Clinical trials: Comprehension
Menopause Surgical, Estrogen Deficiency
Understanding the Roles of Hormones in Adipocyte Remodeling Following Menopause
The overarching aims of this study are to: 1. Characterize the rate of in vivo adipogenesis, and changes in adipose tissue gene and protein expression, in the scABD and scFEM depots of women undergoing surgical menopause (↓E2…
- Conditions
- Menopause Surgical, Estrogen Deficiency, Adiposity, Follicle-Stimulating Hormone Deficiency
- Trial name
- RESUME-2 (NCT03856268)
- Testing
- 'Surgical Menopause' Group, 'Drug-Induced Menopause' Group
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Pregnancy; Spina Bifida, Fetal, Environmental Exposure
Understanding Effects of Folic Acid on the Methylosome and Transcriptome of Women With Spina Bifida Affected Pregnancies
Folic acid is currently considered to be the standard of care for primary and secondary prevention of spina bifida, but the mechanisms underlying folic acid's benefits are unknown.
- Trial name
- NCT05500690
- Testing
- Folic Acid Tablet
- Where
- Bangladesh
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Asthma
Bronchodilator Response in 4-12 Years Chinese Controller Naive Asthmatic Children
Objectives: 1. To observe BDR distribution curve for Chinese non-asthmatic and controller-naïve asthmatic children from 4-12 years respectively 2.
- Trial name
- NCT01500525
- Where
- China
- Volunteers
- 587 people, healthy volunteers welcome
- Sponsor
- Capital Institute of Pediatrics, China
Overweight and Obese Adults
Effects of Obesity on Autophagy and mTORC1 Signalling in Skeletal Muscle
It is well known that individuals living with overweight or obesity are not able to activate skeletal muscle growth processes to the same extent as lean individuals following activities such as weightlifting (resistance exercise)…
- Trial name
- NCT07774676
- Testing
- Skeletal muscle biopsy, venous blood sampling, Protein-Rich Beverage
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Barrett's Esophagus, Esophageal Adenocarcinoma
Micro-RNA (miR) Expression in Upper Gastrointestinal Mucosal Tissue
This is a laboratory-based, exploratory study using tissue obtained from our clinical practice. The purpose of this study is to confirm our ability to characterize miR expression in various tissues (proximal and distal esophagus…
- Trial name
- NCT00909350
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Colon Cancer, Breast Cancer
Understanding the Value of Community Vital Signs in Primary Care
Social determinants of health (e.g. the income, education, and environment of patients) may exert greater influence on health outcomes than traditional clinical factors (e.g. lab results, diagnoses, and family history).
- Conditions
- Colon Cancer, Breast Cancer, Cervical Cancer, Prostate Cancer
- Trial name
- NCT02512835
- Testing
- Community vital signs
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Diet Quality
Understanding Food Choices in Saudi Arabia
Using a 3-arm randomized controlled trial, the investigators aim to rigorously evaluate the effects of two front-of-pack (FOP) food labels on diet quality.
- Trial name
- NCT05007184
- Testing
- Chilean Warning Labels, Nutri-Score Labels
- Where
- Singapore
- Volunteers
- 656 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Amyotrophic Lateral Sclerosis, Parkinson Disease
A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria
The goal is to improve the fundamental knowledge about articulatory motor performance in people with Lou Gehrig's disease (also known as ALS) and Parkinson's disease (PD), in order to develop more sensitive assessments for…
- Trial name
- NCT03613038
- Testing
- Phonetic complexity effects on speech motor performance
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hearing Impairment, Deafness
RoboHear™ Device: Advanced Haptic Technology That Allows the Deaf to Understand Speech
Pilot study to test the feasibility of translating the English language into haptics (touch sensations)
- Trial name
- NCT03966144
- Testing
- RoboHear Device
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arkansas
Vitamin D Deficiency
Improving the Understanding of the Response to Vitamin D Supplementation
It is the investigators hypothesis that the current method of evaluating vitamin D status, measuring circulating 25-hydroxy vitamin D is not providing the full metabolic picture, and is therefore inadequate.
- Trial name
- NCT01465178
- Testing
- cholecalciferol
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Food Insecurity, Food Security
The Indiana SNAP-Ed Long-term Study
The goal of the study is to determine the immediate and long-term effects of SNAP-Ed on the food insecurity of the entire household, household adults, and household children.
- Conditions
- Food Insecurity, Food Security, Education
- Trial name
- NCT03436589
- Testing
- Indiana SNAP-Ed
- Where
- United States
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- Purdue University
Autonomic Function
Understanding Individual Variability in Neuronal Signal Transmission to Target Organs in Health and Disease
The goal of this clinical trial is to evaluate the influence of parasympathetic transmission from the brain to different metabolic organs. This transmission can be blocked with the muscarinic antagonist atropine.
- Trial name
- CPB_Atropine (NCT06912048)
- Testing
- Oral glucose tolerance test with double-tracer dilution and atropine infusion
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Knowledge, Attitude
Evaluating FDA's Proposed Patient Medication Information Handout
The goal of this study is to assess how useful the proposed one-page FDA-template PMI is to potential users. The main questions it aims to answer are: How does the proposed one-page FDA-template PMI compare with the current drug…
- Trial name
- NCT06320808
- Testing
- FDA template PMI, Decision Critical PMI, Standard Information
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Carnegie Mellon University
Social Interaction
Name Generator Order Effects in Social Networks
The objective of our study was to determine the extent to which the order of specific items in a multiple name generator survey affects how social networks are measured.
- Trial name
- NCT02217748
- Testing
- Survey questionnaire
- Where
- Uganda
- Volunteers
- 1,557 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
High School 11th Grade Students, Absence of Any Language, Hearing, Mental or Psychological Disability
The Effect of Motivational Support Program Applied to Adolescents on Sleep Quality and Academic Achievement
It was planned as a randomized controlled experimental study with a single-blind technique, pretest-posttest control group and repetitive measurements, in order to determine the effect of motivational support program applied to…
- Conditions
- High School 11th Grade Students, Absence of Any Language, Hearing, Mental or Psychological Disability, Turkish Speaking and Understanding, Having a PUKI Index Above 5ı
- Trial name
- NCT06004778
- Testing
- Motivational Support Program, Educational support
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Lewy Body Disease, Healthy Aging
Language and Lewy Body Diseases: Sentence Comprehension Problems and Modifying Noninvasive Brain Stimulation Treatment
Lewy body diseases (LBDs) represents a group of neurodegenerative disorders characterized by the abnormal accumulation of aggregates of α-synuclein protein leading to the formation of Lewy bodies (LB) and Lewy neurites resulting…
- Trial name
- LANG-LBD (NCT05847985)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Stroke, Stroke, Ischemic
Understanding the Need and Feasibility of Transitional Care Training Program Among Family Caregivers of Geriatric Stroke Survivors in Pakistan
The main intention of the study is to understand the need and feasibility of transitional care training program among family caregivers of geriatric stroke survivors in Pakistan
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- NCT06341881
- Testing
- Transitional Care Training Program
- Where
- 3 sites in Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Vitamin D, Vitamin D and Calcium Homeostasis
Free Vitamin D and Steroid Metabolism in Endocrine Disorders
This clinical study aims to gain a better understanding of how different forms of vitamin D are processed in the body in healthy individuals, pregnant women, and patients with various hormonal (endocrine) and kidney (renal)…
- Trial name
- FREEDOM (NCT07268742)
- Testing
- Blood draw for the laboratory assessment
- Where
- Belgium
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Malignant Neoplasm
Medical Physics Direct Patient Care for the Improvement of Patient Understanding of Care
This phase II trial studies how well medical physics direct patient care works in improving patients' understanding of their cancer treatment.
- Trial name
- NCT04266522
- Testing
- Informational Intervention, Counseling, Questionnaire Administration
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Psychological Disorder
Understanding the Impact of Death Conditions Linked to the COVID-19 Crisis on the Grieving Process in Bereaved Families
This study aims to analyze the grieving process of people who have lost a close first degree relative, understand the impact of death conditions and model a "theory of mourning" in the context of the COVID-19 crisis .
- Trial name
- COVIDAAD (NCT05566366)
- Testing
- Qualitative research interview
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris