Clinical trials: Con, open to volunteers
Severe Aortic Stenosis, TAVI(Transcatheter Aortic Valve Implantation)
Observational Study Relating to the Long-term Follow-up of Patients with Severe Aortic Stenosis Evaluated for Percutaneous Aortic Valve Replacement (TAVI).
All patients with severe aortic stenosis undergoing evaluation for TAVI are routinely subjected to a series of assessments: Pre-implantation: thoraco-abdominal CT angiography, coronary angiography, echocardiography, clinical…
- Trial name
- ROARING-TAVI (NCT06679517)
- Testing
- TAVI
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- University Hospital of Ferrara
Colorectal Cancer Control and Prevention
Clinical and Endoscopic Characterization of Patients With Multiple Colorectal Adenomas: A Multicenter Study in Spain (ESPAPOLYP Study)
The aim is to clinically, endoscopically, and molecularly characterize patients with multiple colorectal adenomas, establish the indication for genetic testing to rule out hereditary syndromes and identify the genes to be…
- Trial name
- ESPAPOLYP (NCT06625788)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Asociación Española de Gastroenterología
Cervical Spinal Cord Injury
Efficacy of a Brain-Computer Interface Controlled Functional Electrical Stimulation Therapy for Spinal Cord Injury Neurorehabilitation
The study's main goal is to determine the efficacy of a therapy with brain-computer interface controlled functional electrical stimulation for neurorehabilitation of spinal cord injury patients' upper limbs.
- Trial name
- NCT05343130
- Testing
- Brain-Computer Interface
- Where
- Mexico
- Volunteers
- 32 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Friedreich Ataxia
Efficacy of Stabilometric Platform to Improve Standing Balance in Patients With Friedreich's Ataxia
The primary objective is to evaluate the potential effectiveness of an individualized intensive rehabilitation intervention using the "Prokin 252" stabilometric platform in the treatment of adolescent and adult patients with…
- Trial name
- NCT06692296
- Testing
- Balance training over stabilometric platform, Balance training by means of conventional rehabilitation
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS Eugenio Medea
Antenatal Care, Maternal Health
AI Blind-Sweep Ultrasound for Antenatal Screening by Non-Specialist Health Workers in Rural DR Congo
FS2 evaluates the diagnostic accuracy and implementation feasibility of an AI-assisted blind-sweep obstetric ultrasound (SPAQ E-con AI), operated by trained non-specialist health workers, for antenatal screening in rural…
- Conditions
- Antenatal Care, Maternal Health, Gestational Age, Placenta Praevia
- Trial name
- FS2 (NCT07677670)
- Testing
- SPAQ E-con AI blind-sweep ultrasound
- Where
- Democratic Republic of the Congo
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- SOIK Corporation Sarl
Acute Myeloid Leukemia
This Study Aims to Improve the Stratification of Patients With Acute Myeloid Leukemia to Enable More Personalized and Effective Treatments, and to Identify and Functionally Validate, at the Single-cell Level, Biomarkers That Can Predict Response to Venetoclax.
The current classification of acute myeloid leukemias (AML) includes more than 20 different diseases, grouped based on their distinctive genomic characteristics, which reflect substantial heterogeneity.
- Trial name
- AMANITA (NCT07874100)
- Testing
- Bulk genotyping of AML samples at diagnosis and relapse, scRNA analysis at diagnosis, scRNAseq and genotyping analysis at day 28 after therapy, spatial transcriptomic analysis at day 0 and 28
- Where
- Italy
- Volunteers
- 420 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Bone Tumor
Evaluation of Tumor Resection and Reconstruction With Prosthetic Implants
Bone can be the site of primary malignant tumors or, more commonly, secondary lesions. The most frequent primary tumors are osteosarcoma, chondrosarcoma, and Ewing sarcoma, whereas the malignancies that most commonly metastasize…
- Trial name
- RERIO (NCT07337018)
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Diabetes, Gestational
Effect of Strength-resistance Exercise in the Reduction of Gestational Diabetes in Pregnant Women with Overweight or Obesity
The aim of this trial is to test the efficacy of regular resistance exercise in early pregnancy to prevent gestational diabetes mellitus in overweight/ obese pregnant women.
- Trial name
- NCT05840497
- Testing
- Resistance exercise
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Fundacion Miguel Servet
HIV-1-infection, Multi-Antiviral Resistance
Italian Registry of HIV-1 Infected Patients With Drug-RESistant Virus to Reverse Transcriptase Inhibitors, InteGrasE and Viral Protease.
The PRESTIGIO Registry is an Observational, prospective, multicentre study that includes patients, regularly followed by Italian Infectious Disease Centres, with HIV-1 infection and documented resistance to the 4 classes of…
- Trial name
- PRESTIGIO (NCT04098315)
- Testing
- REGISTER CREATION
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Castagna Antonella
Neurodevelopmental Disorders
Innovative Methodologies for Neuroplasticity in Developmental Age With the Use of Virtual Reality
Neurodevelopmental disorders, such as Cerebral Palsy (CP), Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), are complex conditions that affect various aspects of children's development.
