Clinical trials: Condition
Acute Lymphoblastic Leukemia, in Relapse, Chemotherapeutic Toxicity
Efficacy of the Use of Bortezomib for the Treatment of Relapsed Leukemia or Positive MRD
Various drugs have been added to different treatment regimens in order to improve the response rate in patients with Acute Lymphoblastic Leukemia, however, it has been shown that adding Bortezomib to the relapsing regimen…
- Conditions
- Acute Lymphoblastic Leukemia, in Relapse, Chemotherapeutic Toxicity, Minimal Residual Disease
- Trial name
- NCT05137860
- Testing
- Bortezomib
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Hospital General de Mexico
Craniometaphyseal Dysplasia
Genetic and Functional Analysis of Craniometaphyseal Dysplasia (CMD)
CMD can be inherited in an autosomal dominant or recessive trait. CMD may also be caused by de novo mutations. The goal of this study is to identify genes and regulatory elements on chromosomes that are the cause for CMD.
- Trial name
- CMD (NCT01630460)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- UConn Health
Parkinson's Disease
Tango for Treatment of Motor and Non-motor Manifestations in Parkinson's Disease.
Parkinson's disease involves many motor difficulties as well as non-motor ones. Recent research has strongly suggested that exercise is very important for Parkinson's disease.
- Trial name
- NCT01573260
- Testing
- Argentinean Tango classes, Simple pamphlet about the exercise in PD
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Bladder Cancer
Xpert Bladder Cancer Monitor; Prospective, Single, Tertiary-care Center Implementation Study
The primary objective of this prospective, single-centre study is to establish the clinical performance characteristics of Xpert Bladder Cancer Monitor on the GeneXpert Instrument Systems in comparison to the methods currently…
- Trial name
- NCT03715660
- Testing
- Xpert bladder cancer monitor
- Where
- Egypt
- Volunteers
- 198 people
- Sponsor
- Mansoura University
Acute Kidney Injury
Evaluation of Catheter Placement for Renal Replacement Therapy in Patients With Acute Kidney Injury
The purpose of this study is to examine the placement, timing, associated complications, efficacy of temporary and tunneled catheters for renal replacement therapy in patient with acute kidney injury.
- Trial name
- NCT02200120
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Brigham and Women's Hospital
Colon Cancer, Colorectal Cancer
Yttrium Microspheres With Cetuximab Plus Irinotecan for Patients With Advanced Colorectal Cancer Mets to Liver
The goal of this clinical research study is to find out what effects radioactive particles, SIR-spheres, have when injected into the liver, followed by systemic chemotherapy with a combination of cetuximab and irinotecan compared…
- Trial name
- NCT00766220
- Testing
- SIR-spheres Agent Administration, Cetuximab, Irinotecan
- Sponsor
- M.D. Anderson Cancer Center
Leukemia, Leukemia, B-Cell, Chronic
Treatment of B-CLL With Human IL-2 and CD40 Ligand and Plasmid Gene Modified Autologous Tumor Cells
This study is for patients that have chronic lymphocytic leukemia (CLL). This research study aims to determine the safety and dosage of special cells that may make the patients own immune system fight the cancer.
- Trial name
- CLIPA (NCT00078520)
- Testing
- Dose Level 1, Dose Level 2, Dose Level 2- Fixed Dose
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Baylor College of Medicine
Mild Cognitive Impairment (MCI), Mild Alzheimer Disease
iTBS in MCI and Mild AD
This study aims to examine the effects of iTBS on cognitive function in individuals with MCI or mild AD, with a secondary objective of exploring prefrontal TBS mechanisms for cognitive function and the effect of iTBS on BDNF.
- Trial name
- NCT06670820
- Testing
- Active rTMS
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Defense Medical Center, Taiwan
Malignant Solid Tumor, Pain
Pragmatic Research of Acupuncture and Counseling eXtended to Inpatient Services
Despite improved assessment and pharmacologic management, cancer pain is still undertreated. Using non-pharmacologic treatments alongside medications may better address patients' total pain experience by relieving physical and…
- Trial name
- PRACXIS (NCT03905720)
- Testing
- Acupuncture, Pain Counseling
- Where
- 2 sites in United States
- Volunteers
- 448 people
- Sponsor
- University of California, San Francisco
Healthy, Stroke
Influence of Brain Oscillation-Dependent TMS on Motor Function
Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move their arms and hands.
- Conditions
- Healthy, Stroke, Normal Physiology, Aging
- Trial name
- NCT03288220
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Substance Use Disorders, Substance Use
Examining Feasibility and Acceptability of Telemedicine for Substance Use Disorder (SUD)
The objective of this pilot intervention study is to iteratively refine motivational interviewing and psychosocial intervention programs delivered via telehealth (Teletx) to help improve substance use and other related outcomes…
- Conditions
- Substance Use Disorders, Substance Use, Substance Dependence
- Trial name
- NCT04768920
- Testing
- MI-CBT Teletx
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Advanced Pancreatic Cancer
Gemcitabine and Oxaliplatin (Gem-Ox) Plus Glivec in Gemcitabine-refractory Pancreatic Cancer
The main research objective is to work out the optimal doses of the novel combination of gemcitabine, oxaliplatin and imatinib mesylate (glivec) in patients with advanced pancreatic cancer that has progressed during or after…
- Trial name
- RPGOG1 (NCT01048320)
- Testing
- Gemcitabine, Oxaliplatin, Imatinib
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Inflammatory Bowel Diseases, Crohns Disease
A Study on Administration Choices of Vedolizumab and Outcomes for Adults With Inflammatory Bowel Disease (IBD) (VARIETY - CROATIA AND SLOVENIA)
Inflammatory bowel disease consists of either ulcerative colitis (UC) or Crohn's disease (CD). The main aim of this study is to describe real-world treatment patterns in adults with moderate to severe ulcerative colitis or…
- Conditions
- Inflammatory Bowel Diseases, Crohns Disease, Colitis, Ulcerative
- Trial name
- NCT04885920
- Where
- 8 sites in Croatia, Slovenia
- Volunteers
- 120 people
- Sponsor
- Takeda
Osteoarthritis, Knee, Perfusion
Evaluation of Patients With Knee Osteoarthritis Receiving a Prosthesis
Patients with osteoarthritis of the knee undergo visible joint changes in radiology and Magnetic resonance imaging (MRI) tests, but also clinically and histologically.
- Conditions
- Osteoarthritis, Knee, Perfusion, Bone Marrow, Magnetic Resonance Imaging
- Trial name
- Chondrolike (NCT03644420)
- Testing
- Clinical evaluation, Radiology, Dynamic contrast-enhanced magnetic resonance imaging
- Volunteers
- 22 people
- Sponsor
- Lille Catholic University
Vitamin D Deficiency, Neurocognitive Dysfunction
Vitamin D Supplementation and Neurocognition
This study will evaluate the effect of vitamin D supplementation on the neurocognitive function of older people with lower than normal levels of vitamin D at baseline
- Trial name
- Dcog (NCT03019120)
- Testing
- Vitamin D
- Where
- Israel
- Sponsor
- Rambam Health Care Campus
Bladder Cancer
A Study of Intravesical Qapzola (Apaziquone) as a Surgical Adjuvant in Participants Undergoing Transurethral Resection of Bladder Tumor (TURBT)
This is a randomized, multicenter, two-arm, double-blind, placebo-controlled study of Qapzola in participants with low- to intermediate-risk non-muscle invasive bladder cancer (NMIBC), assessed according to the 2016 American…
- Trial name
- NCT03224182
- Testing
- Qapzola
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Spectrum Pharmaceuticals, Inc
IVF, Infertility
Is Adding E2 to P4 Luteal Support In High Responder Long Gn-RH Agonist ICSI Cycles Detrimental to Outcome? RCT
Study if supporting luteal phase of high responder (high egg production or high Estradiol level) long Gn_Rh agonist protocol ICSI/IVF cycle by combined Estradiol and progesterone impairs or improves outcome in terms of pregnancy…
- Trial name
- NCT01790282
- Testing
- estradiol plus progesterone 100 mg IM injection, Progesterone IM of 100 mg
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Mansoura Integrated Fertility Center
Stroke, Ischemic
The Efficacy of Citalopram Treatment in Acute Stroke
We wish to conduct a prospective, randomized, double blind, placebo controlled multi center study of the combined neuroprotective and antithrombotic effects of SSRI treatment after stroke.
- Trial name
- TALOS (NCT01937182)
- Testing
- Citalopram
- Where
- 3 sites in Denmark
- Volunteers
- 642 people
- Sponsor
- University of Aarhus
Osteoporosis, Postmenopausal, Osteoporosis, Steroid Induced
Adherence to Osteoporosis Treatment and Physicians' Perception Regarding Osteoporosis Medication
This is a study aiming to investigate a possible correlation between the parameters affecting the physicians' therapeutic choice with the patients' overall adherence to osteoporosis treatment.
- Trial name
- IASIS (NCT02472782)
- Testing
- Teriparatide
- Where
- Greece
- Volunteers
- 851 people
- Sponsor
- 251 Hellenic Air Force & VA General Hospital
Non-small Cell Lung Cancer
Firmonertinib Combined With Chemotherapy as Neoadjuvant Therapy for Resectable Stage Ⅱ-ⅢB EGFR Sensitive Mutanted NSCLC
This is a phase II study aimed to assess the efficacy and safety of firmonertinib combined with carboplatin/cisplatin and pemetrexed as neoadjuvant therapy in stage II-IIIB resectable NSCLC patients.
- Trial name
- NCT06890182
- Testing
- Firmonertinib combined with Carboplatin/Cisplatin and Pemetrexed
- Volunteers
- 31 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
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