Clinical trials: Concentration
Sepsis, Infections
Improving Therapeutic Drug Monitoring and Dosing for Vancomycin in Young Infants With Infections (VANCAPP) (Part 2)
A challenge to intermittent vancomycin dosing in young infants is the avoidable delay caused by the need to wait until steady state (i.e.
- Conditions
- Sepsis, Infections, Bacteremia
- Trial name
- VANCAPP (NCT05770622)
- Testing
- First-dose trough dose adjustment calculator - using early TDM (first-dose trough) to determine an early dose adjustment if the predicted steady-state trough is outside of target range (10-20mg/L)
- Where
- 4 sites in Australia
- Volunteers
- 40 people
- Sponsor
- Murdoch Childrens Research Institute
Fatigue, Attention Deficit Hyperactivity Disorder
A Trial of Dyanavel XR in Treating Co-occurring Fatigue Symptoms in Adults With Attention Deficit Hyperactivity Disorder (ADHD).
The goal of this clinical trial is to study the impact of Dyanavel on co-occuring fatigue in adults with Attention Deficit/Hyperactivity Disorder.
- Conditions
- Fatigue, Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder
- Trial name
- NCT06248229
- Testing
- Dyanavel XR
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rochester Center for Behavioral Medicine
ADHD, ADHD - Attention Deficit Disorder With Hyperactivity
Comparative Efficacy of Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI)
This randomized control trial comparing Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI) among adolescents with a pre-existing ADHD diagnosis presenting to the Duke ADHD Program.
- Trial name
- NCT07089745
- Testing
- Mindfulness-Based Intervention, Organizational Skills Training
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy Athletes Aged 18-35 Years
Effect of Long-lasting Adaptation to Endurance and Speed-power Training on Plasma Free Amino Acids Concentration
The goal of this observational study was to detect the long-term effect of two different training modalities - speed-power and endurance training - on changes in plasma free amino acid (PFAA) concentration at rest, during graded…
- Trial name
- AAdaptation (NCT05672758)
- Testing
- Sprint training, Endurance training, Recreational Training
- Where
- Poland
- Volunteers
- 58 people
- Sponsor
- Poznan University of Physical Education
Diabetes Mellitus, Type 2
Assessment of the Skin-concentration of Vildagliptin 50 mg Every 12 Hours for 10 Days in Healthy Subjects and Patients With Type 2 Diabetes
This study will look at the skin accumulation of vildagliptin and its two major metabolites, LAY151 and LAF237-O-Glucuronide, after vildagliptin 50 mg given orally twice a day for 10 days in both healthy volunteers and patients…
- Trial name
- NCT00633997
- Testing
- Vildagliptin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Novartis
ADHD
MRI Investigations in Attention Deficit Hyperactivity Disorder (ADHD) and High Potential (HP) Children for a Better Therapeutic Approach
Impulsivity and/or hyperactivity in children has become one of the main clinical symptom for consultation, among the most frequent, in general or pediatric medicine.
- Trial name
- HP (NCT02823782)
- Testing
- MRI, neuropsychological assessment
- Where
- France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Brain Activity
Brain Activity by Magnetoencephalography for Children
Investigate the differences in activation of brain networks during performing functional tasks for children with attention deficit hyperactivity disorder with developmental delays and typical development
- Trial name
- NCT04629482
- Testing
- Brain networks activity
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Attention Deficit Hyperactivity Disorder
Intensive Executive Function Training
The investigators intent to recruit 80 attention deficit hyperactivity disorder families. The attention deficit hyperactivity disorder families had received executive function training one year before.They will be randomized to…
- Trial name
- NCT02656758
- Testing
- intensive Executive function training
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- ZIli Fan
ADHD
Lifestyle Enhancement for ADHD Program
The purpose of this study is to investigate if physical activity (PA) can increase in children with Attention Deficit/Hyperactivity Disorder (ADHD) using a modified behavioral management training (BMT) program.
- Trial name
- LEAP (NCT03690674)
- Testing
- Lifestyle Enhancement for ADHD Program
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Anxiety Disorder
Augmenting Effects of ABMT on CBT in Anxious Children: A Randomized Clinical Trial
The development of easily disseminated and efficacious treatment of psychiatric disorder is an important goal for translational neuroscience research.
- Trial name
- NCT01730625
- Testing
- Cognitive behavioral therapy for anxiety, Attention Bias Modification Treatment
- Volunteers
- 119 people
- Sponsor
- Tel Aviv University
Anxiety, Anxiety Disorders
Attention Bias Modification for Transdiagnostic Anxiety
This project seeks to identify neural mechanisms underlying the tendency for anxious individuals to pay more attention to threatening information than to other types of information.
