Clinical trials: Congestive Heart Failure, completed
Left Ventricular Function Systolic Dysfunction
Pacemaker Upgrade to Cardiac Resynchronisation Therapy in Patients With Left Ventricular Dysfunction Dependant Upon Right Ventricular Pacing
Patients with pacemakers often have undiagnosed heart muscle weakness. When a pacemaker battery has run down, it is easily replaced by a short procedure.
- Trial name
- PRE-Empt (NCT01652248)
- Testing
- Cardiac resynchronisation therapy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Leeds
Acute on Chronic Heart Failure
Model for Heart Failure ExAcerbation Reduction Trial
Heart failure is the leading cause of hospitalizations and readmissions in the United States and is a tremendous economic strain on our healthcare system.
- Trial name
- HEART (NCT01726985)
- Testing
- Parameter Based Clinical Disposition
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Cleveland Clinic Florida
Ischemic Cardiomyopathy
Radial Strain ECHO-Guided Implantation of Cardiac Resynchronization Therapy
The purpose of this study is to evaluate the use of radial strain imaging using speckle tracking analysis to predict the response to CRT in patients with ischemic cardiomyopathy (ICMP) with NYHA functional class 2-4 heart failure…
- Trial name
- RAISE-CRT (NCT01603706)
- Testing
- Echo guided implantation group
- Where
- 9 sites in United States, Israel
- Volunteers
- 172 people
- Sponsor
- Sheba Medical Center
Acute Heart Failure
VExUS in Patients With Acute Heart Failure
The importance of assessing venous congestion in heart failure patients is widely acknowledged, but its study is hampered by the lack of a practical evaluation tool.
- Trial name
- NCT06397404
- Testing
- Venous excess ultrasound score (VExUS) protocol
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Heart Failure, Central Sleep Apnea
Central Sleep Apnea Prevalence and Impact on Cognitive Function in Patients With Heart Failure With Reduced or Mildly Reduced Left Ventricular Ejection Fraction
Study to assess the prevalence of central sleep apnea in patients with heart failure with reduced or mildly reduced left ventricular ejection fraction (LVEF <50%) followed by case-control study to assess the link between central…
- Trial name
- COG01 (NCT06313840)
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Zoll Medical Corporation
Congestive Heart Failure, Heart Failure, Diastolic
Kyoto Congestive Heart Failure Study
The purpose of this study is to investigate the patient characteristics, selection of treatment, and factors associated with clinical outcomes in Japanese patients with acutely decompensated congestive heart failure.
- Conditions
- Congestive Heart Failure, Heart Failure, Diastolic, Heart Failure, Systolic, Elderly Frail
- Trial name
- KCHF (NCT02334891)
- Testing
- Standard
- Where
- Japan
- Volunteers
- 4,056 people
- Sponsor
- Kyoto University, Graduate School of Medicine
Heart Failure
Telemedicine for Patients Suffering From Heart Failure (Danish Telecare North Trial)
There are two main aims in this study. The first objective is to evaluate whether a particular telehealth solution, in addition to standard treatment and care, lead to a significant decrease in the mortality and an increase in…
- Trial name
- TCN (NCT02860013)
- Testing
- Telemedicine
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Aalborg University
Heart Failure
Sacubitril/Valsartan Versus Valsartan in Heart Failure
The objective of this study was to identify potential prognostic factors of sacubitril/valsartan vs Valsartan treatment response.
- Trial name
- NCT05881720
- Testing
- Sacubitril / Valsartan Oral Tablet, Valsartan 80 mg
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Damanhour University
Breast Cancer, Myocardial Fibrosis
Losartan in Prevention of Radiation-Induced Heart Failure
This study is being done to see if losartan affects the chances of developing radiation-induced heart failure in patients who are receiving radiation therapy as part of standard of care treatment for breast cancer.
- Conditions
- Breast Cancer, Myocardial Fibrosis, Radiation-Induced Fibrosis
- Trial name
- NCT05607017
- Testing
- Losartan, Radiation Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Atrial Fibrillation, Stroke
Atrial Fibrillation Detected by Continuous ECG Monitoring
The LOOP study aims to determine whether screening for atrial fibrillation (AF) with implantable loop recorder and initiation of oral anticoagulation (OAC) if AF is detected will reduce the risk of stroke and systemic arterial…
- Conditions
- Atrial Fibrillation, Stroke, Hypertension, Diabetes
- Trial name
- LOOP (NCT02036450)
- Testing
- Implantable loop recorder (Medtronic Reveal LINQ(TM))
- Where
- Denmark
- Volunteers
- 6,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiac Failure
Anti-Angiotensin-Receptor 1 (ATR1)-, Anti-Endothelin-Receptor A (ETRA)-Antibodies and T Cells in Cardiomyopathy
The study aims 1) to determine autoantibody titers against the AGTR1 receptor and against the ETA receptor, 2) to characterize cytokine expression profiles of heart-specific activated T cells in patients with systolic heart…
- Trial name
- T-CARD (NCT02319590)
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zurich Regional Health Center
Chronic Heart Failure
Effect of an Eccentric Exercise Program on Quality of Life and Function in People With Chronic Heart Failure.
Many studies have shown that exercise training is beneficial for patients with chronic heart failure (CHF). Heart Foundation guidelines strongly recommend regular physical activity and referral to a specifically designed…
- Trial name
- NCT02223624
- Testing
- walking and light weights, eccentric aerobic exercise, concentric aerobic exercise
- Where
- Australia
- Volunteers
- 47 people
- Sponsor
- La Trobe University
Healthy Volunteers
A Single Oral Dose Study to Evaluate Four Different Formulations of AZD9977 and the Effect of Food in Healthy Male Subjects
This study will evaluate pharmacokinetics (PK) of four different formulations with different release profiles of AZD9977 (PART A) in the fasted state, and one of the formulation will be selected for further development (Part B).
- Trial name
- NCT03450759
- Testing
- AZD9977 Oral suspension (reference), AZD9977 capsule, AZD9977 ER capsule (fastvrate)
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pulmonary Hypertension (World Health Organization Group 2), Heart Failure
A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2
This study is intended to assess the ability of AZD3427 to reduce pulmonary vascular resistance (PVR) after 24 weeks of treatment in participants with heart failure (HF) and pulmonary hypertension (PH) Group 2
- Trial name
- Re-PHIRE (NCT05737940)
- Testing
- AZD3427
- Where
- 60 sites in United States, Austria and 12 more
- Volunteers
- 260 people
- Sponsor
- AstraZeneca
Heart Failure
QP ExCELs: MultiPole Pacing (MPP) Sub-Study
The objective of this MultiPole Pacing (MPP) sub-study of the QP ExCELs study is to demonstrate that the MPP feature is effective by converting a percentage of cardiac resynchronization therapy (CRT) non-responders to responders.
- Trial name
- NCT03155724
- Testing
- MultiPole Pacing
- Where
- 44 sites in United States
- Volunteers
- 53 people
- Sponsor
- Biotronik, Inc.
Heart Failure
A Study of Triple-site Ventricular Pacing in Patients Who Have Not Responded to Conventional Dual Ventricular Site Cardiac Resynchronization Therapy
Patients are randomised to receive ongoing optimised device and medical therapy or triple ventricular site resynchronisation. The hypothesis states that patients receiving triple-site resynchronization will exhibit a better…
- Trial name
- TRIVENT (NCT00941850)
- Testing
- Upgrade to triple ventricular site CRT
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University Hospitals, Leicester
Cardiovascular Diseases, Coronary Disease
Dobutamine Echocardiography In Patients With Ischemic Heart Failure Evaluated for Revascularization
To define the role of the assessment of myocardial viability with dobutamine echocardiography (DE) in the clinical evaluation and selection of the best treatment for a high-risk subset of patients with coronary artery disease.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Failure, Heart Failure, Congestive
- Trial name
- DECIPHER (NCT00074724)
- Testing
- Coronary Artery Bypass, Modern medical management, Dobutamine echocardiography
- Volunteers
- 319 people
- Sponsor
- Medstar Health Research Institute
Heart Failure With Preserved Ejection Fraction
Effects of Sauna on Cardiac and Skeletal Muscle Function in Patients With HFpEF (SAUNA-HFpEF)
Heart failure with preserved ejection fraction (HFpEF) is a type of heart failure where the heart pumps normally but patients still experience symptoms like fatigue, shortness of breath, and reduced ability to exercise.
- Trial name
- SAUNA-HFpEF (NCT06978868)
- Testing
- Sauna Intervention in Clinically Stable Outpatients with HFpEF
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Otto-von-Guericke University Magdeburg
Acute Heart Failure
Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.
The purpose of this study was to assess the effect of in-hospital initiation of sacubitril/valsartan (LCZ696) vs. enalapril on time averaged proportional change in NT-proBNP in patients who have been stabilized following…
- Trial name
- PIONEER-HF (NCT02554890)
- Testing
- sacubitril/valsartan (LCZ696), Enalapril
- Where
- 123 sites in United States
- Volunteers
- 887 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure
Exploring Behavioral Interventions to Improve Heart Failure
The objective of this research is to compare Tai Chi versus Resistance Exercise, Health Education and usual care for changes in cardiac functional capacity measured for ability of the heart to pump by measuring ejection fraction…
- Trial name
- NCT01625819
- Testing
- Tai Chi, Resistance Band, Health Education
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- University of California, San Diego
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