Clinical trials: Confusional State
Postoperative Cognitive Dysfunction, Delirium
Peri-Anesthetic Imaging of Cognitive Dysfunction
Recent data suggests that anesthetics can have prolonged effects on gene expression, protein synthesis and processing as well as cellular function in ways that the investigators are only beginning to understand, especially in the…
- Conditions
- Postoperative Cognitive Dysfunction, Delirium, Dementia, Neurotoxicity
- Trial name
- PAICOD (NCT01322672)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Post-operative Delirium, Children
Parental Anxiety and Its Relationship With Pediatric Patients' Post-operative Responses
Post-operative delirium had multiple risk factors, such as pre-operative anxiety status, post-operative pain, and anesthetic method.
- Conditions
- Post-operative Delirium, Children, Anxiety
- Trial name
- NCT01993992
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Delirium
Use of Dexmedetomidine in Children Undergoing Oral Maxillofacial Surgery to Decrease Emergence Delirium
The purpose of this study is to determine whether dexmedetomidine is effective in the treatment of emergence delirium of preschool children undergoing oral maxillofacial surgery.
- Trial name
- NCT01353378
- Testing
- dexmedetomidine
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Preoperative Anxiety, Emergence Delirium in Pediatric Anesthesia
Personal Versus Hospital-Provided Dolls in Preschool Children
The goal of this study is to evaluate the effects of personal versus hospital-provided dolls on preoperative anxiety and postoperative delirium in preschool children aged 3-7 years undergoing elective adenoidectomy and/or…
- Trial name
- NCT07403773
- Testing
- Hospital-Provided Doll, Personal Doll, No Doll
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Delirium
Analyses of Cerebrospinalfluid in Patients With Delirium
The current project aims to measure biomarkers in the cerebrospinalfluid (CSF) and serum samples from patients with delirium. We hope to uncover new insights into the pathophysiology of delirium and explore its link to dementia.
- Trial name
- NCT05060614
- Testing
- Hip fracture surgery
- Where
- Norway
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Delirium
Interventions for Postoperative Delirium: Biomarker-3
The IPOD-B3 study aims to characterize the relationship between premorbid brain activity and postoperative delirium in patients undergoing major surgery. This is a expansion of the NeuroVISION Bolt-On study, NCT01980511.
- Trial name
- IPOD-B3 (NCT03124303)
- Testing
- High Density-Electroencephalogram, Magnetic Resonance Imaging, Blood specimen collection
- Where
- United States
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Emergence Agitation
Effect of Induction Method in Post Operative Agitation
To compare the effect of two different induction method; mask ventilation and intravenous cannulation on emergence agitation on pediatric adenotonsillectomy
- Trial name
- NCT03252405
- Testing
- mask ventilation, intravenous cannulation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Ahi Evran University Education and Research Hospital
Postoperative Delirium
Study of Postoperative Delirium in Elderly People After Orthopedic Surgery
The purpose of this study is to investigate the possible relationship of microRNA and postoperative delirium.
- Trial name
- NCT02817386
- Testing
- interview
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Delirium
Risk Factors for Delirium Following Cardiac Surgery
This study will evaluate several potential risk factors for postoperative delirium in cardiac surgery patients. The risk factors will include use of specific preoperative, intraoperative, and/or postoperative medications.
- Trial name
- NCT02548975
- Testing
- Statin, beta blocker, Cardiopulmonary bypass
- Volunteers
- 5,600 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Perceptual Disorders, Confusion
Ketamine Challenge Study With JNJ-40411813
The objective of this study is to investigate whether JNJ-40411813 versus placebo reduces psychosis-like symptoms, induced by infusion of a low dose of ketamine.
- Conditions
- Perceptual Disorders, Confusion, Schizophrenia
- Trial name
- NCT01101659
- Testing
- JNJ-40411813, normal saline, ketamine
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Delirium, Hospital Acquired Condition
Earplugs and Eye Masks for Reducing Delirium
There has been some recent evidence to support the use of earplugs and eye masks to prevent delirium, but the existing studies have been small, have not been thoroughly replicated, and have only been conducted with intensive care…
- Trial name
- NCT03471520
- Testing
- Earplugs and eye masks
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Duke University
Ophthalmology
Study on the Effect of Eye-covering Pretreatment on Acute Delirium After General Anesthesia in Pre-school Aged Children
Participants (preschool children), because their cognitive ability and anti pressure ability are obviously weaker than adults, most of the children who have this kind of operation and anesthesia stressors will have perioperative…
- Trial name
- NCT04973150
- Testing
- To explore whether pretreatment with eye covering can reduce the incidence of acute delirium and the score of delirium after general anesthesia in ophthalmology pre-age children.
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cognitive Dysfunction, Emergence Delirium
Effects of Hypothermia on Delayed Neurocognitive Recovery (DNR): an Observational Trial Among Patients Undergoing Cardiac-Surgery
Post-operative cognitive dysfunction is a common disease in patient undergoing general anaesthesia, especially in older patients.
- Conditions
- Cognitive Dysfunction, Emergence Delirium, Hypothermia
- Trial name
- DNR (NCT03636074)
- Testing
- Hypothermia during Extracorporeal Circulation
- Where
- Italy
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Padova
Hearing Loss, Hearing Loss, Age-Related
Sight and Hearing Investigation Into Effects on Delirium
The goal of this observational study is to learn about sensory loss in hospital patients with delirium. The main questions it aims to answer are: Are hearing and vision loss related to increased risk of having delirium? Do…
- Conditions
- Hearing Loss, Hearing Loss, Age-Related, Hearing Disability, Delirium
- Trial name
- SHIELD (NCT06176625)
- Testing
- Communication Signage, Amplifier Use
- Where
- United States
- Volunteers
- 1,543 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Postoperative Confusion
Haloperidol Prophylaxis in Cardiac Surgery for Patients at Risk for Delirium
Will the use of prophylactic Haloperidol for patients undergoing open heart surgery reduce the incidence, duration, and severity of post cardiotomy delirium?
- Trial name
- HALPCARD (NCT01862302)
- Testing
- Haloperidol
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- McMaster University
Emergence Agitation
The Effect of Oral Gabapentin on Emergence Agitation and Delirium in Adult Patients After Nasal Surgery.
Emergence agitation is a postanesthetic phenomenon that develops in the early phase of recovery from general anesthesia, and is characterized by agitation, disorientation, confusion, and possible violent behavior.
- Trial name
- NCT06887998
- Testing
- Gabapentin 600 mg capsules, Gabapentin 400 mg capsules
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Delirium
Researching the Affect of Sevoflurane in Cardiac Surgery on Delirium
Many risk factors have been identified for delirium after open heart surgery . One of the main risk factors; duration of stay on mechanical ventilator .
- Trial name
- NCT05365165
- Testing
- Sevoflurane
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Derince Training and Research Hospital
Delirium, Dementia
Validating Studies to Assess the Diagnostic Accuracy of a Software Application for Detection and Monitoring of Attentional Deficits in Delirium
The study has two phases: Phase B and Phase C. The purpose of the Phase B study is to determine the performance (sensitivity and specificity) of a smartphone application (DelApp) to identify delirium in the whole inpatient…
- Trial name
- NCT02590796
- Testing
- No intervention given to participants
- Where
- 2 sites in United Kingdom
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Delirium
Nursing Intervention to Reduce Incidence and Duration of Delirium in Patients in Intensive Care
Introduction: Delirium is a cognitive alteration of acute onset and fluctuating course, characterized by the reduced capacity to pay attention to the environment, memory impairment, disorientation, language, and perception…
- Trial name
- NCT05172583
- Testing
- Control, Interventions to reduce delirium based on DSM and scientific evidence
- Where
- Colombia
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Universidad Surcolombiana
Delirium, Intensive Care Unit Delirium
Using SMART HOME Strategy to Reduce the Incidence of Delirium in the Intensive Care Unit
Background: Delirium not only has a high incidence rate among hospitalized patients but also increases mortality rates, causes distress to patients and their families, and adds to healthcare costs.
- Trial name
- NCT06030453
- Testing
- SMART HOME strategy, PADIS nursing intervention
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital