Clinical trials: Congestive Heart Failure, completed
Heart Failure
Combining Myocardial Strain and Cardiac CT to Optimize Left Ventricular Lead Placement in CRT Treatment
For patients with advanced heart failure, Cardiac Resynchronization Therapy (CRT) has been a major improvement. The treatment improves symptoms and prolongs life in selected patients with heart failure.
- Trial name
- CRT clinic (NCT01426321)
- Testing
- Imaging guided LV lead positioning
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
Heart Failure, Chronic Kidney Diseases
Creating A Cardiorenal Multidisciplinary Team for Management HF and CKD Patients
Several drugs have been labeled as guideline-directed-medical therapies (GDMT) to improve overall health outcomes and slow the progression of disease in patients with heart failure (HF).
- Trial name
- NCT05531214
- Testing
- Multidisciplinary Care Coordination Team
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- George Washington University
Chronic Disease, Diabetes Mellitus
Social Risk Score, Clinical Decision Support Tool and Closed Loop Referral for Social Risk Screen and Referral
The overarching goal of this project is to leverage health information technology (HIT) to integrate available digital information on social needs to improve care for racial and ethnic minorities and socially disadvantaged…
- Conditions
- Chronic Disease, Diabetes Mellitus, Hypertension, Congestive Heart Failure
- Trial name
- NCT05574699
- Testing
- Social Risk Score and CDS Tool, Standard of Care
- Where
- 5 sites in United States
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dyspnea, Acute Heart Failure
Impact of Validated Diagnostic Prediction Model of Acute Heart Failure in the Emergency Department
The purpose of this study is to evaluate a validated diagnostic prediction model in the appropriate diagnosis of Acute Heart Failure (AHF) in patients presenting at the emergency department with undifferentiated dyspnea.
- Conditions
- Dyspnea, Acute Heart Failure, Shortness of Breath
- Trial name
- NCT01193998
- Testing
- Treatment as per model probability, Treatment as per usual care
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 186 people
- Sponsor
- Unity Health Toronto
Chronic Total Occlusion Vessel
Benefits of CTO-PCI in Selected Cases With HFrEF (CTOHFrEF)
The investigators studied the effect of CTO-PCI on left ventricular function and clinical parameters in patients with HFrEF.
- Trial name
- CTOHFrEF (NCT02570087)
- Testing
- chronic total coronary occlusion percutaneous intervention
- Volunteers
- 39 people
- Sponsor
- Hospital Clinic of Barcelona
Asymptomatic Left Ventricular Systolic Dysfunction (Disorder), Heart Failure
ECG AI-Guided Screening for Low Ejection Fraction
This is a randomized controlled trial (RCT) to test a novel artificial intelligence (AI)-enabled electrocardiogram (ECG)-based screening tool for improving the diagnosis and management of left ventricular systolic dysfunction.
- Trial name
- EAGLE (NCT04000087)
- Testing
- AI-enabled ECG-based Screening Tool
- Where
- United States
- Volunteers
- 358 people
- Sponsor
- Mayo Clinic
Heart Failure
Brain Natriuretic Peptide (BNP) Usefulness In Elderly Dyspneic Patients (BED)
The purpose of this study is to test the usefulness of measuring plasma brain natriuretic peptide (BNP) for diagnosis and prognosis in very elderly dyspneic patients.
- Trial name
- BED (NCT00658216)
- Where
- France
- Volunteers
- 390 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Heart Failure, Nutrition
Nutritional Interventions in Chronic Heart Failure
This study recruited patients diagnosed with heart failure by cardiologists and cardiac outpatients whose cardiac functions were graded from 1 to 4 according to the New York Heart Association as the study participants.
- Trial name
- NCT03845309
- Testing
- Self-Care Behavior
- Where
- Taiwan
- Volunteers
- 95 people
- Sponsor
- National Taiwan University Hospital
Heart Failure
Brain Alterations and Cognitive Impairment in Older Adults With Heart Failure
Cognitive impairment, commonly reported as difficulty with memory and executive function, is a widely recognized clinical challenge for older persons with heart failure (HF).
- Trial name
- NCT01821638
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Wisconsin, Madison
Heart Failure, Arrhythmias, Cardiac
Monitoring of Fluid Status in Heart Failure Patients by Intrathoracic Impedance Measurement in Japan (J-HomeCARE II)
The new BIOTRONIK implantable cardioverter defibrillator (ICD) family Lumax 540 is capable of measuring the intrathoracic impedance on a daily basis and transmission of impedance trend data via the Home Monitoring technology.
- Trial name
- NCT01221649
- Testing
- ICD/CRT-D
- Where
- 4 sites in Japan
- Volunteers
- 198 people
- Sponsor
- Biotronik Japan, Inc.
Heart Failure
Trial of a Tailored Message Program to Implement CHF Guidelines
Congestive heart failure is a serious health problem in the United States and is associated with excessive morbidity and mortality. Several classes of medications have been shown to improve mortality in patients with CHF.
- Trial name
- NCT00013026
- Testing
- CHF Self-management Education (Web-based Education)
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Heart Failure, Systolic
Safety and Tolerability of Sacubitril/Valsartan in Heart Failure Patient With Reduced Ejection Fraction
This proof-of-concept, open-label non-randomized clinical trial was conducted at a tertiary care cardiac center in Karachi, Pakistan.
- Trial name
- NCT05387967
- Testing
- Sacubitril/valsartan
- Where
- Pakistan
- Volunteers
- 121 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Breast Cancer, Heart Failure
Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy
Women treated for breast cancer are at increased risk for cardiovascular disease, including heart failure. In this study, by using magnetic resonance imaging (MRI), the investigators want to assess if heart failure medications…
- Trial name
- PRADA (NCT01434134)
- Testing
- Metoprolol, Candesartan
- Where
- Norway
- Volunteers
- 130 people
- Sponsor
- University Hospital, Akershus
Heart Failure
Oral Nitrite for Older Heart Failure With Preserved Ejection Fraction
This is a randomized double blinded controlled trial of 20-40 mg sodium nitrite tid in subjects with HFpEF. Primary outcomes are measures of physical function with non-invasive and invasive cardiopulmonary exercise testing, and…
- Trial name
- ONOH (NCT02918552)
- Testing
- sodium nitrite, Control
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Gladwin, Mark, MD
Congestive Heart Failure
Candesartan Cilexetil in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM Added)
A study to evaluate the effect of Atacand on patients with heart failure with depressed left ventricular function
- Trial name
- NCT00634309
- Testing
- Candesartan
- Volunteers
- 597 people
- Sponsor
- AstraZeneca
Heart Failure
Levosimendan Efficacy Assessment by Cardiopulmonary Exercise Test (CPET)
The present study was conceived to evaluate the effects of levosimendan on cardiopulmonary exercise test (CPET) and DLCO ( Diffusion capacity of Lung for carbon monoxide) in patients with severe heart failure in stable clinical…
- Trial name
- NCT02261948
- Testing
- Levosimendan
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Centro Cardiologico Monzino
Heart Failure
Attain Stability™ Quad Clinical Study
The purpose of this clinical study is to evaluate the safety and efficacy of the Attain Stability Quadripolar MRI SureScan Left Ventricular (LV) lead (Model 4798).
- Trial name
- NCT03099655
- Testing
- Attain Stability Quad Left Ventricular Pacing Lead
- Where
- 50 sites in United States, Canada and 8 more
- Volunteers
- 471 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure
Rapid Emergency Department Heart Failure Outpatient Trial (REDHOT II)
The purpose of this study is to test whether physicians can make more informed treatment, admission, and discharge decisions related to patient care by having serial Triage® BNP test results available to assess disease severity…
- Trial name
- NCT00206843
- Testing
- Triage BNP Test
- Where
- 10 sites in United States
- Volunteers
- 630 people
- Sponsor
- Abbott RDx Cardiometabolic
Heart Failure
A Safety, Tolerability, Pharmacokinetic Study of SHR-6934 Injection in Healthy Subjects
This study was a randomized, double-blind, single-dose and multi-dose, placebo-controlled phase Ⅰ clinical trial. Six dose groups were planned for the SAD part of the study and four dose groups were planned for the MAD part.
- Trial name
- NCT06700083
- Testing
- SHR-6934 injection
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Heart Failure
Access BNP Clinical Performance Evaluation: Testing and Clinical Concordance Study
The goal is to establish clinical performance of a BNP assay on the intended use population and establish clinical concordance on a separate device.
- Trial name
- NCT07217431
- Testing
- BNP
- Where
- 3 sites in United States
- Volunteers
- 1,361 people
- Sponsor
- Beckman Coulter, Inc.
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