Clinical trials: Comprehension
Language Disorders in Children
Let's Know!2: Language-focused Intervention for Children at Risk of Comprehension Difficulties
In the proposed project, the investigators will conduct a multisite randomized controlled trial (RCT) to determine the efficacy of Let's Know!2, a small-group, language focused comprehension intervention, on children's lower- and…
- Trial name
- LK!2 (NCT05133479)
- Testing
- Let's Know! small-group or TierL 2 Intervention
- Where
- 2 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Sleep Deprivation, Sleep Fragmentation
Understanding Sleep in Hospitalized Older Patients
The overall goal of this research is to elucidate how environmental, healthcare, and patient-level factors and patients' level of perceived control impact sleep duration and quality in hospitalized older patients and to assess…
- Trial name
- NCT01057823
- Where
- United States
- Volunteers
- 771 people
- Sponsor
- University of Chicago
Hand Hygiene, Hand Washing
Hand Hygiene of Kindergarten Children
Randomized controlled trial to further assess the impact of a digital intervention on hand hygiene of young children. Children in intervention kindergartens will see live instructions and feedback on their hand washing activity…
- Trial name
- NCT05395988
- Testing
- Digital hand washing instructions, Digital hand washing reward
- Where
- 2 sites in Finland, Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Otto-Friedrich-University Bamberg
Cardiac Resynchronization Therapy
ECGi of SyncAV With MultiPoint Pacing
The objective of this clinical study was to evaluate the impact of Multipoint Pacing (MPP) and SyncAV programming on ventricular electrical activation time and activation sequence using noninvasive electrocardiographic imaging…
- Trial name
- NCT06444386
- Testing
- MPP + SyncAV
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Abbott Medical Devices
Terminal Cancer
Towards Cancer Patient Empowerment for Optimal Use of Antithrombotic Therapy at the End of Life
Despite the fact that antithrombotic therapy (ATT) has little or even negative effects on the well-being of cancer patients during their last year of life, stopping ATT is rare in clinical practice.
- Trial name
- SERENITY (NCT05706740)
- Testing
- Physician survey on antithrombotic medication during end-of-life care in cancer patients
- Where
- 12 sites in Denmark, France and 6 more
- Volunteers
- 467 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Down Syndrome, Chromosome Disorders
Collaboration for Down Syndrome Progress (CDP)
The Collaboration for Down Syndrome Progress (CDP) is a long-term study that follows people with Down syndrome of all ages. The goal is to better understand their health, development, and everyday experiences over time.
- Conditions
- Down Syndrome, Chromosome Disorders, Intellectual and Developmental Disabilities
- Trial name
- CDP (NCT07625579)
- Where
- 16 sites in United States
- Volunteers
- 1,400 people
- Sponsor
- RTI International
COVID-19
Predictive Immune Biomarkers for COVID-19 Pathogenesis
The spectrum of the COVID-19 disease ranges from benign to asymptomatic to viral pneumopathy that can progress to acute respiratory distress syndrome (ARDS).
- Trial name
- COVIDBioToul (NCT04385108)
- Testing
- Blood collection on admission and longitudinally, Blood collection on their first consultation and 10 to 14 days later
- Where
- France
- Volunteers
- 565 people
- Sponsor
- University Hospital, Toulouse
Pediatric Cancer, Physical Activity
Pediatric Physical Activity for Children With Cancer
The goal of this pilot study is to test the feasibility and participant adherence (pediatric patients diagnosed with childhood cancer) to a virtual, 12-week physical activity program. The aims of this project are to: 1.
- Trial name
- PePA (NCT06012825)
- Testing
- Physical Activity
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Hawaii
Microvascular Angina
Understanding of Chest Pain in Microvascular Disease Proved by Cardiac Magnetic Resonance Image
Current therapeutic options for a well-recognized group of patients with anginal symptoms-a positive exercise tolerance testing, SPECT or perfusion defect in MRI but angiographically normal coronary arteries-are limited.
- Trial name
- UMPIRE (NCT01769482)
- Testing
- Udenafil
- Where
- 2 sites in South Korea
- Volunteers
- 70 people
- Sponsor
- Samsung Medical Center
Motivation
Moving Towards Learning: Understanding Teachers' Motivation
Since 2014 45 minutes of physical activity (PA) has been a mandatory part of all public schools in Denmark. PA has to be part of subject teaching, including Physical Education (PE), and of so-called support teaching.
- Trial name
- MTL (NCT02894346)
- Testing
- Teachers
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Oesophageal Cancer
Understanding the Variation of Modern Endoscopic Ultrasound Use in Patients With Oesophageal Cancer (VALUE)
This is an observational trial that will look at patients undergoing endoscopic ultrasound (EUS) in patients with oesophageal cancer and to determine the proportion of cases in which EUS changes disease management in these…
- Trial name
- VALUE (NCT06440174)
- Testing
- endoscopic ultrasound
- Where
- 14 sites in United Kingdom
- Volunteers
- 160 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Defibrillators, Tachycardia
Observational Study of Patient Comprehension, Perception, Fears and Appreciation Following Home-Monitoring Implementation
Describe the mutual influences between trainings realized in implantation centers, medico-technical knowledges, technical implementation, perception, fears and appreciation felt by the patients during Home Monitoring…
- Trial name
- Educ@t (NCT01006746)
- Testing
- Remote monitoring by Home Monitoring system
- Where
- France
- Volunteers
- 571 people
- Sponsor
- Biotronik France
Exercise, Fitness
Understanding Fitness' Function in Determining Activity
The purpose of the study is to determine how measuring strength (by squeezing a tool called a hand grip dynamometer) and cardiorespiratory fitness (by climbing stairs) and sharing the results with subjects impacts exercise.
- Conditions
- Exercise, Fitness, Strength
- Trial name
- UFFDA (NCT03518931)
- Testing
- Fitness testing
- Volunteers
- 1,315 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cystic Fibrosis (CF), Cardiovascular Disease Risk Factors
Remote Exercise to Improve Physical Activity Levels and Markers of Heart Health in Cystic Fibrosis (RHH-CF)
With advances in genetic therapies, many people with Cystic Fibrosis (CF) are living longer. With the improvement in life expectancy has emerged an increased risk of cardiovascular disease (CVD).
- Trial name
- RHH-CF (NCT07027553)
- Testing
- Mobile health exercise programme, Lifestyle maintenance
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Bath
HIV-1-infection, Breastfeeding
Understanding Practices of Lactation and Infant Feeding Together With Women With HIV in the United States
IMPAACT 2046/UPLIFT (Understanding Practices of Lactation and Infant Feeding decisions Together with women with HIV) is a multi-site, mixed-methods, observational cohort study.
- Conditions
- HIV-1-infection, Breastfeeding, Pregnancy Related
- Trial name
- UPLIFT (NCT07293559)
- Testing
- No intervention provided in this study
- Where
- 11 sites in United States
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Chronic Kidney Disease, Hypertension
Genetic Testing to Understand and Address Renal Disease Disparities Across the United States
GUARDD-US is a prospective, multicenter, unblinded, two arm randomized pragmatic clinical trial. Participants will be randomized in a 1:1 ratio to immediate APOL1 gene testing and return of results (ROR) to participant and…
- Trial name
- GUARDD-US (NCT04191824)
- Testing
- Timing of return of results
- Where
- 14 sites in United States
- Volunteers
- 6,789 people
- Sponsor
- Duke University
Aphasia
Strategies to Accommodate Reading (STAR)
People with aphasia often understand spoken utterances better than written sentences. They also benefit from having content appear in multiple rather than single modalities.
- Trial name
- STAR (NCT03312270)
- Testing
- Multimodality information comprehension
- Where
- 2 sites in United States
- Volunteers
- 152 people
- Sponsor
- Miami University
Obesity, Body Representation
SENSing Inner BodiLy State: Understanding the Role of Interoception in obEsity
Successfully perceiving the flow of interoceptive cues and integrating them with exteroceptive information are fundamental aspects of countering the body's inherent instability and guaranteeing homeostatic regulation.
- Trial name
- SENSIBLE (NCT06855251)
- Testing
- The crossmodal dual-task
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Chronic Renal Failure, Kidney Transplantation
Calorimetry, Insulin Resistance and Energy Metabolism Study to Understand the Risk of Obesity in Kidney Transplanted Patients
Weight gain is a common complication after transplantation. It has adverse effects such as hypertension, dyslipidemia, and insulin resistance.
- Conditions
- Chronic Renal Failure, Kidney Transplantation, Weight Gain, Insulin Resistance
- Trial name
- CALIMERO (NCT01800851)
- Testing
- Energy expenditure evaluation in calorimetric chamber
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Lung Cancer, Pulmonary Nodule, Solitary
Prospective Post-market Data Collection for Ion Endoluminal System to Understand CT to Body Divergence
The goal of this study is to collect post-market data for the Ion Endoluminal System to understand CT to body divergence.
- Trial name
- NCT04735341
- Testing
- Ion Endoluminal System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Intuitive Surgical