Clinical trials: Confusional State
Mild Cognitive Impairment, Dementia
Multimodal Imaging in the Study of Disorientation in the Hospital
The purpose of this study is to investigate whether markers of brain structure and function from MRI are associated with different levels of spatial orientation and gait parameters in people with mild cognitive impairment or…
- Conditions
- Mild Cognitive Impairment, Dementia, Disorientation, Older Adults
- Trial name
- NCT04387357
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Medical Center Rostock
Delirium in the Intensive Care Unit, Sleep Quality
Precision ICU Care: Evaluating an AI-Driven Nursing Decision Support System for Delirium Prevention
Delirium affects up to 83% of mechanically ventilated patients in the Intensive Care Unit (ICU), often leading to longer hospital stays and long-term memory or cognitive problems.
- Trial name
- NCT07631494
- Testing
- MLP-based Clinical Decision Support System (MLP-CDSS), VR-based Cognitive Intervention, VR-assisted Early Mobility Exercise
- Where
- Taiwan
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Delirium - Postoperative
Effectiveness of Electroencephalography Guided Anesthesia
This study will use brain wave information, known as electroencephalography (EEG), to help guide anesthesia delivery during surgery.
- Trial name
- EEG Anesthesia (NCT07567729)
- Testing
- EEG-guided anesthesia training program for anesthesia providers, EEG-Guided Intervention
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sagital Cervical Disorientation
Efficacy Of Clinical Pilates Exercises İn Desk-Based Workers With Sagital Cervical Disorientation
The aim of this study is to compare the effects of clinical pilates exercises and home exercise program on postural disorders, pain intensity, normal range of motion, muscle strength, endurance, muscle shortness, joint position…
- Trial name
- NCT03352921
- Testing
- clinical pilates exercises, home exercises program
- Where
- Cyprus
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Postoperative Confusion
Magnesium Sulphate, Dexemeditomedine and Emergency Agitation
Emergence agitation is a postanesthetic phenomenon that develops in the early phase of general anesthesia recovery, and is characterized by agitation, confusion, disorientation, and possible violent behavior.
- Trial name
- agitation (NCT04531371)
- Testing
- Dexmedetomidine injection
- Where
- Egypt
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- South Valley University
Postoperative Delirium (POD), Hip Fracture
Is the CRP-Albumin-Lymphocyte (CALLY) Index Effective in Predicting Postoperative Delirium in Geriatric Patients Undergoing Hip Fracture Surgery
Introduction: Postoperative delirium (POD) is a common complication in elderly surgical patients and is significantly associated with prolonged hospital stays, cognitive impairment, functional decline, and increased mortality…
- Conditions
- Postoperative Delirium (POD), Hip Fracture, CRP, Albumin
- Trial name
- NCT06818409
- Testing
- The Diagnostic and Statistical Manual of Mental Disorders (DSM) - 5 criteria for delirium diagnosis
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Preoperative Anxiety, Maladaptive Postoperative Behavior
Effects of Virtual Reality on Perioperative Pediatric Anxiety
This study evaluates the effect of virtual reality on anxiety levels in a pediatric surgical population. Half of participants will receive standard perioperative treatment, while the other half will receive additionally a virtual…
- Conditions
- Preoperative Anxiety, Maladaptive Postoperative Behavior, Emergence Delirium
- Trial name
- VIRTUALPED (NCT04043663)
- Testing
- Virtual Reality glasses, standard perioperative care without virtual reality program
- Where
- Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Germans Trias i Pujol Hospital
Delirium
Clinical Investigation of an Eye-Tracking Device as a Predictor of Delirium in the Recovery Room After Surgery With General Anesthesia
Neurotrack™ is an FDA-approved device for measuring and tracking cognitive decline, as may occur with age-related cognitive decline and Alzheimer's disease.
- Trial name
- NCT05579093
- Testing
- Cognitive test + Pupillary measure
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Columbia University
Post-operation Delirium, Alpha-synucleinopathy Related Non-motor Symptom
Exploring the Relationship Between Alpha-synucleinopathy Related Non-motor Symptom and Post-op. Delirium in Elderly Patients With Spine Surgery
Hypothesis is that the presence of a-synucleinopathy related non motor symptoms could be predictive factor for post-operative delirium.
- Trial name
- NCT02550626
- Where
- South Korea
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Elderly (People Aged 65 or More), Hip Fracture
The Role of Precision Anesthesia Strategy on Perioperative Organ Protection in Hip Surgery [PASPOP]
The goal of this clinical trial is to investigate the effect of three anesthetic strategies on organ protection in elderly patients undergoing hip fracture surgery.
- Conditions
- Elderly (People Aged 65 or More), Hip Fracture, Delirium - Postoperative, Organ Protection
- Trial name
- PASPOP (NCT06696404)
- Testing
- Combined Lumbar Plexus and Sacral Plexus Block, iliac fascial block, spinal anesthesia
- Where
- 2 sites in China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Delirium
Standardization of a Novel Self-administered Tablet Computer-based Clinical Screening Tool for Adverse Postoperative Cognitive Outcomes
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are common complications after surgery and may affect elderly patients in particular.
- Trial name
- CogCheck-Norm (NCT02708823)
- Testing
- CogCheck application
- Where
- Switzerland
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Nicolai Goettel
Emergence Delirium
Emergence Delirium in Children: Total Intravenous Anesthesia With Propofol and Remifentanil Versus Inhalational Sevoflurane Anesthesia
Emergence delirium (ED) refers to a wide variety of behavioural disturbances that are commonly seen in children following emergence from anesthesia.
- Trial name
- NCT00885443
- Testing
- Propofol, sevoflurane
- Where
- Canada
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Delirium
Reducing Delirium in the Surgical Intensive Care Unit
Delirium is an acute disturbance in mental abilities and confusion that affects many patient in the hospital and is caused by multiple factors including and altered sleep/wake cycles and multiple sedating medications.
- Trial name
- NCT02856737
- Testing
- eye masks and earplugs
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Medical Center
Delirium
CURATE.Dtx as a Diagnostic and Management Tool for Delirium
Inpatient delirium incidence is widely documented in international and local studies, however, there is no viable and labour-free delirium detection and management tool.
- Trial name
- NCT06240897
- Testing
- CURATE.Dtx, Optional games
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institute for Digital Medicine (WisDM)
Delirium
Psychosocial Nursing Interventions on Sleep, Anxiety and Delirium in Patients Undergoing Open Heart Surgery
The goal of this study is to determine the effects of psychosocial nursing interventions applied to a patient with cardiac surgery on sleep quality, anxiety and delirium.
- Trial name
- NCT05864482
- Testing
- Psychosocial nursing intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mersin University
Delirium
Interventions for Postoperative Delirium: Biomarker-3
The IPOD-B3 study aims to characterize the relationship between premorbid brain activity and postoperative delirium in patients undergoing major surgery. This is a expansion of the NeuroVISION Bolt-On study, NCT01980511.
- Trial name
- IPOD-B3 (NCT03124303)
- Testing
- High Density-Electroencephalogram, Magnetic Resonance Imaging, Blood specimen collection
- Where
- United States
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Post-operative Cognitive Dysfunction
Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly
BACKGROUND: Post-operative cognitive dysfunction (POCD) is a potentially irreversible loss of brain functions observed in elderly patients after surgical operations under general anaesthesia.
- Trial name
- THE BRIDGE (NCT02428062)
- Testing
- Hemodynamic target, Phenylephrine, Intravenous fluids
- Where
- Italy
- Volunteers
- 1,812 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Delirium, Sedation Complication
The Relationship Between Fasting Time and Delirium
We investigated the relationship between fasting times and delirium in children undergoing MRI under anesthesia. Paediatric Anaesthesia Emergence Delirium (PAED) scale, last oral intake time and type of food (solid-liquid) and…
- Conditions
- Delirium, Sedation Complication, Magnetic Resonance Imaging, Fasting
- Trial name
- NCT05567718
- Testing
- Paediatric Anaesthesia Emergence Delirium scale
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Cohort Studies
The Relationship Between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients
This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the the relationship between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients: a…
- Trial name
- NCT06861764
- Where
- China
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Delirium
Rate of Postoperative Delirium and Postoperative Cognitive Dysfunction After Spinal Anesthesia
The aim of this investigation is to compare the standard of general anesthesia used in these patients with these short-acting local anesthetics (Chloroprocain (Ampres®) and Prilocain (Takipril®)) for spinal anesthesia as well as…
- Trial name
- NCT03715244
- Testing
- Spinal anesthesia with short-acting local anesthetics, General anesthesia (current standard)
- Where
- Germany
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany