Clinical trials: Complication of Infusion
Neonatal Infection
Impact of a Multi-infusion Strategy in Neonatology on the Rate of Central Line-associated Bloodstream Infections
The management of premature infants hospitalized in neonatal units requires the simultaneous intravenous (IV) infusion of several drugs and parenteral nutrition solutions, when oral administration is impossible or unsuitable.
- Trial name
- EDELVAISS (NCT06656104)
- Testing
- Reference strategy, Experimental strategy
- Where
- 3 sites in France
- Volunteers
- 569 people
- Sponsor
- Hospices Civils de Lyon
Arthroplasty, Replacement, Knee
Postoperative Analgesia After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is associated with moderate to severe postoperative pain. Although epidural treatment provides good and reliable postoperative pain relief after THA, it may cause urinary retention, nausea…
- Trial name
- NCT00421967
- Testing
- Ropivacaine, Ketorolac, adrenaline, Ropivacaine Ketorolac
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Hysteroscopy, Hysteroscopy Technique
UTERINE EVALUATION FOR THE IDENTIFICATION OF PATHOLOGY. This Study Will Compare the Intrauterine Pathology Detection Rate Between Standard of Care Hydrosonography, and a New Visual Saline Infusion Device Providing Direct Visualization of the Uterus.
This is a prospective, single center, multiple arm cohort study intended to compare the diagnostic accuracy of a Visual Saline Infusion Device (VSI) device, vs standard of care Hydrosonography in reproductive aged women to…
- Conditions
- Hysteroscopy, Hysteroscopy Technique, Fertility Issues, Uterus Abnormal
- Trial name
- NCT06394752
- Testing
- Visual Saline Infusion, Hydrosonography
- Where
- 2 sites in United States, Mexico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Center for Reproductive Health & Gynecology
Post-operative Pain
Initial Local Anesthetic Dose With Continuous Interscalene Analgesia
Objective: To determine a minimally effective initial local anesthetic bolus required to provide satisfactory analgesia using continuous brachial plexus infusion following arthroscopic shoulder surgery using a double-blind…
- Trial name
- NCT00672100
- Testing
- Ropivacaine
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Corewell Health East
Delirium - Postoperative, Delirium Prevention
Dexmedetomidine for Prevention of Delirium After Hip Fracture Surgery
Postoperative delirium is common after hip fracture surgery and is associated with delayed recovery and serious postoperative complications.
- Conditions
- Delirium - Postoperative, Delirium Prevention, Dexmedetomidine, Dexmedetomidine Infusion
- Trial name
- DEXLIR (NCT07867899)
- Where
- Denmark
- Volunteers
- 242 people
- Sponsor
- Peter Gaarsdal Uhrbrand
Fanconi Anemia Complementation Group A
A Clinical Trial to Evaluate the Safety of RP-L102 in Pediatric Subjects With Fanconi Anemia Subtype A
The objective of this study is to assess the therapeutic safety and preliminary efficacy of a hematopoietic cell-based gene therapy consisting of autologous CD34+ enriched cells transduced with a lentiviral vector carrying the…
- Trial name
- NCT03814408
- Testing
- RP-L102
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Rocket Pharmaceuticals Inc.
Postoperative Cognitive Dysfunction (POCD)
Intravenous Anesthesıa and Cognıtıve Functıon ın Spınal Surgery
The aim of this study is to investigate the effect of these two different intravenous infusion techniques [manuel controlled infusion (MCI) and Target controlled Infusion( TCI)] on POCD.
- Trial name
- NCT07701187
- Testing
- Manual Controlled Infusion (MCI) of Propofol, Target Controlled Infusion (TCI) of Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Cesarean Section, Hypotension
Effect of Oxytocin Bolus Versus Slow Infusion on Haemodynamic Stability During Caesarean Section Under Spinal Anaesthesia
This study compares two standard ways of giving oxytocin (a medicine that helps the uterus contract) after the baby is born during a planned caesarean section performed under spinal anaesthesia.
- Conditions
- Cesarean Section, Hypotension, Postpartum Hemorrhage, Spinal Anesthesia
- Trial name
- NCT07784478
- Testing
- Oxytocin
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Girls Medical College
Postoperative Pain
Postoperative Pain Therapy With Hydromorphone Using TCI-PCA
Treatment of postoperative pain with hydromorphone (a strong analgesic) using patient-controlled analgesia with target concentrations in blood compared to conventional patient-controlled analgesia after planed cardiac surgery
- Trial name
- TCI-PCA (NCT02035709)
- Testing
- Hydromorphone
- Where
- 2 sites in Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Acute Kidney Injury, Renal Insufficiency, Chronic
Balanced Salt Solution Versus 0.9% Saline Infusion for Prevention of Contrast-induced Acute Kidney Injury (BASIC Trial)
As iodinate contrast media (CM) has been widely used in current medical practice, contrast induced acute kidney injury (CI-AKI) has been an important issue.
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Chronic, Contrast Media Reaction
- Trial name
- NCT02799368
- Testing
- CJ Plasma Solution A Injection, CJ 0.9% Normal Saline Injection
- Where
- South Korea
- Volunteers
- 493 people
- Sponsor
- Seoul National University Hospital
Arginine Vasopressin Deficiency, Primary Polydipsia
Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome
The aim of this study is to evaluate whether a new test using mannitol infusion can diagnose the cause of polyuria-polydipsia syndrome as accurately as the current standard test (hypertonic saline infusion) and to compare which…
- Trial name
- COMPASS (NCT07569861)
- Testing
- Mannitol, Hypertonic Saline
- Where
- Switzerland
- Volunteers
- 144 people
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Pneumonia, Postoperative Pulmonary Atelectasis
Intravenous Lidocaine Infusion Reduce Postoperative Pulmonary Complications in Patients Undergoing Minimally Invasive Esophagectomy
The goal of this double-center, double-blind, randomized controlled clinical trial is to compare the effect of intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing minimally invasive…
- Conditions
- Postoperative Pneumonia, Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Edema
- Trial name
- NCT06138041
- Testing
- intravenous lidocaine infusion, Saline
- Volunteers
- 770 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Head and Neck Surgery, Maxillofacial Surgery
Impact of Nociception Level (NOL)-Guided Remifentanil Infusion on Intraoperative Arterial Pressure and Vasopressor Necessity
The aim of this study is to determine if Nociception Level (NOL)-guided Remifentanil analgesia, combined with Entropy-guided Propofol anesthesia, has a significant beneficial effect on the incidence of intraoperative hypotension…
- Trial name
- NCT04963036
- Testing
- Entropy and NOL-Guided Goal Directed Anesthesia, Standard of Care Group (Entropy and blinded NOL)
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Tooth Extractions
Comparison of Sufentanil and Remifentanil Infusion During General Anaesthesia for Removal of Wisdom Teeth in Ambulatory Surgery
Wisdom teeth removal under general anaesthesia is usually suitable for ambulatory surgery. The choice of opioid in dental day surgery is based on the need for a rapid and full recovery, as well as less morphine administration.
- Trial name
- SUF-REM-DDS (NCT01139671)
- Testing
- Remifentanil
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pain, Postoperative
Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy
This clinical study is a randomized, double-blind, double-dummy, parallel group, multi-center, active and placebo-controlled trial evaluating the analgesic efficacy and safety of NTM-001 in subjects with moderately severe…
- Trial name
- NCT05324358
- Testing
- Ketorolac Tromethamine, Morphine Sulfate
- Where
- 10 sites in United States
- Volunteers
- 341 people
- Sponsor
- Neumentum, Inc.
Neoplasm Malignant, Breast Cancer
Shorter Scalp Cooling Time in Paclitaxel
Chemotherapy-induced alopecia (CIA) is one of the most distressing side effects for patients. Scalp cooling can prevent or minimise CIA in approximately half of all patients, depending on many factors, e.g.
- Conditions
- Neoplasm Malignant, Breast Cancer, Ovarian Cancer
- Trial name
- COP (NCT03266185)
- Testing
- Shorter PICT
- Where
- Netherlands
- Volunteers
- 91 people
- Sponsor
- Leiden University Medical Center
Postoperative Pain
A Comparison of Intra-op Ketamine vs Placebo in Patients Having Spinal Fusion
Postoperative pain is severe after major spine surgery. Opioids such as morphine and hydromorphone are routinely used for postoperative pain control.
- Trial name
- NCT02424591
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- NYU Langone Health
Coronary Artery Bypass Surgery, Coronary Heart Disease
Clinical Study to Evaluate Nesiritide in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery A014 / NAPA
The purpose of this study is to assess the effects of nesiritide compared to placebo when given with standard of care therapies, on kidney function, heart function and the need of other treatments in heart failure patients…
- Conditions
- Coronary Artery Bypass Surgery, Coronary Heart Disease, Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
- Trial name
- NCT00653042
- Testing
- Nesiritide
- Volunteers
- 305 people
- Sponsor
- Scios, Inc.
Postoperative Pain
The Effect Of Ultrasound-guided Modified Pectoral Nerves Block Versus Ketamine Plus Magnesium Infusion On Analgesic Profile In Breast Cancer Surgeries
Background: Postoperative pain is one of the greatest patient concerns following surgery. However, general anesthesia cannot provide adequate postoperative pain control and the routine use of parenteral opioids aggravates…
- Trial name
- NCT04095455
- Testing
- pectoral nerves block group, Ketamine plus magnesium group, Control group
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute, Egypt
Liver Transplant; Complications
Dexmedetomidine to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in Liver Transplantation
the aim of the study is to approve the hypothesis that dexmedetomidine can protect against glycocalyx degradation induced by hepatic ischemia-reperfusion injury and hence can reduce the subsequent complications as early allograft…
- Trial name
- NCT05031026
- Testing
- Dexmedetomidine, Normal Saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University