Clinical trials: Conduction Defect, Cardiac
Bundle-Branch Block
The CRT-KIR Study (Cardiac Resynchronization Therapy [CRT] in the Early Phase After Heart Surgery)
In patients with broad QRS complexes on electrocardiogram (ECG), the delayed electrical activation of the left heart chamber will cause abnormal contraction.This has been shown to be possible to treat by a special pacemaker…
- Trial name
- NCT00192946
- Testing
- Temporary cardiac resynchronization therapy
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Heart Failure, Tachyarrhythmia
Iperia/Sentus QP Study
The objective of this study is to confirm the safety and efficacy of the new Sentus OTW QP LV lead and Iperia ICD family. The study focuses on the safety and efficacy of the QP device system.
- Trial name
- NCT02181686
- Where
- 24 sites in Austria, Denmark and 9 more
- Volunteers
- 152 people
- Sponsor
- Biotronik SE & Co. KG
Ventricular Tachycardia, Ischemic Cardiomyopathy
Ablation-Index Guided Scar-Mediated Ventricular Tachycardia Ablation in Patients With Ischemic Cardiomyopathy
Over the last decade, radiofrequency catheter ablation (RFCA) has become an established treatment for ventricular arrhythmias (VA).
- Trial name
- AIM-VT (NCT06138873)
- Testing
- Ablation-index guided ventricular tachycardia ablation, Ventricular tachycardia ablation with no AI-guidance
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Rush University Medical Center
Ventricular Tachycardia, Ventricular Fibrillation
Registry of Malignant Arrhythmias and Sudden Cardiac Death - Influence of Diagnostics and Interventions
The "Registry of Malignant Arrhythmias and Sudden Cardiac Death - Influence of Diagnostics and Interventions (RACE-IT)" represents a mono-centric registry of patients being hospitalized suffering from malignant arrythmias…
- Conditions
- Ventricular Tachycardia, Ventricular Fibrillation, Sudden Cardiac Death, Coronary Angiography
- Trial name
- RACE-IT (NCT02982473)
- Where
- Germany
- Volunteers
- 3,200 people
- Sponsor
- Universitätsmedizin Mannheim
Long QT Syndrome, Abnormalities, Drug-Induced
Reducing the Risk of Drug-Induced QT Interval Lengthening in Women
This research will determine if oral progesterone attenuates drug-induced QT interval lengthening in a) Postmenopausal women 50 years of age or older, and b) Premenopausal women studied during the ovulation phase of the menstrual…
- Trial name
- NCT03834883
- Testing
- Progesterone, Ibutilide
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Indiana University
Atrial Tachycardia
PVC Response ''Atrial Pace'' Inducing Atrial Tachycardias
Premature ventricular contractions (PVC) are common phenomenon and occasionally retrograde conduction from ventricle to atrium occurs and may cause pacemaker mediated tachycardia.
- Trial name
- NCT05344456
- Testing
- Change in the device PVC algorithm to ''Off''
- Where
- Finland
- Volunteers
- 16 people
- Sponsor
- Helsinki University Central Hospital
Ventricular Tachycardia, Ischemic Heart Disease
Pulsed Field Ablation for Post-Infarction Ventricular Tachycardia
ASCEND is a randomized controlled open-label pilot study evaluating the safety and effectiveness of pulsed field ablation (PFA) with the novel FARAPOINT catheter compared to the standard radiofrequency (RFA) ablation with…
- Conditions
- Ventricular Tachycardia, Ischemic Heart Disease, Sustained VT
- Trial name
- ASCEND-VT (NCT06891456)
- Testing
- RFA Ablation, PFA Ablation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pasquale Santangeli
Inherited Cardiac Conduction Disorder, Cardiomyopathies
A Psychoeducational Intervention Supporting Patients With an Inherited Cardiac Condition
Inherited heart conditions (IHCs) can cause young sudden deaths due to a genetic trait that leads to a thickened heart muscle or abnormal heart rhythms.
- Trial name
- PISICC (NCT03602040)
- Testing
- PISICC
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- King's College London
Premature Ventricular Complex
Electrocardiographic and Cardiac Magnetic Resonance Predictors of Ventricular Arrhythmias in Cardiomyopathic Patients
This study aims to assess ECG changes for predicting ventricular arrhythmia in cardiomyopathic patients
- Trial name
- NCT05078125
- Testing
- Holter monitoring
- Volunteers
- 79 people
- Sponsor
- Assiut University
Brugada Syndrome (BrS)
GenLab: Unveiling the Genetic Landscape of Brugada Syndrome: Novel Biomarker Discovery for Precise Diagnosis
This research makes several significant contributions to the field of BrS. It employs advanced genetic sequencing techniques to develop a genetic signature to improve the accuracy and efficiency of BrS diagnosis.
- Trial name
- GenLaB (NCT06647927)
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- IRCCS Policlinico S. Donato
Heart Failure, Left Bundle-Branch Block
LV Only MPP With SyncAV
The objective of this clinical investigation is to evaluate the clinical benefits of left ventricle (LV) only pacing combined with automatic adjustment of AV timing (SyncAV) in patients receiving cardiac resynchronization therapy…
- Trial name
- NCT03567096
- Testing
- BiV pacing with MPP and SyncAV, LV only pacing with MPP and SyncAV
- Where
- 6 sites in Canada, France and 2 more
- Volunteers
- 101 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Ventricular Premature Complex
Shensong Yangxin Capsule in the Treatment of Heart Failure Complicated With Ventricular Premature Beat
The purpose of this study is to assess the effects of Chinese medicine Shensong Yangxin capsule for the chronic cardiac dysfunction complicated with ventricular premature beats.
- Trial name
- NCT01612260
- Testing
- Shensong Yangxin capsule
- Where
- 20 sites in China
- Volunteers
- 460 people
- Sponsor
- Cong-xin Huang
Atrioventricular Block, Atrioventricular Dyssynchrony
Impact of Atrio-ventricular Optimization With His Bundle Pacing on Treatment of Atrio-ventricular Dromotropathy
This study aims to determine the clinical and hemodynamic benefit of atrio-ventricular (AV) resynchronization with His bundle pacing in patients with symptomatic first degree AV block.
- Trial name
- NCT04544345
- Testing
- His bundle pacing, AV optimized, Backup VVI pacing
- Where
- Slovenia
- Volunteers
- 17 people
- Sponsor
- University Medical Centre Ljubljana
Conduction Block, Atrioventricular, Bundle-Branch Block
Novel Approach to Conduction System Pacing With Use of Ultrasound
Each year, over one million pacemakers are implanted globally using x-rays. Recent developments have been aimed at determining which area of the heart is the best option for lead placement.
- Trial name
- CONDUCT USe (NCT06815783)
- Testing
- Ultrasound guidance, Fluoroscopy guided
- Where
- 2 sites in Canada
- Volunteers
- 152 people
- Sponsor
- Habib Khan
Paroxysmal Supraventricular Tachycardia
The NODE-202 Study (Study of Etripamil Nasal Spray in Pediatric Patients)
NODE-202 is a Phase 2, multicenter, multinational, single dose, open-label, 2-part, sequential design study in pediatric patients with an established diagnosis of paroxysmal supraventricular tachycardia (PSVT) presenting with a…
- Trial name
- NCT05763953
- Testing
- Etripamil NS
- Where
- 10 sites in United States, Canada and 2 more
- Volunteers
- 60 people
- Sponsor
- Milestone Pharmaceuticals Inc.
Ventricular Tachycardia
Randomized Assessment of TcMS for VT Storm
Three-arm randomized clinical trial comparing two strategies of TcMS to sham stimulation in patients with VT storm. The hypothesis of the study is that TcMS will reduce the burden of VT in the 24 hours after randomization…
- Trial name
- NCT05599022
- Testing
- Magnetic Stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Aortic Valve Stenosis, AV Block
Edwards SAPIEN 3 PPI Registry
There are patient related risk factors for PPI that can be identified and assessed in retrospective pooling of 1000+ TAVI patient datasets.
- Conditions
- Aortic Valve Stenosis, AV Block, Bundle-Branch Block
- Trial name
- Conduct (NCT03497611)
- Testing
- transcatheter valve implantation
- Where
- 4 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Cardiac Arrhythmia
Novel Cardiac Signal Processing System
This study is designed to collect parallel intracardiac signal data during pre-defined periods of clinical interest from the PURE EP system and the existing signal recording and mapping systems.
- Trial name
- NCT04112433
- Testing
- PURE EP 2
- Where
- 3 sites in United States
- Volunteers
- 104 people
- Sponsor
- BioSig Technologies, Inc.
Arrhythmias, Cardiac, Atrial Fibrillation
AIMIGo 12L ECG Synthesis Software Pivotal Study for Arrythmia Detection
The study is a prospective single-arm multicenter clinical trial. Adult patients will be consented and enrolled in an outpatient cardiology office or Arrhythmia Clinics.
- Conditions
- Arrhythmias, Cardiac, Atrial Fibrillation, Atrial Flutter, Bradycardia
- Trial name
- VALID-ECG (NCT06123130)
- Testing
- Vectorcardiography (VECG)
- Where
- 5 sites in United States
- Volunteers
- 198 people
- Sponsor
- HeartBeam, Inc.
Arrhythmias, Cardiac, Tachycardia, Ventricular
Cardiac Arrhythmias at Extreme Altitude
Background: Exposure to high altitudes has been associated with an increased risk of cardiac arrhythmias in healthy subjects and an increased risk of sudden cardiac death.
- Conditions
- Arrhythmias, Cardiac, Tachycardia, Ventricular, Tachycardia, Supraventricular, Bradycardia
- Trial name
- SUMMIT (NCT05676398)
- Testing
- Ambulatory rhythm recording
- Where
- Nepal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern