Clinical trials: Congestive Heart Failure(CHF)
Heart Failure, Heart Failure, Diastolic
A Preliminary Study for INFORMED
Investigators will determine whether N-of-1 trials, as a pragmatic, participant-centered approach to medication optimization that can overcome key barriers of deprescribing, can lead to increased participant confidence regarding…
- Conditions
- Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure
- Trial name
- PRE-INFORMED (NCT05585125)
- Testing
- Beta blocker
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Weill Medical College of Cornell University
Heart Failure, Dilated Cardiomyopathy
Myocardial Telomere Recapping Study for Dilated Cardiomyopathy
The aim of this study is to determine the safety and feasibility of giving an adeno-associated viral vector expressing a modified telomerase protein (TERT), driven by cardiac troponin T promoter (AAV9-cTnT-modTERT), to 12 dilated…
- Trial name
- MERCURY-DCM (NCT05837143)
- Testing
- JV001
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Shanghai East Hospital
Heart Failure
A First-in-Human Study to Evaluate the Safety and Efficacy of Left Ventricular Assist Device Combined With Exosome Therapy for Patients With Heart Failure（RESTORATION）
A single-center, randomized, double-blind, placebo-controlled, dose-escalation clinical study to evaluate the safety and tolerability of intravenous infusion of different doses of the investigational exosome preparation in heart…
- Trial name
- NCT07883317
- Testing
- Exosome Preparation
- Volunteers
- 24 people
- Sponsor
- Yining Yang
Heart Failure With Preserved Ejection Fraction, Cardiovascular Diseases
Staging Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is considered a systemic condition in which the prevalence of cardiovascular, metabolic, pulmonary and renal conditions determine the extent of cardiac involvement.
- Conditions
- Heart Failure With Preserved Ejection Fraction, Cardiovascular Diseases, Heart Failure
- Trial name
- StageHFpEF (NCT06931015)
- Testing
- No interventions
- Where
- Russia
- Volunteers
- 700 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Cardiac Failure
Efficacy Study of Digoxin & Ivabradine to Treat Heart Failure
It is established that at a serum concentration 0.5-0.9 ng/ml digoxin is effective in patients with heart failure, especially in the presence of atrial fibrillation (AF).
- Trial name
- Dig&Iva (NCT01699776)
- Testing
- Ivabradine, Digoxin
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- Cocco, Giuseppe, M.D.
Heart Failure Patients
Monitoring and Self-management of Sleep Fatigue and Dyspnea
African Americans have the highest risk for developing heart failure. When African Americans are diagnosed with heart failure (AAHF) it is usually more advanced HF compared to other races.
- Trial name
- NCT04434716
- Testing
- Feasibility of wearing a Readiband to monitor Sleep and Fatigue
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Massachusetts, Amherst
Myeloma, Heart Failure
Cardiovascular Complications of Carfilzomib
Cardiovascular toxicity of carfilzomib, a last generation proteasome inhibitor, is highly incident according to retrospective data. Prospective cohort study of patients initiated on carfilzomib.
- Conditions
- Myeloma, Heart Failure, Hypertension
- Trial name
- ICARE (NCT04407858)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- European Georges Pompidou Hospital
Heart Failure
Is Sacubitril-valsartan Superior to Dapagliflozin in Improving Myocardial Function Performance
The aim of this study is to assess whether sacubitril-valsartan is more effective than dapagliflozin in improving function, myocardial performance in patients undergoing CABG operation or not
- Trial name
- NCT06090487
- Testing
- myocardial function after surgery
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Pleural Effusion, Heart Failure
Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)
To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).
- Conditions
- Pleural Effusion, Heart Failure, Malignant Neoplasm, Fluid Overload
- Trial name
- NCT05797649
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- Chinese University of Hong Kong
Cardiomyopathy, Dilated, Heart Failure
The Persistence of Autoantibody Neutralisation by BC 007 in Patients With Chronic HFrEF and Autoantibodies Against the Beta1-Adrenergic Receptor
Chronic heart failure (CHF) is one of the major causes of death in Western societies. Evidence has accumulated that functionally active autoantibodies directed against the beta1 adrenergic receptor (β1 AAb) are of…
- Conditions
- Cardiomyopathy, Dilated, Heart Failure, Autoantibodies
- Trial name
- NCT04192214
- Testing
- BC 007
- Where
- 3 sites in Serbia
- Volunteers
- 30 people
- Sponsor
- Berlin Cures GmbH
Heart Failure With Preserved Ejection Fraction, Type 2 Diabetes
Remote Ischaemic Conditioning (RIC) in Heart Failure
This study will test the impact of remote ischaemic conditioning combined with exercise on myocardial perfusion in patients with or at risk of heart failure
- Conditions
- Heart Failure With Preserved Ejection Fraction, Type 2 Diabetes, Dilated Cardiomyopathy
- Trial name
- ENRICH (NCT06616233)
- Testing
- Remote Ischaemic Conditioning with exercise, Other: Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Leicester
Heart Failure
ALLEVIATE-HF-HD Study
Patients with heart failure and reduced left ventricular ejection fraction (HFrEF, EF 25-39%), or mid-range left ventricular ejection fraction (HFmrEF, EF 40-49%), or preserved left ventricular ejection fraction (HFpEF, EF ≥…
- Trial name
- NCT05501652
- Testing
- ALV1System
- Where
- Georgia
- Volunteers
- 5 people
- Sponsor
- Alleviant Medical, Inc.
