Clinical trials: Complications, Postoperative
Pain, Postoperative, Post-Mastectomy Chronic Pain Syndrome
Paravertebral Versus Pectoralis Block for Post Mastectomy Pain
Post-mastectomy pain affects more than half of patients undergoing the procedure and can last for years. It has been well established that development of chronic pain is related to experienced pain in the perioperative period.
- Conditions
- Pain, Postoperative, Post-Mastectomy Chronic Pain Syndrome, Opioid Use
- Trial name
- NCT03656679
- Testing
- Pectoralis Blockade (PECs), Paravertebral Blockade
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Postoperative Pain
Clinical Pharmacist-Led Perioperative Pain Management in Orthopedic Surgery: An Effectiveness Evaluation
This study aims to evaluate the effectiveness of a clinical pharmacist-led perioperative pain management model in orthopedic surgery. It is a randomized controlled trial involving patients undergoing major orthopedic procedures.
- Trial name
- NCT07688486
- Testing
- Clinical Pharmacist-Led Pain Management, Standard Perioperative Care
- Volunteers
- 600 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Postoperative Nausea and Vomiting
Aprepitant PO vs Ondansetron IV for Prevention of Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) persists as one of the more common complications of surgery. Although rarely life-threatening, it is the postoperative outcome that is most unfavorable to patients, even more undesirable…
- Trial name
- NCT00699894
- Testing
- aprepitant 40 mg, ondansetron 4 mg
- Where
- United States
- Sponsor
- Northwell Health
Vaginal Hysterectomy, Postoperative Pain
Evaluating the Efficacy and Safety of Preoperative Administration of Duloxetine for Pain Management in Women Undergoing Hysterectomy Via Vaginal Route
Hysterectomy performed through the vaginal route (HVR) is the preferred method for women seeking hysterectomy to address uterine concerns such as premalignant conditions and fibroids.
- Conditions
- Vaginal Hysterectomy, Postoperative Pain, vNOTES
- Trial name
- NCT06429605
- Testing
- duloxetine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Pain, Postoperative, Tonsillar Bleeding
Dexamethasone and Postoperative Bleeding Following Tonsillectomy in Children
Tonsillectomy is one of the most frequently performed surgical interventions in children. However, it is associated with a high incidence of PostOperative Nausea and Vomiting (PONV), severe pain and haemorrhage.
- Conditions
- Pain, Postoperative, Tonsillar Bleeding, Postoperative Nausea and Vomiting
- Trial name
- Blueberry (NCT04188431)
- Testing
- Dexamethasone, Sodium chloride
- Where
- 2 sites in Canada, Switzerland
- Volunteers
- 523 people
- Sponsor
- Walid HABRE
Postoperative Recovery, Lumbar Disc Herniation
Lower Back Muscle Size and Recovery After Lumbar Disc Herniation Surgery
Recovery after surgery for a herniated disc in the lower back differs from person to person. The size of the muscles around the lower spine may be related to recovery, but this relationship is not well understood.
- Trial name
- NCT07768241
- Testing
- Preoperative Psoas and Multifidus Muscle Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Nephrolithiasis
The Use of Belladonna and Opium Suppository in the Treatment of Postoperative Stent Pain
The purpose of this study is to determine if preemptive B\&O suppository placement will decrease post-operative pain in patients undergoing ureteral stent placement.
- Trial name
- B&O (NCT03332056)
- Testing
- Belladonna and Opium
- Volunteers
- 71 people
- Sponsor
- University of Washington
LOS, Postoperative Pain
Effects of Methylprednisolone After Total Hip Arthroplasty
The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after hip arthroplasty.
- Conditions
- LOS, Postoperative Pain, Postoperative Nausea and Vomiting, Sleeping Quality
- Trial name
- NCT00968903
- Testing
- Methylprednisolone
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Hvidovre University Hospital
Perioperative Respiratory Adverse Events, Postoperative Respiratory Complications
Ultrasonographic Subglottic Airway Measurements and Postoperative Respiratory Events in Young Children
This study aims to better understand airway-related respiratory events that may occur in children under three years of age undergoing general anesthesia with a laryngeal mask airway (LMA).
- Trial name
- NCT07394686
- Testing
- Serial subglottic airway ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 139 people
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Apical Periodontitis, Post Operative Pain, Acute
Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation
When a tooth's nerve dies, inflammation can develop at the tip of the tooth's root. Root canal treatment is carried out to allow this inflammation to heal.
- Trial name
- NCT07883486
- Testing
- sonically activated irrigation, laser activated irrigation, conventional needle irrigation
- Where
- 2 sites in Belgium
- Volunteers
- 183 people
- Sponsor
- University Ghent
Postoperative Pain
Effect of Perioperative Oral Pregabalin in Total Knee Replacement
This interventional randomized control trial aim to determine efficacy and safety of Oral pregabalin in improving after surgery pain control in patients undergoing total knee replacement surgeries under regional anesthesia.
- Trial name
- TKR (NCT06187922)
- Testing
- Pregabalin 75mg, adductor canal block
- Where
- Bahrain
- Volunteers
- 120 people
- Sponsor
- Bahrain Defence Force Hospital
Hip Osteoarthritis, Hip Arthroplasty Replacement
Virtual Reality for Intraoperative Anxiolysis and Postoperative Agitation in Elderely Hip Arthroplasty Patients
This study evaluates the effectiveness of Virtual Reality (VR) as a non-pharmacological intervention to reduce intraoperative anxiety and postoperative agitation in elderly patients undergoing elective hip arthroplasty under…
- Conditions
- Hip Osteoarthritis, Hip Arthroplasty Replacement, Emergence Delirium, Anesthesia, Emergence Agitation
- Trial name
- VR (NCT07705451)
- Testing
- immersive virtual reality, standard sedation
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Symptomatic Irreversible Pulpitis (SIP), Dental Pain
Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis
Symptomatic irreversible pulpitis is associated with a high incidence of inadequate pulpal anesthesia during endodontic treatment, particularly in mandibular molar teeth.
- Trial name
- SIPDEX (NCT07672873)
- Testing
- Saline (0.9%, sterile, for infusion), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Marmara University
Hemorrhoids, Pain, Postoperative
HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial
HYPOTHESIS 1. HAL- RAR causes a lower immediate postoperative pain compared with excision hemorrhoidectomy. 2. HAL - RAR achieves similar immediate and long term results compared to the excision hemorrhoidectomy in the control of…
- Trial name
- NCT02216305
- Testing
- Hemorrhoidectomy, HAL-RAR
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Plató
Postoperative Nausea and Vomiting
Effect of Superficial Cervical Plexus Block on Post Operative Nausea and Vomiting in Tympanomastoid Operations
post operative nausea and vomiting are very common after tympanomastoid operations, in this study we are investigating the effect of superficial cervical plexus block on the incidence and severity of those post operative…
- Trial name
- NCT05504551
- Testing
- ultrasound guided superficial cervical plexus block
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Chronic Postoperative Pain
euCPSP: European Observational Study on Chronic Post Surgical Pain,PAIN-OUT Study
This project a European observational study on the incidence and characteristics of chronic post surgical pain (CPSP). Research Questions What is the incidence of chronic post surgical pain (CPSP) in Europe? What are the risk…
- Trial name
- PAIN-OUT (NCT01467102)
- Where
- 24 sites in Belgium, France and 9 more
- Volunteers
- 3,618 people, healthy volunteers welcome
- Sponsor
- European Society of Anaesthesiology
Failed Back Surgery Syndrome
A Novel Approach in Spinal Cord Stimulation: a Combination of Burst and Tonic Waveforms.
Spinal Cord Stimulation (SCS) has been a well-established treatment for chronic neuropathic pain in Failed Back Surgery Syndrome with associated legs and/or low back pain.
- Trial name
- NCT03201705
- Testing
- Burst + Tonic
- Volunteers
- 10 people
- Sponsor
- Massimo Innamorato
Diabetes, Hyperglycemia
The Effect of Tight Glycemic Control on Surgical Site Infection Rates in Patients Undergoing Open Heart Surgery
The purpose of this study was to investigate the effects of three different glycemic treatment conditions (tight, conventional, and standard) in the intraoperative period on: 1) postoperative surgical site infections, and 2)…
- Conditions
- Diabetes, Hyperglycemia, Surgical Site Infection
- Trial name
- NCT01831154
- Testing
- Tight Glycemic, Conventional Glycemic, Standard Glycemic
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- James A. Haley Veterans Administration Hospital
Emergence Agitation
Comparison Between Propofol and Fentanyl for Prevention of Emergence Agitation in Children After Sevoflurane Anesthesia
The occurrence of emergence agitation (EA) in pediatric patients who have received sevoflurane anesthesia is a common postoperative problem.
- Trial name
- NCT01506622
- Testing
- Administration of propofol, Administration of fentanyl, Administration of saline
- Where
- South Korea
- Volunteers
- 222 people
- Sponsor
- Yonsei University
Postoperative Pain
The Effect of Adding Nalbuphine to Intrathecal Morphine on Analgesic Efficacy and Side Effects After Cesarean Section
The primary endpoint of this study is to investigate the effect of adding nalbuphine to intrathecal morphine on quality of postoperative analgesia and Morphine related side effects post- cesarean delivery.
- Trial name
- NCT02716129
- Testing
- Morphine, Morphine plus Nalbuphine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Abdelrady S Ibrahim, MD
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