Clinical trials: Congestive Cardiac Failure
Heart Failure
Trial of a Tailored Message Program to Implement CHF Guidelines
Congestive heart failure is a serious health problem in the United States and is associated with excessive morbidity and mortality. Several classes of medications have been shown to improve mortality in patients with CHF.
- Trial name
- NCT00013026
- Testing
- CHF Self-management Education (Web-based Education)
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Cardiomyopathy, Cardiac Failure
Cardiac Assessment of Patients With Hip Implants
PRIMARY OBJECTIVE To establish the effect of metal ion release from metal hip implants on cardiac function STUDY OUTCOME MEASURES To assess the effect of metal ions from hip implants on cardiac function as measured by Cardiac…
- Trial name
- NCT02331264
- Testing
- Exposure to metal debris
- Where
- 2 sites in United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Royal National Orthopaedic Hospital NHS Trust
Type 2 Diabetes Mellitus, Congestive Heart Failure
Effects of Exenatide in Type 2 Diabetic Patients With Congestive Heart Failure
The purpose of this study is to determine if exenatide will improve global cardiac function in patients with type 2 diabetes mellitus and congestive heart failure, by favorable effects on cardiac metabolism leading to improvement…
- Trial name
- NCT00766857
- Testing
- exenatide, Insulin glargine
- Where
- Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Liver Fibrosis, Liver Cirrhosis
Acoustic Radiation Force Impulse Imaging (ARFI) : a New Technique to Assess Liver Elasticity
Liver stiffness measurement (LSM) by non invasive methods is increasingly used to estimate liver fibrosis in patients with chronic liver diseases.
- Conditions
- Liver Fibrosis, Liver Cirrhosis, Viral Hepatitis, Liver Tumour
- Trial name
- NARFI (NCT01082419)
- Testing
- ARFI measurement
- Where
- France
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Heart Failure, Cardiac Failure
Impact of the Aerobic Exercise Versus Exercise of Force on the Hemodynamic, Lipidic, Anthropometric and Psychological Variables of Patients With Cardiac Failure
Introduction and objectives: At the global level, cardiovascular diseases are the leading cause of mortality. Currently, rehabilitation programs are shown as an effective treatment to mitigate the effects of heart failure.
- Trial name
- NCT03913780
- Testing
- Aerobic exercise more force
- Volunteers
- 920 people, healthy volunteers welcome
- Sponsor
- University Tolteca
Anemia, Congestive Heart Failure
A Study of Repeat-Dose Subcutaneous Darbepoetin Alfa in Subjects With Congestive Heart Failure and Anemia, and a Single Dose in Healthy Age- and Sex-Matched Control Subjects
The purpose of this study is to evaluate the single dose pharmacokinetics (PK) of subcutaneous (SC) darbepoetin alfa in subjects with congestive heart failure (CHF) and anemia.
- Trial name
- NCT00117247
- Testing
- darbepoetin alfa
- Volunteers
- healthy volunteers welcome
- Sponsor
- Amgen
Diastolic Heart Failure, Hypertensive Heart Disease
Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2)
The purpose of this study is to examine how dietary changes affect the heart and blood vessels in patients with hypertension (high blod pressure) who have a condition called 'heart failure with preserved ejection fraction"…
- Trial name
- NCT01942395
- Testing
- DASH/sodium-restricted diet (DASH/SRD), Control Diet
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Infection, Hypervolemia
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients
The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the…
- Conditions
- Infection, Hypervolemia, Hypovolemia, Septic Shock
- Trial name
- PIVA (NCT03736421)
- Testing
- Peripheral Intravenous Analysis (PIVA), Non-invasive fluid response measure, Passive leg raise (PLR)
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Congestive Heart Failure (CHF)
Evaluation of Blood Flow Patterns in Lung Blood Vessels Using Ultrasound Technique in Patients With Congestive Heart Failure
Historically, transthoracic Doppler echocardiography has been unable to provide interpretable data of blood flow within the lung parenchyma because of air attenuation of Doppler signals.
- Trial name
- NCT01744210
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Echosense Ltd.
Health Promotion
Caregiver Stress: Interventions to Promote Health and Wellbeing
More and more family members are providing care to their loved ones with prolonged and progressive illnesses. Chronic intense caregiving represents a situation of chronic stress, which takes a toll on one's mental and physical…
- Trial name
- NCT01188070
- Testing
- Usual Care, Psycho-education, Psycho-education plus physical exercise
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Emory University
Heart Failure, Congestive
Hemodynamic Response to Exercise in HFpEF Patients After Upregulation of SERCA2a
Heart failure with preserved ejection fraction or HFpEF, represents nearly 50% of all heart failure cases and is particularly common in the elderly. The disease has no current treatment options.
- Trial name
- NCT02772068
- Testing
- Istaroxime, Exercise
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Benjamin Levine
Mitral Valve Insufficiency, Dilated Cardiomyopathy
Prospective Study Looking at Quality of Life Measures in Non-ischaemic Cardiomyopathy After Mitral Valve Repair
Chronic severe mitral regurgitation can lead to symptoms and left ventricular dysfunction. The purpose of this study is to prospectively follow patients with non-ischaemic cardiomyopathy who are eligible for mitral valve repair…
- Conditions
- Mitral Valve Insufficiency, Dilated Cardiomyopathy, Congestive Heart Failure
- Trial name
- NCT00483236
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Critical Illness, Chronic Obstructive Lung Disease
Advance Care Planning Evaluation in Hospitalized Elderly Patients
The purpose of the study is to inform decision-makers of the best strategies to implement advanced care planning (ACP). An advanced care plan (ACP) is a verbal or written instruction describing what kind of care an individual…
- Conditions
- Critical Illness, Chronic Obstructive Lung Disease, Congestive Heart Failure, Cirrhosis
- Trial name
- ACCEPT (NCT01362855)
- Where
- 9 sites in Canada
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- Daren K. Heyland
Congestive Heart Failure
Evaluation of the Samsung LABGEO IVD-A20 CHF Test in a Point-of-Care Setting
To establish the performance characteristics of the Samsung LABGEO IVD-A20 CHF Test in intended use settings, by comparing test results of the A20 CHF Test with results obtained from an FDA-cleared comparator assay.
- Trial name
- NCT02107495
- Testing
- Samsung LABGEO IVD-A20 CHF Test
- Where
- 3 sites in United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Samsung Electronics
Hypertension, Congestive Heart Failure
Bioavailability Study of BIA 5-453
The purpose of this study was to compare the bioavailability and tolerability of BIA 5-453 under fasted and fed conditions.
- Trial name
- NCT03090568
- Testing
- BIA 5-453
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Pacemaker Complication, Congestive Heart Failure
Optimised Pacing Program
Permanent pacemakers are a common treatment for slow heart beats. In the UK 300,000 people have a pacemaker, and each year another 36,000 receive them. All of these patients are usually seen yearly to have their device checked.
- Trial name
- OPT-pace (NCT01819662)
- Testing
- Enhanced standard management, Optimised heart failure management, Standard management
- Where
- 3 sites in United Kingdom
- Volunteers
- 1,793 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Congestive Heart Failure (CHF)
Prospective Evaluation of the StatusFirst™ CHF NT-proBNP Device in Human Whole Blood and Plasma Samples
The primary objective of the study is to establish the correlation between NT-proBNP measurements in fresh human whole blood samples and those in plasma samples from the same study subjects, where said samples are collected in…
- Trial name
- WB-13 (NCT00734045)
- Where
- 2 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Nanogen, Inc.
Liver Dysfunction, Liver Insufficiency
An Investigational Study of Experimental Medication BMS-986231 Given in Participants With Different Levels of Liver Function
This is an investigational study of experimental Medication BMS-986231 given to participants with weakened or damaged liver function.
- Conditions
- Liver Dysfunction, Liver Insufficiency, Hepatic Failure, Myocardial Failure
- Trial name
- NCT03515980
- Testing
- BMS-986231
- Where
- 4 sites in Hungary, Poland
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Heart Failure
"Hub and Satellite" Heart Failure Provider's Network Study
The aim of this study is to serve as a pilot showing the feasibility of a "Hub and Satellite" Heart Failure (HF) Provider's Network which will aim to provide improved, evidence-based care to Veterans with HF.
- Trial name
- NCT01246050
- Testing
- HF training, No HF training
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Heart Failure，Congestive
Serum Catestatin Expression and Cardiometabolic Parameters in Patients With Congestive Heart Failure
The congestive heart failure (HF) is a condition associated with substantial morbidity, mortality, and high healthcare expenditures.
- Trial name
- CATSTAT-HF (NCT03389386)
- Testing
- Blood withdrawal for laboratory analysis, Standard-of-care treatment, Transthoracic echocardiography (TTE)
- Where
- Croatia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Josko Bozic