Heart Failure
Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy Post Approval Registry
MADIT-CRT PAR is an FDA mandated follow-up registry for patients that participated in the MADIT-CRT IDE study examining long-term mortality. (MADIT-CRT IDE: NCT00180271)
- Trial name
- MADIT-CRT PAR (NCT01294449)
- Testing
- MADIT-CRT ICD, MADIT-CRT CRT-D
- Where
- United States
- Volunteers
- 394 people
- Sponsor
- Boston Scientific Corporation
Heart Failure, Systolic
The Effect of Yoga on Cardiac Sympathetic Innervation Evaluated by I-123 mIBG
The purpose of this study is to evaluate if yoga practice will reduce cardiac sympathetic activity and subsequently cardiac arrhythmias.
- Trial name
- NCT03227393
- Testing
- Yoga training
- Where
- United States
- Sponsor
- University of Cincinnati
Infection, Hypervolemia
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients
The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the…
- Conditions
- Infection, Hypervolemia, Hypovolemia, Septic Shock
- Trial name
- PIVA (NCT03736421)
- Testing
- Peripheral Intravenous Analysis (PIVA), Non-invasive fluid response measure, Passive leg raise (PLR)
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
End-stage Heart Failure
Cardiac Mitochondrial Function in Explanted Human Hearts
Background: Treatment of heart failure has improved considerably in the past decades. Despite this improvement, the disease may progress into an end-stage ultimately leaving the physicians with no other treatment option than…
- Trial name
- NCT04500938
- Volunteers
- 24 people
- Sponsor
- University of Aarhus
Heart Failure, Acute Kidney Injury
Treatment According to Venous Excess Ultrasound Score in Patients With Heart Failure
Heart failure is a syndrome that progresses with symptoms and signs caused by cardiac dysfunction and results in a shortened life expectancy (1).
- Trial name
- NCT06341816
- Testing
- VEXUS score, NGAL
- Volunteers
- 100 people
- Sponsor
- Inonu University
Heart Failure, Atrial Fibrillation (AF)
Bachmann Bundle Pacing for Prevention of New-Onset Atrial Fibrillation in Patients With Heart Failure
This is a multi-center, prospective, single-blind, randomized controlled clinical trial to evaluate the efficacy and safety of Bachmann bundle pacing (BBP) in preventing new-onset atrial fibrillation (AF) in patients with chronic…
- Conditions
- Heart Failure, Atrial Fibrillation (AF), Cardiac Insufficiency
- Trial name
- NCT07547449
- Testing
- Bachmann Bundle Pacing, Right Atrial Appendage Pacing
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Left Ventricular Hypertrophy, Diastolic Dysfunction
The Effect of Heart Rate on Cardiac Index in Patients With Left Ventricular Hypertrophy
The purpose of this study is to compare the effect of heart rate on cardiac index in patients with or without left ventricular hypertrophy. The study will be conducted in postoperative heart surgery patients with a pacemaker.
- Conditions
- Left Ventricular Hypertrophy, Diastolic Dysfunction, Heart Failure, Heart Rate
- Trial name
- NCT01241838
- Testing
- Pacemaker
- Where
- Denmark
- Volunteers
- 11 people
- Sponsor
- University of Aarhus
Heart Failure
Get With The Guidelines-Heart Failure Registry
Get With The Guidelines-Heart Failure is designed to improve the quality of care in patients hospitalized with heart failure. The program aims to help ensure that eligible patients are initiated on guideline recommended therapies…
- Trial name
- NCT02693509
- Testing
- GWTG Heart Failure program
- Where
- United States
- Volunteers
- 128,026 people, healthy volunteers welcome
- Sponsor
- American Heart Association
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