Clinical trials: Conduct
Depression
Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression
The purpose of the study is to determine whether changing sleep patterns improves response to an antidepressant medication.
- Trial name
- NCT01545843
- Testing
- Sleep scheduling, Fluoxetine
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Michigan
Posttraumatic Stress Disorder, Depression
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Pilot
The goal of this pilot study is to develop and implement a larger scale, multi-site stepped collaborative care trial that targets injured patients with presentations of posttraumatic stress disorder (PTSD) and related…
- Conditions
- Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation
- Trial name
- TSOS6 (NCT02335125)
- Testing
- Motivational Interviewing, Cognitive Behavioral Therapy Elements, Psychotropic Drugs
- Volunteers
- 40 people
- Sponsor
- University of Washington
Child Behavior, Attention Deficit and Disruptive Behavior Disorders
Tantrum Tamers 2.0: The Role of Emotion
This study aims to better understand how to best help parents of young children with problem behavior. Problem behaviors vary between and within children, but can include inattention/hyperactivity, tantrums, and/or noncompliance.
- Conditions
- Child Behavior, Attention Deficit and Disruptive Behavior Disorders, Problem Behavior
- Trial name
- NCT03597789
- Testing
- Helping the Noncompliant Child (HNC)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hoarding Disorder
Comparison of Treatment for Hoarding Disorder
This study proposes to compare two forms of treatment for Hoarding Disorder (HD), a common and impairing neuropsychiatric syndrome that has a profound impact on the lives and functioning of individuals, families, and society.
- Trial name
- NCT02040805
- Testing
- Group Cognitive Behavioral Therapy, Peer Facilitated Support Group
- Where
- 2 sites in United States
- Volunteers
- 323 people
- Sponsor
- University of California, San Francisco
Tobacco Use Disorder
Effect of a Non-Invasive Brain Stimulation Technique on Smoking Cessation Behaviors
In this pilot study, the feasibility of using tDCS (a non-invasive brain stimulation technique) while performing a task requiring cognitive flexibility will be examined in smokers and initial data will be collected regarding the…
- Trial name
- NCT03386253
- Testing
- active tDCS
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Use
A Study to Assess Changes in Cigarette Consumption During a Switch to Very Low Nicotine Cigarettes
This study evaluates the impact of switching from usual brand cigarettes to very low nicotine cigarettes on cigarette consumption, smoking behavior, and biomarkers of exposure.
- Trial name
- NCT03571724
- Testing
- Non-Menthol Very Low Nicotine Cigarettes, Menthol Very Low Nicotine Cigarettes, Subject's UB non-mentholated filtered cigarettes
- Where
- 2 sites in United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- 22nd Century Group, Inc.
Cognitive Function
Mars Flavanol Exercise and Cognitive Function Study
This is a randomized controlled trial to test the impact of a flavonol containing food product and aerobic exercise on cognitive function and brain structure.
- Trial name
- NCT01180127
- Testing
- Flavanol containing food product, Aerobic training, Food product lacking flavanol
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Smoking Cessation, Smoking
A Quit Smoking Study Using Smartphones
The objective of this research is to determine whether smartphone games show promise for helping smokers increase their chances of quitting.
- Conditions
- Smoking Cessation, Smoking, Nicotine Dependence
- Trial name
- NCT02164383
- Testing
- Nicotine patch, Cessation Counseling, Mobile Games
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Wisconsin, Madison
Smoking Cessation, Substance-Related Disorders
Smoking Cessation Treatment for Methadone Maintenance Patients
Patients in substance abuse treatment smoke four times more than non-substance abusers, and suffer high rates of tobacco-related disease and death.
- Trial name
- NCT01027754
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Albert Einstein College of Medicine
Parkinson Disease
Amped-PD: Amplifying Physical Activity Through Music in Parkinson Disease
Regular, habitual exercise is a critical component of the long-term management of Parkinson disease (PD). However, PD-specific motor (e.g. slow and diminished movements, variable step timing) and non-motor (e.g.
- Trial name
- Amped-PD (NCT05421624)
- Testing
- Digital music therapeutic, Active-Control
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Boston University Charles River Campus
Attention Deficit Hyperactivity Disorder (ADHD), Deficient Emotional Self-Regulation (DESR)
Omega-3 Fatty Acid Supplementation to ADHD Pharmacotherapy in ADHD Adults With Deficient Emotional Self-Regulation Traits
The purpose of this study is to a) assess the efficacy of omega-3 fatty acids in the treatment of Deficient Emotional Self-Regulation (DESR) among stimulant treated Attention Deficit Hyperactivity Disorder (ADHD) adults, b)…
- Trial name
- NCT01399827
- Testing
- ADHD Medication, Omega-3 Fatty Acids
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Pediatric Obesity
Pediatric Quality of Life Among Population With Body Mass Index (BMI) Greater Than or Equal to 85%
We are currently experiencing an epidemic of obesity in the Pediatric Population. This epidemic affects many areas including quality of life. We have been conducting a nutrition and exercise program since 2003.
- Trial name
- NCT00714870
- Testing
- Behavioral nutrition and exercise program
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Intermittent Explosive Disorder
A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder
This study will compare the medications fluoxetine (Prozac®) and divalproex (Depakote®) for the treatment of aggressive behavior in individuals with Intermittent Explosive Disorder (IED).
- Trial name
- NCT00078754
- Testing
- Fluoxetine, Divalproex
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Chicago
Obesity, Childhood
Wise Social Psychological Interventions to Improve Outcomes of Behavioral Weight Control in Children With Obesity
A 2-arm, parallel group, randomized controlled trial to evaluate overall differences in body mass index (BMI) trajectories over 6 months between 10-16-year-old children with obesity randomized to receive the wise social…
- Trial name
- NCT04422951
- Testing
- Wise interventions -- values self-affirmation and growth mindset -- plus usual care behavioral treatment, Education plus usual care behavioral treatment
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Stanford University
Major Depressive Disorder
Major Depressive Disorder With Mixed Features - Extension
Lurasidone HCl is a compound that is a candidate for the treatment of major depressive with mixed features.This clinical study is designed to test how well Lurasidone works to treat major depressive disorder with mixed features…
- Trial name
- RESOLVE3 (NCT01423253)
- Testing
- Lurasidone
- Where
- 17 sites in United States
- Volunteers
- 48 people
- Sponsor
- Sumitomo Pharma America, Inc.
Dementia, Alzheimer Disease
Using Technology to Support Care Partners for Persons With Alzheimer's Disease: Tele-STELLA
The purpose of this study is to test a revised psychoeducational intervention to help Care Partners for family members with dementia understand and reduce the distressing behaviors that come with progressive dementia.
- Conditions
- Dementia, Alzheimer Disease, Caregiver Burnout, Family Members
- Trial name
- Tele-STELLA (NCT04627662)
- Testing
- Tele-STELLA
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- Oregon Health and Science University
Spinal Cord Injuries, Metabolic Syndrome
Spinal Cord Injury Exercise and Nutrition Conceptual Engagement
Evaluate and compare the health benefits of an at home exercise program using functional electrical stimulation (FES) for lower extremity exercise with diet versus a diet alone group in adults with spinal cord injury.
- Conditions
- Spinal Cord Injuries, Metabolic Syndrome, Dietary Modification, Paraplegia
- Trial name
- SCIENCE (NCT03495986)
- Testing
- Functional Electrical Stimulation Leg Cycle Ergometry, Diet
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Miami
Parkinson Disease, Depression
The Therapeutic Effect of Transcranial Direct Current Stimulation on Depression in Parkinson's Disease
Parkinson's disease (PD) is one of the most common neurological diseases manifested by movement disturbance. The concomitant psychiatric symptoms, especially depression, are often observed and have also great impact on patients'…
- Trial name
- Parkinson's (NCT02917122)
- Testing
- active tDCS, Sertraline
- Volunteers
- 15 people
- Sponsor
- National Cheng-Kung University Hospital
Vaping
Responses to Message Source and Presentation Using Psychophysiology
The goal of this clinical trial is to use psychophysiological methods to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for…
- Trial name
- NCT06269003
- Testing
- Expert, one-sided, Expert, two-sided, Peer, one-sided
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Tolerance, Adolescent Behavior
Age-Related Effects of THC
Increased accessibility to cannabis and its primary psychoactive constituent THC has raised public health concerns. One major concern surrounds the potential risks associated with acute THC intoxication and who might be most at…
- Conditions
- Tolerance, Adolescent Behavior, THC
- Trial name
- ART (NCT04294966)
- Testing
- Dextrose, Dronabinol
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Chicago
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