Clinical trials: Complications, Postoperative
Preemptive Analgesia, Sex Difference
Sex Difference in Preemptive Analgesic Effects With Flurbiprofen Axetil on Postoperative Pain and Sleep Quality
In humans and animals, circadian rhythm sleep cycle plays an important role on maintaining and regulating basic physiological homeostasis, such as cognitive function, glucose metabolism, memory consolidation, immune function and…
- Conditions
- Preemptive Analgesia, Sex Difference, Flurbiprofen Axetil, Postoperative Pain
- Trial name
- NCT04627779
- Testing
- preemptive analgesia with flurbiprofen axetil
- Volunteers
- 100 people
- Sponsor
- Beijing Friendship Hospital
Chlorzoxazone, Postoperative Pain
The Effect of Chlorzoxazone on Moderate to Severe Postoperative Pain After Spine Surgery
Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.
- Trial name
- NCT01933542
- Testing
- Chlorzoxazone, Morphine, Zofran
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pain, Postoperative
Nicotine Administration and Post-operative Opioid Use With Bariatric Surgery
This prospective, randomized, double-blind study will enroll nonsmoking female subjects undergoing laparoscopic bariatric surgery under general anesthesia.
- Trial name
- NCT01194089
- Testing
- Nasal Nicotine Spray, Nasal Normal Saline Spray
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Toby Weingarten
Laparoscopy, Pain, Postoperative
Effects of Insufflated Gas on Core Temperature and Post-operative Pain During Laparoscopic Surgery
During laparoscopy, administration of cold and dry carbon dioxide (CO2) leads to hypothermia. Different types of gas conditioning have been studied in order to prevent this specific hypothermia.
- Conditions
- Laparoscopy, Pain, Postoperative, Hypothermia
- Trial name
- NCT00372268
- Testing
- Aeroneb® Pro (Nektar® Company)
- Where
- 3 sites in France, Italy
- Volunteers
- 248 people
- Sponsor
- University Hospital, Strasbourg, France
Thoracic Anesthesia, Geriatric Anesthesia
The Effect of Single Lung Ventilation Duration and Intraoperative Brain Oxygenation on Cognitive Function and Postoperative Pain in Geriatric Patients
One lung ventilation (OLV) is commonly used in thoracic surgery. Although the lack of ventilation of the lung in the surgical area (independent lung) during OLV redirects pulmonary blood flow to the dependent lung, shunt…
- Conditions
- Thoracic Anesthesia, Geriatric Anesthesia, One Lung Ventillation (OLV), POCD - Postoperative Cognitive Dysfunction
- Trial name
- NCT07339124
- Testing
- Cognitive Remediation, Pain Medicine
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Pain, Postoperative
Comparison Between Two Different Doses of Nulbuphine _bupivacaine in TAP Block in Cancer Abdominal Surgeries
To compare the analgesic effect of two different doses of nulbuphine (10 mg and 20 mg) added to bupivacaine in bilateral subcostal single injection in ultrasound-guided TAP block for abdominal surgeries.
- Trial name
- NCT05090579
- Testing
- Group I (BN10), Active Comparator:Group ll (BN20), Active Comparator:Group lll (B)
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cesarean Section Complications, Cesarean Wound; Dehiscence
PICO Negative Pressure Wound Therapy in Obese Women Undergoing Elective Cesarean Delivery.
A randomized controlled, parallel group, superiority, open-label, single-institution, Phase 3 interventional clinical trial to evaluate clinical outcomes in obese gravidas undergoing elective cesarean delivery whose wounds were…
- Conditions
- Cesarean Section Complications, Cesarean Wound; Dehiscence, Cesarean Wound Disruption
- Trial name
- NCT03414762
- Testing
- PICO Negative Pressure Wound Therapy, Standard Dressing
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Incisional Hernia, Malignancy
Risk Factors for Development of Incisional Hernia in Transverse Incisions
RESEARCH PROJECT OBJECTIVES The aim of this planned study is to evaluate factors, with particular reference to surgical technique of abdominal closure, accumulation of advanced glycation end products, and collagen content in the…
- Trial name
- NCT03561727
- Testing
- Mass closure technique, Layered closure technique
- Where
- Poland
- Volunteers
- 392 people
- Sponsor
- Medical University of Warsaw
Perioperative/Postoperative Complications
Prospective Study to Evaluate the Clinical Utility of Perioperative Pharmacogenomic Testing
In the perioperative realm, studies have demonstrated an association of genotype with efficacy of medications applicable to the surgical setting.
- Trial name
- NCT03531268
- Testing
- PGx Testing
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Postoperative Pain, Lung Cancer
Implementation of Adjuvants in Intercostal Nerve Blockades for Thoracoscopic Surgery in Pulmonary Cancer Patients
To investigate the effect of intercostal blockade with and without adjuvants.
- Conditions
- Postoperative Pain, Lung Cancer, Video Assisted Thoracoscopic Surgery, Thoracoscopic Surgery
- Trial name
- NCT04633850
- Testing
- Dexamethasone, Bupivacain
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Jannie Bisgaard Stæhr
Surgical Field, Postoperative Pain
Effect of Adding Dexamethasone to Bupivacaine 0.25% in SCPB on Surgical Field Visibility During Tympanomastoid Surgery
The aim of this study is to evaluate the efficacy of adding dexamethasone to bupivacaine 0.25% in ultrasound-guided SCPB on surgical field visibility during tympanomastoid surgery.
- Trial name
- NCT06416891
- Testing
- bupivacaine 0.25%, dexamethasone 2 mg in bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Cairo University
Postoperative Pain, Breast Reconstruction
Effectiveness of Exparel TAP Block in Breast Free Flap Reconstruction
Transversus Abdominis Plane (TAP) block is a useful tool in pain management after abdominal surgery. It is a regional nerve block that targets T6-L1 thoracolumbar nerves running in the plane between internal oblique and…
- Trial name
- NCT04777591
- Testing
- Liposomal bupivacaine TAP block, Bupivacain
- Where
- 2 sites in United States
- Volunteers
- 117 people
- Sponsor
- University of Virginia
Cardiotoxicity
Remote Ischaemic Preconditioning in Childhood Cancer
Survival rates of children with cancers have improved significantly in the recent few decades. Nonetheless, the side effect of this class of drugs on heart function remains to be an issue of concern.
- Trial name
- NCT03166813
- Testing
- Remote Ischaemic Preconditioning, Control
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- The University of Hong Kong
Post-Operative Pain
Rectal Indomethacin Versus Intraperitoneal Lidocaine for Analgesia After Laparoscopic Cholecystectomy
Hospitals, Qena, Egypt in period between May 2020 to May 2021.eighty patients was scheduled to elective laparoscopic cholecystectomy , divided Into two groups randomly using closed envelop method.
- Trial name
- NCT04964180
- Testing
- Indomethacin suppository, Lidocaine 2% Injectable Solution
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- South Valley University
Pain, Postoperative
Role of Propolis Paste in Preventing Pain After Root Canal Treatment.
This study evaluates the role of propolis paste as compared to calcium hydroxide (when used as intracanal medication) in prevention and treatment of pain after root canal treatment in necrotic (infected) teeth.
- Trial name
- NCT03723980
- Testing
- Propolis, Calcium Hydroxide
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Juzer Shabbir Saifee
ExtraCorporeal Life Support (ECLS), Wound Infection
Investigating the Impact of Cold Atmospheric Plasma Treatment on Wound Healing at Cannulation Sites in Patients Following Extracorporeal Life Support
This study aims to evaluate a new wound treatment called cold atmospheric plasma (CAP) for patients receiving extracorporeal life support (ECLS).
- Conditions
- ExtraCorporeal Life Support (ECLS), Wound Infection, Surgical Site Infection, Delayed Wound Healing
- Trial name
- NCT07501897
- Testing
- Cold Atmospheric Plasma (CAP) Therapy, Standard wound care
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- National Taiwan University Hospital
Disc Disease, Instabilities Lumbar
Determining Postoperative Recovery and the Impact of Adverse Events in Neurosurgery Based on Self-reported, App-based Longitudinal Assessment
Analyzing the impact of surgery and adverse events (AEs) on patients' well-being is of paramount importance as it provides essential information for benefit-risk assessment.
- Conditions
- Disc Disease, Instabilities Lumbar, Brain Tumor, Aneurysm
- Trial name
- NCT06352710
- Testing
- OP-Tracker App
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- Cantonal Hospital of St. Gallen
Carcinologic Ear, Nose, and Throat (ENT) Surgery
Intravenous Lidocaine in Carcinologic ENT Surgery: A Trial for Evaluation of Opioid Saving Strategy and Chronic Post-surgical Pain (ELICO)
Lidocaine, local anesthetic used for more than five decades, is being intravenously administered aiming at managing pain in different types of surgeries with promising results.
- Trial name
- ELICO (NCT02894710)
- Testing
- Lidocaine 20mg/ml
- Where
- 2 sites in France
- Volunteers
- 143 people
- Sponsor
- Hospices Civils de Lyon
Hemorrhoids
Symptom Control 1-year After Circular Stapler Anopexy or Diathermy Excision for Prolapsed Haemorhoids
Background: In an international randomised controlled trial we studied how patient self-reported symptoms improved after either a stapled anopexy operation or a diathermy excision of the haemorrhoids.
- Trial name
- NCT00841620
- Testing
- Haemorrhoidectomy a.m. Milligan, Stapled anopexy
- Where
- Denmark
- Volunteers
- 207 people
- Sponsor
- Odense University Hospital
Failed Back Surgery Syndrome
Subcutaneous Peripheral Nerve Stimulation (PNS) as "Hybrid Stimulation" After Failure of Spinal Cord Stimulation (SCS) to Control the Back Pain Component in Failed Back Surgery Syndrome (FBSS) Patients.(CUMPNS Study)
Despite globally favourable outcomes of Spinal Cord Stimulation (SCS), a significant proportion of Failed Back Surgery Syndrome (FBSS) patients do not obtain adequate coverage of low back pain.
- Trial name
- NCT02110888
- Testing
- Subcutaneous peripheral nerve stimulation, SCS Only
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Poitiers University Hospital
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