Clinical trials: Congestive Cardiac Failure
Heart Failure
Tissue Factor Expression in Stage C Heart Failure
Monocyte tissue factor (TF) was characterized in Class C heart failure (HF) vs. 25 age-matched volunteers. TF was 2.9 fold higher (p < 0.001) in HF patients vs. controls.
- Trial name
- TFHF (NCT00935740)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Utah
Congestive Heart Failure
Testosterone Improves Exercise Oxygen Uptake, Insulin Resistance and Muscle Strength in Elderly Patients With Chronic Heart Failure
Background: Patients with congestive heart failure (CHF) show muscle mass wasting and decreased testosterone levels. Long-term testosterone supplementation improves walking distance and glucose metabolism of patients CHF.
- Trial name
- NCT00512408
- Testing
- testosterone
- Where
- Italy
- Sponsor
- IRCCS San Raffaele
COPD, Asthma
Cardiorespiratory Diagnostic Study
This study uses a new breathing device called 'N-Tidal C' handset which measures breathing patterns. Investigators have found that people with cardiac and respiratory illnesses breathe out a gas, called carbon dioxide (CO2), in a…
- Conditions
- COPD, Asthma, Lung Cancer, Anemia
- Trial name
- CARES (NCT04939558)
- Testing
- N-Tidal C handset
- Where
- United Kingdom
- Volunteers
- 744 people, healthy volunteers welcome
- Sponsor
- TidalSense
Hospital Readmission, Post-discharge Care Transitions
Evaluating Sequential Strategies to Reduce Readmission in a Diverse Population
Hospital readmissions are common, costly, and potentially preventable. They are also potentially responsive to health system interventions.
- Conditions
- Hospital Readmission, Post-discharge Care Transitions, Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01619098
- Testing
- Patient Navigator, Usual care
- Where
- 2 sites in United States
- Volunteers
- 1,510 people
- Sponsor
- Alison Galbraith
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Comparative Effectiveness of Telemedicine in Primary Care
Leveraging a natural experiment approach, the investigators will examine rapidly changing telemedicine and in-person models of care during and after the COVID-19 crisis to determine whether certain patients could safely choose to…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease (COPD), Congestive Heart Failure, Diabetes
- Trial name
- NCT04684836
- Testing
- Exposure to telemedicine, after the onset of the pandemic
- Where
- 4 sites in United States
- Volunteers
- 33,100 people
- Sponsor
- Weill Medical College of Cornell University
Diabetes, Asthma
Integrated Care (IC) Models for Patient-Centered Outcomes
Multiple chronic conditions (MCC) are widely recognized as the U.S. public health challenge of the 21st century. These physical and behavioral health conditions take a large toll on those living with chronic diseases, including…
- Conditions
- Diabetes, Asthma, Chronic Obstructive Pulmonary Disease, Hypertension
- Trial name
- IC (NCT03451630)
- Testing
- High-Touch, High-Tech, Optimal Discharge Planning
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cardiovascular Diseases, Coronary Disease
Natural History of Coronary Heart Disease
To examine the natural history of mortality due to coronary heart disease in post-myocardial infarction patients from the Beta-Blocker Heart Attack Trial (BHAT) and the Aspirin Myocardial Infarction Study (AMIS).
- Conditions
- Cardiovascular Diseases, Coronary Disease, Myocardial Infarction, Heart Diseases
- Trial name
- NCT00005265
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Congestive Heart Failure
The Epidemiology of Ventricular Assist Device-Related Infections
Infections often occur after ventricular assist devices (VADs) are placed. These infections can be very serious. The goal of this study is to understand why these infections occur.
- Trial name
- NCT01471795
- Where
- 13 sites in United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Congestive Heart Failure, Left Ventricular Ejection Fraction
Prospective Study of Heart Failure With Preserved Left Ventricular Ejection Fraction
The purpose of this study is to examine electrical and echocardiographic characteristics and prognosis of consecutive patients admitted with acute heart failure and diagnosed to have heart failure with preserved ejection fraction…
- Conditions
- Congestive Heart Failure, Left Ventricular Ejection Fraction, Heart Failure With Preserved Ejection Fraction
- Trial name
- KaRen (NCT01091467)
- Where
- 2 sites in France, Sweden
- Volunteers
- 362 people
- Sponsor
- French Cardiology Society
Congestive Heart Failure, Decompensated Heart Failure
Comparing PA Compliance During and After Decompensation in HFP
Pulmonary Artery Compliance measurements will be obtained with the Respirix device in patients with congestive heart failure decompensation.
- Trial name
- NCT03914222
- Testing
- CardioSpire (Respirix) Device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Theranova, L.L.C.
Ischemic Congestive Cardiomyopathy, Dilated Cardiomyopathy
Optimizing Left Ventricular Lead To Improve Cardiac Output
The purpose of this study is to determine if optimal lead placement, guided by the largest improvement in aortic flow measured by Doppler will: 1. Improve the way the heart's left ventricle functions 2.
- Conditions
- Ischemic Congestive Cardiomyopathy, Dilated Cardiomyopathy, Congestive Heart Failure
- Trial name
- CARE/VOLCANO (NCT01399801)
- Testing
- Doppler flow measurement, standard implantation of the LV lead
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ann Marie Chikowski
Heart Failure, Congestive
Registry of Patients With CardioMEMS
CardioMEMS is an implantable wireless hemodynamic monitoring system which can transmit the pulmonary artery pressure. This device is FDA approved to be used as a diagnostic tool to help management of selected heart failure…
- Trial name
- NCT02729922
- Testing
- Cardiomems
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Heart Failure With Reduced Ejection Fraction (HFrEF), Congestive Heart Failure(CHF)
BIOmarker Based Diagnostic TOOLkit to Personalize Pharmacological Approaches in Congestive Heart Failure
This retrospective study will take advantage of an existing EU-funded dataset, the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF), which was designed to identify biomarkers related to the response to…
- Trial name
- NCT07470554
- Where
- Italy
- Volunteers
- 4,254 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Heart Failure, Heart Decompensation
A Phase IIb Study to Investigate the Efficacy and Tolerability of Cinaciguat (150 µg/h, 100 µg/h, 50 µg/h) Given Intravenously to Subjects With Acute Decompensated Chronic Congestive Heart Failure (ADHF)
A placebo controlled, double-blind and randomized study to assess different doses of a new drug (BAY58-2667) given intravenously, to evaluate if it is safe and can help to improve the well-being of patients with acute…
- Trial name
- COMPOSE EARLY (NCT01064037)
- Testing
- Cinaciguat (BAY58-2667)
- Where
- 70 sites in United States, Canada and 14 more
- Volunteers
- 62 people
- Sponsor
- Bayer
Congestive Heart Failure
Congestive Heart Failure Pilot Study Utilizing Wireless Home Scale and Daily Symptom Monitoring
As the population ages and medicine advances, there has been a significant shift to the management of chronic diseases. Most chronic diseases are managed using evidence based consensus guidelines but clinician and patient…
- Trial name
- CHF (NCT03234088)
- Testing
- Daily weight measured by digital scale and symptom reporting
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Pennsylvania
Congestive Heart Failure
Influence of Pantoprazole on Human Myocardial Contractility at Patients With Congestive Heart Failure
Recently literature revealed facts, that show H+/K+ ATPase expression is not limited tot he stomach. H+/K+ ATPase was also found in smooth muscle cells and in other tissues (McCabe, R.D. et al., Am J Physiol. 1992).
- Trial name
- NCT00699361
- Testing
- Pantoprazole
- Where
- Germany
- Sponsor
- Johann Wolfgang Goethe University Hospital
Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
Use of Beta-agonists in Stable Severe Congestive Heart Failure
The purpose of this study is to determine whether Salbutamol is effective in the treatment of severe heart failure due to ischemic and non- ischemic cardiomyopathy.
- Conditions
- Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy, Heart Failure
- Trial name
- NCT01447069
- Testing
- Salbutamol
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rabin Medical Center
Congestive Heart Failure, Heart Failure, Diastolic
Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFpEF Patients Treated With Allogeneic CDCs
Perform a randomized, double blind, placebo-controlled Phase 2a feasibility study to determine whether treatment of HFpEF patients with intracoronary allogeneic CDCs affects clinical functional status (QOL scores), exercise…
- Trial name
- RegressHFpEF (NCT02941705)
- Testing
- Allogeneic Derived Cells
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Cedars-Sinai Medical Center
Fall, Congestive Heart Failure
Reducing High-Risk Geriatric Polypharmacy Via EHR Nudges: Pilot Phase
Polypharmacy is common among older adults in the United States and is associated with harms such as adverse drug reactions and higher costs of care.
- Conditions
- Fall, Congestive Heart Failure, Chronic Kidney Failure, Adverse Drug Event
- Trial name
- NCT03791580
- Testing
- Commitment nudge, Justification nudge
- Where
- United States
- Sponsor
- RAND
Heart Failure, Systolic
Patient and Physician Survey Determinants of Appropriate ICD Utilization
To better understand the reasons for underutilization of defibrillator therapy in selected populations, the investigators propose a study to assess heart failure patient knowledge and attitudes toward device therapy.
- Trial name
- NCT01514773
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- Todd M Koelling, MD