Clinical trials: Concentration
CML, Philadelphia Chromosome Positive (Ph+)
Study of Nilotinib in Ph+ CML-CP Patients With Low Imatinib Trough Plasma Concentrations
This study is to determine the number of European Leukemia Network (ELN)guideline defined treatment failure events from time of study entry in CML-CP patients with low imatinib trough concentrations treated with nilotinib.
- Conditions
- CML, Philadelphia Chromosome Positive (Ph+), Chronic Myelogenous Leukemia Chronic Phase(CML-CP) Patients With Low Imatinib Trough Levels
- Trial name
- MACS1148 (NCT01131325)
- Testing
- nilotinib
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Novartis Pharmaceuticals
Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD)
Exploring Eye Vergence Markers ADHD) and ASD
The investigators study aims to evaluate the utility of eye vergence, an eye-tracking measure, as an indicator of visuo-spatial attention in children aged 4-17 years and adults, using computer-based eye-tracking tasks.
- Trial name
- NCT06885060
- Testing
- BGaze ADHD Diagnostic Test, Oddball/Alerting Computer Task, Facical Emotion Computer Task
- Where
- 3 sites in Spain, United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Elizabeth Kilbey
Diabetes Mellitus, Type 2
To Observe the Clinical Effect of Femoral Nerve Block With Low Concentration of Ropivacaine Based on DPN Grading
The purpose of this study was to quantitatively standardize the performance of patients with DPN with different course of disease using high-frequency ultrasound, and to design experiments to verify the conclusion that DPN…
- Trial name
- NCT06732362
- Testing
- Different DPN ratings
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zheng Guo
Attention Deficit Hyperactivity Disorder, ADHD
Omega-3 Polyunsaturated Fatty Acids in Youth With ADHD
N-3 polyunsaturated fatty acids(N-3 PUFAs) is important in balancing the immune function and crucial for the developing brain. Deficiency in n-3 PUFAs might be linked to the poor cognitive performances resulting in inattention…
- Trial name
- NCT03542643
- Testing
- n-3 Polyunsaturated fatty acid
- Where
- Taiwan
- Volunteers
- 105 people
- Sponsor
- China Medical University Hospital
ADHD - Attention Deficit Disorder With Hyperactivity
External Trigeminal Nerve Stimulation for Attention Deficit Hyperactivity Disorder - Feasibility Trial
The investigators will assess the use of the Monarch eTNS device as a non-pharmacological treatment for patients aged 7 to 17 years with ADHD. The investigators will compare the eTNS device to a sham device.
- Trial name
- eTNS4ADHD (NCT06655610)
- Testing
- External Trigeminal Nerve Stimulation
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Psychiatric Research Unit, Region Zealand, Denmark
High-flow Nasal Cannula, Exercise Capacity
Exercise Capacity Under Various FiO2 and Oxygen Flow Rates Using HFNC
The purpose of this study is to compare the exercise capacity (6-min walking distance) under the following 4 conditions using High-flow nasal cannula (HFNC); 1.
- Conditions
- High-flow Nasal Cannula, Exercise Capacity, Respiratory Failure
- Trial name
- NCT04471220
- Testing
- High-flow nasal cannula
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- National Hospital Organization Minami Kyoto Hospital
Pulmonary Embolism
Optimization of DE-CTPA Images and Diagnostic Pathway: Using Low Concentration Iodine Contrast Material
The investigators aimed to compare the image quality and diagnostic performance of DECTPA using lower concentration iodine contrast materials and using normal concentration iodine contrast materials in the evaluation of suspected…
- Trial name
- NCT06212882
- Testing
- DE-CTPA with 30 mL iomeprol 300 mg I/mL, DE-CTPA with 50 mL iomeprol 300 mg I/mL, DE-CTPA with 50 mL Ioversol 350 mg I/mL
- Where
- China
- Volunteers
- 2,216 people
- Sponsor
- Wuxi People's Hospital
Healthy Male and Female Subjects
The Effect of Cycling, Running, and Playing Rugby on Three Biomarkers That May Indicate Brain Injury
The goal of this clinical trial was to determine if and how the biomarkers neurofilament light (NfL), brain lipid binding protein (BLBP), and amyloid precursor protein (APP) accumulated over 72 hours in venous blood following…
- Trial name
- NCT06804291
- Testing
- Running, Cycling, Rugby
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Sickle Cell Disease, Attention Deficit
Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease
Children with sickle cell disease (SCD) exhibit significantly reduced cognitive functioning (often difficulties with attention) compared to peers and siblings without SCD.
