid Intimal Media Thickness
Association of Mean Platelet Volume and Cardiovascular Disease in Children With End Stage Renal Disease.
Cardiovascular disease (CVD) is the major risk factor for death in end stage renal diseases (ESRD). Approximately 80% of ESRD patients have some degrees of left ventricular abnormalities at initiation of dialysis.
- Conditions
- Cardiovascular Diseases, Carotid Intimal Media Thickness, Left Ventricular Hypertrophy, Mean Platelet Volume
- Trial name
- NCT03759002
- Testing
- Imaging, Blood sampling
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Chronic Kidney Diseases, Hemodialysis Complication
Exposure Of Bisphenol Analogues In Chronic Kidney Disease and Dialysis Patients
In this retrospective study, the serum levels of Bisphenol A (BPA) and three BPA analogs, namely, bisphenol B (BPB), bisphenol S (BPS), and bisphenol F (BPF), in patients with CKD, patients on dialysis therapy and healthy control…
- Trial name
- NCT04100421
- Where
- China
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Renal Disease, Adherence, Treatment
The Effect of Motivational Interviewing and Education Based on Watson's Theory of Human Caring in Hemodialysis
Motivational interviewing and education based on Watson's Theory of Human Caring have an effect on increasing adherence to fluid intake in individuals receiving hemodialysis treatment.
- Conditions
- Renal Disease, Adherence, Treatment, Quality of Life, Satisfaction, Patient
- Trial name
- NCT04174638
- Testing
- Motivational Interviewing and Education Based on Watson's Theory of Human Caring
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Renal Insufficiency, Kidney Disease
A Study to Evaluate the Pharmacokinetics Of Sativex® in Subjects With Severe Renal Impairment or End Stage Renal Disease, Compared to Matched Subjects With Normal Renal Function.
The study aims to determine the pharmacokinetic (PK) profile of a single oromucosal dose of Sativex® (i.e. how the body absorbs, distributes, metabolises and excretes the drug) when subjects have severe renal impairment or end…
- Trial name
- NCT02325024
- Testing
- Sativex
- Volunteers
- healthy volunteers welcome
- Sponsor
- GW Pharmaceuticals Ltd
Cardiovascular Disease, Chronic Kidney Disease Patients
A Study Using L5 as a Risk Factor of Cardiovascular (CV) Disease in Chronic Renal and Dialytic Patients
The purpose of this study is to determine whether L5, one of the Low Density Lipoproteins, is an effective predicting factor for cardiovascular disease in chronic renal and hemodialytic patients.
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease Patients, Hemodialytic Patients, High LDL Level
- Trial name
- L5 (NCT01236820)
- Where
- Taiwan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Dialysis Access Malfunction, Dialysis; Complications
Balloon Assisted Maceration Versus Rotational Thrombectomy in Dialysis Access Salvage
The purpose of this research study is to compare how well a wire like device disrupts and removes blood clot in your blocked dialysis graft/fistula in comparison to inflating a balloon in your access for the same purpose.
- Trial name
- BART (NCT05782062)
- Testing
- Cleaner XT, Balloon
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hemodialysis, Healthy
Study to Evaluate the Pharmacokinetics and Metabolism of [14C] CR845 (Difelikefalin) in Patients With End Stage Renal Disease on Hemodialysis and in Healthy Subjects
The objectives of this study are to evaluate the in vivo metabolite profiling and characterization of CR845 administered intravenously (IV) in patients on hemodialysis (HD) and in healthy subjects; and to determine the…
- Trial name
- NCT03947970
- Testing
- [14C] CR845
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cara Therapeutics, Inc.