Clinical trials: Congestive Heart Failure, completed
Modified Release Oral Formulation, Left Ventricular Systolic Dysfunction
COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure
The primary objectives of this study are (i) to select an oral modified release (MR) formulation and dose of omecamtiv mecarbil for chronic twice daily (BID) dosing in adults with heart failure and left ventricular systolic…
- Conditions
- Modified Release Oral Formulation, Left Ventricular Systolic Dysfunction, Chronic Heart Failure, History of Chronic Heart Failure
- Trial name
- COSMIC-HF (NCT01786512)
- Testing
- Omecamtiv Mecarbil Matrix F1 Formulation, Omecamtiv Mecarbil Matrix F2 Formulation, Omecamtiv Mecarbil Swellable Core Technology F2
- Where
- 101 sites in United States, Australia and 11 more
- Volunteers
- 544 people
- Sponsor
- Cytokinetics
Heart Failure
Comparative Study of Cardiac Adrenergic Function Explored by I-123-MIBG and CZT Camera (D-SPECT) Versus Anger Camera in Patients With Heart Failure
Cardiological examination constitute one of the major directions in nuclear medicine for detection of myocardial ischemia in patients suspected of coronary disease.
- Trial name
- ADRECARD (NCT02515812)
- Testing
- I-123-MIBG, CZT Camera (D-SPECT), Anger Camera
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Caen
Fetal Heart Failure (Disorder)
The Relationship Between Fetal Baseline Heart-rate and the Level of Acetyl-choline Esterase in Fetal Blood
Pregnant women between 32-41 weeks' gestation designated for either vaginal birth or cesarean section will be recruited for the study.
- Trial name
- NCT03478267
- Testing
- AChE levels
- Where
- Israel
- Volunteers
- 101 people
- Sponsor
- Rambam Health Care Campus
Heart Failure
Attain Model 4196 Left Ventricular (LV) Lead
Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes.
- Trial name
- NCT00271544
- Testing
- Pacing Lead
- Where
- 24 sites in United States, Canada
- Volunteers
- 190 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
COVID-19 Pandemic, Pulmonary Disease, Chronic Obstructive
COVID-19, Patients' Evolution and the Influence of the Pandemic on Health Care and Outcomes in Chronic Diseases
Objectives: 1.- To evaluate the changes in health care and use of services in patients with chronic diseases such as chronic obstructive pulmonary disease (COPD), heart failure and major depression between 2017-2019 and the years…
- Conditions
- COVID-19 Pandemic, Pulmonary Disease, Chronic Obstructive, Heart Failure, Congestive, Depressive Symptoms
- Trial name
- NCT05168722
- Testing
- No interventions
- Where
- 5 sites in Spain
- Volunteers
- 2,220 people
- Sponsor
- Hospital Galdakao-Usansolo
Heart Failure, Type 2 Diabetes Mellitus
SGLT2 Inhibition in Combination With Diuretics in Heart Failure
The RECEDE-CHF trial is a single centre phase IV, randomised, double-blind, placebo-controlled, crossover trial conducted in NHS Tayside, Scotland comparing empagliflozin 25mg, to placebo in patients with Type 2 Diabetes and mild…
- Trial name
- RECEDE-CHF (NCT03226457)
- Testing
- Empagliflozin 25mg, Frusemide
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- University of Dundee
Heart Failure With Reduced Ejection Fraction
Factors Associated With Sub - Targeted Therapeutic Dose Of Renin - Angiotensin Blockage Among Chronic Heart Failure With Reduced Ejection Fraction Patients
Objective: To analyze factors associated with Thai heart failure with reduced ejection fraction patients who received sub-target doses of Angiotensin converting enzyme inhibitors (ACEIs), angiotensin receptor-neprilysin…
- Trial name
- NCT06382571
- Testing
- Renin-Angiotensin System Inhibitor
- Volunteers
- 396 people
- Sponsor
- Chulalongkorn University
Heart Failure
Impact of a Psychological Biofeedback-Relaxation Intervention on Clinical, Physical and Psychological Outcomes in Patients With Heart Failure
The purpose of this study is to determine the effect of biofeedback-relaxation combined with cognitive behavioral therapy on clinical, physical and psychological outcomes in patients with heart failure.
- Trial name
- NCT00255931
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- University of Kentucky
Heart Failure, Endothelium
Effect of Urocortins in Patients With Heart Failure
Despite modern advances in treatment, heart failure continues to carry a poor prognosis with high morbidity and mortality rates.
- Trial name
- NCT01599728
- Testing
- Urocortin 2, Urocortin 3 and Substance P
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Heart Failure
Pharmacokinetics Study of AMG 423 in Healthy Subjects and Subjects With Various Degrees of Renal Insufficiency
A phase 1, open-label study in subjects with normal renal function and subjects with various degrees of renal insufficiency, including patients with end-stage renal disease (ESRD) requiring hemodialysis.
- Trial name
- NCT01737866
- Testing
- AMG 423
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Cytokinetics
Heart-Assist Devices, Heart Failure
Individual Blood Pressure Optimization Based on Cerebral Autoregulation After Implantation of Continuous-flow LVAD
This study will collect retrospective and prospective clinical data regarding the Principal Investigator's patient population to allow for data analysis seeking basic trends and to prepare academic reports, including journal…
- Trial name
- NIRS (NCT03093012)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Baylor College of Medicine
Acute Heart Failure, Chronic Kidney Diseases
Empagliflozin in Acute Heart Failure
The objective is to study in a prospective, interventional, single arm, cohort study the potential synergistic diuretic effect of empagliflozin, in addition to furosemide, in hypervolemic patients admitted with acutely…
- Trial name
- DRIP-AHF-1 (NCT05305495)
- Testing
- Empagliflozin 25 MG
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Diabetes Mellitus, Heart Failure
Mobile Health Behavioral Intervention in Patients With Heart Failure and Diabetes Mellitus
The overall objective of this study is to test a personalized mHealth intervention designed to increase physical activity and improve medication adherence in subjects with heart failure and diabetes mellitus.
- Trial name
- TARGET-HFDM (NCT02918175)
- Testing
- mHealth
- Where
- 6 sites in United States
- Volunteers
- 187 people
- Sponsor
- Duke University
Heart Failure, Cognitive Dysfunction
COgnitive Intervention to Restore Attention Using Nature Environment
Heart failure is a prevalent and serious public health concern with the growing aging population. Patients with heart failure often experience attention impairment that decreases their ability to perform self-care and diminishes…
- Trial name
- CORE (NCT04485507)
- Testing
- Nature-VR, Urban-VR
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Indiana University
Heart Failure, ICD
Guideline-Directed Medical Therapy in Patients After Implantation of Implantable Cardioverter Defibrillators to Improve Long-Term Outcomes
Guideline-directed medical therapy (GDMT) and the mortality benefit it provides in the heart failure with reduced ejection fraction (HFrEF) population are well-established by multiple professional society guidelines.
- Trial name
- NCT04505007
- Testing
- Specialized heart function clinic
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Ratika Parkash
Heart Failure
Home Based Intervention Led by Nurse in Brazil
Home visits (HV) are one of the multidisciplinary approaches that has already shown to benefit the follow-up of Heart Failure (HF) patients.
- Trial name
- HFHELENI (NCT01213862)
- Testing
- Home Based Education
- Volunteers
- 200 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Heart Failure, Congestive
FUSION I Assesses Safety and Tolerability of Two Doses of NATRECOR (Nesiritide) Administered to Patients With Worsening Congestive (Decompensated) Heart Failure Who Are Concurrently Receiving Their Usual Cardiac Medications and Are at High Risk for Hospitalization.
The purpose of this study is to assess the safety and tolerability of two doses of nesiritide (a recombinant form of the natural human peptide normally secreted by the heart in response to heart failure) when administered…
- Trial name
- NCT00270361
- Testing
- nesiritide, usual long term cardiac medications
- Volunteers
- 214 people
- Sponsor
- Scios, Inc.
Heart Failure
Pilot Study on Withdrawal of Spironolactone Among Heart Failure With Improved Ejection Fraction
The study is a randomized controlled pilot trial to evaluate whether withdrawal of spironolactone is safe and associated with re-deterioration of left ventricular function in patients with heart failure with improved ejection…
- Trial name
- NCT04367051
- Testing
- Withdrawal of Spironolactone, Continuation of spironolactone
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Asan Medical Center
Heart Failure, Iron Deficiency Anemia
Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure
Intravenous iron replacement has been shown to benefit patients with heart failure and iron deficiency, but the weekly outpatient regimens studied to date are impractical for many patients.
- Trial name
- NCT01925703
- Testing
- Sodium ferric gluconate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of North Carolina, Chapel Hill
Heart Failure, Ventricular Dysfunction
Wireless Stimulation Endocardially for Cardiac Resynchronization Therapy
The WiCS-LV system is an alternative means to providing left ventricular stimulation for Cardiac Resynchronization Therapy (CRT).
- Conditions
- Heart Failure, Ventricular Dysfunction, Cardiomyopathy
- Trial name
- WiSE-CRT (NCT01294527)
- Testing
- Wireless cardiac stimulator implant to pace the left ventricle for CRT
- Where
- 10 sites in France, Germany and 2 more
- Volunteers
- 17 people
- Sponsor
- EBR Systems, Inc.