Clinical trials: Complication of Dialysis, open to volunteers
End Stage Renal Disease (ESRD), End Stage Kidney Disease (ESRD)
Effect of a Plant-Focused Diet on Nutritional Status in Malnourished Peritoneal Dialysis Patients
The goal of this clinical trial is to determine whether a plant-focused diet improves nutritional and health outcomes of malnourished adults undergoing peritoneal dialysis (PD).
- Conditions
- End Stage Renal Disease (ESRD), End Stage Kidney Disease (ESRD), Peritoneal Dialysis (PD), Malnourished
- Trial name
- NCT07157397
- Testing
- Plant-Focused Diet Counselling, Standard Renal Diet Counselling
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- National University of Malaysia
Chronic Kidney Disease, Stage 5, Sarcopenia
Effects of Intradialytic Exercise on Muscle Oxygenation and Dialysis Adequacy
This randomized controlled trial will evaluate the effects of a 12-week intradialytic combined exercise program, consisting of aerobic and resistance training, in patients with stage 5 chronic kidney disease receiving maintenance…
- Trial name
- NCT07151742
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istinye University
Acute Kidney Injury, Decision Making ,Shared
Shared Decision-Making for Families in Critical Dialysis Initiation
Background:Acute kidney injury (AKI) is a frequent and serious complication in critically ill patients, often necessitating difficult decisions about starting hemodialysis.
- Conditions
- Acute Kidney Injury, Decision Making ,Shared, Emotional Dysfunction
- Trial name
- NCT07150182
- Testing
- The Integrated Shared Decision-making Program
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University WanFang Hospital
Chronic Kidney Disease
Behavioral AI to Predict and Increase Peritoneal Dialysis Uptake
Scaled Insights Behavioral AI will be used to improve clinicians ability to detect and understand: The likelihood of patients with kidney failure opting for peritoneal dialysis and to select the right personalized nudge to get…
- Trial name
- AI (NCT06533254)
- Testing
- Predicting choice of dialysis, Behavioral nudges
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Scaled Insights
Heart Failure, Kidney Diseases
Research on Optimal Diagnosis and Treatment of Cardiorenal Syndrome
To estimate the characteristics, pathogenesis, risk factors and intervention measures for different stages of heart and kidney diseases, and to optimize the curative effects of different treatment schemes
- Conditions
- Heart Failure, Kidney Diseases, Kidney Injury, Heart Valve Diseases
- Trial name
- ODT-CRS (NCT05397392)
- Testing
- guideline recommended routine treatment
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
End Stage Chronic Renal Failure
Study of Patient Preferences in Dialysis Treatment Choice: a Discrete Choice Experiment
Background Compared to in-center dialysis, home dialysis is associated with better quality of life and lower healthcare system costs. However, barriers remain to its wider adoption.
- Trial name
- PREFDOM (NCT07535320)
- Testing
- Questionnaire
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Caen
End Stage Renal Disease (ESRD)
Evaluate the Efficacy and Safety of Amino Acid (15) Peritoneal Dialysis Solution in Peritoneal Dialysis Patients with Malnutrition.
This is a multicenter, randomized, parallel controlled Phase IV clinical study to evaluate the safety and efficacy of amino acid (15) peritoneal dialysis solution in patients undergoing peritoneal dialysis with malnutrition in…
- Trial name
- NCT06597201
- Testing
- amino acid (15) peritoneal dialysis solution, glucose peritoneal dialysis solution
- Where
- 21 sites in China
- Volunteers
- 400 people
- Sponsor
- Chengdu Qingshan Likang Pharmaceutical Co., Ltd
Chronic Kidney Disease, Periodontitis
Effectiveness of Subgingival Instrumentation on Delaying End-stage Renal Disease Among Chronic Kidney Disease Patients
Chronic kidney disease (CKD) and periodontitis share a bidirectional inflammatory relationship, with cytokines such as IL-6, TNF-α, and hsCRP driving progression in both conditions.
- Conditions
- Chronic Kidney Disease, Periodontitis, End Stage Renal Disease (ESRD)
- Trial name
- NCT07635797
- Testing
- Subgingival Instrumentation, Oral Hygiene Instructions
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Acute Kidney Injury, End Stage Chronic Renal Failure
Feasibility of Intradialytic Monitoring During CKRT
This is a pilot observational cohort study to understand whether advanced monitoring techniques can be applied during continuous kidney replacement therapy (CKRT), which is the most common form of dialytic therapy provided in…
- Conditions
- Acute Kidney Injury, End Stage Chronic Renal Failure, Dialysis
- Trial name
- NCT07428395
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Hyperphosphatemia, Chronic Kidney Disease, Receiving Dialysis
A Study of a Novel Iron-based Phosphate Binder AP301 in Patients With Hyperphosphatemia in the U.S. and China
The goal of this clinical trial is to learn if AP301 could work in the patients receiving maintenance dialysis with elevated blood phosphate.