- Trial name
- NCT07426315
- Testing
- CAREN therapy, Conventional interventions
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Malignant Melanoma, Gynecologic Cancer
Carbon Ion Radiation Therapy in the Treatment of Mucous Melanomas of the Female Lower Genital Tract
The present monocentric prospective phase 2 study aims to reproduce the results obtained at NIRS thus offering the possibility of obtaining a promising rate of progression-free survival (PFS) and local control (LC) in patients…
- Trial name
- CYCLE (NCT05478876)
- Testing
- carbon ion radiation therapy CIRT
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- CNAO National Center of Oncological Hadrontherapy
Obesity (Disorder), Type 2 Diabetes Mellitus
Body Composition Changes After Initiation of GLP-1 Receptor Agonists in Adults With Obesity or Type 2 Diabetes
Researchers want to understand what happens to muscle and fat in the body after adults with obesity and/or type 2 diabetes start taking a GLP-1 receptor agonist medication (GLP-1RA), a type of drug already approved and commonly…
- Trial name
- NCT07835360
- Where
- 2 sites in Mexico
- Volunteers
- 200 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Acquired Brain Injury, Balance Disorders
Balance Dimensions-Based Rehabilitation Program in People With Acquired Brain Injury
The purpose of this clinical trial is to find out whether a rehabilitation program based on different dimensions of balance can improve balance, mobility, walking ability, and quality of life in people with acquired brain injury.
- Trial name
- BALANCE-DCA (NCT07696663)
- Testing
- Multimodal Balance Rehabilitation Program, Conventional Physiotherapy
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- University of Castilla-La Mancha
Talar Osteochondral Defect of Ankle, Pain
Clinical and Radiographic Outcomes After AMIC Treatment for Talus Osteochondral Lesion Trattamento Artroscopico Delle Lesioni Osteocondrali Dell'Astragalo Con Tecnica AMIC
Aim of the study is to evaluate clinical and radiographic outcomes in patients undergone all-arthroscopic autologous matrix induced chondrogenesis for symptomatic osteochondral talar lesions
- Conditions
- Talar Osteochondral Defect of Ankle, Pain, Arthroscopy
- Trial name
- NCT03371121
- Testing
- AT-AMIC (arthroscopic talus autologous matrix induced chondrogenesis)
- Where
- Italy
- Volunteers
- 103 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Ictus, Convalescence
Effectiveness of Laser Visual Feedback in Postural Control After a Stroke
Background: Stroke is one of the leading causes of acquired disability and frequently results in impairments in balance and postural control that affect functional independence.
- Conditions
- Ictus, Convalescence, Rehabilitation by Recovery of Function, Rehabilitation Frail Elderly Subjects
- Trial name
- FV-CP (NCT07811843)
- Testing
- Intervention
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Parc Sanitari Pere Virgili
Primary Photoreceptor Disease, Retinitis Pigmentosa (RP)
A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)
Study OpCT-001-101 is a Phase 1/2a first-in-human, multisite, 2-part interventional study to evaluate the safety, tolerability, and the effect on clinical outcomes of OpCT-001 in approximately 54 adults with primary photoreceptor…
- Conditions
- Primary Photoreceptor Disease, Retinitis Pigmentosa (RP), Usher Syndrome, Inherited Retinal Disease (IRD)
- Trial name
- CLARICO (NCT06789445)
- Testing
- OpCT-001
- Where
- 5 sites in United States
- Volunteers
- 54 people
- Sponsor
- BlueRock Therapeutics
Autism Spectrum Disorders
Pilot Study on Collaborative, Comprehensive, Multidimensional and Quality of Life Tools for Priority Definition, Shared Decision Making, Outcome Evaluation and Quality of Care Improvement in ASD Individuals and Programs in the Real World.
ASD is a very complex and lifelong disorder. Patients' functioning is influenced by multiple factors, including treatments, inclusion and life contexts.
- Trial name
- ASD Outcome (NCT07393152)
- Testing
- DD-CGAS (Wagner et al. 2007), Pediatric Quality of Life Inventory (PedsQL)., Child and Adolescent Needs and Strengths (CANS) (Lyons 2022)
- Where
- 3 sites in Italy
- Volunteers
- 400 people
- Sponsor
- Antonella Costantino
Lymphoproliferative Syndrome, Autoimmune, Lymphoma
Retrospective Observational Study of Italian Cohort of Lymphoma Patients (RETRO-LYMPH)
observational, non-interventional, retrospective, single-center study focusing on patients with lymphoma / lymphoproliferative syndrome between January 1980 and September 2021
- Trial name
- RETRO-LYMPH (NCT06781437)
- Where
- Italy
- Volunteers
- 5,500 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hodgkin or Non-Hodgkin Lymphoma
PAX5-NEGATIVE HODGKIN-LIKE LYMPHOMAS: A DIAGNOSTIC CHALLANGE
Hodgkin lymphoma (HL) is a lymphoma that arises from peripheral B lymphocytes. However, the neoplastic cells, Hodgkin cells and Reed-Sternberg cells, typically lack most B-cell markers, usually preserving the expression of the…
- Trial name
- HL PAX5- 2025 (NCT07313943)
- Where
- 2 sites in Germany, Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Vibration
Non-invasive Vibratory Stimulation of the Knee Muscles for the Improvement of the Somatosensory Input and Motor Performance
The goal of this interventional cross-sectional study is to evaluate motor responses to non-invasive vibratory stimulation applied to the hamstring muscle tendons in healthy individuals.
- Trial name
- VIBMOT (NCT07424066)
- Testing
- Vibratory stimulation
- Where
- Italy
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca