Clinical trials: Concentration
Atherosclerosis
A Study Investigating the Concentrations of Darapladib in Blood and the Safety of This Compound in Healthy Japanese Men
This study is being conducted to provide initial safety, tolerability, PK and PD data that will allow further studies with darapladib in Japanese patients
- Trial name
- NCT00551317
- Testing
- Darapladib (SB480848)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Supplementation, Sports
Acute Sodium Bicarbonate Supplementation in Female Basketball Players
This randomized, double-blind, placebo-controlled crossover study aims to evaluate the effect of acute sodium bicarbonate supplementation, compared with placebo, on physical capacity and blood biochemical marker concentrations in…
- Trial name
- NCT07730606
- Testing
- Sodium Bicarbonate (NaHCO3)
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Krzysztof Durkalec-Michalski
Healthy Volunteers
Study Investigating the Safety, Tolerability and Blood Concentration of the Substance SR-878
SR-878 is a newly developed medicine that aims to treat autoimmune disorders. It inhibits a protein (iRhom2), that regulates enzymes that are involved in the production of cytokines (small proteins that are crucial in controlling…
- Trial name
- NCT06607484
- Testing
- SR-878
- Where
- Austria
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- SciRhom GmbH
Mood
Effects of Theobromine and Caffeine on Mood, Cognition and Blood Pressure
The purpose of this study was to measure potential mood, cognition and blood pressure effects of theobromine and caffeine in healthy women
- Trial name
- NCT01288547
- Testing
- theobromine, Caffeine, caffeine + theobromine
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Attention Deficit Disorder With Hyperactivity
Sleepiness and Driving Performances in Adults With Attention-Deficit/ Hyperactivity Disorder (ADHD)
The Attention Deficit/ Hyperactivity Disorder (ADHD) is a developmental disorder which affects 3 to 5 % of school age children. This disorder persists in the adulthood for 60 % of subjects.
- Trial name
- SOMTDA/H (NCT01160874)
- Testing
- Polysomnography, Maintenance Wakefulness Test, Neuropsychological evaluation
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Late Onset Alzheimer Disease
Response to Donepezil, Drug Plasma Concentration and the CYP2D6 and APOE Genetic Polymorphisms
Pharmacological treatment of AD is currently based on cholinesterase inhibitors (ChEI) and memantine, which have been shown to lead to modest, although effective, clinical benefits.
- Trial name
- NCT03349320
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Obese Non Diabetic
The Effects of Sodium Phenylbutyrate on Circulating Branched Chain Amino Acids
The aim of this study is to reduce fasting circulating BCAA concentrations in volunteers using Sodium Phenylbutyrate. In addition, we aim investigate the effect of BCAA lowering on fasting blood glucose levels, insulin…
- Trial name
- NCT05028803
- Testing
- sodium phenylbutyrate
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Inflammation
Flavonoid-rich Supplement Influence on the Human Metabolome
This study will measure the effect of ingesting a flavonoid-rich supplement on various biomarkers in overweight/obese women during a 12-week period.
- Trial name
- NCT03004742
- Testing
- Flavonoid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
ADHD
Probiotic Supplementation in Children With ADHD
This randomised, placebo controlled trial explores the effects of supplementation with a probiotic drink (kefir) in children diagnosed with ADHD on behaviour, sleep, attention and the gut microbiome.
- Trial name
- NCT05155696
- Testing
- Experimental: Kefir probiotic drink (supplied by Nourish)
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- St. Mary's University, Twickenham
Healthy
Serum Metal Ion Concentrations Following Primary Hip Arthroplasty
The objective of this study is to compare serum chromium and cobalt levels of patients who have undergone metal on metal total hip arthroplasty.
- Trial name
- NCT00714610
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Utah
Athletic Performance, Attention
Effects of Play Attention Neurofeedback on Attention and Weightlifting Performance in Adolescent Weightlifters
This study looks at whether a 24-week neurofeedback training program called Play Attention can help adolescent weightlifters pay better attention and lift better.
- Conditions
- Athletic Performance, Attention, Neurofeedback, Weightlifting
- Trial name
- Weightlifter (NCT07837310)
- Testing
- Play Attention Neurofeedback-Based Attention Training
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hasan Erdem Mumcu
Attention Deficit Hyperactivity Disorder
Genetic Liability in the Brain Morphology of Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder (ADHD) is a heritable psychiatric disorder with onset in childhood. Twin and adoption studies indicate that additive genetic factors explain up to 80% of the variance underlying…
- Trial name
- NCT00161161
- Where
- Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Attention Deficit Disorder With Hyperactivity
Preventing Behavior Problems in Children With ADHD
This study will determine the effectiveness of a combination of treatments in preventing behaviors that are typically associated with Attention Deficit Hyperactivity Disorder (ADHD) in young children.
- Trial name
- NCT00057668
- Testing
- Multi-Setting Early Intervention, Community Intervention
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Lehigh University
Reflux Oesophagitis
Effect of 5, 10 or 25 mg of YF476 Daily for 14 Days on Stomach Acidity in Healthy Volunteers
The objective of the study was to assess whether the tolerance to the effect of YF476 on gastric pH observed with repeated doses in a previous study in healthy volunteers can be avoided by using smaller doses of YF476.
- Trial name
- NCT01597674
- Testing
- YF476
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Trio Medicines Ltd.
Attention Deficit Disorder With Hyperactivity, Sleep Disorders, Circadian Rhythm
Sleep Disorders, Chronotype, and Functional Impairment in the Restrictive ADHD Phenotype
This study aims to explore chronotype and sleep disturbances in ADHD subtypes and their relation to functional impairment.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Sleep Disorders, Circadian Rhythm, Quality of Life, Morningness Eveningness Preference
- Trial name
- NCT06970418
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Dr. Behcet Uz Children's Hospital
Heparin, Perioperative
Effects of Different Concentrations of Pressurized-heparin Flushing Fluid on Coagulation and Platelet Function Monitored by the Sonoclot Analyzer
Heparin diluent or normal saline is generally used as the arterial tube flushing in clinical practice, but there is no consensus on the choice of flushing fluid.
- Trial name
- NCT04355273
- Testing
- Heparin, normal saline
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yangzhou University
Pre-myopia
PROTECT-Study: Prospective Research on Optimizing Atropine Concentration Escalation for Children's Myopia Prevention
A prospective multicenter study design was adopted. Children aged 6-9 years with premyopia who met the criteria were screened and administered after completion of baseline assessment. Phase I: 0-24 weeks (0-6M).
- Trial name
- PROTECT (NCT07449247)
- Testing
- 0.01% Atropine
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Eye Hospital
Exercise Intervention
Exercise Intervention on Conflict Monitoring in Children With Attention-deficit Hyperactivity Disorder
The study mainly investigates the effect of high-intensity interval training on conflict monitoring in children with ADHD by using event-related potential and sLORETA techniques.
- Trial name
- ADHD (NCT04112758)
- Testing
- High-intensity interval training
- Where
- Taiwan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Autism, Challenging Behavior
Testing a Measurement Feedback App to Improve Data Quality, Supervision & Outcomes in Behavioral Health
The goal of this clinical trial is to test whether a smartphone-based data collection and feedback application ("Footsteps") improves the quality of behavioral data collected by one-to-one aides and leads to better youth mental…
- Conditions
- Autism, Challenging Behavior, ADHD, Oppositional Defiant Disorder
- Trial name
- Footsteps (NCT07042347)
- Testing
- Behavioral economics strategies, Electronic platform
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Color, Bleaching Sensitivity
Whitening Efficacy and Tooth Sensitivity of Different Concentrations of Hydrogen Peroxide Photoactivated With Violet or Blue LEDs
This is a randomized, controlled, double-blind and repeated-measures clinical trial evaluated the photoactivation of hydrogen peroxide gels in different concentrations with blue or violet LED in terms of whitening efficacy and…
- Trial name
- NCT06165458
- Testing
- 6% hydrogen peroxide gel + violet LED, 6% hydrogen peroxide gel + blue LED, 35% hydrogen peroxide gel + violet LED
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Para
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