Clinical trials: Complication of Dialysis
Chronic Renal Failure
Clinical Study on Optimised Removal of Protein-bound Uremic Toxins With Convective Dialysis Treatment.
Patients will be treated with hemodiafiltration (HDF) in postdilution mode, as a control therapy, during 9 weeks. During week 5 the 1st intervention treatment, predilution hemofiltration (HF) or predilution HDF, will be performed…
- Trial name
- NCT00337831
- Testing
- Performance of predilution hemofiltration, predilution hemodiafiltration or postdilution hemodiafiltration
- Where
- Belgium
- Volunteers
- 17 people
- Sponsor
- University Hospital, Ghent
Hemodialysis Complication
Effect of a Medium Cut-Off Dialyzer - Medical Device on ESA Resistance in 110 Hemodialysis Patients (EXPAND)
It is hypothesized that a consistent use of Medium cut-off membrane (Theranova) increased clearance of pro-inflammatory molecules in a broad molecular weight range attenuates the chronic inflammatory state in patients with poor…
- Trial name
- EXPAND (NCT03874819)
- Testing
- Medium cut-off dialyzer, High-flux dialyzer
- Volunteers
- 110 people
- Sponsor
- Carlo Maria Guastoni
Stage 3 Chronic Kidney Disease
Safety & Tolerability Study of CTP-499 in Patients With Moderate Chronic Kidney Disease
This study is being conducted to evaluate the safety and tolerability of treatment with CTP-499 in non-dialysis patients associated with moderate chronic kidney disease.
- Trial name
- NCT01460199
- Testing
- CTP-499
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Concert Pharmaceuticals
Kidney Failure, Chronic, Anemia
A Study of the Safety and Efficacy of Long-term Correction of Anemia With Epoetin Alfa in Early Hemodialysis Patients
The purpose of this study in early hemodialysis patients (on dialysis 3 to 18 months) is to assess the effect of correction versus partial correction of anemia using epoetin alfa on heart pumping function.
- Trial name
- NCT00261521
- Testing
- epoetin alfa
- Volunteers
- 596 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Chronic Kidney Disease
Niaoduqing Granules in Older Adults With Impaired Kidney Function
This prospective real-world study will evaluate the clinical benefits of Niaoduqing Granules in older adults with impaired kidney function.
- Trial name
- NCT07741292
- Testing
- Intervention Name
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Huashan Hospital
Anemia, Renal Insufficiency, Chronic
A Study of Molidustat for Correction of Renal Anemia in Non-dialysis Subjects
The purpose of this study is to evaluate the efficacy and safety of molidustat in non-dialysis subjects with renal anemia who are not treated with Erythropoiesis-Stimulating Agents (ESAs).
- Trial name
- MIYABI ND-C (NCT03350321)
- Testing
- Molidustat (BAY85-3934), Darbepoetin alfa
- Where
- 61 sites in Japan
- Volunteers
- 162 people
- Sponsor
- Bayer
Chronic Kidney Disease stage3
Effect of Intradialytic Exercises in Chronic Kidney Disease Patients
the purpose of this study is to compare between intradialytic aerobic versus resistive exercises on immunity response in patients with chronic kidney disease.
- Trial name
- NCT06293092
- Testing
- leg pedaling cycling device, sand bags, hemodialysis sessions
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Acute Kidney Injury, Fluid Overload
Restrictive Versus Liberal Rate of Extracorporeal Volume Removal Evaluation in Acute Kidney Injury
Critically ill patients with acute kidney injury and fluid overload who are frequently treated by fluid removal during dialysis are at an increased risk of complications and death.
- Conditions
- Acute Kidney Injury, Fluid Overload, Hypotension, Dialysis; Complications
- Trial name
- RELIEVE-AKI (NCT05306964)
- Testing
- Restrictive UFnet Rate Strategy, Liberal UFnet Rate Strategy
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- University of Pittsburgh
Kidney Failure, Chronic, Angioplasty
Drug-Eluting Balloon in Arteriovenous Graft
The investigators' study aims is to evaluate the safety and efficacy of percutaneous transluminal angioplasty (PTA) with paclitaxel-coated balloon (PCB) at venous anastomotic stenosis of arteriovenous graft (AVG) in patients with…
- Conditions
- Kidney Failure, Chronic, Angioplasty, Dialysis
- Trial name
- NCT03388892
- Testing
- paclitaxel-coated balloon, IN. PACT(Invatec-Medtronic, Brescia, Italy), Plain Balloon
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Fabry Disease, End Stage Renal Disease
Study of the Prevalence of Fabry Disease in French Dialysis Patients
Fabry Disease (FD) is a rare genetic lysosomal storage disease including an X-linked mutation and characterized by an alpha-galactosidase A (GLA) deficiency.
- Conditions
- Fabry Disease, End Stage Renal Disease, Renal Dialysis
- Trial name
- FABRYDIAL (NCT02843334)
- Testing
- Dried blood spot (DBS) sampling
- Where
- 5 sites in France
- Volunteers
- 6,000 people
- Sponsor
- Hospices Civils de Lyon
End Stage Renal Disease
Protein Supplementation in Dialysis Patients
Poor nutritional status as evidenced by low body mass index, low muscle mass or low serum albumin is a strong predictor of morbidity and mortality in dialysis patients.
- Trial name
- NCT01855295
- Testing
- Protein Supplement
- Volunteers
- 73 people
- Sponsor
- University of Utah
Anaemia
Study to Assess the Pharmacokinetics of GSK1278863 in Subjects With End Stage Renal Disease Undergoing Peritoneal Dialysis
GSK1278863 is an orally-active, novel small molecule agent which inhibits hypoxia-inducible factor (HIF) prolyl -4- hydroxylases (PHDs) and is in development for the treatment of anaemia associated with chronic kidney disease…
- Trial name
- NCT02243306
- Testing
- GSK1278863
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- GlaxoSmithKline
Chronic Kidney Disease Stage 5, Dialysis
An Evaluation of the KCCQ Score in Predicting Cardiovascular Risk in Dialysis Patients
Cardiovascular Disease (CVD) is the main complication and the most important cause of death in CKD patients. As the disease progresses, the incidence of cardiovascular disease in CKD patients gradually increases, especially in…
- Conditions
- Chronic Kidney Disease Stage 5, Dialysis, Heart Failure
- Trial name
- NCT06542016
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Shenzhen Second People's Hospital
Renal Dialysis, Kidney Failure, Chronic
Safety and Pharmacokinetics of MK-2060 in Older Participants With End-Stage Renal Disease on Hemodialysis (MK-2060-004)
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of MK-2060 after intravenous (IV) administration of single and multiple doses in older adult participants with…
- Trial name
- NCT03873038
- Testing
- MK-2060
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Renal Failure
A Multicenter, Randomized, Open-labeled, Cross-over, Active-controlled, Phase IV Clinical Trial to Evaluate the Preference of Formulation and the Efficacy and Safety of Renamezin and Kremezin in Pre-dialysis Patients With Chronic Renal Failure
A Multicenter, Randomized, Open-labeled, Cross-over, Active-controlled, Phase IV Clinical Trial to Evaluate the Preference of Formulation and the Efficacy and Safety of Renamezin and Kremezin in Pre-dialysis Patients With Chronic…
- Trial name
- NCT02681952
- Testing
- Renamezin capsule, Kremezin granule
- Where
- South Korea
- Volunteers
- 153 people
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Chronic Kidney Disease Requiring Chronic Dialysis, Vaccine Response
Impact Of Kidney Failure On The Regulation Of Humoral Response To Vaccination
The aim of this observational study is to determine if and how kidney failure affects the development of protective immune responses following vaccination in patients on chronic dialysis.
- Trial name
- Tfh-CKD (NCT06635525)
- Testing
- Influenza vaccination, SARS-CoV-2 vaccine
- Where
- 3 sites in Italy
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
End-stage Renal Disease
Use of Pedometers to Measure and Increase Walking Among Patients With ESRD
Randomized controlled trial using pedometers to increase physical activity among patients on dialysis.
- Trial name
- PED (NCT02623348)
- Testing
- pedometer
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Hyperphosphatemia, End-Stage Renal Disease
A 4-Week Dose-Ranging and Efficacy Trial of KRX-0502 (Ferric Citrate) in Patients With End-Stage Renal Disease
This is a research study for people with high blood phosphorus levels who are on dialysis. This medical condition can cause weakening of the bones and damage other organs.
- Trial name
- NCT01074125
- Testing
- ferric citrate
- Where
- 16 sites in United States, Puerto Rico
- Volunteers
- 154 people
- Sponsor
- Keryx Biopharmaceuticals
Geriatrics, Chronic Kidney Disease
Evaluation of Endothelial Dysfunction in Geriatric Non-dialysis Chronic Kidney Disease Patients
Brief summary template The goal of this clinical trial is to assess endothelial dysfunction in geriatric non-dialysis CKD patients.
- Conditions
- Geriatrics, Chronic Kidney Disease, Carotis Intima-media Thickness
- Trial name
- EDGeriatrCKD (NCT07430982)
- Testing
- Ultrasonographic and Capillary Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Muğla Sıtkı Koçman University
Chronic Kidney Disease
A Study of Intermittent Oral Dosing of ASP1517 in Non-Dialysis Chronic Kidney Disease Patients With Anemia
The objective of this study is to evaluate the efficacy and safety of ASP1517 when converted from recombinant human erythropoietin (rHuEPO) or darbepoetin alfa (DA), compared to DA in the treatment of anemia in non-dialysis…
- Trial name
- NCT02988973
- Testing
- roxadustat, DA
- Where
- 66 sites in Japan
- Volunteers
- 334 people
- Sponsor
- Astellas Pharma Inc
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