Clinical trials: Complications; Arthroplasty
Postoperative Pain
A Phase 3 Study to Evaluate the Safety and Efficacy of SKY0402 in Subjects Undergoing Total Knee Arthroplasty
The primary objective is to demonstrate that SKY0402 is superior when compared to bupivacaine HCl in the management of postoperative pain for patients undergoing total knee arthroplasty.
- Trial name
- TKA (NCT00745290)
- Testing
- Bupivacaine HCl, SKY0402
- Where
- 19 sites in United States
- Volunteers
- 245 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Tensor Fasciae Latae Syndrome, Arthroplasty Complications
Does Vessel-sparing Surgery in Anterior Approach Total Hip Arthroplasty Change Clinical Outcome?
During direct anterior approach (DAA) for total hip arthroplasty (THA), ligation of the lateral femoral circumflex artery and vessel is always conducted.
- Trial name
- USP (NCT06308965)
- Testing
- Vessel sparing technique, Vessel ligation technique
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Ziekenhuis Oost-Limburg
Arthroplasty Complications
Validity and Reliability of High-Activity Arthroplasty Score
Patient-reported Outcome Measures (PROMs) used in total knee arthroplasty focus more on quality of life and pain. For this reason, individuals who can perform activities of daily living normally can get full points.
- Trial name
- NCT05211310
- Testing
- High-Activity Arthroplasty Score (HAAS), Western Ontario and McMaster Universities osteoarthritis score (WOMAC), The Knee injury and Osteoarthritis Outcome Score (KOOS)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Afyonkarahisar Health Sciences University
Knee Arthroplasty, Postoperative Complications
Increased Perioperative Communication Program in Knee Arthroplasty
Total knee replacement (TKA) is a surgical procedure to increase the function of the knee joint. However, in the postoperative period, it takes a long time for patients to gain independence and adapt to daily life, and they need…
- Trial name
- NCT06130813
- Testing
- increased perioperative communication program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hacettepe University
Acute Postoperative Pain, Surgery
Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty
This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty.
- Trial name
- NCT06784882
- Testing
- continuous peripheral nerve block with OnQ pump, single injection nerve block
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Diego
Surgery, Surgical Site Infection
SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty
Comparing the growth of intra-operative tissue cultures of Cutibacterium Acnes after primary shoulder replacement when using a no-prep control group versus antimicrobial wound gel versus betadine applied to the skin layer after…
- Conditions
- Surgery, Surgical Site Infection, Cutibacterium Acnes, Prosthetic-joint Infection
- Trial name
- NCT05919888
- Testing
- Povidone-Iodine, SURGX Wound Gel
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- St. Louis University
Knee Osteoarthritis, Total Knee Arthroplasty
Effect of Preoperative Cold Therapy on Early Postoperative Outcomes in Total Knee Arthroplasty
This prospective, single-center, randomized controlled trial investigates the effects of preoperative cold therapy on early postoperative outcomes in patients undergoing unilateral primary total knee arthroplasty (TKA).
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Cryotherapy, Postoperative Pain Management
- Trial name
- NCT07134283
- Testing
- Preoperative and Postoperative Cold Therapy with Gel Cold Pack, Postoperative Cold Therapy with Gel Cold Pack
- Where
- Turkey (Türkiye)
- Volunteers
- 208 people
- Sponsor
- Ankara City Hospital Bilkent
Total Knee Arthroplasty (Postoperative Pain)
REIKI IN TOTAL KNEE ARTHROPLASTY PATIENTS (REIKI TKA )
Total knee arthroplasty (TKA) is commonly performed to improve mobility and quality of life in patients with degenerative joint diseases.
- Trial name
- REIKI TKA (NCT07442435)
- Testing
- Reiki Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ondokuz Mayıs University
Anesthesia, Catheter Blockage
The Efficacy of Continuous Femoral Nerve Catheter Orifice Configuration for Postoperative Analgesia in Knee Arthroplasty
Femoral nerve catheter for postoperative analgesia will be included in the adult patients undergoing total knee arthroplasty included in the study.
- Conditions
- Anesthesia, Catheter Blockage, Knee Arthropathy, Pain, Postoperative
- Trial name
- NCT04202250
- Testing
- CEMP (closed-ended multiport catheter) group, OESP (open-ended single port catheter) group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gulhane School of Medicine
Arthropathy of Hip, Hip Arthropathy
Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial
This prospective, randomized controlled trial aims to compare two multimodal regional anesthesia strategies for postoperative analgesia in elective total hip arthroplasty (THA) performed via anterior approach.
- Conditions
- Arthropathy of Hip, Hip Arthropathy, Locoregional Anesthesia, Complication of Anesthesia
- Trial name
- Peng_lfcn/WI (NCT07284615)
- Testing
- PENG plus LFCN block, PENG plus WI
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Ospedale Edoardo Bassini
Surgical Wound Infection
A Comparative Study to Assess the Prevention of Surgical Site Infection (SSI's) in Revision Total Joint Arthroplasty Patients Treated With Single-Use Negative Pressure Wound Therapy (PICO™) or Standard Care Dressings (AQUACEL® Ag SURGICAL Dressing)
The aim of this study is to assess the prevention of incision healing complications in patients undergoing revision TKA and THA treated with either Single-Use NPWT (PICO) compared to standard of care dressings (AQUACEL Ag…
- Trial name
- NCT02664168
- Testing
- Aquacel Ag Surgical Dressing, Single-Use Negative Pressure Wound Therapy (PICO)
- Where
- United States
- Sponsor
- Rothman Institute Orthopaedics
Hip Osteoarthritis, Total Hip Arthroplasty (THA)
QIPB vs SI-FICB for Postoperative Analgesia After Total Hip Arthroplasty
Total hip arthroplasty (THA) causes moderate-to-severe postoperative pain. The PROSPECT guideline recommends the supra-inguinal fascia iliaca compartment block (SI-FICB) for THA, whereas evidence for newer…
- Conditions
- Hip Osteoarthritis, Total Hip Arthroplasty (THA), Postoperative Pain, Acute Pain
- Trial name
- NCT07683663
- Testing
- Supra-Inguinal Fascia Iliaca Compartment Block, Quadro-Iliac Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Dokuz Eylul University
Postoperative Pain
The Efficacy of Periarticular Single Drug Compared With Multimodal Drug Injection in Controlling Pain After TKA
The purpose of this study is to determine the periarticular multimodal drug injection has more efficacy for controlling pain after TKA than single anaesthetic drug injection.
- Trial name
- TKA (NCT01898052)
- Testing
- single anaesthetic drug, multimodal drug injection
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Thammasat University
Pain, Postoperative
Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty
Total shoulder arthroplasty (TSA) is considered to be a major surgical procedure resulting in severe postoperative pain, especially in the first 48 hours after surgery.
- Trial name
- NCT02876055
- Testing
- Single shot interscalene nerve block, Continuous interscalene nerve block, Local Infiltration Analgesia (LIA)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hip Osteoarthritis, Hip Arthroplasty Replacement
Virtual Reality for Intraoperative Anxiolysis and Postoperative Agitation in Elderely Hip Arthroplasty Patients
This study evaluates the effectiveness of Virtual Reality (VR) as a non-pharmacological intervention to reduce intraoperative anxiety and postoperative agitation in elderly patients undergoing elective hip arthroplasty under…
- Conditions
- Hip Osteoarthritis, Hip Arthroplasty Replacement, Emergence Delirium, Anesthesia, Emergence Agitation
- Trial name
- VR (NCT07705451)
- Testing
- immersive virtual reality, standard sedation
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Undisplaced Fracture, Femoral Neck Fractures
Arthroplasty Versus Internal Fixation for Undisplaced Femoral Neck Fracture
This is the world's first national orthopedic randomized controlled trial (RCT) involving 19 out of 21 departments in Denmark. Each year, 7,000 patients suffer a hip fracture.
- Conditions
- Undisplaced Fracture, Femoral Neck Fractures, Internal Fixation; Complications, Arthroplasty Complications
- Trial name
- SENSE (NCT04075461)
- Testing
- Arthroplasty, Internal fixation
- Where
- 19 sites in Denmark
- Volunteers
- 330 people
- Sponsor
- University of Southern Denmark
Osteo Arthritis Knee, Pain, Postoperative
Extended Oral Tranexamic Acid After Total Knee Arthroplasty
The utilization of intraoperative tranexamic acid (TXA), whether administered intravenously or orally, has become a standard practice in total joint arthroplasty (TJA).
- Trial name
- NCT06618820
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Campbell Clinic
Knee Arthropathy, Post Operative Pain
Function and Pain Following Knee Replacement
The goal of this interventional study is to compare pain management techniques (femoral nerve block, intra-articular block, none) in TKA patients.
- Conditions
- Knee Arthropathy, Post Operative Pain, Pain, Postoperative
- Trial name
- NCT05478005
- Testing
- Femoral nerve block, Intra-articular block
- Where
- Israel
- Volunteers
- 54 people
- Sponsor
- University of Haifa
Arthritis Knee, Blood Loss
Blood Loss Assessment in the Limited Application of Tourniquet During Primary Unilateral TKA
Tourniquet application in total knee arthroplasty has many benefits and might have a role in the incidence of peri-operative complications the aim of this research: is to look into the effectiveness of the limited application of…
- Conditions
- Arthritis Knee, Blood Loss, Arthroplasty Complications
- Trial name
- NCT05691751
- Testing
- primary unilateral total knee arthroplasty with limited application of tourniquet, primary unilateral total knee arthroplasty with full application of tourniquet
- Where
- Syria
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Damascus University
Postoperative Pain
Pericapsular Nerve Group Block for Elective Hip Arthroplasty
This study examine the effect of Pericapsular Nerve Group (PENG) Block on analgesia after elective hip arthroplasty. Half of participants will receive a PENG Block with local anesthetic, while the other half will receive a PENG…
- Trial name
- NCT04231123
- Testing
- PENG Block with local anesthetic, PENG Block with 0,9% saline
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Tivoli