Clinical trials: Condition
Mild Cognitive Impairment, Alzheimer Disease
Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Parkinson Disease, Healthy Volunteers
- Trial name
- Brain-Muscle (NCT02253732)
- Testing
- 3 months exercise intervention program
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Malaria, HIV
Dolutegravir Interactions With Artemisinin-based Combination Therapies
Malaria and HIV are found in the same regions of the world and developing countries are most affected by both diseases. For malaria, new drugs have been introduced called ACTs.
- Trial name
- DolACT (NCT02242799)
- Testing
- Dolutegravir 50mg od, Artemether-lumefantrine combination, Artesunate-amodiaquine
- Where
- Uganda
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Venous Thrombosis Deep (Limbs), Post Thrombotic Syndrome
EXERT: Exercise Physiology After Thrombosis
Deep vein thrombosis (DVT) can cause long-term scarring and narrowing of veins. When there is extensive damage to the veins in the legs, groin or abdomen it can affect the way that blood is able to flow back up to the heart.
- Trial name
- NCT05296499
- Testing
- Cardiopulmonary exercise test (CPET), Exercise cardiac MRI, 6 minute walk test
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Emergencies
Stocking of a Busy Emergency Department
Stocking of essential supplies in an emergency department (ED) is crucial in order to efficiently and effectively take care of patients.
- Trial name
- NCT01586832
- Where
- United States
- Volunteers
- 565 people, healthy volunteers welcome
- Sponsor
- Lehigh Valley Hospital
Sepsis
Immune Activation, Hypoxia and Vasoreaction in Sepsis of Pulmonary Versus Abdominal Origin
Sepsis remains a common entity in critical care patients with remarkable mortality. Pulmonary and abdominal infections (with subsequent sepsis) are the most common in the ICU.
- Trial name
- NCT01530932
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Infections - Bacterial, Pneumonia - Bacterial
Use of Mobile Phones for Thermal Imaging of the Chest to Save Lives of Children With Pneumonia in Nagpur, India
The purpose of this study is to see if thermal images can be used instead of a chest x-ray to diagnose bacterial pneumonia in children with signs and symptoms of pneumonia in Nagpur, India.
- Trial name
- NCT02381431
- Testing
- FLIR ONE
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hodgkin's Disease, Lymphoma
Alemtuzumab (Campath-1H) Monoclonal Antibody in Patients With Relapsed and Resistant Classical Hodgkin's Disease
Primary Objective: To determine the safety and efficacy of Campath-1H (Alemtuzumab) in patients with relapsed and resistant classical Hodgkin's lymphoma. Secondary Objectives: 1.
- Trial name
- NCT00129753
- Testing
- Alemtuzumab (Campath-1H)
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Attention Deficit Hyperactivity Disorder
The Association Between Executive Functions and Candidate Genes of Dopaminergic and Noradrenergic Systems in Attention Deficit Hyperactivity Disorder (ADHD)
The ultimate goal of this study is to find specific polymorphism of candidate genes (particularly of dopaminergic and noradrenergic systems) associated with intermediate phenotypes (e.g., executive functions, IQ, and other…
- Trial name
- NCT01052753
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Type 2 Diabetes, Circadian Rhythm
Determining Circadian Metabolic and Behavioural Rhythms in Patients with and Without Type 2 Diabetes
The goal of the present clinical descriptive study is to characterize and quantify the potential hormonal chronobiological differences between individuals with type 2 diabetes (T2D) and healthy age and weight-matched controls as…
- Trial name
- Cir-D-Brain (NCT06243172)
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Fibromyalgia, Sexual Dysfunction
Fibromyalgia and Sexual Functıonal Dısorder and Sexual Therapy
investigators aim to re-evaluate the findings of Fibromyalgia in patients whose FSFI scores return to normal levels after sexual therapy, by identifying patients with sexual dysfunction according to the FSFI scale applied in…
- Trial name
- NCT05272345
- Testing
- sexual therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Tooth Erosion
Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion
An in situ model will be used to evaluate and compare enamel remineralization of bovine enamel specimens.
