Clinical trials: Congestion, Nasal
Mucosal Congestion
Changes in Nasal Patency With Changes in Posture, Temperature, Humidity and Nasal Patency Seen by Acoustic Rhinometry
To study nasal physiologic responses to changes in posture, temperatures, humidity and nasal patency with acoustic rhinometry.
- Trial name
- NCT00147888
- Testing
- Acoustic rhinometry (procedure)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Nasal Congestion
The Safety and Efficacy of a SinuSonic Intervention
This study aims to test the safety and effectiveness of the SinuSonic device on adults with moderate to severe nasal congestion.
- Trial name
- NCT03906968
- Testing
- SinuSonic Device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Common Cold, Nasal Congestion
Two Seawater-based Formulations for Relief of Nasal Congestion in Paediatric Subjects
The objective of this clinical trial is to evaluate the tolerance and efficacy of two Stérimar nasal sprays products in children who have nasal congestion due to the common cold.
- Trial name
- NCT05244148
- Testing
- IP1 - Stérimar BLOCKED NOSE Baby nasal spray, IP2 - Stérimar Stop & Protect Cold Baby + standard of care, Standard of Care
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- Church & Dwight Company, Inc.
Chronic Rhinitis
A Randomized Double Dummy Double Blind Dose Determining Place-bo Controlled Study to Evaluate Efficacy of Investigational Product E-RH-06 at 2 Dose Levels for the Metabolic Management of Chronic or Recurrent, Non-infective Nasal Congestion With-or-without Rhinorrhea.
The study will be conducted in two phases. First phase will be 16 weeks study to assess the safety, efficacy \& to determine the most appropriate dose. Will consist of following visits.
- Trial name
- EB-RH-02-11 (NCT01546662)
- Testing
- E-RH-06
- Where
- 4 sites in India
- Volunteers
- 54 people
- Sponsor
- Enovate Biolife Pvt Ltd
Nasal Congestion
Bioequivalence of Single Dose Phenylephrine Extended Release Tablets and Phenylephrine HCl Immediate Release Tablets Dosed Every Four Hours (P08340)(COMPLETED)
This study will assess the food-effect bioavailability of an extended release formulation of phenylephrine HCl and its bioequivalence to the marketed immediate release phenylephrine HCl product.
- Trial name
- NCT01354418
- Testing
- Phenylephrine HCl Extended Release, Phenylephrine HCl Immediate Release
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bayer
Seasonal Allergic Rhinitis
A Phase III Efficacy Study of the Symptomatic Treatment of Seasonal Allergic Rhinitis With Bilastine
The objective of the study was to determine the efficacy and tolerability of 20 mg of Bilastine, compared to Desloratadine and placebo for the treatment of Seasonal Allergic Rhinitis.
- Trial name
- NCT01108783
- Testing
- Bilastine, Desloratadine
- Volunteers
- 720 people
- Sponsor
- Faes Farma, S.A.
Allergic Rhinitis
Comparative Study of Sinol and Sinol-M in Patients With Congestion Due to Allergic Rhinitis
The purpose of this study is to demonstrate the equivalence of two homeopathic capsaicin containing nasal sprays (Sinol-M™ and Sinol) in patients with nasal congestion due to allergic rhinitis.
- Trial name
- SMAN (NCT00825656)
- Testing
- Sinol or Sinol-M nasal spray
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Strategic Biosciences
Chronic Nasal Congestion, Lung Infection
Biomarker for Cystic Fibrosis
International, multicenter, observational, longitudinal study to identify biomarker/s for Cystic fibrosis and to explore the clinical robustness, specificity, and long-term variability of these biomarker/s
- Conditions
- Chronic Nasal Congestion, Lung Infection, Breathlessness, Clubbing Toes
- Trial name
- BioCyFi (NCT02710383)
- Where
- 5 sites in Albania, Georgia and 3 more
- Volunteers
- 54 people
- Sponsor
- CENTOGENE GmbH Rostock
Nasal Stuffiness, Sneezing
Cyanobacteria Allergy in Lake Kineret
People swimming or surfing in lake Kineret , sometimes complain of nasal stuffiness , sneezing and itching .Typically, it happens during or immediately after contact with the lake's water .
- Conditions
- Nasal Stuffiness, Sneezing, Itching
- Trial name
- NCT01693198
- Testing
- Skin test with sterile extracts of different cyanobacteria
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
Atopic Rhinitis, Atopic Asthma
Vibroacoustic Therapy With Oscillating Positive Expiratory Pressure in the Treatment of Nasal Congestion
This is a prospective study. It enrolls subjects with allergic rhinitis, with or without asthma, who have nasal congestion as the main symptom and meet the inclusion criteria, aiming to evaluate the efficacy and safety of…
- Trial name
- VAT (NCT07114107)
- Testing
- VPAT (Vibratory Positive Pressure Therapeutic Apparatus）, basic medications (antihistamines, mometasone furoate nasal spray, ICS-LABA, OPEP（Oscillating Positive Expiratory Pressure device）
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Nasal Congestion, Cough
Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Diphenhydramine + Pseudoephedrine + Dropropizine in the Control of Cough and the Relief of Nasal Symptoms, Suffering From Non-productive Cough and Acute Rhinitis
Multicenter clinical trial, phase III, controlled by active medicine, double-blind, randomized, enroll 208 subjects, above 12 years old, that suffer acute inflammation upper airway characterized by non-productive cough…
- Trial name
- NCT01199497
- Testing
- Group 1, Group 2
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Seasonal Allergic Rhinitis
New Nasal Applicator / New Formulation - User Study
The purpose of this study is to compare the efficacy of once daily dosing with Rhinocort Aqua (new formulation) against Rhinocort Aqua (current formulation) and placebo in reliving the symptoms of seasonal allergic rhinitis (SAR).
- Trial name
- NCT00641979
- Testing
- budesonide
- Volunteers
- 200 people
- Sponsor
- AstraZeneca
Covid19, Nasopharyngitis
BNO 1030 Extract (Imupret) in the Treatment of Mild Forms of COVID-19
According to WHO (World Health Organisation) data, about 40% of patients with COVID-19 (Corona Virus SARS-CoV-2) have a mild course of the disease, namely, cases of mild course are of great danger from the point of view of the…
- Conditions
- Covid19, Nasopharyngitis, Anosmia, Fever
- Trial name
- NCT04797936
- Testing
- BNO 1030, Standard care
- Where
- Ukraine
- Volunteers
- 133 people
- Sponsor
- Ivano-Frankivsk National Medical University
Sleep Disturbance
Sleep Disturbance in Chronic Rhinitis
The aim of this study is to evaluate the characteristic of sleep disturbance in allergic and non-allergic rhinitis in Dr. Cipto Mangunkusumo Hospital, Jakarta.
- Trial name
- NCT05312723
- Where
- Indonesia
- Volunteers
- 22 people
- Sponsor
- Universitas Indonesia
Chronic Rhinitis
Oxymetazoline Hydrochloride in Combination With Nasal Glucocorticosteroid for Perennial Allergic and Non-allergic Rhinitis in Subjects With Persistent Nasal Congestion
Nasal glucocorticosteroids (GCS) are considered first-line therapy for both allergic and non-allergic rhinitis.1-3 Nasal congestion can persist despite maximum treatment with intranasal GCS.
- Trial name
- NCT00584662
- Testing
- Oxymetazoline Hydrochloride
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of South Florida
Nasal Congestion
Functional Magnetic Resonance Imaging (fMRI) Study of Nasal Strips in Nasal Congestion
The aim of the study is to evaluate the effect of the nasal strip (relative to the placebo strip) on the nasal passages using anatomical MRI scans and to demonstrate the effect of the strip on breathing correlated cortical…
- Trial name
- NCT02275364
- Testing
- Test strip, Nasal spray
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Sleep Disordered Breathing, Congestion, Nasal
To Characterize the Performance of the Nasal Dilator Strip in Lowering Nasal Resistance During Sleep, Promoting Nasal Route Breathing and Reducing the Signs and Symptoms of Sleep Disordered Breathing in a Group of Chronic Nocturnal Nasal Congestion Sufferers Who Report Trouble With Their Sleep.
To characterize the performance of the nasal dilator strip in lowering nasal resistance during sleep, promoting nasal route breathing and reducing the signs and symptoms of sleep disordered breathing in a group of chronic…
- Trial name
- NCT03105297
- Testing
- Prototype nasal dilator strip, No strip
- Where
- Australia
- Volunteers
- 91 people
- Sponsor
- GlaxoSmithKline
Seasonal Allergic Rhinitis
4"S" - Seasonal Symptoms Suppression Study
ASIT naïve patients sensitized to grass pollens will be recruited for the study. All of them will be instructed to treat bothersome in-season symptoms when they appear (on as needed, pro re nata basis) with rescue medication.
- Trial name
- 4"S" (NCT02557269)
- Testing
- Xylometazoline - intranasal application, Azelastine - intranasal application, Mometasone furoate - intranasal application
- Where
- Bulgaria
- Volunteers
- 60 people
- Sponsor
- Association Asthma, Bulgaria
Nasal Congestion
To Determine if Diphenhydramine Works for Nasal Congestion at Two Different Doses
The study was to determine if the drug worked to relieve nasal congestion experienced by people with seasonal allergies.
- Trial name
- NCT00648973
- Testing
- Diphenhydramine 50 mg, Diphenhydramine 25 mg, Pseudoephedrine 120 mg
- Where
- 12 sites in United States
- Volunteers
- 1,021 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Chronic Rhinitis, Chronic Sinus Congestion
Proof-of-Concept Interventional Study With a Nasal Spray of JT-1 in Patients With Chronic Rhinitis or Chronic Sinusitis
Proof-of-concept study with a novel nasal spray in chronic rhinitis or chronic sinusitis. The study will involve 25 patients completing the study for a per protocol analysis.
- Trial name
- NCT05331222
- Testing
- JT-1
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Jantar GmbH