- Trial name
- NCT02303691
- Testing
- Attention Bias Modification, Neutral Training
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Pittsburgh
Chronic Kidney Disease
Darbepoetin Alfa Once Monthly Dosing Schedule Maintains Hemoglobin Concentration Comparable to Every 2 Weeks Dosing Schedule in Advanced Chronic Kidney Disease Patients Not on Dialysis: A Multicenter, Phase 4 Study
This open-label, multicenter, single-arm phase 4 trial evaluated the efficacy and safety of once-monthly subcutaneous administration of darbepoetin alfa (DARB) compared with biweekly dosing in Korean patients with non-dialysis…
- Trial name
- NCT07025460
- Testing
- darbepoetin alfa
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Gangnam Severance Hospital
Mild Cognitive Impairment, Dementia
An Imaging Study to Investigate the Distribution of GSK239512 in the Brain.
GSK239512 is being developed for the treatment of symptoms of cognitive impairment in many diseases. GSK239512 is a drug that binds to the Histamine 3 receptor (a protein) in the brain (receptor occupancy).
- Trial name
- NCT00474513
- Testing
- GSK239512
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Attention Deficit Hyperactivity Disorder
A Comparative Effectiveness Study Evaluating OROS Methylphenidate HCl, Ritalin (Methylphenidate HCl), and Placebo for the Treatment of Attention Deficit Hyperactivity Disorder in Children
The purpose of this study is to compare the effectiveness (onset of effect, time to loss of effect, and overall efficacy) of methylphenidate given as an OROS® (methylphenidate HCl) formulation, compared to immediate-release…
- Trial name
- NCT00269789
- Testing
- Ritalin, OROS Methylphenidate HCl
- Sponsor
- Alza Corporation, DE, USA
Healthy
Ocular Availability in Human Tears After Topical Administration of 1.5% Levofloxacin Compared to Active Comparators
The primary objective of this study is to compare the concentration in human tears of levofloxacin and the active comparators at 15 minutes, 2,6, 12, and 24 hours after instillation of a single drop of medication.
- Trial name
- NCT00703313
- Testing
- 1.5% levofloxacin ophthalmic solution, 0.5% moxifloxacin hydrochloride ophthalmic solution, 0.3% gatifloxacin ophthalmic solution
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Santen Inc.
Attention Deficit Disorder With Hyperactivity, Placebo Effect
Attention and Pain in Children With and Without Attention Deficit and/or Hyperactivity Disorder
In Quebec, there has been an important increase of Attention Deficit Hyperactivity Disorder (ADHD) diagnosis since 2015. ADHD symptoms, related to behavioural and/or concentration difficulties, are very similar to other disorders…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Placebo Effect, Nocebo Effect, Pain
- Trial name
- ADE (NCT04766580)
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder
Video-conferencing FACT for Young Children With Special Needs
Objective: This RCT evaluates the efficacy of Focused Acceptance and Commitment Therapy (FACT) delivered via videoconferencing for parents of special needs children, targeting reducing parental stress (primary outcome), symptoms…
- Conditions
- Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Specific Learning Disorder, Communication Disorders
- Trial name
- NCT06262646
- Testing
- Focused Acceptance and Commitment Therapy, Control Group
- Where
- Hong Kong
- Volunteers
- 254 people
- Sponsor
- Chinese University of Hong Kong
Healthy
The Effects of Losartan on Attention Control: An Eye-tracking Study
The main aim of the present study is to investigate the effects of orally administered Losartan on bottom-up and top-down attentional control to socio-emotional stimuli by combining a validated saccade/antisaccade eye-tracking…
- Trial name
- NCT06329050
- Testing
- Losartan
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Cancer, Surgery
Anesthesia Feasibility Study With the CONCERT-CL® Station
This is a feasibility study of anesthesia in closed loop with the CONCERT-CL® station, on the effect of the hypnotic agent, measured by the bispectral index of the electroencephalogram, to maintain the hypnosis level within the…
- Trial name
- CONCERT (NCT02889718)
- Testing
- CONCERT-CL® station, Surgery
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut Cancerologie de l'Ouest
Healthy Volunteers
Study of the Blood Concentrations of Two Formulations of REGN2222 in Healthy Subjects
Primary Objective: Determine blood concentrations of two formulations of REGN2222 Secondary Objective: Assess safety and tolerability of REGN2222
- Trial name
- NCT02828397
- Testing
- REGN2222
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
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