Clinical trials: Conduct
Major Depressive Disorder
Vagus Nerve Stimulation: Integration of Behavior and Cardiac Modulation
This study characterized the impact of respiratory-gated transcutaneous vagus nerve stimulation (tVNS) on the modulation of the stress response circuitry, vagal tone and depressed mood in patients with major depressive disorder…
- Trial name
- tVNS-MDD (NCT04467164)
- Testing
- exhalatory-gated transcutaneous vagus nerve stimulation (e-RAVANS), Inhalatory-gated transcutaneous vagus nerve stimulation (i-RAVANS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Sex Trafficking, Sex Crimes
Preventing Commercial Sexual Exploitation of Children
The overall goal of the 5-year project is to conduct both a process and rigorous outcome evaluation of The Set Me Free Projects (SMFP) READY to Stand (RTS) curriculum with an eye toward widespread dissemination to other U.S.
- Conditions
- Sex Trafficking, Sex Crimes, Commercial Sex, Sexual Violence
- Trial name
- Project LIVE (NCT05988398)
- Testing
- READY To Stand Curriculum
- Where
- United States
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Stigma, Social, Opioid Use
SMART Trial: Intrapersonal and Interpersonal Stigma Reduction
The goal of this project is to develop a multicomponent stigma reduction intervention to address intrapersonal (individual) stigma regarding Opioid Use Disorder (OUD).
- Conditions
- Stigma, Social, Opioid Use, Opioid-use Disorder, Substance Use Disorders
- Trial name
- NCT04693416
- Testing
- Intrapersonal Stigma Reduction, Interpersonal Stigma Reduction
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Tennessee
Anxiety Disorders
Anxiety in Older Veterans
Anxiety leads to poor quality of life, avoidance of activities, decreased social engagement, functional decline, and disability in older patients.
- Trial name
- BREATHE (NCT02400723)
- Testing
- Progressive Muscle Relaxation, Diaphragmatic Breathing
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- VA Office of Research and Development
Obsessive Compulsive Disorder, Trichotillomania
Developing Effective Response Inhibition Training for Symptom Relief in OCD and Trichotillomania
Obsessive-compulsive disorder (OCD) and its related disorders (e.g., trichotillomania) are characterized by the marked difficulty in inhibiting unwanted or inappropriate responses.
- Trial name
- NCT02059980
- Testing
- Response inhibition training
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Wisconsin, Milwaukee
Opioid-use Disorder
Stress Response in Opioid Use Disorder
Opioid use disorder is a major public health problem. Although there are effective treatments for this disorder, many people still relapse and thus there is a need for new treatments to improve outcomes.
- Trial name
- NCT03616379
- Testing
- Psychoeducational Control, Affect Regulation, Affect Labelling
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Mclean Hospital
Body Weight, Contraceptive Usage
Oral Contraceptives and Body Mass Index
The main hypothesis for this study is that increased Body Mass Index (BMI) alters oral contraceptive metabolism in a manner which results in decreased effectiveness in obese women.
- Trial name
- NCT01170390
- Testing
- All participants (Aviane), Portia, Aviane
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Healthy Subject
Behavioral Intervention in Reducing Indoor Tanning
This randomized clinical trial tests the efficacy of a behavioral intervention works in reducing indoor tanning. Artificial ultraviolet indoor tanning increases the chance of developing skin cancers.
- Trial name
- NCT03448224
- Testing
- Questionnaire Administration, Internet-Based Intervention
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Jerod L Stapleton, PhD
Cancer, Quality of Life
The PRISM Intervention: a Multi-site Randomized Controlled Trial for Adolescents and Young Adults With Advanced Cancer
Multi-Site Randomized Controlled Trial testing the efficacy of the Promoting Resilience in Stress Management (PRISM) intervention among Adolescents and Young Adults with Advanced Cancer
- Conditions
- Cancer, Quality of Life, Anxiety, Depression
- Trial name
- PRISM-AC (NCT03668223)
- Testing
- Promoting Resilience in Stress Management (PRISM)
- Where
- 5 sites in United States
- Volunteers
- 269 people
- Sponsor
- Dana-Farber Cancer Institute
Smoking Cessation, Smoking Behaviors
Varenicline Light Smoking Pilot
The goal of this study is to assess varenicline vs. placebo for its effect on decreasing cue reactivity in light and intermittent smokers.
