Clinical trials: Concussion (Diagnosis)
Traumatic Brain Injury
Early Digital, Analyte and Neurologic Biomarkers of Acute and Chronic Brain Injury and Recovery in CQT Instructors
Repetitive blast exposure has been shown to lead to more severe neurobehavioral impairments versus a single exposure. Blast-induced Traumatic Brain Injury (TBI) can lead to short- and long-term adverse outcomes Even mild brain…
- Trial name
- NCT05917665
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Mild Traumatic Brain Injury (mTBI)
Symptom-Targeted Approach to Rehabilitation for Concussion (STAR-C)
Purpose: Investigators propose a three-arm RCT across two military treatment facilities:1) in-person STAR-C, 2) telehealth STAR-C, and 3) no treatment control.
- Trial name
- STAR-C (NCT06855186)
- Testing
- Symptom-Targeted Approach to Rehabilitation for Concussion
- Where
- 2 sites in United States
- Volunteers
- 222 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Post-traumatic Stress Disorder (PTSD), Mild Traumatic Brain Injury (mTBI)
Acupressure and Stress Resilience
The current study will assess the efficacy of acupressure, a type of complementary and alternative medicine (CAM) in the Veteran population.
- Trial name
- NCT01614444
- Testing
- Active Acupressure Treatment
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Eastern Colorado Health Care System
Convergence Insufficiency, Traumatic Brain Injury
Eye Recovery Automation for Post Injury Dysfunction (iRAPID)
This study will test a portable virtual reality (VR) system with integrated eye tracking called Virtual Eye Rotation Vision Exercises (VERVE). The proposed VERVE platform will deliver vergence therapy in an automated manner.
- Conditions
- Convergence Insufficiency, Traumatic Brain Injury, Concussion, Mild
- Trial name
- iRAPID (NCT06105892)
- Testing
- Virtual Eye Rotation Vision Exercise (VERVE)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- New Jersey Institute of Technology
Traumatic Brain Injury, Fatigue
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
Patients with a history of mild traumatic brain injury (mTBI) or post acute sequelae of SARS-CoV-2 (PASC) and abnormal growth hormone secretion, as measured by glucagon stimulation test, will be treated with replacement growth…
- Conditions
- Traumatic Brain Injury, Fatigue, Cognitive Impairment, COVID-19
- Trial name
- NCT03554265
- Testing
- Somatropin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Mild Traumatic Brain Injury
Sub-symptom Threshold Aerobic Exercise After Mild Traumatic Brain Injury
This Randomized Controlled Trial (RCT) will explore the effect of sub-symptom threshold aerobic exercise on persistent post-concussion symptoms and exercise intolerance in patients with mild Traumatic Brain Injury (TBI).
- Trial name
- NCT05086419
- Testing
- Sub-symptom threshold aerobic exercise
- Where
- Norway
- Volunteers
- 105 people
- Sponsor
- Oslo University Hospital
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
BIOmarkers of TRAumatic Brain Injury Spain (BIOTRABIS)
Traumatic brain injury (TBI) is defined as a structural alteration of brain function caused by external causes, where mild traumatic brain injury (mTBI) represents approximately 80% of all TBI, and although its prognosis is…
- Trial name
- BIOTRABIS (NCT04641767)
- Where
- 9 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitario Virgen Macarena
Concussion
Mindfulness and Yoga Training for Athletes With Concussion (MYTAC)
The purpose of this study is to establish the tolerability of mindfulness and yoga therapy in the post-concussion period.
- Trial name
- (MYTAC) (NCT03304327)
- Testing
- Mindfulness and Yoga Training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Mild Traumatic Brain Injury
Behavioral Profile Matching: A Precision Medicine Approach to Concussion Rehabilitation
At least 1 in 5 people who sustain a concussion will have persistent symptoms and difficulties with daily activities. The researchers have identified two unhelpful coping styles following a concussion - avoidance and endurance.
- Trial name
- NCT03972579
- Testing
- Graded exposure therapy, Pacing + mindfulness
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Traumatic Brain Injury, Intracranial Injury
Usefulness of Biomarkers in the Management of Mild Traumatic Brain Injury in Adults (Biotraumap)
The indication of cranial computed tomography (CCT) is difficult to define for patients with mild traumatic brain injury (mTBI).
- Trial name
- Biotraumap (NCT04543162)
- Where
- France
- Volunteers
- 1,025 people
- Sponsor
- University Hospital, Clermont-Ferrand
Mild Traumatic Brain Injury
Remediation of Impaired Self-Regulation in Patients With Mild TBI
The ability to regulate impulses enables us to plan for the future, to maintain focus in the face of distractions (i.e. to encode memories), and to manage emotions.
