Clinical trials: Conduction Block, Atrioventricular
Diastolic Function, Cardiac Output
Impact of Pacing Mode and Diastolic Function on Cardiac Output
Background It is known from previous research that in patients with complete AV (atrioventricular) block and pacemaker stimulation stroke volume and cardiac output are higher with AV-synchronous than with AV-dyssynchronous…
- Conditions
- Diastolic Function, Cardiac Output, Pacemaker Stimulation Mode, Stroke Volume
- Trial name
- PADIAC (NCT04068233)
- Testing
- Pacemaker stimulation mode
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kepler University Hospital
Bradycardia, Atrioventricular Block
BIOTRONIK Conduction System Pacing With the Solia Lead
The purpose of the BIO-CONDUCT study is to demonstrate the safety and effectiveness of the BIOTRONIK Solia S pacing lead when implanted in the left bundle branch (LBB) area.
- Conditions
- Bradycardia, Atrioventricular Block, Left Bundle-Branch Block, Cardiomyopathies
- Trial name
- BIO-CONDUCT (NCT05251363)
- Testing
- Solia S lead
- Where
- 14 sites in United States
- Volunteers
- 194 people
- Sponsor
- Biotronik, Inc.
Aortic Stenosis, Severe
Predictive Value of Pre-TAVI Infrahissian Conduction Time in the Occurrence of Complete Atrioventricular Block
The purpose of the study is implantation of a Pacemaker at 30 days for occurrence of a high-grade conduction disorder per- or post-procedure (yes/no)
- Trial name
- TAVHIS (NCT05714579)
- Testing
- Transcatheter Aortic Valve Implantation
- Where
- France
- Volunteers
- 35 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Heart Failure
Choosing the Right Pacing Mode in Heart Failure - The CHOICE Trial
The aim of the study is to see if biventricular pacemakers offer any advantage over conventional pacemakers in patients with heart failure who require pacemakers.
- Trial name
- CHOICE (NCT00875732)
- Testing
- Bi Ventricular Pacing, Right Ventricular Pacing
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Dundee
Atrioventricular Block, Left Bunde Branch Area Pacing
Left Bundle Branch Area Pacing Versus Right Ventricular Pacing in Atrioventricular Block With Preserved Ejection Fraction
Conventional right ventricular pacing (RVP) has been associated with ventricular dyssynchrony and an increased risk of pacing-induced cardiomyopathy, which may lead to worse clinical outcomes.
- Conditions
- Atrioventricular Block, Left Bunde Branch Area Pacing, Conduction System Pacing
- Trial name
- NOVEL II (NCT07464041)
- Testing
- Left Bundle Branch Area Pacing, Right venticular pacing
- Where
- 4 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Complete Heart Block, Second Degree Atrioventricular Block Möbitz Type II
Left Septal or Deep Septal Pacing to Prevent Pacing-induced Cardiomyopathy
Multicenter randomized controlled trial which will include patients with left ventricular ejection fraction >50% requiring a first implant of a cardiac pacemaker with expected high pacing percentages.
- Trial name
- DEEP (NCT06474819)
- Testing
- Pacemaker implant
- Where
- 6 sites in Spain
- Volunteers
- 326 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Lupus Erythematosus, Systemic, Atrioventricular Block
Systemic Lupus Erythematous and Heart Conduction Disorders
Connective tissue diseases have been related to heart conduction disorders. The anti-Ro/SSA antibodies are thought to have a pathogenic role, and they most prevalent in systemic lupus erythematous (SLE).
- Conditions
- Lupus Erythematosus, Systemic, Atrioventricular Block, Sudden Death
- Trial name
- NCT02162992
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 151 people
- Sponsor
- Germans Trias i Pujol Hospital
Atrioventricular Block, Sick Sinus Syndrome
AV Delay Optimization vs. Intrinsic Conduction in Pacemaker Patients With Long PR Intervals
This is a randomized, prospective clinical trial to determine the effects of two different pacemaker atrioventricular delay (AV delay) settings on heart function in patients with dual chamber pacemakers implanted for symptomatic…
- Conditions
- Atrioventricular Block, Sick Sinus Syndrome, Symptomatic Bradycardia, Cardiac Arrhythmia
- Trial name
- AV Delay (NCT02154750)
- Testing
- Long, fixed AV delay, Short, optimized AV delay
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, San Diego
Atrioventricular Block, Cardiac Surgery
OPTImizing Lead Placement in Patients Requiring Pacemaker After Cardiac Surgery
Conventional right ventricular pacing has been associated with ventricular dyssynchrony and an increased risk of pacing-induced cardiomyopathy, which may lead to worse clinical outcomes.
- Trial name
- OPTI-PACS (NCT07795541)
- Testing
- Left bundle branch area pacing, Conventional pacing strategy
- Volunteers
- 110 people
- Sponsor
- Sahlgrenska University Hospital
Transcatheter Aortic Valve Implantation, Physiological Pacing
Physiological vs Right Ventricular Pacing in Patients With Normal Ventricular Function Post-TAVI
Single-center randomized trial in patients with pacing indication (AV block) after TAVI (transfemoral aortic valve implantation) and LVEF> 50%, that aims to study the percentage of patients who improve at 12 months in a combined…
- Conditions
- Transcatheter Aortic Valve Implantation, Physiological Pacing, Right Ventricular Pacing, AV Block
- Trial name
- PHYS-TAVI (NCT04482816)
- Testing
- Physiological pacing, Right ventricular pacing
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Josep Lluis Mont Girbau
Atrial Fibrillation (AF), Pacemaker Therapy
Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF
This prospective, randomized controlled trial aims to evaluate the effect of left bundle branch pacing (LBBP) compared with conventional right ventricular (RV) pacing on the cumulative duration (total time) of atrial high-rate…
- Conditions
- Atrial Fibrillation (AF), Pacemaker Therapy, Atrioventricular Block, Preserved Ejection Fraction
- Trial name
- LBBP-AHRE (NCT07250529)
- Testing
- Right Ventricular Pacing, Left Bundle Branch Pacing
- Where
- Greece
- Volunteers
- 244 people
- Sponsor
- University Hospital of Patras
Heart Block, Aortic Stenosis
Glucocorticoid Treatment in Transaortic Valve Replacement to Reduce the Incidence of Conduction Disturbances (GLUCO-TAVR).
The goal of this phase IV, randomized, controlled and open-label study is to assess the efficacy of peri-procedure glucocorticoid treatment in the prevention of conduction abnormalities and the need for pacemaker implantation in…
- Conditions
- Heart Block, Aortic Stenosis, Bundle-Branch Block
- Trial name
- GLUCO-TAVR (NCT06076824)
- Testing
- Methylprednisolone
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital General Universitario de Alicante
Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation, Persistent
Pulmonary Artery Pressure and Right Heart Evaluation for Patients Requiring Physiological Pacing Treatment
With the aging of society, the use of cardiac pacing in patients with irreversible bradycardia is increasingly widespread. As early as the 1950s, right ventricular pacing (RVP) began to be used in patients with atrioventricular…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation, Persistent, Sick Sinus Syndrome, Atrioventricular Block
- Trial name
- NCT05575557
- Testing
- Right heart catheterization
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 10th People's Hospital
Atrioventricular Block, Second and Third Degree
Physiologic Cardiac Pacing to Prevent Left Ventricular Dysfunction Post TAVI
The study aims to compare permanent Conduction System Pacing (CSP) with the standard therapy - Right Ventricular Pacing (RVP) or Biventricular Pacing (BVP) - in preventing the development and progression of symptomatic Chronic…
- Trial name
- PACE-4-TAVI (NCT05966675)
- Testing
- conduction system pacing, right ventricular or biventricular pacing
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Medical University of Silesia
Myocardial Infarction, Coronary Artery Disease
Arrhythmias in Post-Myocardial Infarction Patients
Patients are screened for significant arrhythmias and other possibly significant ECG-patterns directly after discharge and two weeks after myocardial infarction using wearable devices.
- Conditions
- Myocardial Infarction, Coronary Artery Disease, Arrythmia, ECG Electrical Alternans
- Trial name
- NCT03231826
- Where
- Finland
- Volunteers
- 445 people
- Sponsor
- Tampere University
Leadless Pacemaker, Bradycardia
BIOTRONIK Investigation of the LivIQ Leadless Pacemaker System
The objective of this Investigational Device Exemption trial is to confirm the safety and performance of the LivIQ leadless pacemaker system, in patients with a Class I or II indication for ventricular pacing (VVI/VDD) according…
- Conditions
- Leadless Pacemaker, Bradycardia, AV Block, Cardiac Rhythm Disorder
- Trial name
- BIO-LivIQ (NCT07118358)
- Testing
- LivIQ Leadless Pacemaker System
- Where
- 43 sites in United States, Australia and 6 more
- Volunteers
- 325 people
- Sponsor
- Biotronik, Inc.
Heart Failure, AV Block
Synchrony in Cardiac Conduction: Assessing the Effects of Pacing on Cardiac Performance Through Magnetic Resonance Imaging and Advanced ECG-imaging
Rationale Right ventricular pacing (RVP) is an established and effective therapy for patients with atrioventricular (AV) block. However, frequent RVP has been associated with left ventricular (LV) dyssynchrony and may progess…
- Trial name
- HARMONY (NCT06843135)
- Testing
- Ventricular pacing
- Volunteers
- 88 people
- Sponsor
- Amsterdam UMC, location VUmc
Atrio-Ventricular Block
Efficacy and Safety of Left Bundle Area Pacing Vs Right Ventricular Apical Pacing in Patients with Atrioventricular Block
This study will address whether LBBaP is superior to RVAP in terms of safety and efficacy
- Trial name
- NCT06674967
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Assiut University
Atrioventricular Block
Protection of Cardiac Function With Left Bundle Branch Pacing in Patients With Atrioventricular Block
OptimPacing study has been designed as a prospective, multi-center, randomized, controlled trial. A total of 11 medical centers across China will enroll 683 patients over an estimated recruitment period of 2 years.
- Trial name
- OptimPacing (NCT04624763)
- Testing
- Left bundle branch pacing, Right ventricular pacing
- Where
- China
- Volunteers
- 683 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Patients Implanted With a Pacemaker
Natural Evolution of AV Conduction Disorders in Patients Implanted With Cardiac Pacemakers
Observational study to assess AV block incidence and their evolution according to paroxysmal atrial arrhythmia.
- Trial name
- NATURE (NCT00531037)
- Where
- 129 sites in United States, Belgium and 9 more
- Volunteers
- 1,440 people
- Sponsor
- LivaNova