- Conditions
- Hyperphosphatemia, Chronic Kidney Disease, Receiving Dialysis, ESRD (End-Stage Renal Disease), Dialysis
- Trial name
- RESPOND-2 (NCT06933472)
- Testing
- AP301, AP301 Low Dose
- Where
- 42 sites in United States, China
- Volunteers
- 264 people
- Sponsor
- Alebund Pharmaceuticals
Acute Kidney Injury
Comparison of RCA and RACD in Extra-renal Purification by SLED
One of the main RRT issues is anticoagulation of the ECC, because blood contact with biomaterials causes bio-incompatibility reactions, including activation of the coagulation cascade.
- Trial name
- ARDC-SLED (NCT04968587)
- Testing
- Sustained Low-Efficiency Dialysis
- Where
- France
- Volunteers
- 138 people
- Sponsor
- Groupe Hospitalier Sud Ile-de-France
End Stage Renal Disease on Dialysis
Assessment of D-dimer and CRP for Cardiovascular Risk Prediction in Hemodialysis Patients
This study aims to assess whether two blood markers - C-reactive protein (CRP) and D-dimer - can help predict cardiovascular complications in patients undergoing regular hemodialysis.
- Trial name
- BIOCARD-HD (NCT07130721)
- Testing
- C-Reactive Protein (CRP) Test, D-dimer Test, Electrocardiogram (ECG)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
ESRD (End Stage Renal Disease), Dialysis
Laser Acupuncture for Fatigue in Hemodialysis Patients
The goal of this clinical trial is to learn if laser acupuncture (low-level laser therapy) works to treat fatigue and improve quality of life in adults with end-stage renal disease (ESRD) undergoing hemodialysis.
- Conditions
- ESRD (End Stage Renal Disease), Dialysis, Fatigue
- Trial name
- LA-HD-Fatigue (NCT07538310)
- Testing
- Low-Level Laser Acupuncture (LA)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei City Hospital
Chronic Kidney Disease Requiring Chronic Dialysis, Vaccine Response
Impact Of Kidney Failure On The Regulation Of Humoral Response To Vaccination
The aim of this observational study is to determine if and how kidney failure affects the development of protective immune responses following vaccination in patients on chronic dialysis.
- Trial name
- Tfh-CKD (NCT06635525)
- Testing
- Influenza vaccination, SARS-CoV-2 vaccine
- Where
- 3 sites in Italy
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Carcinoma, Renal Cell
Study of Orellanine in Metastatic Clear-Cell or Papillary Renal Cell Carcinoma
A phase I/II, open-label, study to determine the safety and preliminary efficacy of orellanine in patients with metastatic clear-cell or papillary renal carcinoma who have failed standard-of-care therapy.
- Trial name
- NCT05287945
- Testing
- Orellanine
- Where
- 10 sites in United States, France and 3 more
- Volunteers
- 75 people
- Sponsor
- Oncorena AB
Atrial Fibrillation, Peritoneal Dialysis Complication
Safety and Efficacy of Apixaban Versus Warfarin in Peritoneal Dialysis Patients With Non Valvular Atrial Fibrillation: a Prospective, Randomised, Open-label, Blinded End-point Trial (APIDP2)
Introduction: Several randomised controlled trials have demonstrated that novel oral anticoagulants (NOACs) are safer compared to vitamin K antagonists for the management of non valvular atrial fibrillation (NVAF) to prevent…
- Trial name
- APIDP2 (NCT06045858)
- Testing
- Anticoagulation Agents
- Volunteers
- 178 people
- Sponsor
- University Hospital, Caen
Chronic Kidney Diseases
Intradialisis Physical Exercise in Quality of Life and Health
Evaluate the effectiveness of different modalities of physical exercise about clinical health indicators and quality of life of patients with chronic kidney disease undergoing hemodialysis.
- Trial name
- EJERINTRA (NCT05207527)
- Testing
- cardiovascular exercise, Muscle strength, Mixed
- Volunteers
- 120 people
- Sponsor
- Universidad del Rosario
Kidney Failure, Chronic, Hyperphosphatemia
Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)
During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested.
- Trial name
- PHOSPHATE (NCT03573089)
- Testing
- Liberal phosphate target, Intensive phosphate target
- Where
- 126 sites in Australia, Brazil and 7 more
- Volunteers
- 3,600 people
- Sponsor
- The University of Queensland
Kidney Failure, Chronic Therapy; Hemodialysis
Web-based Advance Care Planning Intervention for Patients With Kidney Failure on Dialysis: Pilot Testing of 'My Voice'
'My Voice' is a website intervention developed to enable advance care planning (ACP) conversations for patients with kidney disease on dialysis, educate patients on their illness, help identify their goals and preferences for EOL…
- Trial name
- NCT07309367
- Testing
- My Voice website intervention with patient and caregiver modules
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Renal Failure, Chronic Kidney Disease
Clinical Performance of the Therapy Option FlexPoint of the PD Cycler Sleep•Safe Harmony
Analysis and comparison of treatments with and without the FlexPoint technology (flexible volume and dwell time management) of the PD cycler sleep•safe harmony
- Trial name
- FlexPoint (NCT06390592)
- Testing
- PD cycler
- Volunteers
- 24 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH