Clinical trials: Congestion, Venous
Hemodynamic, Fluid Responsiveness
Fluid Responsiveness and Venous Congestion Evolution During Volume Expansion
Fluid responsiveness is a critical determinant guiding fluid therapy in critically ill patients. However, excessive fluid administration can result in fluid overload, leading to venous congestion and worse clinical outcomes.
- Conditions
- Hemodynamic, Fluid Responsiveness, Venous Congestion, Fluid Challenge
- Trial name
- FREVO (NCT06772038)
- Where
- 3 sites in China, France
- Volunteers
- 64 people
- Sponsor
- Bicetre Hospital
Pulmonary Hypertension, Cardiorenal Syndrome
Predictive Value of Renal Venous Flow Profiles for Adverse Outcomes in Right Heart Failure
Predictive value of renal venous flow profiles for adverse outcomes in patients with right heart failure
- Conditions
- Pulmonary Hypertension, Cardiorenal Syndrome, Heart Failure
- Trial name
- NCT03039959
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 421 people
- Sponsor
- University of Giessen
Pelvic Pain, Varicose Veins Pelvic
Neuropeptides and Venous Pelvic Pain
Mechanisms of the development of pain in chronic venous diseases (CVD), including pelvic congestion syndrome (PCS), are studied incompletely.
- Conditions
- Pelvic Pain, Varicose Veins Pelvic, Pelvic Congestion Syndrome
- Trial name
- NVPP (NCT03921788)
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Pirogov Russian National Research Medical University
Pelvic Congestive Syndrome, Pelvic Pain
Quantify the Degree of Pain Relief of Pelvic Congestion Syndrome Following Gonadal Vein Embolization
The primary objective is to quantify the degree of pain relief in patients undergoing gonadal vein embolization with coils as well as identify clinical or imaging factors that are predictive of a positive response to treatment…
- Trial name
- NCT03794466
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Blindness
Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours
The purpose of this study is to provide data that would give the investigators a better understanding of the physiologic changes that occur and may contribute to post operative blindness.
- Trial name
- NCT00875043
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Acute Heart Failure (AHF), Congestion, Venous
Simple Urine Composition-based Personalized Algorithm for Effective Congestion Relief in Decompensated Heart Failure
The aim of this study is to evaluate the effectiveness of loop diuretic adaptative algorithm that is based on machine learning, urine output prediction tool, in decongestion of acute heart failure patients.
- Trial name
- SAFER-DHF (NCT07099885)
- Testing
- Standard of Care (SOC), Algorithhm-based decongestion
- Where
- 2 sites in Poland
- Volunteers
- 90 people
- Sponsor
- Wroclaw Medical University
Pachychoroid Disease
Choroidal Venous Congestion Following Scleral Buckling - An Imaging Study
This study aims to understand how blood flow at the back of the eye changes over time after this surgery. By studying these changes, the investigators hope to gain insights that could help improve the understanding of other eye…
- Trial name
- SB (NCT07260097)
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore National Eye Centre
Renal Venous Return
Relationship Between Renal Venous Return and Prognosis of Renal Function in Patients With AKI in ICU
A single-center prospective longitudinal observational study was carried out. Assessments were made on Days 1, 3, 5, and 7 after ICU admission in 90 patients with sepsis AKI, and 19 patients with septic without AKI only made…
- Trial name
- NCT06159010
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Peking Union Medical College Hospital
Patency, Hepatic Venous Congestion
Usability of Ringed Polytetrafluoroethylene Graft for Venous Vascular Reconstruction of Living Donor Liver Transplantation
Middle hepatic vein (MHV) reconstruction with an interposition vessel graft has been settled as a standard procedure for living donor liver transplantation (LDLT) using a right lobe graft.
- Trial name
- MHVLDLT (NCT01205802)
- Testing
- MHV reconstruction
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Asan Medical Center
Cardiorenal Syndrome, Heart Failure
Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart Failure
The purpose of this study is to assess the feasibility, safety and effectiveness of VExUS guided organ decongestion compared to standard of care in patients hospitalized with acute decompensated heart failue (ADHF).
- Conditions
- Cardiorenal Syndrome, Heart Failure, Acute Kidney Injury, Acute Decompensated Heart Failure
- Trial name
- VExOUS-ADHF (NCT06714409)
- Testing
- VExUS guided decongestion
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Oslo University Hospital
Acute Heart Failure (AHF), Fluid Over-load
Training Medical Residents in the Use of the Venous Excess UltraSound (VExUS) Score for Bedside Volume Assessment.
This randomized controlled trial evaluates the effectiveness of two training approaches (in-person versus remote) for teaching medical residents to apply the Venous Excess Ultrasound (VExUS) score for bedside volume assessment in…
- Conditions
- Acute Heart Failure (AHF), Fluid Over-load, Congestion, Congestion, Venous
- Trial name
- NCT07541768
- Testing
- In-person VExUS Training Program, Remote VExUS Training Program, No intervention
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Varicocele, Pelvic Congestion Syndrome
Evaluation of PerformanCe of the Peripheral EOS in the Treatment of Varicocele or Pelvic Congestion SynDromE
To collect confirmatory data in support of the safety and performance of the ArtVentive Medical Group Endoluminal Occlusion System.
- Trial name
- OCCLUDE-I (NCT02033863)
- Where
- 3 sites in Belgium, Poland and 1 more
- Volunteers
- 40 people
- Sponsor
- ArtVentive Medical Group, Inc.
Cardiac Surgery, Diuresis
Natriuresis-guided Depletion After Cardiac Surgery
Fluid overload (FO) is a common complication after cardiac surgery, associated with increased morbidity and mortality. Loop diuretics, especially furosemide, are routinely used to manage FO, but their use is often empirical.
- Conditions
- Cardiac Surgery, Diuresis, Congestion, Venous, Sodium Depletion
- Trial name
- EASY-CS (NCT07077772)
- Testing
- Furosemide intravenous titration based on natriuresis, Furosemide intravenous titration based on clinical examination
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acne, Bites
Implementation of a Minor Ailment Service in Community Pharmacy Practice
Self-care and self-medication are commonly the treatments of choice for the management of minor ailments. Minor ailments can be treated through community pharmacy using a Minor Ailment Service (MAS).
- Conditions
- Acne, Bites, Burns, Cold
- Trial name
- INDICA+PRO (NCT05247333)
- Testing
- Minor ailment service
- Where
- Spain
- Volunteers
- 20,987 people
- Sponsor
- Universidad de Granada
Right Ventricular Dysfunction
Right Ventricular Function Changes After CIED Implantation: The RIGHT-CIED Study
This study aims to understand how the right side of the heart changes in people who receive an implantable cardiac electronic device (CIED), such as a pacemaker, ICD, or CRT device.
- Trial name
- RIGHT-CIED (NCT07272395)
- Testing
- Multimodal Right Ventricular Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University - Cerrahpasa
Venous Congestion
Changes in Portal Vein Pulsatility Variability During a Tidal Volume Challenge Can Predict Fluid Tolerance
In critically ill patients, appropriate fluid administration is one of the cornerstones of hemodynamic management, as both hypovolemia and fluid overload can negatively impact clinical outcomes.
- Trial name
- SERLU (NCT07131228)
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Pelvic Congestive Syndrome, Pelvic Varices
Endovascular Versus Medical Treatment for the Pelvic Congestion Syndrome
Compare the efficacy and safety of endovascular treatment with sandwich technique (controlled release coils and 2% polidocanol foam) associated with diosmin-hisperidine and ibuprofen medical treatment and only the best chronic…
- Conditions
- Pelvic Congestive Syndrome, Pelvic Varices, Venous Disease
- Trial name
- ENDPCS (NCT04358497)
- Testing
- Medtronic® Concerto® detachable coil system, sclerosis, Diosmin / Hesperidin
- Volunteers
- 120 people
- Sponsor
- Hospital de Clínicas Dr. Manuel Quintela
Acute Kidney Injury, Acute Kidney Disease
Effect of CVP and IOH on AKI and AKD
This study was aimed to explore the effect of intraoperative venous congestion and intraoperative hypotension (IOH) on acute adverse kidney events, defined as acute kidney injury (AKI) and acute kidney disease (AKD), after…
- Trial name
- NCT05222074
- Testing
- Venous congestion, Introperation hypotension
- Where
- China
- Volunteers
- 5,127 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Venous Congestion, Microcirculation
Evaluation of the Microcirculatory Response to Fluids in Critically Ill Patients With Venous Congestion: A Prospective Observational Study
The hypothesis is that fluid-responsive patients who show signs of venous congestion experience a worsening of microcirculatory status after fluid administration compared to patients without signs of venous congestion
- Conditions
- Venous Congestion, Microcirculation, Volume Expansion
- Trial name
- MICRO-CONGEST (NCT07499401)
- Testing
- fluid challenge
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università Politecnica delle Marche
Septic Shock, Sepsis
Venous Excess Ultrasound for Personalized Resuscitation in Septic Shock
The goal of this pilot clinical trial is to determine if conducting a larger study using venous excess ultrasound (VEXUS) to guide fluid management in patients with septic shock is feasible.
- Conditions
- Septic Shock, Sepsis, Shock, Critical Care, Intensive Care
- Trial name
- VESPER (NCT06696391)
- Testing
- Venous Excess Ultrasound (VEXUS)-Guided Management
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Western University, Canada