Clinical trials: Conduct
Cocaine Dependence, Depressive Symptoms
Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans
To examine the clinical efficacy of sertraline (200 mg/day) alone or sertraline in combination with gabapentin. The purpose of this study is to examine whether the antidepressant sertraline alone or combined with gabapentin…
- Trial name
- NCT00654953
- Testing
- sertraline, gabapentin
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Arkansas
Major Depressive Disorder
Dopaminergic Effects of Adjunctive Aripiprazole on the Brain in Treatment-Resistant Depression
Aripiprazole has been approved by the FDA for augmenting ineffective/partially effective oral antidepressant therapy in patients suffering from major depression. The mechanism by which this augmentation is achieved is not known.
- Trial name
- NCT00953745
- Testing
- Escitalopram, Aripiprazole
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Binge Eating Disorder, Overweight and Obesity
Neural Response to Food Stimuli: fMRI Changes Following Cognitive Behavioral Therapy for Binge Eating Disorder
The purpose of this research is to conduct a randomized controlled trial (RCT) assessing the impact of CBT on neural responses to binge eating stimuli.
- Trial name
- NCT03604172
- Testing
- Cognitive behavioral therapy, Waitlist
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nocturnal Enuresis
Study With Two Different Doses of Desmopressin Orally Lyophilisate Tablet With Nocturnal Enuresis
This is multi-center, randomized, placebo-controlled, parallel-group, double-blind, dose-escalating clinical trial designed to assess the efficacy and safety of desmopressin orally lyophilisate for the treatment of nocturnal…
- Trial name
- PNE (NCT01078753)
- Testing
- Desmopressin
- Where
- 15 sites in Japan
- Volunteers
- 89 people
- Sponsor
- Ferring Pharmaceuticals
Glaucoma
The Support, Educate, Empower (SEE) Program
This study will test whether the Support, Educate, Empower (SEE) personalized Glaucoma Coaching Program improves eye drop medication adherence among glaucoma patients compared to enhanced standard care in a randomized controlled…
- Trial name
- SEE (NCT04735653)
- Testing
- Personalized Glaucoma Coaching, Enhanced Standard care
- Where
- 2 sites in United States
- Volunteers
- 236 people
- Sponsor
- University of Michigan
Pulmonary Disease, Chronic Obstructive, E-cigarettes
Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study
Determination of the acute pulmonary toxicities of e-cigarettes in young adults is of major public health importance, as e-cigarette vapor contains established toxicants that as hypothesized cause acute damage to the airways and…
- Trial name
- VaPE-Tox (NCT02783768)
- Testing
- E-cigarette, Hyperpolarized 3-Helium, Gadolinium
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Columbia University
Pediatric Obesity
Family-based Lifestyle Intervention Program and Carotenoid Supplementation for Children With Obesity
This is a pilot study of children between the ages of 8 to 11 years of age who are obese and participating in an intense family based intervention with a family-focused multi-component lifestyle intervention.
- Trial name
- NCT02060279
- Testing
- Lifestyle intervention and carotenoid supplements
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nemours Children's Clinic
Cocaine-Related Disorders, Heroin Dependence
Employment-based Reinforcement of Naltrexone Ingestion and Abstinence
A randomized study is planned over 5 years to evaluate the effectiveness of the Therapeutic Workplace in promoting naltrexone ingestion and abstinence in unemployed opiate-dependent injection drug users.
- Conditions
- Cocaine-Related Disorders, Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
- Trial name
- NCT00149669
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Johns Hopkins University
Mood Disorder, Bipolar Disorder
A Pilot Study on Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Bipolar Depression
This is a pilot project to study if repetitive Transcranial Magnetic Stimulation (rTMS) will benefit patients with bipolar depression safely.
- Conditions
- Mood Disorder, Bipolar Disorder, Major Depression, Depression
- Trial name
- TMS-BD (NCT00699218)
- Testing
- Magnetic Stimulator Rapid2 made by Magstim Company Ltd. U.K.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Davis
Smoking
Pilot Study: Preoperative Nicotine Lozenges
The goal of this pilot study is to determine the feasibility and potential effect size of nicotine lozenges as an adjunct to maintain brief preoperative abstinence, defined as not smoking the day of surgery.
- Trial name
- NCT00586482
- Testing
- Nicotine Lozenge, Abstinence Advisement
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Mayo Clinic
Purchasing Behaviors, Nutrition
Increasing Engagement With a Healthy Food Benefit
In collaboration with Vitality/Discovery in South Africa, an RCT amongst adult enrolled in the lowest tier of Vitality's HealthyFood benefit will be conducted.
- Trial name
- NCT02486588
- Testing
- Messaging, Financial incentives
- Volunteers
- 7,314 people
- Sponsor
- University of Pennsylvania
Chemotherapy Effect
Effect of Nurse-led Education on Parent's Anxiety and Depression on Managing Side Effects of Chemotherapy
ABSTRACT Background: Today, a wide range of pediatric cancers is treated by chemotherapy. More than 21 side effects of chemotherapy have been identified. Among those nausea; vomiting, infection and anemia are most common.
- Trial name
- NCT03753542
- Testing
- Multimedia education, booklet Providence and tele-nursing follow-up
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nomi Waqas Gul
Depression
Using Peer Mentors to Deliver Depression Care
Can peer mentors be integrated into depression care to older adults with mental health professional supervision? We will assess whether peer mentors who are lay persons who are in recovery from depression can provide depression…
- Trial name
- NCT02261818
- Testing
- Meetings with peer mentors
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse
This is a residential pilot trial to evaluate the pharmacodynamic interaction between zonisamide and cocaine, with the goal of evaluating zonisamide's potential for the treatment of cocaine dependence.
- Trial name
- NCT01137890
- Testing
- Zonisamide, Cocaine Hydrochloride, Neurocognitive and Performance Battery
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Social Anxiety Disorder
Effect of D-cycloserine Plus Cognitive Behavioral Therapy on People With Social Phobia
This study will assess the effectiveness of D-cycloserine combined with cognitive-behavior therapy in treating people with social anxiety disorder.
- Trial name
- NCT00515879
- Testing
- D-cycloserine, Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Boston University Charles River Campus
Major Depressive Disorder
Safety and Effectiveness of NeuroStar® Transcranial Magnetic Stimulation (TMS) Therapy in Depressed Adolescents
To evaluate the safety and efficacy of daily, active Neurostar® TMS (when compared with sham treatment) in adolescents meeting criteria for Major Depressive Disorder (MDD).
- Trial name
- NCT02586688
- Testing
- Active NeuroStar® Transcranial Magnetic Stimulation (TMS)
- Where
- 13 sites in United States
- Volunteers
- 112 people
- Sponsor
- Neuronetics
Smoking Cessation, Alcohol Drinking
Varenicline Augmentation of Patch Outcomes in Heavy Drinkers' Smoking Cessation
The purpose of this study is to learn if the combination of a study drug and patch is more effective in helping heavy drinkers stop smoking than just the patch alone The study drug, varenicline, has been approved by the Food and…
- Trial name
- NCT02859142
- Testing
- Chantix, Behavioral Counseling Sessions, NicodermCQ
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Anxiety Disorders in Youth With Autism, Asperger's Syndrome, and Pervasive Developmental Disorder Not Otherwise Specified
Cognitive Behavioral Therapy (CBT) for Anxiety Disorders in Autism: Adapting Treatment for Adolescents
Comorbid anxiety disorders affect as many as 80% of youth with autism spectrum disorders, causing substantial distress and impairment over and above the autism spectrum diagnosis alone.
- Trial name
- NCT01177969
- Testing
- Cognitive-Behavioral Therapy, Wait-list
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Attention Deficit Hyperactivity Disorder
Treatment of Impulsive Aggression (IA) in Adolescent With ADHD in Conjunction With Standard ADHD Treatment
The purpose of this study was to evaluate the effect of SPN-810 for the treatment of impulsive aggression (IA) in adolescents diagnosed with ADHD when taken in conjunction with standard ADHD treatment.
- Trial name
- NCT03597503
- Testing
- SPN-810
- Where
- 38 sites in United States
- Volunteers
- 41 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Smoking Cessation
A Multi-National Study To Assess How Effective And Safe The Smoking Cessation Medicine Varenicline Is In Smokers Who Have Already Tried Varenicline In The Past As A Prescription Medicine From Their Usual Healthcare Provider
The main purpose of this study is to compare the effectiveness and safety of the re-treatment of smokers with varenicline with placebo for smoking cessation during the last 4 weeks of a 12 week course of treatment.
- Trial name
- NCT01244061
- Testing
- Varenicline
- Where
- 37 sites in United States, Australia and 6 more
- Volunteers
- 498 people
- Sponsor
- Pfizer
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.