- Conditions
- Sickle Cell Disease, Attention Deficit, Cognitive Deficit in Attention
- Trial name
- ACT (NCT05099874)
- Testing
- EndeavorRx
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's National Research Institute
Cerebral Palsy, Mental Retardation
Development and Application of a Diagnosis and Treatment System for Children's Brain Diseases Based on Knowledge Graphs and Large Models
Using the knowledge graph and big model technology of combining Chinese and Western medicine we construct a popularization and prevention system for childhood encephalopathy an assisted decision-making system for childhood…
- Conditions
- Cerebral Palsy, Mental Retardation, Tourette's Syndrome, Attention Deficit Hyperactivity Disorder
- Trial name
- NCT06848959
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Yun Liu,PhD
Lupus Nephritis
Fixed-dose Versus Concentration-controlled Mycophenolate Mofetil for the Treatment of Active Lupus Nephritis
A randomized open-label study of fixed-dose versus concentration-controlled mycophenolate mofetil for treatment of active lupus nephritis.
- Trial name
- NCT03920059
- Testing
- Mycophenolate Mofetil
- Where
- Thailand
- Volunteers
- 2 people
- Sponsor
- Chulalongkorn University
Medication Adherence, HIV
Development of a Urine-Based Point-of-Care Test for Adherence to Antiretroviral Drugs
This is a single-center, open label study to identify adherence levels of commonly prescribed FDA-approved antiretroviral agents by tracking the decline of drug concentrations in plasma, urine and saliva following abrupt drug…
- Trial name
- APTAMER (NCT04302896)
- Testing
- dolutegravir oral tablet 50mg, emtricitabine/tenofovir alafenamide oral tablet 200mg/25mg, tenofovir disoproxil fumarate oral tablet 300mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rhonda Brand
Cataract
Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients
Evaluation of the aqueous concentrations of 2 topical NSAIDS as well as the PGE2 inhibition in human patients.
- Trial name
- NCT00347503
- Testing
- ketorolac 0.4%, bromfenac 0.09%
- Where
- United States
- Sponsor
- Innovative Medical
ADHD
Long-Term Safety of PRC-063 in Adolescents and Adults With ADHD
The purpose of this six month, open-label study is to evaluate the long-term safety and efficacy of PRC-063 in adults and adolescents with ADHD.
- Trial name
- NCT02168127
- Testing
- Drug: PRC-063, PRC-063
- Where
- 35 sites in United States, Canada
- Volunteers
- 360 people
- Sponsor
- Rhodes Pharmaceuticals, L.P.
Critical Illness, Multi Organ Failure
Parathyroid Hormone Kinetics During CRRT
The objective of this study is to assess the parathyroid hormone serum concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multi-organ failure and undergoing citrate anticoagulation…
- Conditions
- Critical Illness, Multi Organ Failure, Renal Failure, Circulatory Failure
- Trial name
- NCT03873675
- Testing
- parathyroid hormone
- Where
- 3 sites in Poland
- Volunteers
- 30 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Psoriasis
Study to Investigate Dose-related Efficacy of LAS41004 in the Treatment of Psoriasis
The aim of the study is to intra-individually compare the dose-related efficacy of LAS41004 in a Psoriasis Plaque Test (PPT)
- Trial name
- NCT01119339
- Testing
- LAS 41004, LAS 41004 dosage 6, Reference
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Almirall, S.A.
Attention Deficit Hyerpactivity Disorder
Novel Approaches to Supporting Students With ADHD in Multi-Tiered Systems of Support
Children with attention-deficit/hyperactivity disorder (ADHD) are likely to exhibit behavioral difficulties in the classroom that inhibit learning (Daley \& Birchwood, 2010; DuPaul \& Stoner, 2003; Fabiano et al., 2006; Friedman…
- Trial name
- NCT07836972
- Testing
- Academic Competency Enhancement (ACE) classroom, School as Usual Classroom Supports
- Volunteers
- 544 people
- Sponsor
- Florida International University
Obesity
Saliva and Plasma Endocannabinoids Concentrations According to Feeding Status and Body Mass Index
Up till now, the evaluation of the endocannabinoid system (ECS) in humans needs invasive procedures. The investigators managed in the lab to determine the levels of endocannabinoids in a small number of subjects.
- Trial name
- SALIVENDO (NCT01223157)
- Testing
- Biological data
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
ADHD
Non-invasive Brain Stimulation for Pediatric ADHD
The possibility of influencing brain activity and steadily enhancing behavioral performance through external intervention has long fascinated neuroscientists.
- Trial name
- NCT03104972
- Testing
- tDCS, tRNS
- Where
- Israel
- Volunteers
- 47 people
- Sponsor
- Hebrew University of Jerusalem
C.Delivery; Surgery (Previous), Gynecological
The Effective Effect-Site Propofol Concentration for Induction and Intubation for Schnider Model in Parturients
The aim of this study was to determine the target propofol concentration needed to provide adequate hypnosis for induction and tracheal intubation for Schnider model using total body weight (TBW) in parturients.
- Trial name
- NCT02554175
- Testing
- Propofol
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Fudan University
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