- Trial name
- NCT01128972
- Testing
- Sodium fluoride, Sodium monoflurophosphate, Sterile water
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Maturity-onset Diabetes of the Young
Pathophysiological Implications of the Incretin Hormones in Maturity Onset of Diabetes of the Young (MODY)
The purpose of this study is to describe the incretin effect and postprandial incretin response in patients with MODY2 and MODY3 and a group of matched healthy subjects.
- Trial name
- NCT01342939
- Testing
- Oral Glucose Tolerance Test (OGTT), iso glycaemic intravenous (iv) glucose infusion (IIGI), Meal test
- Where
- Denmark
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Coronary Artery Ectasia
Endothelial Function in Patients With Ectatic Compared to Normal Coronary Arteries
The aim of this study is to show the frequency of endothelial dysfunction in patients suffering from ectatic coronary arteries as compared to those who have normal coronary arteries.
- Trial name
- NCT00548457
- Where
- Israel
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Focus: Anabolic Response to Food Intake in Young Individuals, Condition Relevance: Skeletal Muscle Health, Sarcopenia
Manipulation of Dietary Protein and the Anabolic Response
In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.
- Trial name
- PRO-ADAPT (NCT01820975)
- Testing
- High protein intake
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Asphyxia Neonatorum, Birth Asphyxia
Augmented Infant Resuscitator (AIR): Transitioning a Novel Behavior Change Innovation to Drive Newborn Ventilation Skills Enhancement
Augmented Infant Resuscitator (AIR) is an inexpensive add-on, compatible with nearly every existing bag-valve mask and many types of ventilation equipment.
- Conditions
- Asphyxia Neonatorum, Birth Asphyxia, Perinatal Asphyxia
- Trial name
- NCT05349175
- Testing
- Augmented Infant Resuscitator (AIR)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Upper Respiratory Tract Infection
A Study to Evaluate the Efficacy of EQ-778 on Upper Respiratory Tract Health Status in Healthy Adults
This study is a randomized, double-blind, Placebo Controlled study to evaluate the efficacy of 180 days administration of EQ-778 on upper respiratory tract health status in healthy adults
- Trial name
- NCT05835375
- Testing
- EQ-778
- Where
- 13 sites in India
- Volunteers
- 374 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Infertility
Progesterone Microspheres Pharmacokinetic - Pharmacodynamic (PK-PD) Study
Phase: I pharmacokinetic - pharmacodynamic (PK-PD) study. Main objective: To establish the minimum effective dose of progesterone microspheres suspension, which administered by weekly intramuscular injection, will be able to…
- Trial name
- NCT01176175
- Testing
- Progesterone
- Where
- Mexico
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Productos Científicos S. A. de C. V.
Heart Failure
Necklace-Shaped Sensor for Non-Invasive Monitoring of Stroke Volume and Cardiac Output
Study will compare measurements made with Necklace device for stroke volume/cardiac output with values from a FDA-approved reference device. The gold standard that will be used is Cardiac MRI.
- Trial name
- NCT02719301
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Tumor, Brain, Tumor, Breast
Microscopy Imaging of Whole-mount Stained Human Tissues
The goal of this clinical trial is to develop an imaging platform for intraoperative tumor margin delineation in 250 cases of tumor-suffered patients.
- Conditions
- Tumor, Brain, Tumor, Breast, Tumor Skin
- Trial name
- NCT05689112
- Where
- Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Premature Ejaculation
Investigation of the Changes of Brain Structure and Function in Premature Ejaculation Patients and the Effects of Dapoxetine on Central Neural Activity in Premature Ejaculation Patients
Lifelong premature ejaculation (LPE) is a common male sexual dysfunction with a high prevalence in global. Up to now, the etiology of LPE remains unclear.
- Trial name
- NCT03583112
- Testing
- Dapoxetine Hydrochloride Tablet
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xidian University
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