- Conditions
- Smoking Cessation, Smoking Behaviors, Smoking
- Trial name
- NCT04089982
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Duke University
Vaping
Responses to E-cigarette Message Source and Presentation
The goal of this clinical trial is to use crowdsourcing to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for young adults who…
- Trial name
- NCT06274723
- Testing
- Expert, one-sided, Expert, two-sided, Peer, one-sided
- Where
- United States
- Volunteers
- 848 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Obesity
Pilot Behavioral Support Intervention After Bariatric Surgery
Prospective, randomized pilot trial to evaluate a comprehensive postoperative behavioral support intervention using a 4-month bi-weekly program in 40 bariatric surgery patients (all surgical procedure types) from the Geisinger…
- Trial name
- NCT03092479
- Testing
- Behavioral Intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Duchenne Muscular Dystrophy
Tadalafil as Adjuvant Therapy for DMD
This project will assess the vascular responsiveness in leg muscles of boys with Duchenne muscular dystrophy (DMD) to one single dose of tadalafil, a common vasodilator drug, using non-invasive techniques (MRI or Doppler…
- Trial name
- NCT05195775
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Florida
Aged, Experiential Learning
Community Beauty and Health Program for Older Adults: An Experiential Learning Trial
This study develops and evaluates a "Senior Beauty and Health Care" course designed to improve students' awareness, attitudes, and skills in caring for older adults' appearance and well-being.
- Conditions
- Aged, Experiential Learning, Health Education
- Trial name
- NCT07053592
- Testing
- Geriatric Ｂeauty and Ｈealth Care Learning Program
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung University of Science and Technology
Schizophrenia
Atomoxetine for Treatment of Weight Gain in Olanzapine or Clozapine Patients
The study investigates the use of Atomoxetine in combination with exercise and a diet support group (Weight Watchers)to treat weight gain associated with Olanzapine or clozapine.
- Trial name
- NCT00176436
- Testing
- Diet support group, Group counseling and exercise
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Cardiovascular Diseases, Hypertension
Cardiovascular Risk Screening and Risk Reduction in Women Vets
Cardiovascular (CV) disease is the number one cause of death in American women, and all adult women are potentially at risk for CV disease.
- Conditions
- Cardiovascular Diseases, Hypertension, Hyperlipidemias, Dyslipidemias
- Trial name
- NCT02991534
- Testing
- CV Toolkit Components
- Where
- 4 sites in United States
- Volunteers
- 6,009 people
- Sponsor
- VA Office of Research and Development
Impaired Glucose Tolerance, Obesity
Enhancing Fitness in Older Pre-diabetic Veterans
This study targets older adults (ages 60 and over) who are overweight (body mass index 25-40) with impaired fasting glucose (100 - 125).
- Conditions
- Impaired Glucose Tolerance, Obesity, Diabetes
- Trial name
- NCT00594399
- Testing
- Physical Activity Counseling
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- US Department of Veterans Affairs
Systemic Lupus Erythematosus, Rheumatoid Arthritis
Breaking Implicit Bias Habits: An Individuation Pilot Study In Rheumatology
The first aim of this study is to test the efficacy of a real-time provider-based individuation intervention to improve the receipt of high-quality rheumatic disease care among Black/African American and lower socioeconomic…
- Conditions
- Systemic Lupus Erythematosus, Rheumatoid Arthritis, Inflammatory Arthritis, Osteoarthritis
- Trial name
- NCT05116163
- Testing
- Individuation Intervention plus implicit bias educational modules, Implicit bias educational modules
- Where
- 2 sites in United States
- Volunteers
- 201 people
- Sponsor
- Brigham and Women's Hospital
Catatonia
Prospective Treatment Study of Catatonia Patients
The purpose of this treatment study is to compare the effectiveness of different electrode placements used in Electroconvulsive Therapy (ECT) in the treatment of catatonia.
- Trial name
- NCT02734498
- Testing
- Electroconvulsive Treatment (ECT) Right Unilateral, Electroconvulsive Treatment (ECT) - Bilateral
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes Mellitus
Physical Activity and Participation
The purpose of the study is to investigate if the investigators can improve physical activity and social participation level among Veterans with diabetes.
- Trial name
- NCT02268916
- Testing
- Counseling, Usual education
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- VA Office of Research and Development
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