Clinical trials: Congestive Heart Failure, completed
Chronic Kidney Disease Stage 5, Heart Failure
AVF Volume Blood Flow Reduction in HD Patients
Heart failure with preserved / high cardiac output is a well-known syndrome in patients with high-flow arteriovenous fistula (AVF). However, the threshold for classifying an AVF as high-flow is currently undefined.
- Trial name
- NCT06807138
- Where
- Russia
- Volunteers
- 86 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Heart Failure
Levosimendan for Cardiac Patients Undergoing Major Abdominal Cancer Surgeries
The objective of this pilot study is to evaluate the efficacy and safety of preoperative administration of levosimendan in patients with chronic heart failure scheduled for major abdominal cancer surgery assuming the reduction of…
- Trial name
- NCT03557255
- Testing
- Levosimendan, Saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Pediatric Heart Failure
Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LCZ696 Followed by a 52-week, Double-blind Study of LCZ696 Compared With Enalapril in Pediatric Patients With Heart Failure
This study consists of two parts (Part 1 and Part 2). The purpose of Part 1 is to evaluate the way the body absorbs, distributes, metabolizes and removes the drug LCZ696.
- Trial name
- NCT02678312
- Testing
- LCZ696, Enalapril
- Where
- 98 sites in United States, Argentina and 27 more
- Volunteers
- 393 people
- Sponsor
- Novartis Pharmaceuticals
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope with Rising Temperatures: an Observational Study, 2nd Wave
The CLIMATE-II Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-II (NCT06407154)
- Where
- Germany
- Volunteers
- 578 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Heart Failure With Reduced Ejection Fraction, Chronic Heart Failure
Emulation of the EMPEROR-Reduced Trial Using Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials.
- Trial name
- NCT07599345
- Testing
- Empagliflozin, Sitagliptin
- Where
- United States
- Volunteers
- 23,955 people
- Sponsor
- Brigham and Women's Hospital
Heart Failure With Preserved Ejection Fraction
The Relationship Between Epicardial Fat Tissue and Cardiac Function in HFpEF Patients
Heart failure with preserved ejection fraction (HFpEF) refers to a group of symptoms and signs of heart failure, normal or near-normal left ventricular systolic function (EF>50%), and ventricular muscle diastolic dysfunction and…
- Trial name
- NCT05068934
- Where
- China
- Volunteers
- 1,083 people
- Sponsor
- Dongying Zhang
Heart Failure
Safety and Efficacy of the Combination of Loop With Thiazide-type Diuretics in Patients With Decompensated Heart Failure
The purpose of this study is to determine whether a combined diuretic therapy (loop diuretics with thiazide-type diuretics) is more effective (in terms of improving fluid overload symptoms) among patients with decompensated heart…
- Trial name
- CLOROTIC (NCT01647932)
- Testing
- hydrochlorothiazide
- Where
- Spain
- Volunteers
- 232 people
- Sponsor
- Spanish Society of Internal Medicine
Heart Failure With Reduced Ejection Fraction
EVOlocumab in Stable Heart Failure With Reduced Ejection Fraction of Ischemic Etiology: EVO-HF Pilot
Evolocumab has been able to reduce the incidence of cardiovascular events in patients that had at least one cardiovascular risk factor [28].
- Trial name
- EVO-HF (NCT03791593)
- Testing
- Evolocumab
- Where
- 3 sites in Spain
- Volunteers
- 46 people
- Sponsor
- Fundació Institut Germans Trias i Pujol
Heart Failure
Impact of a Novel Heart Failure Medication Decision Aid
A modified Zelen design randomised controlled trial over 6 months period is designed to investigate the influence of a heart failure medication decision aid prior to clinic session on shared decision making and its long term…
- Trial name
- NCT06247371
- Testing
- Decision aid
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National University of Singapore
Cardiovascular Diseases, Heart Diseases
Heart Failure in the Community
To monitor trends in congestive heart failure in Olmsted County, Minnesota.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Heart Failure, Coronary Disease
- Trial name
- NCT00053534
- Sponsor
- Mayo Clinic
Congestive Heart Failure
Remote Monitoring of Patients With CHF in Central Greece
The purpose of this study is to evaluate whether telemonitoring of patients with chronic heart failure produces a reduction in the combined end point of all cause mortality and number of hospitalisations, and whether it improves…
- Trial name
- RHCluster7GR (NCT01503463)
- Testing
- Home telemonitoring of patients with CHF
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Regional Health Authority of Sterea & Thessaly
Congestive Heart Failure
Phase I Study of OPC-61815
To investigate the effects of intravenous administration of OPC-61815 at 16 and 32 mg on QT/QTc interval in healthy male subjects
- Trial name
- NCT03510663
- Testing
- OPC-61815 16mg, OPC-61815 32mg, Moxifloxacin
- Where
- Japan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Heart Failure
Strategic Management to Optimize Response To Cardiac Resynchronization Therapy
The primary objective is to evaluate the benefit of the SmartDelay™ algorithm in patients with a prolonged RV-LV interval.
- Trial name
- SMART CRT (NCT03089281)
- Testing
- CRT-D
- Where
- 72 sites in United States, Canada and 9 more
- Volunteers
- 699 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Heart Failure
EntrestoTM (LCZ696) In Advanced Heart Failure (LIFE Study)
The primary objective of the study is to determine whether, in patients with symptomatic, advanced heart failure due to left ventricular systolic dysfunction, treatment with LCZ696 for 24 weeks will improve Pro-B-type Natriuretic…
- Trial name
- HFN-LIFE (NCT02816736)
- Testing
- LCZ696, valsartan
- Where
- 38 sites in United States
- Volunteers
- 365 people
- Sponsor
- Duke University
Chronic Disease, Frail
Functional Exercise and Nutrition Education Program for Older Adults
There is strong evidence that specific types of exercise can improve health and physical function in older adults. While community exercise classes exist, many older adults with chronic conditions may need guidance from…
- Conditions
- Chronic Disease, Frail, Diabetes Mellitus, Cancer
- Trial name
- MoveStrong (NCT04037436)
- Testing
- Strength and Balance Training & Nutrition Education, Usual Care
- Where
- 5 sites in Canada
- Volunteers
- 44 people
- Sponsor
- University of Waterloo
Renal Insufficiency, Congestive Heart Failure
Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency
The purpose of the current study is to assess the safety and tolerability of intravenous tonapofylline.
- Trial name
- TRIDENT-1 (NCT00709865)
- Testing
- tonapofylline
- Where
- 189 sites in United States, Argentina and 16 more
- Volunteers
- 420 people
- Sponsor
- Biogen
Heart Failure
Resistance Exercise Program and Branched Chain Amino Acid Supplementation in Heart Failure Patients
Heart Failure (HF) is a complex syndrome which can include the physiological, neural hormonal and metabolic complications known as "Cardiac Cachexia" (CC).
- Trial name
- NCT02240511
- Testing
- RE and BCAA Supplementation, Resistance Exercise
- Where
- Mexico
- Volunteers
- 66 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
ANOCA - Angina With Non-obstructive Coronary Arteries, HFpEF - Heart Failure With Preserved Ejection Fraction
Peripheral Microvascular Blood Flow in ANOCA
An observational cross-sectional cohort study investigating whether peripheral endothelial function assessed using Laser speckle contrast analysis and coronary endothelial function measured with invasive coronary function testing…
- Trial name
- NCT05610410
- Testing
- Laser speckle contrast analysis
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Amsterdam UMC, location VUmc
Heart Failure
Cardiac Rehabilitation and Noninvasive Ventilation in Heart Failure
The study aims to demonstrate the efficacy of NIV continuously in cardiac rehabilitation programs, improvement of exercise tolerance, with consequent reflection in functional capacity and quality of life of this population.
- Trial name
- NCT02811146
- Testing
- Bilevel Positive Pressure Airway, Heart rehabilitation
- Where
- 2 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Heart Failure
Monitoring Pulmonary Artery Pressure by Implantable Device Responding to Ultrasonic Signal
The purpose of this study is to evaluate and document appropriate clinical safety and performance of the Remon CHF Implantable Pressure Sensor including the corresponding delivery system, the Remon CHF Home Unit, the Remon CHF…
- Trial name
- PAPIRUSII (NCT00604903)
- Testing
- Implant of Pressure sensor.
- Volunteers
- 42 people
- Sponsor
- Boston Scientific Corporation
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