- Trial name
- NCT02260570
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Concussion
Smart Phone Application for Postconcussion Symptom Reduction
The proposed study will address a very important issue for the VA both currently and in the future -- the high percentage of OIF/OEF/OND Veterans who have been medically diagnosed with a mild traumatic brain injury (mild TBI) and…
- Trial name
- NCT02501642
- Testing
- Concussion Coach, Treatment as usual
- Where
- 2 sites in United States
- Volunteers
- 479 people
- Sponsor
- VA Office of Research and Development
Trauma, Head, Headaches Posttraumatic
Frequency Specific Microcurrent Therapy for Mild Traumatic Brain Injury
Patients with mild traumatic brain injury (mTBI) may experience spontaneous recovery within 7-10 days, but some continue to exhibit symptoms such as headache, dizziness, vertigo, poor concentration, and cognitive dysfunction.
- Conditions
- Trauma, Head, Headaches Posttraumatic, Dizziness, Brain Concussion
- Trial name
- NCT06245967
- Testing
- Frequency specific microcurrent therapy
- Volunteers
- 52 people
- Sponsor
- China Medical University Hospital
Physiological Post-Concussion Disorder, Post-Concussion Syndrome
Sub-maximal Exercise Prescription in Adolescents With Physiological Post-concussion Disorder
Although the vast majority of individuals sustaining a sport-related concussion (SRC) will receive medical clearance to return to sport within 7-10 days, approximately 30% of children and adolescents reporting to the emergency…
- Conditions
- Physiological Post-Concussion Disorder, Post-Concussion Syndrome, Traumatic Brain Injury, Rehabilitation
- Trial name
- NCT03367507
- Testing
- Sub-symptom aerobic exercise
- Where
- 2 sites in Canada
- Volunteers
- 136 people
- Sponsor
- Sport Injury Prevention Research Centre
Concussion, Brain
One Team: Changing the Culture of Youth Sport With Pregame Safety Huddles
Randomized controlled trial of a behavioral intervention (Pre-Game Safety Huddles) designed to study the impact of huddles on concussion safety in youth sport, primarily regarding intention to report concussive symptoms.
- Trial name
- NCT04099329
- Testing
- Pre-game Safety Huddles
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Seattle Children's Hospital
Brain Concussion, Post-Concussion Syndrome
Exercise in Postconcussion Symptoms and Posttraumatic Headache
The goal of this clinical trial is to compare two models of delivery of guided exercise in patients with exercise intolerance after mild head injury.
- Conditions
- Brain Concussion, Post-Concussion Syndrome, Post-Traumatic Headache, Craniocerebral Trauma
- Trial name
- NCT06015451
- Testing
- Sub-symptom threshold exercise
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- St. Olavs Hospital
Acupuncture, Mild Traumatic Brain Injury
Acupuncture for Mild Traumatic Brain Injury：A Functional Magnetic Resonance Imaging Study
The overall goal of this study is to examine if acupuncture intervention can reduce the post-concussion symptom (PCS), and affective and cognitive complaints among mild traumatic brain injury (TBI).
- Conditions
- Acupuncture, Mild Traumatic Brain Injury, MRI
- Trial name
- NCT02868671
- Testing
- acupuncture
- Where
- China
- Volunteers
- 66 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Fixation, Ocular, Brain Concussion
Concussion Pen Screening Tool
To compare the use of the Concussion Pen to current clinical care practice. This will be a prospective study of a maximum of 24 subjects, with a goal enrollment of 20 subjects (10 in each cohort).
- Trial name
- NCT05432752
- Testing
- Concussion Pen
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Children's Mercy Hospital Kansas City
Post-Traumatic Headache
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 2
Anesthetic greater occipital nerve (GON) blockade is a simple, inexpensive, and safe procedure that has demonstrable headache pain suppressing effects.
- Trial name
- NCT07796074
- Testing
- Bupivacaine bilateral greater occipital nerve block
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Yale University
Rugby Professionals, Concussion
Analysis of the Variation in Thickness of Per-papillary Retinal Optic Nerve Fibres in Professional Rugby Players
The main hypothesis is that exposure to repeated shocks is associated with a greater decrease in the thickness of optical nerve fibres.
- Trial name
- ON RUGBY (NCT03958110)
- Testing
- OCT A
- Where
- France
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild