Clinical trials: Congestive Heart Failure
Heart Failure With Preserved Ejection Fraction (HFpEF)
DevElopMent of Clinical PATHwaYs to the Diagnosis of Heart Failure With Preserved Ejection Fraction
Prevalence of heart failure with preserved ejection fraction (HFpEF) continues to increase in the developed world, likely because of the increasing life expectancy and an increasing number of elderly patients.
- Trial name
- EMPATHY-HF (NCT05792059)
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Heart Failure, Cardiac Implantable Electrical Devices
Seasonal Physical Activity in Patients With Heart Failure With Cardiac Implantable Electronic Devices
The aim of this observational study is to determine the effect of seasonal changes on physical activity levels in heart failure patients with cardiac implantable electronic devices.
- Conditions
- Heart Failure, Cardiac Implantable Electrical Devices, Physical Activities
- Trial name
- CIED (NCT07420088)
- Testing
- follow-up study
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Erol Olcok Corum Training and Research Hospital
Chronic Heart Failure
Telehealth Management in HF Disparity Patients
In the US, racial and ethnic disparities persist, even when income, health insurance and care access are addressed. For example, there is a greater prevalence of chronic heart failure (CHF), higher rates of hospital use and…
- Trial name
- NCT02196922
- Testing
- Telehealth Self Management (TSM), Standard of Care
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Northwell Health
Refractory Heart Failure, Cardiovascular Diseases (CVD)
European Study of the BrioVAD Heart Pump for Advanced Heart Failure
This clinical investigation evaluates the safety and clinical performance of the BrioVAD Left Ventricular Assist System in patients with advanced, refractory left ventricular heart failure who require mechanical circulatory…
- Trial name
- BRIOLIFE (NCT07252531)
- Testing
- LVAD implantation
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- BrioHealth BV
Myocardial Infarction, Percutaneous Transluminal Coronary Angioplasty
Integration of Telemedicine and Home-Based Cardiac Rehabilitation: Feasibility, Efficacy, and Adherence
The aim of this study is to evaluate feasibility, efficacy, and adherence of home-based cardiac rehabilitation with the integration of telemedicine.
- Conditions
- Myocardial Infarction, Percutaneous Transluminal Coronary Angioplasty, Coronary Artery Bypass, Stable Angina
- Trial name
- NCT05972070
- Testing
- ROMTech Portable Connect
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- ROM Technologies, INC
Diabetes, Hypertension
Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence
Socioeconomically disadvantaged populations with multiple chronic conditions have high rates of nonadherence to essential chronic disease medications after hospital discharge.
- Conditions
- Diabetes, Hypertension, High Cholesterol/Hyperlipidemia, Coronary Artery Disease
- Trial name
- MedAAAction (NCT06374277)
- Testing
- Med AAAction intervention
- Where
- 2 sites in United States
- Volunteers
- 388 people
- Sponsor
- University of Tennessee
Chronic Heart Failure
National Heart Failure Registry
A prospective-retrospective observational registry of patients diagnosed with chronic heart failure in the regions of the Russian Federation.
- Trial name
- NCT06683001
- Where
- Russia
- Volunteers
- 20,000 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Heart Failure, Ventricular Tachycardia
Biomarkers in Risk Stratification of Sustainted Ventricular Tachycardia or Electrical Storm After Ablation
Prevalence of HF reaches 1-2% of developed populations, and consequently a significant problem becomes more frequent occurrence of ventricular arrhythmias (VA) - sustained ventricular tachycardia (sVT) and electrical storm (ES)…
- Conditions
- Heart Failure, Ventricular Tachycardia, Ventricular Dysfunction
- Trial name
- STORM (NCT02784912)
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Heart Diseases, Heart Failure
Global Utilization And Registry Database for Improved heArt preservatioN
The primary objective of this study is to collect real-world clinical performance data to assess the clinical outcomes of patients receiving heart transplants using donor hearts transported via the SherpaPak CTS System.
- Conditions
- Heart Diseases, Heart Failure, Heart Defects, Congenital
- Trial name
- GUARDIAN (NCT04141605)
- Testing
- SherpaPak Cardiac Transport System
- Where
- 22 sites in United States, Austria and 2 more
- Volunteers
- 4,000 people
- Sponsor
- Paragonix Technologies
Heart Failure With Preserved Ejection Fraction (HFpEF)
UK Heart Failure With Preserved Ejection Fraction
Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness.
- Trial name
- UK HFpEF (NCT05441839)
- Where
- 26 sites in United Kingdom
- Volunteers
- 10,000 people
- Sponsor
- Manchester University NHS Foundation Trust
Heart Failure, Overactive Bladder
Effect of Extended Release Torsemide in Patients With Congestive Heart Failure and Overactive Bladder
This research study is being done to compare the effectiveness two drugs: an Extended Release Torsemide (ERT) versus generic Immediate Release Torsemide (IRT) in reducing the worsening of symptoms of Overactive Bladder (OAB…
- Conditions
- Heart Failure, Overactive Bladder, Incontinence
- Trial name
- NCT06206512
- Testing
- Extended release torsemide, Immediate release torsemide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Sarfez Pharmaceuticals, Inc.
Acute Heart Failure
Early and Comprehensive Care Bundle in Elderly for Acute Heart Failure: a Stepped Wedge Cluster Randomized Trial
This is a prospective multicentre (N=15), stepped-wedge randomized trial that aims to evaluate the benefit of a protocolised comprehensive care bundle for early management of acute heart failure in the ED.
- Trial name
- ELISABETH (NCT03683212)
- Testing
- Early intensive care bundle
- Where
- France
- Volunteers
- 503 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiogenic Shock
Cardiogenic Shock Working Group Registry
The Cardiogenic Shock Working Group is a multicenter registry where we collect de-identified clinical variables from the medical records and follow-up phone calls of shock patients from multiple institutions and centralize this…
- Trial name
- CSWG (NCT04682483)
- Testing
- Vasopressor, Inotrope, Acute Mechanical Circulatory Support Devices
- Where
- 16 sites in United States
- Volunteers
- 20,000 people
- Sponsor
- Tufts Medical Center
Heart Failure
Ambulatory Heart Failure Service Model Study
The aim of the study is to assess the efficacy of this new ambulatory service model in reducing heart failure hospitalization (HHF), improving clinical as well as functional outcomes of post-discharge patients with Heart Failure…
- Trial name
- REDUCE-HF (NCT05556031)
- Testing
- Standard care
- Where
- Hong Kong
- Volunteers
- 500 people
- Sponsor
- Chinese University of Hong Kong
Chronic Heart Failure
Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) Trial
To determine the effect of hawthorn extract 450 mg bid vs. placebo, in addition to standard medical therapy in ambulatory patients with NYHA class II to IV chronic heart failure on submaximal exercise as measured by the 6-minute…
- Trial name
- NCT00343902
- Testing
- Crataegus Special Extract WS 1442
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Congestive Heart Failure, Cancer
Team-based Versus Primary Care Clinician-led Advance Care Planning in Practice-based Research Networks
This project compares two models of the Serious Illness Care Program (SICP) in primary care: clinician-focused SICP and team-based SICP.
- Conditions
- Congestive Heart Failure, Cancer, Chronic Obstructive Pulmonary Disease, Cerebrovascular Accident
- Trial name
- NCT03577002
- Testing
- Serious Illness Care Program (SICP)
- Where
- 7 sites in United States, Canada
- Volunteers
- 1,120 people
- Sponsor
- Oregon Health and Science University
Polymorphic Ventricular Tachycardia, Heart Failure
Radiofrequency Ablation for Polymorphic Ventricular Tachycardia With Heart Failure (RFCA for PMVT-HF)
This is a prospective, randomized, controlled trial to investigate the efficacy of radiofrequency catheter ablation (RFCA) combined with guideline-directed medical therapy (GDMT) compared to GDMT alone in patients with…
- Trial name
- NCT07130175
- Testing
- Radiofrequency Catheter Ablation, Guideline-Directed Medical Therapy (GDMT)
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Qian Feng
Cardiovascular Diseases, Heart Diseases
Maintenance of Physical Activity After Cardiac Rehabilitation
Physical activity is a key element in cardiac rehabilitation and prevention of cardiovascular mortality and hospitalizations. After cardiac rehabilitation programs end, physical activity levels and participation in continued…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Ischemia, Heart Failure
- Trial name
- FAIR (NCT05011994)
- Testing
- Maintenance intervention
- Where
- 3 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- Slagelse Hospital
Heart Failure
Interleukin-1 Receptor Antagonist for the Treatment of Heart Failure in Patients With Left Ventricular Assist Devices
Heart failure remains a major cause of morbidity and mortality. Many patients with heart failure receive support from a left ventricular assist device (LVAD) at some point in the course of their disease.
- Trial name
- NCT02547766
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Utah
Arrhythmias, Cardiac, Heart Failure, Systolic
Reasons for Variations in Health Related Quality of Life and Symptom Burden in Patients With Atrial Fibrillation
Atrial fibrillation is the most common cardiac arrhythmia. There is a large variation in symptoms; from almost none to severe but the reason for this is unclear.
- Conditions
- Arrhythmias, Cardiac, Heart Failure, Systolic, Atrial Fibrillation
- Trial name
- SMURF (NCT01553045)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- University Hospital, Linkoeping