Clinical trials: Confusion
Delirium
Computer-assisted Cognitive Stimulation Treatment for Delirium
The objectives of our study are to determine whether people with delirium in a subacute care unit improve after one week with non-pharmacological therapies based on improving sleep schedules, mobility, and cognitive stimulation…
- Trial name
- Delitract (NCT07563244)
- Testing
- Specific computer-based cognitive stimulation intervention, Usual care intervention
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Delirium
Methylphenidate, Rivastigmine or Haloperidol in Hypoactive Delirium in Intensive Care Patients
The purpose of this pilot-trial is the feasibility of a large randomized, placebo controlled, doubleblind clinical trial to investigate the use of methylphenidate, rivastigmine or haloperidol in hypoactive ICU-delirium.
- Trial name
- NCT00599287
- Testing
- Haloperidol, Methylphenidate, Rivastigmine
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- UMC Utrecht
COVID-19
Brainstem Dysfunction in COVID-19 Critically Ill Patients: a Prospective Observational Study
The purpose of this study is to determine the prevalence of brainstem dysfunction in critically ill ventilated and deeply sedated patients hospitalized in the Intensive Care Unit (ICU) for a SARS-CoV-s2 infection.
- Trial name
- BRAINSTEM-COV (NCT04527198)
- Testing
- Brainstem Responses Assessment Sedation Score (BRASS), Electroencephalogram with EKG lead
- Where
- 2 sites in France
- Volunteers
- 52 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Delirium, Postoperative Stroke
Postoperative Stroke and Epiaortic Ultrasound in CABG
This study aims to investigate the incidence of postoperative stroke and neurocognitive impairment in patients undergoing coronary artery bypass grafting (CABG), with or without the use of epi-aortic ultrasound (EAU).
- Trial name
- EAU and POCD (NCT07101393)
- Testing
- Intraoperative Epiaortic Ultrasound (EAU)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ataturk University
Stem Cell Transplant Complications, Delirium
Delirium in Children Undergoing Stem Cell Transplantation
Children undergoing stem cell transplants are at risk for delirium, a temporary change in thinking and behavior. This study will define delirium rates, risk factors, and outcomes.
- Trial name
- NCT04937400
- Testing
- Daily screening for delirium
- Where
- 6 sites in United States, Canada
- Volunteers
- 1,040 people
- Sponsor
- Weill Medical College of Cornell University
Oral Melatonin, Nebulized Dexmedetomidine
Oral Melatonin Versus Nebulized Dexmedetomidine on Emergence Agitation in Children Undergoing Adenotonsillectomy
This study aims to compare the efficacy of using oral Melatonin versus nebulized Dexmedetomidine in limitation of emergence agitation in children undergoing adenotonsillectomy.
- Conditions
- Oral Melatonin, Nebulized Dexmedetomidine, Emergence Agitation, Children
- Trial name
- NCT07345715
- Testing
- Normal saline, Oral melatonin syrup, Nebulized dexmedetomidine
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Tanta University
Critical Illness and Mechanical Ventilation
Early Goal-Directed Sedation Compared With Standard Care in Mechanically Ventilated Critically Ill Patients
The Use of sedative drugs in intensive care is widespread. A cohort study conducted in Australia and New Zealand in 2010 revealed a high prevalence of deep sedation within the first 48 hours of mechanical ventilation which was…
- Trial name
- SPICE III RCT (NCT01728558)
- Testing
- Early goal Directed Sedation, Standard care sedation
- Where
- 74 sites in Australia, Ireland and 6 more
- Volunteers
- 4,000 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Delirium
VoiceLove Digital Therapy for Delirium in the ICU
The study is a single-center, single-arm, prospective trial to evaluate the feasibility, safety, and acceptability of VoiceLOVE digital therapy for the management of delirium in surgical ICU patients.
- Trial name
- NCT07218484
- Testing
- VoiceLove therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The Methodist Hospital Research Institute
Brain Injuries, Traumatic, Confusional State
Multisensory Stimulation and Enriched Environments During Post-traumatic Amnesia
The objective of this Phase II trial is to evaluate the feasibility of this study protocol to progress to a large-scale Phase III RCT in the future.
- Conditions
- Brain Injuries, Traumatic, Confusional State, Sensory Motor System Disorder, Alteration of Cognitive Function
- Trial name
- NCT02792985
- Testing
- Multisensory stimulation protocol, Control protocol
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Institut Guttmann
Delirium
Testing the Validity of the "Modified Confusion Assessment Method for the Emergency Department" (mCAM-ED)"
The proposed Study validates the accuracy of the modified Confusion Assessment Method for the Emergency Department
- Trial name
- Val_mCAM-ED (NCT02782143)
- Where
- Switzerland
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Dementia, Cognitive
Cognitive Health Awareness Program in Surgical Patients
Addressing brain health and cognitive impairment (CI) in the aging population is important, especially in those undergoing surgery.
- Trial name
- NCT06540638
- Testing
- Web based education program
- Where
- 2 sites in Canada
- Volunteers
- 164 people
- Sponsor
- University Health Network, Toronto
Perioperative Anxiety, Emergence Delirium
The Effects of Familiar Toy and Parental Presence Combination on Perioperative Pediatric Anxiety
This study will evaluate the effect of presence of favorite toy and parent during perioperative period on pediatric anxiety and emergence delirium.
- Trial name
- NCT06459089
- Testing
- Selection of the parent according to children preference, Bringing the favorite toy of the children that will accompany the child during their perioperative period
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Karaman Training and Research Hospital
Pain, Postoperative
Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
The ongoing opioid epidemic is a public health crisis, and surgical patients are particularly vulnerable to opioid-dependency and related risks. Emerging data suggest that caffeine may reduce pain after surgery.
- Trial name
- NCT03577730
- Testing
- Caffeine Citrate, Dextrose Water
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Michigan
Spine Surgery, Postoperative Delirium and Chills
Scheme of Limb Warming Blanket Combined With Dexmedetomidine
Objective: To observe the clinical effect of lower limb warming blanket combined with dexmedetomidine (DEX) in preventing postoperative delirium (POD) and chills in elderly patients undergoing spinal surgery.
- Trial name
- NCT05857410
- Testing
- Dexmetomidine, Lower limb heating blanket
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Jincheng General Hospital
Cohort Studies
Effect of Dexmedetomidine on Postoperative Mental Disorders and Long-term Survival in Elderly Patients
China's aging population is causing an increase in the number of senior persons undergoing surgery. More and more clinicians are paying attention to the postoperative survival and mental health of elderly surgical patients.
- Trial name
- NCT06362408
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Chinese PLA General Hospital
Delirium, Dementia Alzheimers
Identifying Novel Aging Targets for Treatment of Delirium
The long-term goal of this research program is to improve understanding of the mechanistic link between Alzheimer's disease (AD) neuropathology, acute delirium, and cognitive impairment following acute respiratory failure.
- Conditions
- Delirium, Dementia Alzheimers, Respiratory Failure
- Trial name
- INNOVATE (NCT03682874)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Wake Forest University Health Sciences
Postoperative Delirium, Postoperative Cognitive Dysfunction
Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction
This research study will evaluate the effectiveness and estimate the feasibility of administering an investigational drug called 'CN-105' (the study drug), to prevent postoperative cognitive decline, delirium (serious confusion)…
- Trial name
- MARBLE (NCT03802396)
- Testing
- CN-105
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Miles Berger, MD PhD
Delirium in Old Age
The Incidence and Risk Factors of Postoperative Delirium
Delirium is known to be one of the most common postoperative complications in elderly patients undergoing surgery. Because postoperative delirium can affect the length of hospital stay and prognosis significantly, it is important…
- Trial name
- NCT04656379
- Testing
- spine surgery
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Hospital
Delirium
DeltaScan Validation Study for the Assessment of Delirium in the ICU and on Wards
Rationale: Delirium is associated with prolonged hospitalization, an increased risk of dementia, institutionalization and mortality, as well as increased costs.
- Trial name
- Val3 (NCT03966274)
- Where
- Netherlands
- Volunteers
- 434 people
- Sponsor
- UMC Utrecht
Postoperative Delirium, Postoperative Recovery in Elderly Patients
Recovery After Upper Extrimety Surgery
The goal of this randomized clinical trial is to determine whether Bispectral Index (BIS)-guided general anesthesia improves postoperative cognitive recovery and overall quality of recovery in adults undergoing elective hand or…
- Conditions
- Postoperative Delirium, Postoperative Recovery in Elderly Patients, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- Recovery (NCT07714928)
- Testing
- BIS-Guided General Anesthesia, Clinically Guided General Anesthesia
- Where
- Sweden
- Volunteers
- 112 people
- Sponsor
- Region Örebro County