Clinical trials: Concentration
PreDiabetes, Impaired Fasting Glucose (IFG)
Metformin and Its Impact on the Substances Associated With NO Production in Prediabetes Patients.
This study evaluates the effect of different doses of metformin on the function of endothelium in people with pre-diabetes. One group of the patients will receive metformin in dose: 1500 mg, the second one will receive 3000…
- Conditions
- PreDiabetes, Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (IGT)
- Trial name
- NCT03398356
- Testing
- Metformin
- Where
- Poland
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Subjective Cognitive Decline
Cholinergic Mechanisms of Attention in Aging
This study will use an anticholinergic pharmacological probe to examine attention network function in SCD using EEG. The overall hypothesis is that in older adults with SCD, normal cognitive performance is maintained by…
- Trial name
- NCT04756232
- Testing
- Mecamylamine Challenge
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Attention Deficit Hyperactivity Disorder
The Association Between Executive Functions and Candidate Genes of Dopaminergic and Noradrenergic Systems in Attention Deficit Hyperactivity Disorder (ADHD)
The ultimate goal of this study is to find specific polymorphism of candidate genes (particularly of dopaminergic and noradrenergic systems) associated with intermediate phenotypes (e.g., executive functions, IQ, and other…
- Trial name
- NCT01052753
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy Volunteers
A Trial to Investigate Teprotumumab (High-concentration Formulation) Subcutaneous Administration in Healthy Adult Non-Japanese and Japanese Participants
The primary objective of this trial are to assess the pharmacokinetics (PK) of a single subcutaneous (SC) administration of teprotumumab high-concentration formula (HCF) in healthy adult non-Japanese and Japanese participants and…
- Trial name
- NCT06674941
- Testing
- Teprotumumab
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Amgen
Nicotine Dependence, Drug Abuse
Effects of Nicotine on Cognitive Task Performance and Brain Activity as Measured by fMRI
Background: Many cigarette smokers claim that smoking improves their ability to think and concentrate, and have reported problems in thinking and concentration after quitting smoking.
- Trial name
- NCT01036711
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Attention Deficit Hyperactivity Disorder (ADHD)
Methodology of Super-Early Training of Developer Engineers and Leading Analysts With a Diagnosis of ADHD/ASD for Ensuring the Engineering Sovereignty of the State: Time Horizon: 2026-2038-2050
This document outlines a clinical study focused on the transition from diagnosis to profession: the calibration of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) into a strategic sovereign…
- Trial name
- DOCUMENT (NCT07845292)
- Testing
- Voice of Sleep "MamaBee" training modules (Fairy Tales)
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Pisareva Citadel Group LLC
Healthy
Assessment Of The Effects Of Single Doses Of An Investigational Drug, Given Alone Or With Donepezil, On Scopolamine-Induced Changes In Memory And Learning In Healthy Adults
This study is designed to look at the potential for an investigational drug (PF-04995274, under development by Pfizer, Inc. as a potential treatment for Alzheimer's disease) to reverse changes in memory and learning/problem…
- Trial name
- NCT01345864
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Pfizer
Insomnia
Relationship of Nocturnal Concentrations of Melatonin, γ-aminobutyric Acid and Total Antioxidants With Insomnia
To analyze the relationship of nocturnal concentrations of melatonin, γ-aminobutyric acid and total antioxidants with insomnia after stroke.
- Trial name
- NCT03202121
- Testing
- insomnia group, non-insomnia group, normal control
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- China Rehabilitation Research Center
Endometriosis
Urinary Concentration of Phthalate Metabolites in Women With and Without Endometriosis
Exposure to endocrine-disrupting chemicals can considerably affect female reproductive system. Exposure can occur in living environments and in specific workplaces in which these substances are produced or used.
- Trial name
- FTALATENDO (NCT05551494)
- Testing
- Urinary sample
- Where
- Italy
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Phase 1, Single Dose
A First In Human Study In Healthy People To Evaluate Safety, Toleration And Time Course Of Plasma Concentration Of Single Inhaled Doses Of PF-05212372.
The purpose of this study in healthy people is to evaluate safety, toleration and time course of plasma concentration of single inhaled doses of PF-05212372.
- Conditions
- Phase 1, Single Dose, Safety, Toleration
- Trial name
- NCT01415102
- Testing
- PF-05212372
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Breathing Exercises, Healthy Volunteers
Three Breathing Techniques for Heart Rate Variability, Attention, Reaction Time, and Anxiety
This randomized controlled trial compared the effects of Mindfulness Breathing, Box Breathing, and Nadi Shodhana Pranayama on heart rate variability, attention performance, reaction time, and anxiety in healthy adults aged 18-40…
- Trial name
- NCT07810595
- Testing
- Mindfulness Breathing, Box Breathing, Nadi Shodhana Pranayama
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Atlas University
Atherosclerosis, Cardiovascular Disease
A Study Investigating Blood Concentrations Of Rosuvastatin When Co-administered With GW856553 In Healthy Men
This study is being conducted to provide initial safety and tolerability data as well as to provide PK data on potential interactions when GW856553 and rosuvastatin are co-administered in healthy male adults
- Trial name
- NCT00549653
- Testing
- GW856553
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Postprandial Amino Acid Concentrations in Healthy Adults
Effects of P24 on Postprandial Aminoacidemia
The purpose of this study is to quantify the acute effects of an acid-active protease enzyme supplement (P24) on postprandial aminoacidemia following consumption of a standardized mixed-protein meal containing both plant- and…
- Trial name
- NCT07479173
- Testing
- Protease enzyme supplement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Amplifye
Normal Physiology
Pharmacokinetics of Granulocyte Colony Stimulating Factor in the Breast Milk of Volunteer Peripheral Blood Stem Cell Donor
Background: The drug filgrastim (rGCSF) increases the number of blood-forming cells in the bloodstream. These cells can be collected from donors bloodstreams and used for transplant.
- Trial name
- NCT02322151
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Performance Improvement in Beginner Archers
The Effect of Imagery Exercises on Attention and Performance in Olympic Archers
The goal of this clinical trial is to for beginners in archery in to examine the effects of Imagination and breathing exercises given in addition to 8-week archery training on archery target score, postural sway, attention, hand…
- Trial name
- NCT06739681
- Testing
- Routine Intervention, Mental Imagery Intervention, Breathing Exercise Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medipol University
Healthy
A Study In Healthy People To Evaluate Safety, Toleration And Time Course Of Plasma Concentration Of Multiple Oral Doses Of PF-04895162
The purpose of this study in healthy people is to investigate safety, toleration and time course of plasma concentration of PF-04895162, following multiple oral doses for 14 days.
- Trial name
- NCT01691274
- Testing
- PF-04895162
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cardiovascular Response to Epinephrine
Comparing Cardiovascular Effects of 1:100,000 and 1:200,000 Epinephrine Solutions
The study aim to evaluate systemic response of patients when 2 different concentrations of Epinephrine are injected during inferior alveolar nerve block for wisdom teeth extraction.
- Trial name
- NCT02735018
- Testing
- Epinephrine 1:100,000, Epinephrine 1:200,000
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Vitamin D Receptor Target Gene Expression, Serum 25(OH)D Concentration
Efficiency of Vitamin D3 and 25-hydroxyvitamin D3 on Transcriptomic Changes of Low Vitamin D Responders
The purpose of the study is to investigate in vivo whether a high-dose vitamin D3 oral bolus (2000 micrograms) produces marked vitamin D receptor target gene expression response and whether there is large inter-individual…
- Trial name
- VitDHiD (NCT03537027)
- Testing
- Vitamin D3
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Anti-Infective Agents
Cross Over Study to Prove Bioequivalence Between Two Brands of Cefalexin Suspension
A single dose, two treatments (two cephalexin suspension brands), two sequences, cross-over design was used with a washout of 7 days between the two study periods.
- Trial name
- NCT01105208
- Testing
- Cephalexin suspension (Optocef, BAYO5448 ), Cephalexin suspension (Keflex)
- Where
- Mexico
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Bayer
Attention, Cognition
Acute Effects of Mango Leaf Extract on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study
The primary aim of this randomised, double-blind, placebo-controlled, cross-over study is to assess the short-term cognitive effects of a single dose (300 mg) of Mango Leaf Extract compared to a placebo on cognitive function…
- Conditions
- Attention, Cognition, Mood
- Trial name
- NCT05182450
- Testing
- Mango leaf extract capsule
- Where
- United Kingdom
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
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